Burcu Bayoglu | İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi (original) (raw)

Papers by Burcu Bayoglu

Research paper thumbnail of Review for "Molecular genetic associations between a prominent serotonin transporter gene polymorphism (5‐HTTLPR/rs25531) and individual differences in tendencies toward autistic traits and generalized internet use disorder in China and Germany

Research paper thumbnail of Techni̇ques and Procedures for Di̇seases Diagnostics

Research paper thumbnail of Theory and Practice for Medical Diagnosis

With this volume, we complete a successful international collaboration with collaborators from IP... more With this volume, we complete a successful international collaboration with collaborators from IP Erasmus project entitled “Classic and Modern Methods for Molecular Diagnostics in Human Pathology“, MDHP, coordinated from Faculty of Medicine, Transilvania University of Brasov, Romania, three years, from 2011 to 2013. Partners universities and project teachers, from different countries below. Radboud University Nijmegen, NL Istanbul University Cerrahpasa Medical Faculty and Istanbul Medical Faculty TR Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, SL University of Pardubice, CZ University of Medicine, Pecs, HU Universite Claude Bernard Lyon I, FR University of Pharmacy and Medicine, Iuliu – Haţieganu Cluj- Napoca, RO University of Pharmacy and Medicine, Targu – Mures, RO. Beside the project, took part, as lecturer, Proffessor Ilya Azizov from Karaganda Medical University, KZ. Additional prestigious collaborators mentioned at the end but not the last, Mr. Tim Sandle PhD, Head of Microbiology at Bio Products Laboratory, UK. I would thank Mr. Sandle for his assessment for publishing this book.

Research paper thumbnail of The roles of the GPX1 Pro198Leu and OGG1 Ser326Cys variants in coronary artery disease / GPX1 geni Pro198Leu ve OGG1 geni Ser326Cys varyantlarının koroner arter hastalığındaki rolleri

Turkish Journal of Biochemistry, 2016

Objective: Coronary artery disease (CAD) is caused by plaque formation on inner walls of coronary... more Objective: Coronary artery disease (CAD) is caused by plaque formation on inner walls of coronary arteries. Glutathione peroxidase-1 (GPX1), prevents oxidative damage by detoxifying hydrogen and lipid peroxides. GPX1 Pro198Leu polymorphism results in oxidant/antioxidant imbalance. 8-oxoguanine DNA glycosylase-1 (OGG1) is the key enzyme in DNA repair pathway. OGG1 Ser326Cys polymorphism leads to 8-oxoG accumulation and may play a role in cardiovascular diseases. Thus, our study aims to investigate GPX1 Pro198Leu and OGG1 Ser326Cys polymorphisms in CAD patients and the possible relationship of genotypes with serum lipids and CAD severity. Methods: A total of 169 CAD patients and 173 angiographically documented healthy controls were included in our study. The lesion severity in CAD patients was determined by Gensini scoring system. The genomic DNA was isolated from peripheral blood. Real-time polymerase chain reaction (RT-PCR) was used to genotype GPX1 Pro- 198Leu and OGG1 Ser326Cys po...

Research paper thumbnail of COMT rs4680 and DRD2 rs6275 variants and their association with YMRS scores in children with early-onset bipolar disorder

The European Journal of Psychiatry

Research paper thumbnail of Association between MTHFR C677T polymorphism and folate, vitamin B12, homocysteine, and DNA fragmentation in patients with ovarian cancer

Turkish Journal of Biochemistry, 2016

Objective:Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme that regulates the m... more Objective:Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme that regulates the metabolism of methionine and folate.Materials and methods:This case-control study was conducted in Istanbul University Cerrahpasa Medical Faculty. We studied 50 ovarian cancer patients and 54 healthy controls. TheResults:We found no correlation between theConclusion:Our findings suggest that

Research paper thumbnail of Roles of OLR1 and IL17A variants on clinical phenotypes of Turkish patients undergoing coronary artery bypass surgery

