Martin Martinez Ripoll | CSIC (Consejo Superior de Investigaciones Científicas-Spanish National Research Council) (original) (raw)
Papers by Martin Martinez Ripoll
labor investigadora en el CSIC (siempre desde el Instituto de Química-Física Rocasolano) se ha ce... more labor investigadora en el CSIC (siempre desde el Instituto de Química-Física Rocasolano) se ha centrado en la Cristalografía, primero aplicada a la Química y desde 1990 a la Biología Estructural. Ha dirigido 8 Tesis Doctorales, es coautor de más de 230 publicaciones científicas en revistas internacionales y su experiencia técnica se ha dirigido a la programación informática y automatización de equipos de difracción.
ConCIENCIAS.digital: revista de divulgación científica de las Facultad de Ciencias de Zaragoza, 2016
Journal of Molecular Structure, Jun 1, 1995
A series of esters derived from 3,7-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-ol has been synthesiz... more A series of esters derived from 3,7-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-ol has been synthesized and studied using 1H and 13C NMR spectroscopy and the crystal structure of 9-(3-indolycarbonyloxy)-3,7-dimethyl-3,7-diazabicyclo[3.3.1]nonane hydrochloride (V·HCl) has been determined by X-ray diffraction. In CDCl3 solution, these compounds adopt an almost perfect chair-chair conformation with the N-substituents in equatorial positions. By comparing the NMR parameters of these compounds with those of
Transition Metal Chemistry, 1985
HETEROCYCLES, 1988
Etude de la tautomerie des composes du titre en solution par spectroscopies UV, RMN ( 13 C et 15 ... more Etude de la tautomerie des composes du titre en solution par spectroscopies UV, RMN ( 13 C et 15 N) et a l'etat solide par cristallographie par diffraction RX
Anales de la Real Sociedad Española de Química, Oct 1, 2010
Resumen: Durante el año 2011, el mundo entero celebrará el Año Internacional de la Química y en t... more Resumen: Durante el año 2011, el mundo entero celebrará el Año Internacional de la Química y en tal conmemoración no puede quedar olvidada la Cristalografía. En dicho contexto los cristalógrafos españoles han hecho un esfuerzo digno de mención, trayendo por primera vez a España el
Arbor Ciencia Pensamiento Y Cultura, 1985
Anales de la Real Sociedad Española de Química, 2003
Tetrahedron Letters, 1996
... Javier G. Luis * a , El Hassane Lahlou a , Lucía S. Andrés a , Geeta HN Sood b and Martín M. ... more ... Javier G. Luis * a , El Hassane Lahlou a , Lucía S. Andrés a , Geeta HN Sood b and Martín M. Ripoll b. a Instituto Universitario de Bio-Orgánica Antonio González. Universidad de La Laguna. ... Canary Islands., Spain. b Instituto Rocasolano CSIC 28006, Madrid, Spain. ...
Journal of Organometallic Chemistry, 1992
ABSTRACT The di-μ-hydroxo-complex [NBu4]2[Ni(C6F5)2(μ-OH)2] reacts with protic electrophiles H(LL... more ABSTRACT The di-μ-hydroxo-complex [NBu4]2[Ni(C6F5)2(μ-OH)2] reacts with protic electrophiles H(LL) in the 1/2 molar ratio to give (NBu4) [Ni(C6F5)2(LL)][(LL) = acetylacetonate (acac) (I), benzoylacetonate (bzac) (II), 8-hydroxyquinolinate (oxin) (III), pyridine-2-thiolate (pyt) (IV), pyrimidine-2-thiolate (pymt) (V), 2,6-dimethyl-5-oxo-1,2,4-triazine-3-thiolate (tazt) (VI), N-methylimidazole-2-thiolate (mimt) (VII), thiazolidine-2-thiolate (tzt) (VIII), benzoimidazole-2-thiolate (bimt) (IX) or benzothiazole-2-thiolate (btzt) (X)]. The new compounds have been characterized by analysis, conductivity measurements, and spectroscopic (IR, UV-VIS, 1H, and 19F) methods. The crystal structure of compound IV has been determined by X-ray diffraction. It crystallizes in the monoclinic space group P21/n with a 11.7076(4), b 22.183(1), c 14.0280(6) Å, β 105.012(3)°. Final R = 0.075 and Rw = 0.067 based on 3815 reflections.
