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TY - JOUR AU - Desiere, Frank AU - Deutsch, Eric W. AU - Nesvizhskii, Alexey I. AU - Mallick, Parag AU - King, Nichole L. AU - Eng, Jimmy K. AU - Aderem, Alan AU - Boyle, Rose AU - Brunner, Erich AU - Donohoe, Samuel AU - Fausto, Nelson AU - Hafen, Ernst AU - Hood, Lee AU - Katze, Michael G. AU - Kennedy, Kathleen A. AU - Kregenow, Floyd AU - Lee, Hookeun AU - Lin, Biaoyang AU - Martin, Dan AU - Ranish, Jeffrey A. AU - Rawlings, David J. AU - Samelson, Lawrence E. AU - Shiio, Yuzuru AU - Watts, Julian D. AU - Wollscheid, Bernd AU - Wright, Michael E. AU - Yan, Wei AU - Yang, Lihong AU - Yi, Eugene C. AU - Zhang, Hui AU - Aebersold, Ruedi PY - 2004 DA - 2004/12/10 TI - Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry JO - Genome Biology SP - R9 VL - 6 IS - 1 AB - A crucial aim upon the completion of the human genome is the verification and functional annotation of all predicted genes and their protein products. Here we describe the mapping of peptides derived from accurate interpretations of protein tandem mass spectrometry (MS) data to eukaryotic genomes and the generation of an expandable resource for integration of data from many diverse proteomics experiments. Furthermore, we demonstrate that peptide identifications obtained from high-throughput proteomics can be integrated on a large scale with the human genome. This resource could serve as an expandable repository for MS-derived proteome information. SN - 1474-760X UR - https://doi.org/10.1186/gb-2004-6-1-r9 DO - 10.1186/gb-2004-6-1-r9 ID - Desiere2004 ER -