Turkish Journal of Biochemistry

Objectives Coronary artery disease (CAD) is a pathological condition resulting from atheroscleros... more Objectives Coronary artery disease (CAD) is a pathological condition resulting from atherosclerosis in the coronary arteries. IL17A has been shown to recruit and activate macrophages in atherosclerotic lesions, thereby participating in plaque destabilization. Currently, whether OLR1 and IL17A variants are involved in the pathogenesis of CAD is unclear. This case-control study aimed to investigate their roles in CAD etiology and prognosis. Methods In this study, 100 severe CAD patients who had undergone the coronary artery bypass graft surgery and 100 healthy controls were genotyped for OLR1 rs11053646, IL17A rs3819025, and rs8193037 variants via RT-PCR. Results The patients with OLR1 rs11053646 CG + GG genotype demonstrated a higher frequency of multi-vessel stenosis (18%) than single- (11.10%) or double-vessel (13.30%) stenosis (p=0.77). Additionally, although not statistically significant, this group of patients had 6.280 times more CAD risk than CC genotype carriers (p=0.089). Fu...

Research paper thumbnail of Downregulation of MMP-2 and MMP-9 genes in obesity patients and their relation with obesity-related phenotypes

Turkish Journal of Biochemistry

Objectives Adipose tissue mediates various bioactive molecules and cytokine discharge. The anti-i... more Objectives Adipose tissue mediates various bioactive molecules and cytokine discharge. The anti-inflammatory cytokine, interleukin-10 (IL-10), has roles in systemic inflammation. Matrix metalloproteinases (MMPs) are endopeptidases implicating in tissue remodeling, and extracellular matrix degradation. Interleukins and MMPs may have specific roles in obesity development. In this investigation, we marked the roles of IL-10, MMP-2, and MMP-9 in obesity and its related clinical phenotypes. Methods Using real-time quantitative polymerase chain reaction (RT-qPCR), also ELISA, IL-10, MMP-2, and MMP-9 mRNA and protein levels were detected respectively in the subcutaneous adipose tissues of 34 patients with obesity and 36 healthy individuals. Results MMP-2 and MMP-9 gene expression were significantly downregulated in obesity patients compared to controls (p=0.004, p=0.045). Nevertheless, IL-10 was elevated in the obesity group as to controls (p=0.010). MMP-2 mRNA expression was correlated wi...

Research paper thumbnail of Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis

Balkan Medical Journal, 2018

Research paper thumbnail of Genetic variants rs1994016 and rs3825807 in ADAMTS7 affect its mRNA expression in atherosclerotic occlusive peripheral arterial disease

Journal of Clinical Laboratory Analysis, 2017

Peripheral artery disease (PAD) is a vascular disease affecting peripheral circulation. Recently,... more Peripheral artery disease (PAD) is a vascular disease affecting peripheral circulation. Recently, genome-wide association studies revealed a relationship between single nucleotide polymorphisms (SNPs) in ADAMTS7 (a disintegrin and metalloprotease with thrombospondin motif 7) and atherosclerosis. In this study, we aimed to determine ADAMTS7 expression in peripheral blood mononuclear cells (PBMCs) and the frequency of ADAMTS7 rs1994016 and rs3825807 polymorphisms in a sample of Turkish patients with PAD, and to evaluate the association of matrix metalloproteinase (MMP) levels with PAD development. Methods: In this case-control study, ADAMTS7 mRNA and protein expression was determined using reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) and western blot, respectively, and rs1994016 and rs3825807 variants in ADAMTS7 were determined by real-time PCR in 115 PAD patients and 116 healthy controls. Plasma levels of nine MMPs were determined using a multiplex immunoassay system. Results: ADAMTS7 mRNA levels were significantly higher in PAD patients than in controls (t=−2.75, P=.007). There was no significant difference in the frequencies of rs1994016 and rs3825807 between PAD patients and controls (P>.05). In PAD patients, ADAMTS7 mRNA levels were significantly increased for the CC genotype of rs1994016 (t=−2.31, P=.026) and TT genotype of rs3825807 (t=−2.23, P=.032).