Inorganic Chemistry, 1991
_ _ _ _ _ ~ _ _ _ ~ ~ ... (24) Gutmann, VTThe Lbno~Acceptor Approach io Molecular Inreracrions; P... more _ _ _ _ _ ~ _ _ _ ~ ~ ... (24) Gutmann, VTThe Lbno~Acceptor Approach io Molecular Inreracrions; Plenum Press: New York, 1978. ... We also acknowledge the help of Dr. John Bear with the ther-mogravimetric analysis experiments. Retry NO. TBAP, 1923-70-2; THF, ...
Journal of Molecular Catalysis B: Enzymatic, 2005
We have investigated activation of two isoenzymes (lip1 and lip3) from Candida rugosa in polyethy... more We have investigated activation of two isoenzymes (lip1 and lip3) from Candida rugosa in polyethylene glycol (PEG) media. Aqueous solutions of PEG 8000 and 20,000 activate lip3 but not lip1 from C. rugosa. Maximum activation (260%) of lip3 requires 6 h of pre-incubation with PEG 8000 (4%, w/v). PEG seems to shift the equilibrium between the open and the closed forms of lip3 towards the active conformation. Inhibition experiments demonstrate that ligands have easier access to the lip3 active site than to the lip1 active site, both in the presence and the absence of PEG. The presence of PEG in the crystallization medium is responsible for reported differences in the crystal structures of lip1 and lip3. A comparative analysis of crystallographic models of lip1 and lip3 suggests a role for PEG in activation of lip3 and further stabilization of the activated/open form via dimerization in aqueous media.
Polyhedron, 2011
Reactions of N,N-diisopropylisonicotinamide (L) with anhydrous CuCl2, CuBr2 and Cu(ClO4)2·6H2O yi... more Reactions of N,N-diisopropylisonicotinamide (L) with anhydrous CuCl2, CuBr2 and Cu(ClO4)2·6H2O yielded: (a) an ionic product with the molecular composition of [CuL2(H2O)4]·2[CuLCl3] 1; (b) a coordination polymer [CuL2Br2]n2 and (c) a mononuclear complex [CuL4(C3H8O)2]·(ClO4)2] 3, respectively. Similarly, the reaction of N,N-diisobutylisonicotinamide (L′) with Cu(NO3)2·3H2O yielded a coordination polymer [{CuL′2(H2O)2}(NO3)2]n4. The ligands L and L′ coordinate in a monodentate fashion through the
Nature Communications, 2014
Separation of daughter cells during bacterial cell division requires splitting of the septal cros... more Separation of daughter cells during bacterial cell division requires splitting of the septal cross wall by peptidoglycan hydrolases. In Streptococcus pneumoniae, PcsB is predicted to perform this operation. Recent evidence shows that PcsB is recruited to the septum by the transmembrane FtsEX complex, and that this complex is required for cell division. However, PcsB lacks detectable catalytic activity in vitro, and while it has been proposed that FtsEX activates PcsB, evidence for this is lacking. Here we demonstrate that PcsB has muralytic activity, and report the crystal structure of full-length PcsB. The protein adopts a dimeric structure in which the V-shaped coiled-coil domain of each monomer acts as a pair of molecular tweezers locking the catalytic domain of each dimeric partner in an inactive configuration. This suggests that the release of the catalytic domains likely requires an ATP-driven conformational change in the FtsEX complex, conveyed towards the catalytic domains through coordinated movements of the coiled-coil domain.
