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TY - JOUR AU - Polavarapu, Nalini AU - Mariño-Ramírez, Leonardo AU - Landsman, David AU - McDonald, John F. AU - Jordan, I. King PY - 2008 DA - 2008/05/17 TI - Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA JO - BMC Genomics SP - 226 VL - 9 IS - 1 AB - The majority of human non-protein-coding DNA is made up of repetitive sequences, mainly transposable elements (TEs). It is becoming increasingly apparent that many of these repetitive DNA sequence elements encode gene regulatory functions. This fact has important evolutionary implications, since repetitive DNA is the most dynamic part of the genome. We set out to assess the evolutionary rate and pattern of experimentally characterized human transcription factor binding sites (TFBS) that are derived from repetitive versus non-repetitive DNA to test whether repeat-derived TFBS are in fact rapidly evolving. We also evaluated the position-specific patterns of variation among TFBS to look for signs of functional constraint on TFBS derived from repetitive and non-repetitive DNA. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-9-226 DO - 10.1186/1471-2164-9-226 ID - Polavarapu2008 ER -