Research paper thumbnail of Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease

Experimental and Therapeutic Medicine, 2017

Research paper thumbnail of Evaluation of association between common genetic variants on chromosome 9p21 and coronary artery disease in Turkish population

Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology, 2015

Research paper thumbnail of The Severity of Internal Carotid Artery Stenosis is Associated with the Cyclin-Dependent Kinase Inhibitor 2A Gene Expression

Journal of Atherosclerosis and Thrombosis, 2014

Research paper thumbnail of IL-18 gene expression levels are associated with patients with carotid atherosclerosis

Research paper thumbnail of Lack of association between endothelial nitric oxide synthase glu298Asp variation, visceral obesity and insulin related phenotypes in Turkish type 2 diabetic patients

Nitric oxide (NO) is an endothelium derived relaxing factor(EDRF) important in regulating heart-v... more Nitric oxide (NO) is an endothelium derived relaxing factor(EDRF) important in regulating heart-vessel physiology. Theobjective of this study was to investigate whether the eNOSgene Glu298Asp variation influenced the lipid parameters,visceral obesity, insulin related phenotypes and type 2 diabetesmellitus (T2DM) development, for the first time in a Turkishstudy group. We analyzed the the eNOS gene Glu298Aspgenotype frequencies in 115 type 2 diabetic and 68 healthycontrol subjects. Serum lipids and insulin-related phenotypeswere also analyzed. No significant difference for genotypicfrequencies was observed for the Ban II (Eco241) restrictionsite in T2DM patients as compared to controls. eNOSGlu298Asp polymorphism was not found to affect visceralobesity and insulin related phenotypes. However, T2DM patientswith Asp/Asp genotype were found to have lower hepaticinsulin sensitivity (HIS) in comparison to Glu/Glu. Inhealthy controls, the insulin and HOMA levels were foundto be lower in Gl...

Research paper thumbnail of The effects of 5-HTTLPR/rs25531 serotonin transporter gene polymorphisms on antisocial personality disorder among criminals in a sample of the Turkish population

Molecular biology reports, 2021

Antisocial personality disorder (ASPD) is a cluster B personality disorder characterized by a dis... more Antisocial personality disorder (ASPD) is a cluster B personality disorder characterized by a disposition for criminal behaviors. It has been determined by previous studies that ASPD may have a genetic origin and the human serotonin transporter gene (SLC6A4) is one of the two serotonergic genes expected to be associated with this disorder. 5-HTT-linked polymorphic promoter region (5-HTTLPR) is a degenerate repeat polymorphic region in SLC6A4, the gene that codes for the serotonin transporter. Among many polymorphisms in SLC6A4, 5-HTTLPR an insertion/deletion (indel) polymorphism and rs25531 single nucleotide polymorphism (SNP) in the 5-HTTLPR polymorphic region contribute to the regulation of SLC6A4 expression. In this study, we aimed to reveal the relationship between frequencies of 5-HTTLPR variants and ASPD among criminals in the Turkish population. Moreover, it was also attempted to figure out the SLC6A4 gene expression level differences regarding these polymorphisms. The 5-HTTL...

Research paper thumbnail of Glucose and connections with OLR1 and IL17A genes

Inflammation has a significant role in glucose metabolism and vascular disease development. Many ... more Inflammation has a significant role in glucose metabolism and vascular disease development. Many factors including hyperglycemia, high insulin and triglyceride levels, oxidized low-density lipoprotein (LDL) cholesterol caused by reactive oxygen species (ROS), and released proinflammatory cytokines play a role in the development of inflammation. Disruptions in glucose metabolism trigger ROS formation. ROS induce the oxidation of LDL cholesterol leading to endothelial dysfunction. Oxidized LDL causes endothelial and vascular smooth muscle cell (VSMC) damage, stimulates monocytes, and promotes foam cell formation. Foam cells cause VSMC proliferation and atherogenesis. Proinflammatory cytokines also play a role in vascular damage. IL17A is one of the proinflammatory cytokines produced by T helper 17 cells in the immune system. IL17A overexpression and its variants were associated with various vascular diseases. Besides, LDL oxidation was reported to upregulate IL17 receptors in aorta. F...

Research paper thumbnail of OP-149 THE ASSESSMENT OF RELATIONSHIP BETWEEN VARIANTS AT 9p21 CHROMOSOME AND CORONARY ARTERY DISEASE IN TURKISH POPULATION

International Journal of Cardiology, 2012

Research paper thumbnail of AGT rs699 and AGTR1 rs5186 gene variants are associated with cardiovascular-related phenotypes in atherosclerotic peripheral arterial obstructive disease

Irish Journal of Medical Science (1971 -)

Research paper thumbnail of Catechol-O-Methyltransferase Val158Met and brain-derived neurotrophic factor Val66Met gene polymorphisms in paraphilic sexual offenders

