Dr. Chanchal Deep Kaur | CHHATTISGARH SWAMI VIVIEKANAND TECHNICAL UNIVERSITY (original) (raw)

Papers by Dr. Chanchal Deep Kaur

Current Drug Targets, 2020

Background: Lymphatic filariasis is a pervasive and life-threatening disease for human beings. Cu... more Background: Lymphatic filariasis is a pervasive and life-threatening disease for human beings. Currently, 893 million people in 49 countries worldwide affected by lymphatic filariasis as per WHO statistics. The concealed aspects of lymphatic diseases such as delayed disease detection, inappropriate disease imaging, the geographical outbreak of infection, and lack of preventive chemotherapy have brought this epidemic to the edge of Neglected Tropical Diseases. Many medications and natural bioactive substances have seen to promote filaricidal activity against the target parasitic species. However, the majority of failures have occurred in pharmaceutical and pharmacokinetic issues. Objective: The purpose of the study is to focus on the challenges and therapeutic issues in the treatment of filariasis. The review brings novel techniques and therapeutic approaches for combating lymphatic filariasis. It also offers significant developments and opportunities for such therapeutic interventio...

The aim of the study was the comparative study of the wound healing potential of the bark of Ficu... more The aim of the study was the comparative study of the wound healing potential of the bark of Ficus religiosa and Ficus benghalensis. The locally available plants like Ficus religiosa and Ficus bengalensis have the capability to cure diseases traditionally since long years, due to this reasons these two plants were selected for the study. It was found that ethanol and hydroalcoholic extraction of two plants that is Ficus religiosa and Ficus benghalensis showed high wound healing activity. The plant extracts were used to study their phytochemical compositions i.e. total phenols contents, flavonoids contents, terpenoids content and proteins contents. Most of the biologically active phytochemical presents in the ethanol extract. The results obtained that Wound healing potential of the bark of Ficus religiosa is higher than the bark of Ficus benghalensis. The antimicrobial activity was evaluated by well diffusion method while wound healing effect in rats was evaluated using the in vitro ...

Ageing and hormones are inter-related terms playing crucial role in human's life. Dehydroepia... more Ageing and hormones are inter-related terms playing crucial role in human's life. Dehydroepiandrosterone, commonly known DHEA, is among those hormones which directly interfere with the ageing process and its effects is remarkably visible. The role of DHEA in fighting against the signs of aging have been tested for a long time. Recent researches in the field of hormones and steroids has provided the researcher with new insights to investigate the potentials of DHEA and its sulfate esters in the field of skin aging complications. DHEA, which is an adrenal cortex hormone act as mediator in various biochemical pathways, essentially required for maintaining the homeostasis of the body. The present aim of this review is to focus on the role of DHEA and its sulfate esters in skin aging process and in its related disorders. The review also highlights different delivery systems available for targeting this drug to the desired site of action for better therapeutic activity.

International Journal of Pharmacology, 2011

... Tang et al., 2003) antimetastatic (Jung and Ellis, 2001), proapoptotic (Qanungo et al., 2005)... more ... Tang et al., 2003) antimetastatic (Jung and Ellis, 2001), proapoptotic (Qanungo et al., 2005) and cell cycle perturbation (Ahmad et al ... or dosage of UV light irradiation sufficient to produce a minimal, perceptible erythema on unprotected skin (Aburjai and Natsheh, 2003; Bendova ...

International Journal of Biological Chemistry, 2015

In the genus Orthosiphon (Lamiaceae), Orthosiphon aristatus, Orthosiphon pallidus, Orthosiphon th... more In the genus Orthosiphon (Lamiaceae), Orthosiphon aristatus, Orthosiphon pallidus, Orthosiphon thymiflorus, Orthosiphon stamineus are widely used in traditional medicine to prevent different diseases such as diabetes, kidney stone, edema, rheumatism, hepatitis, hypertensive and jaundice. A different variety of phytoconstituents has been isolated from the Orthosiphon species which include monoterpenes, diterpenes, triterpenes, saponins, organic acid and flavonoids compound. Antidiabetic, anti-inflammatory, antioxidant, hepatoprotective, analgesic and nephroprotective activities have been reported in the plant extract and phytoconstituents. Hence, the purpose of this review is to provide a comprehensive report about the Orthosiphon genus based on its toxicity in order to identify its therapeutic potential and future prospects for betterment of research.

Medical Isotopes, 2021

Malignancy and many inflammatory diseases have become a major concern for mankind over the years.... more Malignancy and many inflammatory diseases have become a major concern for mankind over the years. The conventional therapy of these diseases lacks the effectiveness of the better diagnosis and targeted treatment of these diseases, but nuclear medicine can be regarded as a savior in the current scenario. Over the years, radioactivity of radioisotopes has been employed for treatment of many diseases. Nuclear medicines came up with radiopharmaceuticals that impart the ability to destroy specific diseased cells with high-energy-emitting radionuclides. Moreover, the emergence of theranostics, which is a combination of single drug used both for diagnostic as well as therapeutic purpose, has added a new feather in the field of nuclear medicines for providing a specific and personalized treatment to the patient. The current chapter discusses about techniques used for imaging of these radionuclides for better therapy and diagnosis of the root cause of the concerned disease by positron emissi...