Journal of the American Chemical Society, 1992
Imines derived from N-(tert-butyloxycarbonyl) (N-Boc) α-amino aldehydes react with alkoxyketenes,... more Imines derived from N-(tert-butyloxycarbonyl) (N-Boc) α-amino aldehydes react with alkoxyketenes, generated from their corresponding acid chlorides and triethylamine, to produce homochiral cis-3-alkoxy-4-(1-aminoalkyl) β-lactams with virtually complete control of diastereoselectivity. In a similar manner, the reaction of phthalimidoacetyl chloride with these imines in the presence of triethylamine afforded the corresponding 3-phthalimido β-lactams as single diastereomers
![Research paper thumbnail of Addition compounds of dichlorodioxomolybdenum(VI) with sulfoxides. Molecular structure of [MoO2Cl2(Me2SO)2]](https://attachments.academia-assets.com/83197946/thumbnails/1.jpg)
](Inorganica Chimica Acta, 2003
MoO 2 Cl 2 L 2 (L 0/dimethyl sulfoxide (Me 2 SO), deuterated dimethyl sulfoxide (Me 2 SOd 6), din... more MoO 2 Cl 2 L 2 (L 0/dimethyl sulfoxide (Me 2 SO), deuterated dimethyl sulfoxide (Me 2 SOd 6), din -buthyl sulfoxide (Bu 2 SO), tetramethylene sulfoxide (C 4 H 8 SO), dibenzyl sulfoxide (Bz 2 SO), diphenyl sulfoxide (Ph 2 SO), dip -tolyl sulfoxide (p-Tol 2 SO), di-pchloro-phenyl sulfoxide (p-Cl-Ph 2 SO) and methyl phenyl sulfoxide (MePhSO)) have been prepared by reacting a solution of MoO 2 Cl 2 (H 2 O) 2 in diethyl ether with the respective ligand. The molecular structure of MoO 2 Cl 2 (Me 2 SO) 2 has been established by X-ray diffraction analysis. The ability of representative complexes to work as oxotransfer catalysts has been tested.
Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2011
Acta Crystallographica Section E Structure Reports Online, 2003
labor investigadora en el CSIC (siempre desde el Instituto de Química-Física Rocasolano) se ha ce... more labor investigadora en el CSIC (siempre desde el Instituto de Química-Física Rocasolano) se ha centrado en la Cristalografía, primero aplicada a la Química y desde 1990 a la Biología Estructural. Ha dirigido 8 Tesis Doctorales, es coautor de más de 230 publicaciones científicas en revistas internacionales y su experiencia técnica se ha dirigido a la programación informática y automatización de equipos de difracción.
ConCIENCIAS.digital: revista de divulgación científica de las Facultad de Ciencias de Zaragoza, 2016
Journal of Molecular Structure, Jun 1, 1995
A series of esters derived from 3,7-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-ol has been synthesiz... more A series of esters derived from 3,7-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-ol has been synthesized and studied using 1H and 13C NMR spectroscopy and the crystal structure of 9-(3-indolycarbonyloxy)-3,7-dimethyl-3,7-diazabicyclo[3.3.1]nonane hydrochloride (V·HCl) has been determined by X-ray diffraction. In CDCl3 solution, these compounds adopt an almost perfect chair-chair conformation with the N-substituents in equatorial positions. By comparing the NMR parameters of these compounds with those of
Transition Metal Chemistry, 1985
HETEROCYCLES, 1988
Etude de la tautomerie des composes du titre en solution par spectroscopies UV, RMN ( 13 C et 15 ... more Etude de la tautomerie des composes du titre en solution par spectroscopies UV, RMN ( 13 C et 15 N) et a l'etat solide par cristallographie par diffraction RX
Anales de la Real Sociedad Española de Química, Oct 1, 2010
Resumen: Durante el año 2011, el mundo entero celebrará el Año Internacional de la Química y en t... more Resumen: Durante el año 2011, el mundo entero celebrará el Año Internacional de la Química y en tal conmemoración no puede quedar olvidada la Cristalografía. En dicho contexto los cristalógrafos españoles han hecho un esfuerzo digno de mención, trayendo por primera vez a España el
Arbor Ciencia Pensamiento Y Cultura, 1985
Anales de la Real Sociedad Española de Química, 2003
Tetrahedron Letters, 1996
... Javier G. Luis * a , El Hassane Lahlou a , Lucía S. Andrés a , Geeta HN Sood b and Martín M. ... more ... Javier G. Luis * a , El Hassane Lahlou a , Lucía S. Andrés a , Geeta HN Sood b and Martín M. Ripoll b. a Instituto Universitario de Bio-Orgánica Antonio González. Universidad de La Laguna. ... Canary Islands., Spain. b Instituto Rocasolano CSIC 28006, Madrid, Spain. ...