Indian Journal of Psychiatry

Research paper thumbnail of Review for "Molecular genetic associations between a prominent serotonin transporter gene polymorphism (5‐HTTLPR/rs25531) and individual differences in tendencies toward autistic traits and generalized internet use disorder in China and Germany

Research paper thumbnail of Techni̇ques and Procedures for Di̇seases Diagnostics

Research paper thumbnail of Theory and Practice for Medical Diagnosis

With this volume, we complete a successful international collaboration with collaborators from IP... more With this volume, we complete a successful international collaboration with collaborators from IP Erasmus project entitled “Classic and Modern Methods for Molecular Diagnostics in Human Pathology“, MDHP, coordinated from Faculty of Medicine, Transilvania University of Brasov, Romania, three years, from 2011 to 2013. Partners universities and project teachers, from different countries below. Radboud University Nijmegen, NL Istanbul University Cerrahpasa Medical Faculty and Istanbul Medical Faculty TR Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, SL University of Pardubice, CZ University of Medicine, Pecs, HU Universite Claude Bernard Lyon I, FR University of Pharmacy and Medicine, Iuliu – Haţieganu Cluj- Napoca, RO University of Pharmacy and Medicine, Targu – Mures, RO. Beside the project, took part, as lecturer, Proffessor Ilya Azizov from Karaganda Medical University, KZ. Additional prestigious collaborators mentioned at the end but not the last, Mr. Tim Sandle PhD, Head of Microbiology at Bio Products Laboratory, UK. I would thank Mr. Sandle for his assessment for publishing this book.

Research paper thumbnail of The roles of the GPX1 Pro198Leu and OGG1 Ser326Cys variants in coronary artery disease / GPX1 geni Pro198Leu ve OGG1 geni Ser326Cys varyantlarının koroner arter hastalığındaki rolleri

Turkish Journal of Biochemistry, 2016

Objective: Coronary artery disease (CAD) is caused by plaque formation on inner walls of coronary... more Objective: Coronary artery disease (CAD) is caused by plaque formation on inner walls of coronary arteries. Glutathione peroxidase-1 (GPX1), prevents oxidative damage by detoxifying hydrogen and lipid peroxides. GPX1 Pro198Leu polymorphism results in oxidant/antioxidant imbalance. 8-oxoguanine DNA glycosylase-1 (OGG1) is the key enzyme in DNA repair pathway. OGG1 Ser326Cys polymorphism leads to 8-oxoG accumulation and may play a role in cardiovascular diseases. Thus, our study aims to investigate GPX1 Pro198Leu and OGG1 Ser326Cys polymorphisms in CAD patients and the possible relationship of genotypes with serum lipids and CAD severity. Methods: A total of 169 CAD patients and 173 angiographically documented healthy controls were included in our study. The lesion severity in CAD patients was determined by Gensini scoring system. The genomic DNA was isolated from peripheral blood. Real-time polymerase chain reaction (RT-PCR) was used to genotype GPX1 Pro- 198Leu and OGG1 Ser326Cys po...

Research paper thumbnail of COMT rs4680 and DRD2 rs6275 variants and their association with YMRS scores in children with early-onset bipolar disorder

The European Journal of Psychiatry

Research paper thumbnail of Association between MTHFR C677T polymorphism and folate, vitamin B12, homocysteine, and DNA fragmentation in patients with ovarian cancer

Turkish Journal of Biochemistry, 2016

Objective:Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme that regulates the m... more Objective:Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme that regulates the metabolism of methionine and folate.Materials and methods:This case-control study was conducted in Istanbul University Cerrahpasa Medical Faculty. We studied 50 ovarian cancer patients and 54 healthy controls. TheResults:We found no correlation between theConclusion:Our findings suggest that

Research paper thumbnail of Roles of OLR1 and IL17A variants on clinical phenotypes of Turkish patients undergoing coronary artery bypass surgery

