Update on Membranoproliferative GN : Clinical Journal of the American Society of Nephrology (original) (raw)
Moving Points in Nephrology
Update on Membranoproliferative GN
*Division of Nephrology, Winthrop University Hospital, Mineola, New York; and
†Division of Kidney Diseases and Hypertension, Hofstra North Shore–Long Island Jewish School of Medicine, Great Neck, New York
Correspondence: Dr. Naveed Masani, Division of Nephrology, Winthrop University Hospital, 200 Old Country Road, Suite 135, Mineola, NY 11590. Email: [email protected]
Clinical Journal of the American Society of Nephrology 9(3):p 600-608, March 2014. | DOI: 10.2215/CJN.06410613
Abstract
Membranoproliferative GN represents a pattern of injury seen on light microscopy. Historically, findings on electron microscopy have been used to further subclassify this pathologic entity. Recent advances in understanding of the underlying pathobiology have led to a proposed classification scheme based on immunofluorescence findings. Dysregulation of the complement system has been shown to be a major risk factor for the development of a membranoproliferative GN pattern of injury on kidney biopsy. Evaluation and treatment of this complex disorder rest on defining the underlying mechanisms.
Copyright © 2014 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.
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