Journal of Organometallic Chemistry, 1992
ABSTRACT The di-μ-hydroxo-complex [NBu4]2[Ni(C6F5)2(μ-OH)2] reacts with protic electrophiles H(LL... more ABSTRACT The di-μ-hydroxo-complex [NBu4]2[Ni(C6F5)2(μ-OH)2] reacts with protic electrophiles H(LL) in the 1/2 molar ratio to give (NBu4) [Ni(C6F5)2(LL)][(LL) = acetylacetonate (acac) (I), benzoylacetonate (bzac) (II), 8-hydroxyquinolinate (oxin) (III), pyridine-2-thiolate (pyt) (IV), pyrimidine-2-thiolate (pymt) (V), 2,6-dimethyl-5-oxo-1,2,4-triazine-3-thiolate (tazt) (VI), N-methylimidazole-2-thiolate (mimt) (VII), thiazolidine-2-thiolate (tzt) (VIII), benzoimidazole-2-thiolate (bimt) (IX) or benzothiazole-2-thiolate (btzt) (X)]. The new compounds have been characterized by analysis, conductivity measurements, and spectroscopic (IR, UV-VIS, 1H, and 19F) methods. The crystal structure of compound IV has been determined by X-ray diffraction. It crystallizes in the monoclinic space group P21/n with a 11.7076(4), b 22.183(1), c 14.0280(6) Å, β 105.012(3)°. Final R = 0.075 and Rw = 0.067 based on 3815 reflections.
Inorganic Chemistry, 1991
_ _ _ _ _ ~ _ _ _ ~ ~ ... (24) Gutmann, VTThe Lbno~Acceptor Approach io Molecular Inreracrions; P... more _ _ _ _ _ ~ _ _ _ ~ ~ ... (24) Gutmann, VTThe Lbno~Acceptor Approach io Molecular Inreracrions; Plenum Press: New York, 1978. ... We also acknowledge the help of Dr. John Bear with the ther-mogravimetric analysis experiments. Retry NO. TBAP, 1923-70-2; THF, ...
Journal of Molecular Catalysis B: Enzymatic, 2005
We have investigated activation of two isoenzymes (lip1 and lip3) from Candida rugosa in polyethy... more We have investigated activation of two isoenzymes (lip1 and lip3) from Candida rugosa in polyethylene glycol (PEG) media. Aqueous solutions of PEG 8000 and 20,000 activate lip3 but not lip1 from C. rugosa. Maximum activation (260%) of lip3 requires 6 h of pre-incubation with PEG 8000 (4%, w/v). PEG seems to shift the equilibrium between the open and the closed forms of lip3 towards the active conformation. Inhibition experiments demonstrate that ligands have easier access to the lip3 active site than to the lip1 active site, both in the presence and the absence of PEG. The presence of PEG in the crystallization medium is responsible for reported differences in the crystal structures of lip1 and lip3. A comparative analysis of crystallographic models of lip1 and lip3 suggests a role for PEG in activation of lip3 and further stabilization of the activated/open form via dimerization in aqueous media.
