elisa ferri | Conservatorio di musica di Perugia (original) (raw)
Papers by elisa ferri
Journal of Hepatology, 2000
The liver plays a central role in bone metabolism. Several studies reported low bone mineral dens... more The liver plays a central role in bone metabolism. Several studies reported low bone mineral density (BMD) in chronic liver disease especially cholestatic, alcoholic, corticosteroid-treated chronic hepatitis, bemochromatosis. Aim of the present study was to examine the prevalence of osteoporosis and/or osteopenia in a consecutive series of patients affected by chronic viral hepatitis. Twenty five male patients, aged 41-59 years, affected by biopsy-proven chronic hepatitis correlated to C virus were studied. Exclusion criteria were: body mass index (BMI) <20 and >25 Kg/m 2, hyperbilirubinemia, advanced liver cirrhosis, cholestatic and alcoholic liver disease, previous therapy or disease affecting bone mass. BMD was evaluated by dual energy X-ray absorptiometry (DEXA) at lumbar spine (LI-IA) and femural neck (FN) using a hologic QDR 1000 densitometer. The results are expressed as BMD (g/cm2), T score (SD from the mean value obtained in 30-years-old subjects) and Z score (SD from the mean value obtained in subjects of the same age and sex). Serum calcium, phosphorus, ALP, gonadotropins, testosterone, thyroid hormones, cortisol, PTH, urinary calcium and hydroxyproline were evaluated. A complete clinical, biochemical and ultrasonographic evaluation of liver desease was performed. The results showed an alteration of bone mass in 16 out of 25 patients (64%): in fact, T score resulted <-1 SD in 11 (44%), and <-2.5 SD in 5 patients (20%). Moreover an inverse correlation (p< 0.05) was found only among BMD at lumbar spine, serum calcium and duration of liver disease. At femoral neck a direct correlation between BMD and BMI (p<0.05) and an inverse one between BMD and cortisol (p<0.05) were found. No correlation was found with patient's age. The reduction of BMD in patients with non advanced viral liver disease suggests that more attention should be paid to BMD in patients without eholestasis, alcoholic consumption, malnutrition, and/or factors affecting bone metabolism.
Journal of Viral Hepatitis, 2001
Journal of Hepatology, 2000
Journal of Hepatology, 2000
The liver plays a central role in bone metabolism. Several studies reported low bone mineral dens... more The liver plays a central role in bone metabolism. Several studies reported low bone mineral density (BMD) in chronic liver disease especially cholestatic, alcoholic, corticosteroid-treated chronic hepatitis, bemochromatosis. Aim of the present study was to examine the prevalence of osteoporosis and/or osteopenia in a consecutive series of patients affected by chronic viral hepatitis. Twenty five male patients, aged 41-59 years, affected by biopsy-proven chronic hepatitis correlated to C virus were studied. Exclusion criteria were: body mass index (BMI) <20 and >25 Kg/m 2, hyperbilirubinemia, advanced liver cirrhosis, cholestatic and alcoholic liver disease, previous therapy or disease affecting bone mass. BMD was evaluated by dual energy X-ray absorptiometry (DEXA) at lumbar spine (LI-IA) and femural neck (FN) using a hologic QDR 1000 densitometer. The results are expressed as BMD (g/cm2), T score (SD from the mean value obtained in 30-years-old subjects) and Z score (SD from the mean value obtained in subjects of the same age and sex). Serum calcium, phosphorus, ALP, gonadotropins, testosterone, thyroid hormones, cortisol, PTH, urinary calcium and hydroxyproline were evaluated. A complete clinical, biochemical and ultrasonographic evaluation of liver desease was performed. The results showed an alteration of bone mass in 16 out of 25 patients (64%): in fact, T score resulted <-1 SD in 11 (44%), and <-2.5 SD in 5 patients (20%). Moreover an inverse correlation (p< 0.05) was found only among BMD at lumbar spine, serum calcium and duration of liver disease. At femoral neck a direct correlation between BMD and BMI (p<0.05) and an inverse one between BMD and cortisol (p<0.05) were found. No correlation was found with patient's age. The reduction of BMD in patients with non advanced viral liver disease suggests that more attention should be paid to BMD in patients without eholestasis, alcoholic consumption, malnutrition, and/or factors affecting bone metabolism.
Journal of Viral Hepatitis, 2001
Journal of Hepatology, 2000