Clara Joseph | University of Nice Sophia Antipolis, Nice, France (original) (raw)

Papers by Clara Joseph

Quintessence international (Berlin, Germany : 1985), Oct 11, 2022

European Journal of Dental Education

Journal of the American Academy of Dermatology, 2021

International Journal of Paediatric Dentistry, 2020

The study aimed to compare the efficacy of three caries removal techniquescomplete caries removal... more The study aimed to compare the efficacy of three caries removal techniquescomplete caries removal (CCR), selective caries removal (SCR) and stepwise caries removal (SWR)for deep carious lesions in vital temporary teeth by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs). Electronic databases (PubMed MEDLINE, Cochrane Library, EMBASE) were searched for corresponding references up to 31 May 2019. Possible outcomes were pulp exposure, pulpo-periodontal complications or restorative failures. Three reviewers independently selected studies, extracted data, and assessed the risk of bias using RoB 2. Meta-analyses for intention-to-treat and per-protocol scenarios were performed using Revman5. Of 1374 potentially eligible articles, ten relevant references corresponding to eight studies were included. Pooled results showed decreased risk of pulp exposure after SCR (OR: 0.10, 95%CI [0.04, 0.25]) or SWR (OR: 0.20, 95%CI [0.09, 0.44]), compared with CCR. There was a higher risk of composite restorative failure (OR: 2.61, 95%CI [1.05, 6.49]) using USPHS criteria, after SCR compared with CCR only in intention-to-treat analysis. Risk of clinical or radiographic failure of pulpoperiodontal complications was unchanged when compared with SCR and CCR or SWR. SCR and SWR may result in lower pulp exposure risk than CCR. RCTs with lower risk of bias, higher power and longer follow-up are required to choose between these three caries removal techniques for deep carious lesions in vital temporary teeth. Accepted Article This article is protected by copyright. All rights reserved Caries removal strategies for deep carious lesions in primary teeth: systematic review In vital teeth diagnosed with deep carious lesions, the priorities of cavity preparation are preservation of healthy and mineralisable tissue, achieving a restorative seal, maintaining pulpal health, and maximising restorative success (1). If selective carious tissue removal is recommended in permanent teeth, supported by evidence drawn from clinical studies (2-5), recommendations are proposed by extension for primary teeth because there is little literature comparing caries removal techniques in such teeth (6-8): complete caries removal (CCR or non-selective caries removal to hard dentine: excavation to hard dentine in the entire cavity), selective caries removal (SCR: excavation method by which carious dentine is removed from the peripheral walls of a deep cavitated caries lesion, followed by partial removal of soft dentine from the pulpal wall), and stepwise caries removal (SWR: caries excavation in two steps with a time interval between the steps, to stimulate mineral deposition in the dentine prior to final excavation; the first step is partial caries excavation followed by additional caries removal to firm dentine at a later date) (1,9). Since, two

Oral health & preventive dentistry, 2018

Inadequate gingival thickness (GT) may lead to gingival recession. Thus, early identification of ... more Inadequate gingival thickness (GT) may lead to gingival recession. Thus, early identification of patients/teeth at risk would be advantageous. In adults, the probe's visibility through the marginal gingiva (reference test) has been considered a reliable criterion to describe a thin gingiva. This study aimed to evaluate in children two more convenient methods: the whitening of the attached gingiva with coronal labial traction (GW test) and the visibility of the gingival blood supply (BS test). In 69 children, the GT of primary and/or permanent central and lateral incisors, first primary molars and/or first premolars was assessed with the three tests. The sensitivity and specificity of the GW and BS tests and their odds ratio with probing were calculated. According to probing, 39% of children in the studied population had thin gingiva. The GW and BS tests reported different percentages of GT compared to probing, except for primary teeth, maxillary permanent incisors and mandibular...

European Archives of Paediatric Dentistry, 2017

Aim To assess the validity and reliability of a recent light fluorescence device, Soprolife Ò (So... more Aim To assess the validity and reliability of a recent light fluorescence device, Soprolife Ò (Sopro-Acteon group) in detecting occlusal caries in children and adolescents and to compare its diagnostic performance with DIAGNOPen Ò (Kavo). Methods A multi-centre study was carried out to validate Soprolife Ò in 103 children, aged from 5-15 years, on 310 primary and 433 permanent posterior teeth. The sensitivity (SE), specificity (SP) and the area under the Receiver Operating Characteristic (ROC) curve (AUC) were evaluated using visual International Caries Detection and Assessment System (ICDAS) and radiographic examinations as the gold standards. The performance of the Soprolife Ò was compared with that of the DIAGNOPen Ò on the same teeth. The reproducibility was assessed using weighted Kappa coefficient. Results When all carious lesions using ICDAS 1-6 were considered, SE, SP and AUC for the Soprolife Ò were 88.50, 70.73 and 0.84 respectively. The validity was significantly higher for primary teeth (AUC = 0.90) than for permanent teeth (0.80); the validity of the Soprolife Ò (0.84) was significantly higher than that of DIAGNOPen Ò (0.80). The inter-and intra-examiner kappa coefficients were 0.87 and 0.85 respectively. Conclusion The Soprolife Ò was a valid instrument providing reproducible results, particularly for primary teeth.