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, hyperlipidemia, hyperam... more Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, hyperlipidemia, hyperaminoacidemia, and hypoinsulinaemia which leads to reduce in both insulin secretion and insulin action. It is often connected with the development of micro and macro vascular diseases which include a long term damage, dysfunction and failure of various organs especially the eye, nerves, heart, kidney and blood vessels. Various approaches have been developed for the treatment of diabetes, like insulin management and use of a variety of oral hypoglycemic agents but these synthetic drugs are costly and often associated with high chances of side effects. A wide number of medicinal plants are described in Ayurveda and traditional medicinal system which are used for the treatment of diabetes from ancient time. The present paper is an attempt to represent the list of the anti-diabetic plants, and their active constituents with a particular mechanism of action. The active principles present in med...

Embilica officinalis (Euphorbiacea) and Glycine max Merrill (Papllionaceae) are the most common m... more Embilica officinalis (Euphorbiacea) and Glycine max Merrill (Papllionaceae) are the most common medicinal plants and it’s having strong anticancer properties against ovarian cancer. It having a great curing properties for treatment of ovarian cancer. The dried fruits and seeds were identified and collected from, Raipur, Chhattisgarh. The aim of present work is focused on analysis phytochemical properties and antioxidant properties of Embilica officinalis and Glycine max Merrill. In the phytochemical analysis estimation of phytoconstituents glycosides, alkaloids, tannin, saponin and flavonoids were estimated for crude powder. The antioxidant properties of ethanolic extract were analysis by DPPH percentage free radical inhibition activity. By this analysis were found Embilica officinalis fruit extract have greater antioxidant activity comparsion then Glycine max Merrill ethanolic extract. In future work design novel drug delivery system of combination with ethanolic extract of Embilic...

Publications make scientific information publically available, and allow the rest of the academic... more Publications make scientific information publically available, and allow the rest of the academic audience to evaluate the quality of the research. There are various types of publications like Scholarly Journals, Professional or Trade Publications, Popular and General Interest Magazines. Scientific publications have their own identity, place and necessity. The Academic publications have a peer review system which maintains novelty, applicability and advancement in a given field of knowledge. There is fast online publication process to enhance the publication frequency and reduce the in process time expenditure. Scientometrics have developed which is the scientific measurement of the work of scientists, especially by way of analysing their publications and the citations within them. Citations of the references in the publications give credit to authors whose work they use and avoid plagiarism. Impact factor is used for the relative importance of a journal within its field, with journ...

Advance Pharmaceutical Journal, 2018

International Journal of Pharmaceutical Sciences and Developmental Research, 2015

Recent progress in combinatorial drug has led to the generation of a large number of new compound... more Recent progress in combinatorial drug has led to the generation of a large number of new compounds. microemulsions are versatile systems of great technological and scientific interest to the researchers because of their potential to incorporate a wide range of drug molecules (hydrophilic and hydrophobic) due to the presence of both lipophilic and hydrophilic domains. A micro emulsion is a transparent, thermodynamically stable mixture of two immiscible liquid stabilized by surfactant (or mixture of surfactant). Microemulsions have many advantages for instance, more drug solubility, thermodynamic stability, manufacturing and permeation is easy over conventional formulations that convert them to important drug delivery systems. The design and development of microemulsions aimed at controlling or improving required bioavailability levels of therapeutic agents. Through this review an attempt has been made to focus on several recent developments occurred in the field of microemulsions based applications and which confirms its role as a suitable cargoes for delivery of drugs. In that note, the relevance of this paper and the truncated basic aspects and application on microemulsions are discussed. permeation. Interest in these versatile carriers is increasing and their applications have been diversified to various administration routes in addition to the conventional oral route. This can be attributed to their unique solubilization properties and thermodynamic stability which has drawn attention for their use as novel vehicles for drug delivery [5-7]. Microemulsions have advantages over both colloidal systems under investigation and conventional emulsions, suspensions and micellar solutions and may provide alternative drug carriers [8]. They are promising delivery systems which allow sustained or controlled drug release for percutaneous, peroral, topical, transdermal, ocular and parenteral administration of medicaments. They offer the advantage of spontaneous formation, ease of manufacturing and scale-up, thermodynamic stability, improved drug solubilization of hydrophobic drugs and bioavailability. Also, microemulsions that have inverse micellar structure may be less comedogenic than either creams or solutions [9,10]. Microemulsions are quaternary systems composed of an oil phase, a water system, surfactants and a cosurfactant [11]. These spontaneously formed systems possess specific physicochemical properties such as transparency, optical isotropic, low viscosity and thermodynamic stability. The observed transparency of these systems is due to the fact that the maximum size of the droplets of the dispersed phase is not larger than one-fourth of the wavelength of visible light approximately 150 nm. Droplet diameter in stable microemulsions is usually within the range of 10-100 nm (100-1000 °A), which means that the term 'micro emulsion' is misleading and these systems are actually Nano-sized emulsions. Many studies have shown that micro emulsion formulations possessed improved transdermal and dermal delivery properties, mostly in vitro [12-21] and several in vivo [22-24].

