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TY - CHAP AU - Tessarollo, Lino ED - Tymms, Martin J. ED - Kola, Ismail PY - 2001 DA - 2001// TI - Manipulating Mouse Embryonic Stem Cells BT - Gene Knockout Protocols SP - 47 EP - 63 PB - Humana Press CY - Totowa, NJ AB - In recent years, gene targeting technology has been rapidly evolving and has been used by a number of laboratories to systematically alter the mouse genome and to generate mice with specific targeted gene mutations. The improvement in the quality of reagents (embryonic stem (ES) cells and media) available to the scientific community has made this technology accessible to many laboratories. SN - 978-1-59259-220-3 UR - https://doi.org/10.1385/1-59259-220-1:47 DO - 10.1385/1-59259-220-1:47 ID - Tessarollo2001 ER -