Polyhedron, 2011
Reactions of N,N-diisopropylisonicotinamide (L) with anhydrous CuCl2, CuBr2 and Cu(ClO4)2·6H2O yi... more Reactions of N,N-diisopropylisonicotinamide (L) with anhydrous CuCl2, CuBr2 and Cu(ClO4)2·6H2O yielded: (a) an ionic product with the molecular composition of [CuL2(H2O)4]·2[CuLCl3] 1; (b) a coordination polymer [CuL2Br2]n2 and (c) a mononuclear complex [CuL4(C3H8O)2]·(ClO4)2] 3, respectively. Similarly, the reaction of N,N-diisobutylisonicotinamide (L′) with Cu(NO3)2·3H2O yielded a coordination polymer [{CuL′2(H2O)2}(NO3)2]n4. The ligands L and L′ coordinate in a monodentate fashion through the
Nature Communications, 2014
Separation of daughter cells during bacterial cell division requires splitting of the septal cros... more Separation of daughter cells during bacterial cell division requires splitting of the septal cross wall by peptidoglycan hydrolases. In Streptococcus pneumoniae, PcsB is predicted to perform this operation. Recent evidence shows that PcsB is recruited to the septum by the transmembrane FtsEX complex, and that this complex is required for cell division. However, PcsB lacks detectable catalytic activity in vitro, and while it has been proposed that FtsEX activates PcsB, evidence for this is lacking. Here we demonstrate that PcsB has muralytic activity, and report the crystal structure of full-length PcsB. The protein adopts a dimeric structure in which the V-shaped coiled-coil domain of each monomer acts as a pair of molecular tweezers locking the catalytic domain of each dimeric partner in an inactive configuration. This suggests that the release of the catalytic domains likely requires an ATP-driven conformational change in the FtsEX complex, conveyed towards the catalytic domains through coordinated movements of the coiled-coil domain.
Journal of the American Chemical Society, 1992
Imines derived from N-(tert-butyloxycarbonyl) (N-Boc) α-amino aldehydes react with alkoxyketenes,... more Imines derived from N-(tert-butyloxycarbonyl) (N-Boc) α-amino aldehydes react with alkoxyketenes, generated from their corresponding acid chlorides and triethylamine, to produce homochiral cis-3-alkoxy-4-(1-aminoalkyl) β-lactams with virtually complete control of diastereoselectivity. In a similar manner, the reaction of phthalimidoacetyl chloride with these imines in the presence of triethylamine afforded the corresponding 3-phthalimido β-lactams as single diastereomers
Inorganica Chimica Acta, 2003
MoO 2 Cl 2 L 2 (L 0/dimethyl sulfoxide (Me 2 SO), deuterated dimethyl sulfoxide (Me 2 SOd 6), din... more MoO 2 Cl 2 L 2 (L 0/dimethyl sulfoxide (Me 2 SO), deuterated dimethyl sulfoxide (Me 2 SOd 6), din -buthyl sulfoxide (Bu 2 SO), tetramethylene sulfoxide (C 4 H 8 SO), dibenzyl sulfoxide (Bz 2 SO), diphenyl sulfoxide (Ph 2 SO), dip -tolyl sulfoxide (p-Tol 2 SO), di-pchloro-phenyl sulfoxide (p-Cl-Ph 2 SO) and methyl phenyl sulfoxide (MePhSO)) have been prepared by reacting a solution of MoO 2 Cl 2 (H 2 O) 2 in diethyl ether with the respective ligand. The molecular structure of MoO 2 Cl 2 (Me 2 SO) 2 has been established by X-ray diffraction analysis. The ability of representative complexes to work as oxotransfer catalysts has been tested.
Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2011
Acta Crystallographica Section E Structure Reports Online, 2003
A website to learn Crystallography, written in two languages, Spanish and English
e-ISBN (obra completa): 978-84-00-09299-3 e-ISBN (n.º 9): 978-84-00-09659-5 e-NIPO: 723-13-039-9 ... more e-ISBN (obra completa): 978-84-00-09299-3 e-ISBN (n.º 9): 978-84-00-09659-5 e-NIPO: 723-13-039-9 Diseño y maquetación: Alejandro Martínez de Andrés Ilustraciones: Luis Martínez Sánchez y Alejandro Martínez de Andrés Catálogo general de publicaciones oficiales: http://publicacionesoficiales.boe.es/ © CSIC Reservados todos los derechos por la legislación en materia de Propiedad Intelectual. Ni la totalidad ni parte de este libro, incluido el diseño de la cubierta, puede reproducirse, almacenarse o transmitirse en manera alguna por medio ya sea electrónico, químico, óptico, informático, de grabación o de fotocopia, sin permiso previo por escrito de la editorial.
