Paul Oneill | Central Queensland University (original) (raw)
Papers by Paul Oneill
Researching Educational Capital in a Technological Age, 2005
O'Neill, Paul, Knight, Bruce Allen and Walker-Gibbs, Bernadette 2005, Issues for teacher... more O'Neill, Paul, Knight, Bruce Allen and Walker-Gibbs, Bernadette 2005, Issues for teacher education in an information age : the role of collegial learning, in Researching Educational Capital in a technological age, Post Pressed, Teneriffe, Qld., pp.203-217. ... Unless expressly stated ...
Advances in Human Factors/ergonomics, 1995
In [1], we conclude that the flexible manipulation, by a human operator, of virtual objects in ar... more In [1], we conclude that the flexible manipulation, by a human operator, of virtual objects in artificial realities is augmented by a gesture interface. Such an interface is described here and it can recognise static gestures, posture-based dynamic gestures, pose-based dynamic gestures, a “virtual control panel” involving posture and pose and simple pose-based trajectory analysis of postures.The interface is based on a novel, application independent technique for recognising gestures. Gestures are represented by what we term approximate splines, sequences of critical points (local minima and maxima) of the motion of degrees of freedom of the hand and wrist. This scheme allows more flexibility in matching a gesture performance spatially and temporally and reduces the computation required, compared with a full spline curve fitting approach. Training the gesture set is accomplished through the interactive presentation of a small number of samples of each gesture.
International Journal of Knowledge Culture and Change Management, 2006
British journal of cancer, 1989
Mice were injected with tritiated misonidazole (750 mg/kg-1), killed after 24h and the excised ti... more Mice were injected with tritiated misonidazole (750 mg/kg-1), killed after 24h and the excised tissues prepared for autoradiography (ARG) to identify sites of accumulation. The previously reported high grain count associated with bound misonidazole metabolite(s) was observed in the liver. The ratio of grain count in the emulsion above the centrilobular hepatocytes to the count over connective tissue (stroma) was 12. A higher count ratio for 'target' cells to stroma was observed in the following cells/tissues: meibomian gland (ducts 110, acini 65), oesophagus (keratinised layer 60), incisor (enamel organ 17), nasal septum (subepithelial glands 13). For some of these tissues the explanation might appear to lie with localised hypoxia, but for others which were probably normoxic there is as yet no obvious reason for these findings.
Lecture Notes in Computer Science, 2003
![Research paper thumbnail of Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles](https://attachments.academia-assets.com/50350695/thumbnails/1.jpg)
](Organic & Biomolecular Chemistry, 2013
PATAI'S Chemistry of Functional Groups, 2009
Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria,... more Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the emergence of artemisinin-resistant parasites. Artemisinins are embryotoxic in animal models and induce apoptosis in sensitive mammalian cells. Understanding the cytotoxic propensities of antimalarial drug candidates is crucial to their successful development and utilization. Here, we demonstrate that, similarly to the model artemisinin artesunate (ARS), a synthetic tetraoxane drug candidate (RKA182) and a trioxolane equivalent (FBEG100) induce embryotoxicity and depletion of primitive erythroblasts in a rodent model. We also show that RKA182, FBEG100 and ARS are cytotoxic toward a panel of established and primary human cell lines, with caspase-dependent apoptosis and caspase-independent necrosis underlying the induction of cell death. Although the toxic effects of RKA182 and FBEG100 proceed more rapidly and are relatively less cell-selective than that of ARS, all three compounds are shown to be dependent upon heme, iron and oxidative stress for their ability to induce cell death. However, in contrast to previously studied artemisinins, the toxicity of RKA182 and FBEG100 is shown to be independent of general chemical decomposition. Although tetraoxanes and trioxolanes have shown promise as next-generation antimalarials, the data described here indicate that adverse effects associated with artemisinins, including embryotoxicity, cannot be ruled out with these novel compounds, and a full understanding of their toxicological actions will be central to the continuing design and development of safe and effective drug candidates which could prove important in the fight against malaria.
Clinical and Translational Allergy, 2014
Journal of Medicinal Chemistry, 2014
The use of artemisinin or other endoperoxides in combination with other drugs is a strategy to pr... more The use of artemisinin or other endoperoxides in combination with other drugs is a strategy to prevent development of resistant strains of Plasmodium parasites. Our previous work demonstrated that hybrid compounds, comprising endoperoxides and vinyl sulfones, were capable of high activity profiles comparable to artemisinin and chloroquine while acting through two distinct mechanisms of action: oxidative stress and falcipain inhibition. In this study, we adapted this approach to a novel class of falcipain inhibitors: peptidomimetic pyrimidine nitriles. Pyrimidine tetraoxane hybrids displayed potent nanomolar activity against three strains of Plasmodium falciparum and falcipain-2, combined with low cytotoxicity. In vivo, a decrease in parasitemia and an increase in survival of mice infected with Plasmodium berghei was observed when compared to control. All tested compounds combined good blood stage activity with significant effects on liver stage parasitemia, a most welcome feature for any new class of antimalarial drug.
Trends in Molecular Medicine, 2001
Trends in Molecular Medicine, 2001
Trends in Molecular Medicine, 2001
The Modern Law Review, 1975
The Computer Journal, 2005
ABSTRACT
Tetrahedron Letters, 1997
... Images Images, Journal/Book title, Volume, Issue, Page, Search tips. ... 0.00 The Biomimetic ... more ... Images Images, Journal/Book title, Volume, Issue, Page, Search tips. ... 0.00 The Biomimetic IronMediated Degradation of Arteflene (Ro421611),an Endoperoxide Antimalarial: Implications for the ... 2. Homolytic cleavage of the peroxide bridge by single electron donation from iron (II ...