Objectives: Following the request of the HAS (haute Autorit de Sant) in the guidelines to assess ... more Objectives: Following the request of the HAS (haute Autorit de Sant) in the guidelines to assess individual caries risk (http://www.has-sante.fr), on an evidence based dentistry methodology, a cross sectional study was firstly carried out to identify caries risk factors in a French population of school children. Methods: After sample size calculation, 341 schoolchildren aged 6-7 y.o. (164 boys and 177 girls) were examined in 7 randomized schools of PACA (Provence Alpes Cote d'Azur) region, France. Dental caries (following the OMS criteria), dmft, DMFT, fluorosis (Dean index) and oral hygiene (Le & Silness index) were recorded. So were used salivary test (Test Cario analyse- Pierre Fabre) to determine buffer capacity and the levels of Streptococcus mutans (SM) and Lactobacillus in the saliva. The children's parents completed a questionnaire concerning socioeconomic level and caries history. Others questions concerned the child, his dietary and oral hygiene habits, and these o...

Rfop Revue Francophone D Odontologie Pediatrique, 2010

Rfop Revue Francophone D Odontologie Pediatrique, 2012

Journal, 2008

Over the past 4 years, numerous cases of osteonecrosis of the jaw in patients treated with bispho... more Over the past 4 years, numerous cases of osteonecrosis of the jaw in patients treated with bisphosphonates have been reported. Since 1998, children and adolescents with osteogenesis imperfecta have received bisphosphonates to increase their bone density and reduce the incidence of bone fractures. The results have been convincing, but recent reports of osteonecrosis of the jaw have caused great concern when these patients require dental extractions. The dental records of 15 children and adolescents with osteogenesis imperfecta, involving 60 dental extractions, mostly of primary teeth, done between 2001 and 2006, were reviewed. All patients but one had had or were having bisphosphonate treatment at the time of the extractions. No patient developed osteonecrosis. Further studies and data that allow clinicians to design adequate and safe treatment plans for this unique population are needed.

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Journal of Medical Genetics, 2015

Orodental diseases include several clinically and genetically heterogeneous disorders that can pr... more Orodental diseases include several clinically and genetically heterogeneous disorders that can present in isolation or as part of a genetic syndrome. Due to the vast number of genes implicated in these disorders, establishing a molecular diagnosis can be challenging. We aimed to develop a targeted next-generation sequencing (NGS) assay to diagnose mutations and potentially identify novel genes mutated in this group of disorders. We designed an NGS gene panel that targets 585 known and candidate genes in orodental disease. We screened a cohort of 101 unrelated patients without a molecular diagnosis referred to the Reference Centre for Oro-Dental Manifestations of Rare Diseases, Strasbourg, France, for a variety of orodental disorders including isolated and syndromic amelogenesis imperfecta (AI), isolated and syndromic selective tooth agenesis (STHAG), isolated and syndromic dentinogenesis imperfecta, isolated dentin dysplasia, otodental dysplasia and primary failure of tooth eruption. We discovered 21 novel pathogenic variants and identified the causative mutation in 39 unrelated patients in known genes (overall diagnostic rate: 39%). Among the largest subcohorts of patients with isolated AI (50 unrelated patients) and isolated STHAG (21 unrelated patients), we had a definitive diagnosis in 14 (27%) and 15 cases (71%), respectively. Surprisingly, COL17A1 mutations accounted for the majority of autosomal-dominant AI cases. We have developed a novel targeted NGS assay for the efficient molecular diagnosis of a wide variety of orodental diseases. Furthermore, our panel will contribute to better understanding the contribution of these genes to orodental disease. NCT01746121 and NCT02397824.