Turkish Journal of Biochemistry

Objectives Coronary artery disease (CAD) is a pathological condition resulting from atheroscleros... more Objectives Coronary artery disease (CAD) is a pathological condition resulting from atherosclerosis in the coronary arteries. IL17A has been shown to recruit and activate macrophages in atherosclerotic lesions, thereby participating in plaque destabilization. Currently, whether OLR1 and IL17A variants are involved in the pathogenesis of CAD is unclear. This case-control study aimed to investigate their roles in CAD etiology and prognosis. Methods In this study, 100 severe CAD patients who had undergone the coronary artery bypass graft surgery and 100 healthy controls were genotyped for OLR1 rs11053646, IL17A rs3819025, and rs8193037 variants via RT-PCR. Results The patients with OLR1 rs11053646 CG + GG genotype demonstrated a higher frequency of multi-vessel stenosis (18%) than single- (11.10%) or double-vessel (13.30%) stenosis (p=0.77). Additionally, although not statistically significant, this group of patients had 6.280 times more CAD risk than CC genotype carriers (p=0.089). Fu...

Research paper thumbnail of Downregulation of MMP-2 and MMP-9 genes in obesity patients and their relation with obesity-related phenotypes

Turkish Journal of Biochemistry

Objectives Adipose tissue mediates various bioactive molecules and cytokine discharge. The anti-i... more Objectives Adipose tissue mediates various bioactive molecules and cytokine discharge. The anti-inflammatory cytokine, interleukin-10 (IL-10), has roles in systemic inflammation. Matrix metalloproteinases (MMPs) are endopeptidases implicating in tissue remodeling, and extracellular matrix degradation. Interleukins and MMPs may have specific roles in obesity development. In this investigation, we marked the roles of IL-10, MMP-2, and MMP-9 in obesity and its related clinical phenotypes. Methods Using real-time quantitative polymerase chain reaction (RT-qPCR), also ELISA, IL-10, MMP-2, and MMP-9 mRNA and protein levels were detected respectively in the subcutaneous adipose tissues of 34 patients with obesity and 36 healthy individuals. Results MMP-2 and MMP-9 gene expression were significantly downregulated in obesity patients compared to controls (p=0.004, p=0.045). Nevertheless, IL-10 was elevated in the obesity group as to controls (p=0.010). MMP-2 mRNA expression was correlated wi...

Research paper thumbnail of Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis

Balkan Medical Journal, 2018

Research paper thumbnail of Genetic variants rs1994016 and rs3825807 in ADAMTS7 affect its mRNA expression in atherosclerotic occlusive peripheral arterial disease

Journal of Clinical Laboratory Analysis, 2017

Peripheral artery disease (PAD) is a vascular disease affecting peripheral circulation. Recently,... more Peripheral artery disease (PAD) is a vascular disease affecting peripheral circulation. Recently, genome-wide association studies revealed a relationship between single nucleotide polymorphisms (SNPs) in ADAMTS7 (a disintegrin and metalloprotease with thrombospondin motif 7) and atherosclerosis. In this study, we aimed to determine ADAMTS7 expression in peripheral blood mononuclear cells (PBMCs) and the frequency of ADAMTS7 rs1994016 and rs3825807 polymorphisms in a sample of Turkish patients with PAD, and to evaluate the association of matrix metalloproteinase (MMP) levels with PAD development. Methods: In this case-control study, ADAMTS7 mRNA and protein expression was determined using reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) and western blot, respectively, and rs1994016 and rs3825807 variants in ADAMTS7 were determined by real-time PCR in 115 PAD patients and 116 healthy controls. Plasma levels of nine MMPs were determined using a multiplex immunoassay system. Results: ADAMTS7 mRNA levels were significantly higher in PAD patients than in controls (t=−2.75, P=.007). There was no significant difference in the frequencies of rs1994016 and rs3825807 between PAD patients and controls (P>.05). In PAD patients, ADAMTS7 mRNA levels were significantly increased for the CC genotype of rs1994016 (t=−2.31, P=.026) and TT genotype of rs3825807 (t=−2.23, P=.032).

