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TY - JOUR AU - Marques, Ana C. AU - Ponting, Chris P. PY - 2009 DA - 2009/11/06 TI - Catalogues of mammalian long noncoding RNAs: modest conservation and incompleteness JO - Genome Biology SP - R124 VL - 10 IS - 11 AB - Despite increasing interest in the noncoding fraction of transcriptomes, the number, species-conservation and functions, if any, of many non-protein-coding transcripts remain to be discovered. Two extensive long intergenic noncoding RNA (ncRNA) transcript catalogues are now available for mouse: over 3,000 macroRNAs identified by cDNA sequencing, and 1,600 long intergenic noncoding RNA (lincRNA) intervals that are predicted from chromatin-state maps. Previously we showed that macroRNAs tend to be more highly conserved than putatively neutral sequence, although only 5% of bases are predicted as constrained. By contrast, over a thousand lincRNAs were reported as being highly conserved. This apparent difference may account for the surprisingly small fraction (11%) of transcripts that are represented in both catalogues. Here we sought to resolve the reported discrepancy between the evolutionary rates for these two sets. SN - 1474-760X UR - https://doi.org/10.1186/gb-2009-10-11-r124 DO - 10.1186/gb-2009-10-11-r124 ID - Marques2009 ER -