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TY - JOUR AU - Banerjee, Pratik AU - Merkel, Glenn J. AU - Bhunia, Arun K. PY - 2009 DA - 2009/04/27 TI - Lactobacillus delbrueckii ssp. bulgaricus B-30892 can inhibit cytotoxic effects and adhesion of pathogenic Clostridium difficile to Caco-2 cells JO - Gut Pathogens SP - 8 VL - 1 IS - 1 AB - Probiotic microorganisms are receiving increasing interest for use in the prevention, treatment, or dietary management of certain diseases, including antibiotic-associated diarrhea (AAD). Clostridium difficile is the most common cause of AAD and the resulting C. difficile – mediated infection (CDI), is potentially deadly. C. difficile associated diarrhea (CDAD) is manifested by severe inflammation and colitis, mostly due to the release of two exotoxins by C. difficile causing destruction of epithelial cells in the intestine. The aim of this study was to determine the effect of probiotic bacteria Lactobacillus delbrueckii ssp. bulgaricus B-30892 (LDB B-30892) on C. difficile-mediated cytotoxicity using Caco-2 cells as a model. SN - 1757-4749 UR - https://doi.org/10.1186/1757-4749-1-8 DO - 10.1186/1757-4749-1-8 ID - Banerjee2009 ER -