Abiodun Aborisade | College of the Mainland (original) (raw)

Uploads

Papers by Abiodun Aborisade

Research paper thumbnail of Qualitative Phytochemical Screening of Bologi (Senecio biafrae) and Bitter Leaf (Vernonia amygdalina) Leaves

Chemical Science International Journal, 2017

Research paper thumbnail of Phytochemical and Proximate Analysis of Some Medicinal Leaves

Clinical Medicine Research

Research paper thumbnail of Health risk assessment and heavy metal accumulation in fish species (Clarias gariepinus and Sarotherodon melanotheron) from industrially polluted Ogun and Eleyele Rivers, Nigeria

Research paper thumbnail of Alkaloid and terpenoid fractions from the leaves of Launaea taraxacifolia (Willd.) repressed the proliferation of Plasmodium berghei in mice

Comparative Clinical Pathology, 2020

Research paper thumbnail of Effects of selected aqueous plant extracts on heamatological parameters of Plasmodium berghei infected mice

Cymbopogon citrates leaves, Khaya senagalesis stem bark, Parquetina nigrescens leaves, Psidium gu... more Cymbopogon citrates leaves, Khaya senagalesis stem bark, Parquetina nigrescens leaves, Psidium guajava leaves, Terminalia glaucescens stem bark and Zingiber officinale rhizome are used traditionally to treat malaria. This study evaluate the effects of the aqueous extracts of C. citrates leaves, K. senagalesis stem bark, P. nigrescens leaves, P.guajava, T. glaucescens stem bark and Z. officinale rhizome respectively on the heamatological status of NK 65 Plasmodium berghei (chloroquine sensitive parasite) infected mice. Fourty five (45) albino mice with average weight 25.5 ± 1.45g were randomly grouped into nine (9). Mice in group A serve as control not infected. Groups B, C, D, E, F, G, H and I were inoculated intraperitoneally with P. berghei. Groups C, D, E, F, G, H and I were treated with 5 mg/kg body weight of chloroquine, 200mg/kg body weight of C. citrates, K. senagalesis, P. nigrescens, P. guajava, T. glaucescens and Z. officinale aqueous extracts respectively. On day 5, red blood cell count (RBC), white blood cell count (WBC), packed cell volume, haemoglobin count (Hb), lymphocyte and neutrophil counts were assessed. There were significant (p<0.05) increase in the Hb count, RBC and PCV levels of the extract treated P. berghei infected mice in each group when compared with the untreated P. berghei infected mice. In the extracts treated infected mice, lymphocyte count was significantly (p<0.05) increased with concomitant decrease in neutrophil count. Our Findings show that all the extracts used has anti-anaemic properties and anti-inflammatory potential with extracts of P. nigrescens, P. guajava, T. glaucescens and Z. officinale demonstrating higher potential.

Research paper thumbnail of Evaluation of the Effectiveness of Telfairia occidentalis Leave Extracts in the Amelioration of Carbon Tetrachloride Induced Liver Injuries and Oxidative Damage in Rats

Aims: The study was aimed to investigate the efficacy of Telfairia occidentalis (T. occidentalis)... more Aims: The study was aimed to investigate the efficacy of Telfairia occidentalis (T. occidentalis) extracts in the attenuation of CCl 4-mediated oxidative stress. Place and Duration of Study: Methodology: Twenty-four male wistar albino rats (180-220 g) were divided into four groups (1-4) of six rats each. In group 1 the rats received only water, group 2 received single dose of equal mixture of carbon tetrachloride (CCl 4) and olive oil (50%, v/v, 1.25 mL/kg i.p.), while animals in group 3 and 4 received CCl 4 + 50 mg/kg of T. occidentalis and CCl 4 + 100 mg/kg of T. occidentalis respectively. The antioxidant activity of T. occidentalis was evaluated in vitro using DPPH and ABTS radical scavenging assay. Results: Our results showed that CCl 4 induction elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and thiobarbituric acid reactive substances (TBARS) levels significantly (P<0.05) while activity of superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) were significant (P<0.05) reduced. However, administering T. occidentalis extract at the doses of 50 and 100 mg/kg caused reversal of the effects significantly. T. occidentalis was found to contain high level of total phenolic content (34.65 mg/g in GAE/g dried weight). The implication of these results is that T. occidentalis may be useful in the management of oxidative stress-related organ injuries. Conclusion: The antioxidant and hepatoprotective activities observed in this study could be due to the ability of phenolic compounds constituents of T. occidentalis which are able to absorb, neutralize and quench free radicals.

