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TY - JOUR AU - Liu, Que AU - Adams, Lisa AU - Broyde, Anatoly AU - Fernandez, Rayne AU - Baron, Alain D. AU - Parkes, David G. PY - 2010 DA - 2010/08/03 TI - The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats JO - Cardiovascular Diabetology SP - 32 VL - 9 IS - 1 AB - Activation of glucagon-like peptide-1 (GLP-1) receptors improves insulin sensitivity and induces vasodilatation and diuresis. AC3174 is a peptide analogue with pharmacologic properties similar to the GLP-1 receptor agonist, exenatide. Hypothetically, chronic AC3174 treatment could attenuate salt-induced hypertension, cardiac morbidity, insulin resistance, and renal dysfunction in Dahl salt-sensitive (DSS) rats. SN - 1475-2840 UR - https://doi.org/10.1186/1475-2840-9-32 DO - 10.1186/1475-2840-9-32 ID - Liu2010 ER -