Researching Educational Capital in a Technological Age, 2005
O'Neill, Paul, Knight, Bruce Allen and Walker-Gibbs, Bernadette 2005, Issues for teacher... more O'Neill, Paul, Knight, Bruce Allen and Walker-Gibbs, Bernadette 2005, Issues for teacher education in an information age : the role of collegial learning, in Researching Educational Capital in a technological age, Post Pressed, Teneriffe, Qld., pp.203-217. ... Unless expressly stated ...
Advances in Human Factors/ergonomics, 1995
In [1], we conclude that the flexible manipulation, by a human operator, of virtual objects in ar... more In [1], we conclude that the flexible manipulation, by a human operator, of virtual objects in artificial realities is augmented by a gesture interface. Such an interface is described here and it can recognise static gestures, posture-based dynamic gestures, pose-based dynamic gestures, a “virtual control panel” involving posture and pose and simple pose-based trajectory analysis of postures.The interface is based on a novel, application independent technique for recognising gestures. Gestures are represented by what we term approximate splines, sequences of critical points (local minima and maxima) of the motion of degrees of freedom of the hand and wrist. This scheme allows more flexibility in matching a gesture performance spatially and temporally and reduces the computation required, compared with a full spline curve fitting approach. Training the gesture set is accomplished through the interactive presentation of a small number of samples of each gesture.
International Journal of Knowledge Culture and Change Management, 2006
British journal of cancer, 1989
Mice were injected with tritiated misonidazole (750 mg/kg-1), killed after 24h and the excised ti... more Mice were injected with tritiated misonidazole (750 mg/kg-1), killed after 24h and the excised tissues prepared for autoradiography (ARG) to identify sites of accumulation. The previously reported high grain count associated with bound misonidazole metabolite(s) was observed in the liver. The ratio of grain count in the emulsion above the centrilobular hepatocytes to the count over connective tissue (stroma) was 12. A higher count ratio for 'target' cells to stroma was observed in the following cells/tissues: meibomian gland (ducts 110, acini 65), oesophagus (keratinised layer 60), incisor (enamel organ 17), nasal septum (subepithelial glands 13). For some of these tissues the explanation might appear to lie with localised hypoxia, but for others which were probably normoxic there is as yet no obvious reason for these findings.
Lecture Notes in Computer Science, 2003
Organic & Biomolecular Chemistry, 2013
PATAI'S Chemistry of Functional Groups, 2009
Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria,... more Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the emergence of artemisinin-resistant parasites. Artemisinins are embryotoxic in animal models and induce apoptosis in sensitive mammalian cells. Understanding the cytotoxic propensities of antimalarial drug candidates is crucial to their successful development and utilization. Here, we demonstrate that, similarly to the model artemisinin artesunate (ARS), a synthetic tetraoxane drug candidate (RKA182) and a trioxolane equivalent (FBEG100) induce embryotoxicity and depletion of primitive erythroblasts in a rodent model. We also show that RKA182, FBEG100 and ARS are cytotoxic toward a panel of established and primary human cell lines, with caspase-dependent apoptosis and caspase-independent necrosis underlying the induction of cell death. Although the toxic effects of RKA182 and FBEG100 proceed more rapidly and are relatively less cell-selective than that of ARS, all three compounds are shown to be dependent upon heme, iron and oxidative stress for their ability to induce cell death. However, in contrast to previously studied artemisinins, the toxicity of RKA182 and FBEG100 is shown to be independent of general chemical decomposition. Although tetraoxanes and trioxolanes have shown promise as next-generation antimalarials, the data described here indicate that adverse effects associated with artemisinins, including embryotoxicity, cannot be ruled out with these novel compounds, and a full understanding of their toxicological actions will be central to the continuing design and development of safe and effective drug candidates which could prove important in the fight against malaria.
Clinical and Translational Allergy, 2014
Journal of Medicinal Chemistry, 2014
The use of artemisinin or other endoperoxides in combination with other drugs is a strategy to pr... more The use of artemisinin or other endoperoxides in combination with other drugs is a strategy to prevent development of resistant strains of Plasmodium parasites. Our previous work demonstrated that hybrid compounds, comprising endoperoxides and vinyl sulfones, were capable of high activity profiles comparable to artemisinin and chloroquine while acting through two distinct mechanisms of action: oxidative stress and falcipain inhibition. In this study, we adapted this approach to a novel class of falcipain inhibitors: peptidomimetic pyrimidine nitriles. Pyrimidine tetraoxane hybrids displayed potent nanomolar activity against three strains of Plasmodium falciparum and falcipain-2, combined with low cytotoxicity. In vivo, a decrease in parasitemia and an increase in survival of mice infected with Plasmodium berghei was observed when compared to control. All tested compounds combined good blood stage activity with significant effects on liver stage parasitemia, a most welcome feature for any new class of antimalarial drug.
Trends in Molecular Medicine, 2001
Trends in Molecular Medicine, 2001
Trends in Molecular Medicine, 2001
The Modern Law Review, 1975
The Computer Journal, 2005
ABSTRACT
Tetrahedron Letters, 1997
... Images Images, Journal/Book title, Volume, Issue, Page, Search tips. ... 0.00 The Biomimetic ... more ... Images Images, Journal/Book title, Volume, Issue, Page, Search tips. ... 0.00 The Biomimetic IronMediated Degradation of Arteflene (Ro421611),an Endoperoxide Antimalarial: Implications for the ... 2. Homolytic cleavage of the peroxide bridge by single electron donation from iron (II ...