Journal of Analytical & Pharmaceutical Research, 2017

Indian Journal of Pharmaceutical Education and Research, 2016

Background: Leaf juice as well as leaves of Barleria prionitis Linn and Barleria grandiflora Dalz... more Background: Leaf juice as well as leaves of Barleria prionitis Linn and Barleria grandiflora Dalz (Acanthaceae) is used by rural people across various regions of India in treatment of oral ailments such as dental troubles, gum ailments, pyorrhoea, dental carries and mouth ulcers. Methods: An antimicrobial activity was carried on aqueous and ethanolic extracts of both herbs and compared with standard chlorhexidine. Cell line study was carried using Human Gingival Fibroblast on ethanolic extracts of leaves of both the herbs and compared with standard marketed preparation Zyrtee. Cytotoxicity and anti gingivitis activity were evaluated using MTT assay. Results of cytokine secretion assay and cytokine measurement assay were analyzed using ANOVA followed by Dunnett multiple comparison test. P values less than 0.05 were considered as significant. Results: Results of antimicrobial activity suggest significant potency for ethanolic extracts of both the herbs. CTC50 values for ethanolic extracts was found to be 848 µg/ml and more than 1000 µg/ml respectively for Barleria prionitis and Barleria grandiflora. The cytokine secretion significantly increased by S. mutans control, whereas the cytokine level was reduced in a dose-dependent manner by ethanolic extracts in Streotococcus mutans stimulated HGF cells. The ethanolic extracts EBG and EBP showed 65.31383 ± 1.087%, 75.0425 ± 1.268% inhibition of TNF-α at tested concentration respectively. Conclusion: Thus based on findings of this study, we conclude the usefulness of Barleria prionitis and Barleria grandiflora in treatment of oral ailments such as gingivitis.

Research Journal of Pharmacy and Technology, 2016

Over the years, different formulation technologies intended for gastro retentive dosage delivery ... more Over the years, different formulation technologies intended for gastro retentive dosage delivery were investigated and patented. Oral drug administration has been the predominant route for drug delivery. During the past two decades, numerous oral delivery systems have been developed to act as drug reservoirs from which the active substance can be released over a defined period of time at a predetermined and controlled rate. From a pharmacokinetic point of view, the ideal sustained and controlled release dosage form should be comparable with an intravenous infusion, which supplies continuously the amount of drug needed to maintain constant plasma levels once the steady state is reached. Although some important applications, including oral administration of peptide and protein drugs, can be used to prepare colonic drug delivery systems, targeting drugs to the colon by the oral route. This review article clearly explains the advantages, limitations and need of gastro-retentive drug delivery system. It also covers the various criteria for drugs suitable and not suitable for such delivery. Also, the different types of gastro retentive delivery systems are described with suitable examples.

Pharmacognosy Research, 2010

Journal of Drug Targeting, 2008

The present investigation was aimed at lymphatic targeting of zidovudine (ZDV)-loaded surface-eng... more The present investigation was aimed at lymphatic targeting of zidovudine (ZDV)-loaded surface-engineered liposomes (SE liposomes). Surface of liposomes was engineered by incorporation of charges (positive or negative) and site-specific ligand (mannose) in order to enhance localization to lymphatics, specifically to lymph node and spleen. Positively and negatively charged nanosized SE liposomes (120 +/- 10 nm) were prepared using stearylamine (SA) and dicetyl phosphate (DCP), respectively, while ligand-coated SE liposomes were prepared using mannose-terminated SA (mannose conjugate). The SE liposomes were characterized for shape and surface morphology, size, entrapment efficiency, and in vitro drug release. All the SE liposomes formulations showed biphasic ZDV release, whereas mannose-coated liposomes (MAN-Lip) significantly reduced (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) drug release compared with conventional liposome (Lip). The organ distribution pattern of the SE liposomes exhibited significant reduction in free ZDV concentration in serum, whereas significantly increased quantity was detected in the spleen and lymph nodes (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). Fluorescent microscopy suggested enhanced uptake and localization of the SE liposomes in the lymph nodes and spleen, which were in the order: mannose coated &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; negatively charged &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; positively charged &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; Lip. Thus, the SE liposomes appeared to be promising novel vesicular system for enhanced targeting of ZDV to lymphatics, in AIDS chemotherapy.