Research paper thumbnail of Evaluation of the Effectiveness of Telfairia occidentalis Leave Extracts in the Amelioration of Carbon Tetrachloride Induced Liver Injuries and Oxidative Damage in Rats

The study was aimed to investigate the efficacy of Telfairia occidentalis (T. occidentalis) extra... more The study was aimed to investigate the efficacy of Telfairia occidentalis (T. occidentalis) extracts in the attenuation of CCl 4 -mediated oxidative stress. Place and Duration of Study: Methodology: Twenty-four male wistar albino rats (180-220 g) were divided into four groups (1-4) of six rats each. In group 1 the rats received only water, group 2 received single dose of equal mixture of carbon tetrachloride (CCl 4 ) and olive oil (50%, v/v, 1.25 mL/kg i.p.), while animals in group 3 and 4 received CCl 4 + 50 mg/kg of T. occidentalis and CCl 4 + 100 mg/kg of T. occidentalis respectively. The antioxidant activity of T. occidentalis was evaluated in vitro using DPPH and ABTS radical scavenging assay. JAMPS, 10(2): xxx-xxx, 2016; Article no.JAMPS.29199 2 Results: Our results showed that CCl 4 induction elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and thiobarbituric acid reactive substances (TBARS) levels significantly (P<0.05) while activity of superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) were significant (P<0.05) reduced. However, administering T. occidentalis extract at the doses of 50 and 100 mg/kg caused reversal of the effects significantly. T. occidentalis was found to contain high level of total phenolic content (34.65 mg/g in GAE/g dried weight). The implication of these results is that T. occidentalis may be useful in the management of oxidative stress-related organ injuries. Conclusion: The antioxidant and hepatoprotective activities observed in this study could be due to the ability of phenolic compounds constituents of T. occidentalis which are able to absorb, neutralize and quench free radicals.

Research paper thumbnail of Qualitative Phytochemical Screening of Bologi (Senecio biafrae) and Bitter Leaf (Vernonia amygdalina) Leaves

Chemical Science International Journal, 2017

Research paper thumbnail of Phytochemical and Proximate Analysis of Some Medicinal Leaves

Clinical Medicine Research

Research paper thumbnail of Health risk assessment and heavy metal accumulation in fish species (Clarias gariepinus and Sarotherodon melanotheron) from industrially polluted Ogun and Eleyele Rivers, Nigeria

Research paper thumbnail of Alkaloid and terpenoid fractions from the leaves of Launaea taraxacifolia (Willd.) repressed the proliferation of Plasmodium berghei in mice

Comparative Clinical Pathology, 2020

Research paper thumbnail of Effects of selected aqueous plant extracts on heamatological parameters of Plasmodium berghei infected mice

Cymbopogon citrates leaves, Khaya senagalesis stem bark, Parquetina nigrescens leaves, Psidium gu... more Cymbopogon citrates leaves, Khaya senagalesis stem bark, Parquetina nigrescens leaves, Psidium guajava leaves, Terminalia glaucescens stem bark and Zingiber officinale rhizome are used traditionally to treat malaria. This study evaluate the effects of the aqueous extracts of C. citrates leaves, K. senagalesis stem bark, P. nigrescens leaves, P.guajava, T. glaucescens stem bark and Z. officinale rhizome respectively on the heamatological status of NK 65 Plasmodium berghei (chloroquine sensitive parasite) infected mice. Fourty five (45) albino mice with average weight 25.5 ± 1.45g were randomly grouped into nine (9). Mice in group A serve as control not infected. Groups B, C, D, E, F, G, H and I were inoculated intraperitoneally with P. berghei. Groups C, D, E, F, G, H and I were treated with 5 mg/kg body weight of chloroquine, 200mg/kg body weight of C. citrates, K. senagalesis, P. nigrescens, P. guajava, T. glaucescens and Z. officinale aqueous extracts respectively. On day 5, red blood cell count (RBC), white blood cell count (WBC), packed cell volume, haemoglobin count (Hb), lymphocyte and neutrophil counts were assessed. There were significant (p<0.05) increase in the Hb count, RBC and PCV levels of the extract treated P. berghei infected mice in each group when compared with the untreated P. berghei infected mice. In the extracts treated infected mice, lymphocyte count was significantly (p<0.05) increased with concomitant decrease in neutrophil count. Our Findings show that all the extracts used has anti-anaemic properties and anti-inflammatory potential with extracts of P. nigrescens, P. guajava, T. glaucescens and Z. officinale demonstrating higher potential.

