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TY - JOUR AU - Zmasek, Christian M. AU - Zhang, Qing AU - Ye, Yuzhen AU - Godzik, Adam PY - 2007 DA - 2007/10/24 TI - Surprising complexity of the ancestral apoptosis network JO - Genome Biology SP - R226 VL - 8 IS - 10 AB - Apoptosis, one of the main types of programmed cell death, is regulated and performed by a complex protein network. Studies in model organisms, mostly in the nematode Caenorhabditis elegans, identified a relatively simple apoptotic network consisting of only a few proteins. However, analysis of several recently sequenced invertebrate genomes, ranging from the cnidarian sea anemone Nematostella vectensis, representing one of the morphologically simplest metazoans, to the deuterostomes sea urchin and amphioxus, contradicts the current paradigm of a simple ancestral network that expanded in vertebrates. SN - 1474-760X UR - https://doi.org/10.1186/gb-2007-8-10-r226 DO - 10.1186/gb-2007-8-10-r226 ID - Zmasek2007 ER -