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TY - JOUR AU - Kuo, Chih-Horng AU - Ochman, Howard PY - 2009 DA - 2009/09/29 TI - Inferring clocks when lacking rocks: the variable rates of molecular evolution in bacteria JO - Biology Direct SP - 35 VL - 4 IS - 1 AB - Because bacteria do not have a robust fossil record, attempts to infer the timing of events in their evolutionary history requires comparisons of molecular sequences. This use of molecular clocks is based on the assumptions that substitution rates for homologous genes or sites are fairly constant through time and across taxa. Violation of these conditions can lead to erroneous inferences and result in estimates that are off by orders of magnitude. In this study, we examine the consistency of substitution rates among a set of conserved genes in diverse bacterial lineages, and address the questions regarding the validity of molecular dating. SN - 1745-6150 UR - https://doi.org/10.1186/1745-6150-4-35 DO - 10.1186/1745-6150-4-35 ID - Kuo2009 ER -