Research paper thumbnail of Evaluation of the Effectiveness of Telfairia occidentalis Leave Extracts in the Amelioration of Carbon Tetrachloride Induced Liver Injuries and Oxidative Damage in Rats

Aims: The study was aimed to investigate the efficacy of Telfairia occidentalis (T. occidentalis)... more Aims: The study was aimed to investigate the efficacy of Telfairia occidentalis (T. occidentalis) extracts in the attenuation of CCl 4-mediated oxidative stress. Place and Duration of Study: Methodology: Twenty-four male wistar albino rats (180-220 g) were divided into four groups (1-4) of six rats each. In group 1 the rats received only water, group 2 received single dose of equal mixture of carbon tetrachloride (CCl 4) and olive oil (50%, v/v, 1.25 mL/kg i.p.), while animals in group 3 and 4 received CCl 4 + 50 mg/kg of T. occidentalis and CCl 4 + 100 mg/kg of T. occidentalis respectively. The antioxidant activity of T. occidentalis was evaluated in vitro using DPPH and ABTS radical scavenging assay. Results: Our results showed that CCl 4 induction elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and thiobarbituric acid reactive substances (TBARS) levels significantly (P<0.05) while activity of superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) were significant (P<0.05) reduced. However, administering T. occidentalis extract at the doses of 50 and 100 mg/kg caused reversal of the effects significantly. T. occidentalis was found to contain high level of total phenolic content (34.65 mg/g in GAE/g dried weight). The implication of these results is that T. occidentalis may be useful in the management of oxidative stress-related organ injuries. Conclusion: The antioxidant and hepatoprotective activities observed in this study could be due to the ability of phenolic compounds constituents of T. occidentalis which are able to absorb, neutralize and quench free radicals.

Research paper thumbnail of Evaluation of the Effectiveness of Telfairia occidentalis Leave Extracts in the Amelioration of Carbon Tetrachloride Induced Liver Injuries and Oxidative Damage in Rats

The study was aimed to investigate the efficacy of Telfairia occidentalis (T. occidentalis) extra... more The study was aimed to investigate the efficacy of Telfairia occidentalis (T. occidentalis) extracts in the attenuation of CCl 4 -mediated oxidative stress. Place and Duration of Study: Methodology: Twenty-four male wistar albino rats (180-220 g) were divided into four groups (1-4) of six rats each. In group 1 the rats received only water, group 2 received single dose of equal mixture of carbon tetrachloride (CCl 4 ) and olive oil (50%, v/v, 1.25 mL/kg i.p.), while animals in group 3 and 4 received CCl 4 + 50 mg/kg of T. occidentalis and CCl 4 + 100 mg/kg of T. occidentalis respectively. The antioxidant activity of T. occidentalis was evaluated in vitro using DPPH and ABTS radical scavenging assay. JAMPS, 10(2): xxx-xxx, 2016; Article no.JAMPS.29199 2 Results: Our results showed that CCl 4 induction elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and thiobarbituric acid reactive substances (TBARS) levels significantly (P<0.05) while activity of superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) were significant (P<0.05) reduced. However, administering T. occidentalis extract at the doses of 50 and 100 mg/kg caused reversal of the effects significantly. T. occidentalis was found to contain high level of total phenolic content (34.65 mg/g in GAE/g dried weight). The implication of these results is that T. occidentalis may be useful in the management of oxidative stress-related organ injuries. Conclusion: The antioxidant and hepatoprotective activities observed in this study could be due to the ability of phenolic compounds constituents of T. occidentalis which are able to absorb, neutralize and quench free radicals.