Objective: In France, the prevalence of tooth wear has only been studied on buccal and lingual su... more Objective: In France, the prevalence of tooth wear has only been studied on buccal and lingual surfaces in young adults (Bartlett et al, 2013).The aim of this descriptive study was to assess the prevalence of tooth erosion in a sample of French adolescents considered as an at-risk population and to identify related risk factors. Method: A stratified sample of 339 adolescents, aged from 12 to 16 years, was observed in AM (Alpes Maritimes, France) by one trained examiner. Lesions were scored using the basic erosive wear examination (BEWE) index whereas risk factors were looked for, with a previously validated questionnaire. Each subject obtained a total BEWE score recorded using all scoreable surfaces of permanent teeth. Multivaried logistic regression analysis assessed the tooth erosion in relation to a range of demographic, dietary and oral care variables. Result: The highest total BEWE score (cumulative score of all sextants) in our study reached 9-13 (medium risk level) for only o...

Odonto-stomatologie tropicale = Tropical dental journal, 2012

Evaluation of caries status has changed with emergence of modified ways of managing the condition... more Evaluation of caries status has changed with emergence of modified ways of managing the condition. There is a need to assess the relationship between the old and new methods of registering caries. To identify the ICDAS II codes to be used to record the D-component of the DMF index as defined in the WHO Basic Methods, 1997 publication. A review of literature published between January 2002 and January 2012 was undertaken using "ICDAS" as keyword in an electronic search. Only epidemiological studies that used ICDAS II as an evaluation criterion calculated the DMF indices and gave the ICDAS II codes for the diagnosis of caries lesions, were included. Fourteen studies met the inclusion criteria. The DMF designations that corresponded with the WHO definition were D(3-6)MF (10 studies), D(4-6)MF (4 studies) or D(5-6)MF (3 studies). The D-component referred to cavitated carious lesions (7 studies) or dentine caries (7 studies), but there was no consensus on the ICDAS II codes that...

Journal (Canadian Dental Association)

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2000

A case of familial hypophosphatemic vitamin D-resistant rickets or X-linked hypophosphatemia (XLH... more A case of familial hypophosphatemic vitamin D-resistant rickets or X-linked hypophosphatemia (XLH) accompanied by specific systemic and dental findings is reported. A 15-year-old boy with XLH visited our facility complaining of a toothache in the left lower canine region. Two other family members of the patient, his younger sister and their mother, also had XLH, whereas the other 2 members, his younger brother and father, are healthy. Those with XLH show systemic signs of the disease, such as growth retardation, limb deformity, and spinal curvature disorders; however, these symptoms are more severe in the patient than in the others. The patient had multiple periodontal abscesses, but no evidence of dental caries, trauma, or periodontal disease on the corresponding teeth at the time of his oral examination. A radiographic examination showed root dysplasia and enlarged pulp chambers.A histologic examination of an extracted third molar showed marked globular dentin and an increased predentin width. The abscess was thought to be caused by pulpal infection, which came from bacterial invasion through enamel cracks and dentinal microcleavage of the teeth. The treatments provided in this case are discussed.

European Archives of Paediatric Dentistry, 2011

To describe the dental health status of 6-year-old children using the ICDAS-II advanced method an... more To describe the dental health status of 6-year-old children using the ICDAS-II advanced method and to evaluate the association between the known caries risk factors with the cavitated caries lesion (WHO basic method) or with both non-cavitated and cavitated caries lesion caries (ICDAS II). In this cross-sectional study, a questionnaire was used to evaluate oral health and dietary habits of children. A clinical examination and a Cario analysis test (Pierre Fabre Oral care) were performed. Logistic regression analyses were used to assess the association between caries and daily tooth-brushing, dietary habits, visible plaque and salivary factors. There were 341 children (52% female and 6.25+/-0.46 years of age) in this study. Using the ICDAS-II advanced method, 39% of the children were caries-free. This proportion was larger (67.2%) using the WHO method. In multivariate models, visible dental plaque and Streptococcus mutans count were associated with caries experience registered as ICDAS-II codes 1-6 or codes 3-6. The absence of daily tooth-brushing with fluoridated toothpaste was associated only with caries experience ICDAS-II codes 3-6. The use of WHO or ICDAS-II method changed the proportion of caries-free children but not the clinical caries risk factors associated with caries experience.

Archives de Pédiatrie, 2006

Lors de sa consultation, le pédiatre est souvent confronté à des urgences liées à la sphère orofa... more Lors de sa consultation, le pédiatre est souvent confronté à des urgences liées à la sphère orofaciale. Celles-ci peuvent être de plusieurs ordres : un problème infectieux et/ou inflammatoire (caries, abcès), une situation traumatique (chute sur les dents), des lésions sur les muqueuses orales (stomatites).