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TY - JOUR AU - Das, Pritam AU - Smithson, Lisa A. AU - Price, Robert W. AU - Holloway, Vallie M. AU - Levites, Yona AU - Chakrabarty, Paramita AU - Golde, Todd E. PY - 2006 DA - 2006/07/26 TI - Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Aβ immunotherapy JO - Journal of Neuroinflammation SP - 17 VL - 3 IS - 1 AB - Microglial activation has been proposed to facilitate clearance of amyloid β protein (Aβ) from the brain following Aβ immunotherapy in amyloid precursor protein (APP) transgenic mice. Interleukin-1 receptor 1 knockout (IL-1 R1-/-) mice are reported to exhibit blunted inflammatory responses to injury. To further define the role of IL-1-mediated inflammatory responses and microglial activation in this paradigm, we examined the efficacy of passive Aβ immunotherapy in Tg2576 mice crossed into the IL-1 R1-/- background. In addition, we examined if loss of IL-1 R1-/- modifies Aβ deposition in the absence of additional manipulations. SN - 1742-2094 UR - https://doi.org/10.1186/1742-2094-3-17 DO - 10.1186/1742-2094-3-17 ID - Das2006 ER -