Research paper thumbnail of Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease

Experimental and Therapeutic Medicine, 2017

Research paper thumbnail of Evaluation of association between common genetic variants on chromosome 9p21 and coronary artery disease in Turkish population

Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology, 2015

Research paper thumbnail of The Severity of Internal Carotid Artery Stenosis is Associated with the Cyclin-Dependent Kinase Inhibitor 2A Gene Expression

Journal of Atherosclerosis and Thrombosis, 2014

Research paper thumbnail of IL-18 gene expression levels are associated with patients with carotid atherosclerosis

Research paper thumbnail of Lack of association between endothelial nitric oxide synthase glu298Asp variation, visceral obesity and insulin related phenotypes in Turkish type 2 diabetic patients

Nitric oxide (NO) is an endothelium derived relaxing factor(EDRF) important in regulating heart-v... more Nitric oxide (NO) is an endothelium derived relaxing factor(EDRF) important in regulating heart-vessel physiology. Theobjective of this study was to investigate whether the eNOSgene Glu298Asp variation influenced the lipid parameters,visceral obesity, insulin related phenotypes and type 2 diabetesmellitus (T2DM) development, for the first time in a Turkishstudy group. We analyzed the the eNOS gene Glu298Aspgenotype frequencies in 115 type 2 diabetic and 68 healthycontrol subjects. Serum lipids and insulin-related phenotypeswere also analyzed. No significant difference for genotypicfrequencies was observed for the Ban II (Eco241) restrictionsite in T2DM patients as compared to controls. eNOSGlu298Asp polymorphism was not found to affect visceralobesity and insulin related phenotypes. However, T2DM patientswith Asp/Asp genotype were found to have lower hepaticinsulin sensitivity (HIS) in comparison to Glu/Glu. Inhealthy controls, the insulin and HOMA levels were foundto be lower in Gl...

Research paper thumbnail of The effects of 5-HTTLPR/rs25531 serotonin transporter gene polymorphisms on antisocial personality disorder among criminals in a sample of the Turkish population

Molecular biology reports, 2021

Antisocial personality disorder (ASPD) is a cluster B personality disorder characterized by a dis... more Antisocial personality disorder (ASPD) is a cluster B personality disorder characterized by a disposition for criminal behaviors. It has been determined by previous studies that ASPD may have a genetic origin and the human serotonin transporter gene (SLC6A4) is one of the two serotonergic genes expected to be associated with this disorder. 5-HTT-linked polymorphic promoter region (5-HTTLPR) is a degenerate repeat polymorphic region in SLC6A4, the gene that codes for the serotonin transporter. Among many polymorphisms in SLC6A4, 5-HTTLPR an insertion/deletion (indel) polymorphism and rs25531 single nucleotide polymorphism (SNP) in the 5-HTTLPR polymorphic region contribute to the regulation of SLC6A4 expression. In this study, we aimed to reveal the relationship between frequencies of 5-HTTLPR variants and ASPD among criminals in the Turkish population. Moreover, it was also attempted to figure out the SLC6A4 gene expression level differences regarding these polymorphisms. The 5-HTTL...

Research paper thumbnail of Glucose and connections with OLR1 and IL17A genes

Inflammation has a significant role in glucose metabolism and vascular disease development. Many ... more Inflammation has a significant role in glucose metabolism and vascular disease development. Many factors including hyperglycemia, high insulin and triglyceride levels, oxidized low-density lipoprotein (LDL) cholesterol caused by reactive oxygen species (ROS), and released proinflammatory cytokines play a role in the development of inflammation. Disruptions in glucose metabolism trigger ROS formation. ROS induce the oxidation of LDL cholesterol leading to endothelial dysfunction. Oxidized LDL causes endothelial and vascular smooth muscle cell (VSMC) damage, stimulates monocytes, and promotes foam cell formation. Foam cells cause VSMC proliferation and atherogenesis. Proinflammatory cytokines also play a role in vascular damage. IL17A is one of the proinflammatory cytokines produced by T helper 17 cells in the immune system. IL17A overexpression and its variants were associated with various vascular diseases. Besides, LDL oxidation was reported to upregulate IL17 receptors in aorta. F...

Research paper thumbnail of OP-149 THE ASSESSMENT OF RELATIONSHIP BETWEEN VARIANTS AT 9p21 CHROMOSOME AND CORONARY ARTERY DISEASE IN TURKISH POPULATION

International Journal of Cardiology, 2012

Research paper thumbnail of AGT rs699 and AGTR1 rs5186 gene variants are associated with cardiovascular-related phenotypes in atherosclerotic peripheral arterial obstructive disease

Irish Journal of Medical Science (1971 -)

Research paper thumbnail of Catechol-O-Methyltransferase Val158Met and brain-derived neurotrophic factor Val66Met gene polymorphisms in paraphilic sexual offenders

Indian Journal of Psychiatry