Rasheed Ahemad | JNTU , hyderabad (original) (raw)

Papers by Rasheed Ahemad

The aim of this study was to investigate the antioxidant activity and phytochemical analysis of t... more The aim of this study was to investigate the antioxidant activity and phytochemical analysis of the leaves extracts of Melia azedarach L. The phytochemical screening was carried on the leaves extracts of Melia azedarach, revealed the presence of some active ingredients such as Alkaloids, Tannins, Saponins, Phenols, glycosides, steroids, terpenoids and flavonoids. The ethanolic leaves extract were also evaluated for their total phenolic contents and antioxidant activity using DPPH radical scavenging assay. The result of the present study showed that the ethanolic leaves extract of Melia azedarach. which contains highest amount of phenolic compounds exhibited the greatest anti-oxidant activity than petroleum ether and aqueous extracts. The high scavenging property of may be due to hydroxyl groups existing in the phenolic compounds.

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The aim of the study is to investigate the phytochemicals and hepatoprotective activity of Melia ... more The aim of the study is to investigate the phytochemicals and hepatoprotective activity of Melia azedarach L leaves extracts against carbon tetrachloride (CCl4) induced hepatotoxicity. The phytochemical screening was carried on the leaves extracts of Melia azedarach revealed the presence of some active ingredients such as Alkaloids, Tannins, Saponins, Phenols, glycosides, steroids, terpenoids and flavonoids. Leaves of Melia azedarach was successively extracted with ethanol against carbon tetrachloride (CCl4) induced hepatotoxicity using Standard drug Silymarin (25 mg/kg). There was a significant changes in biochemical parameters (increases in serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), alanine phosphatase (ALP),serum bilirubin and decrease the total proteins content.) in CCl4 treated rats, which were restored towards normalization in Melia azedarach (500 mg/kg) treated animals. Thus the present study ascertains that the leaf extrac...

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Object: To evaluate antidiabetic activity of ethanolic extract of Holostemma ada Kodien Schults (... more Object: To evaluate antidiabetic activity of ethanolic extract of Holostemma ada Kodien Schults (EEHK) in normal, glucose fed , alloxan-induced diabetic rats and to perform phytochemical and toxicity studies. Material and Methods: The alcoholic extract ofHolostemma ada Kodien (Asclepiadaceae) was studied for antidiabetic activity in normal, glucose fed and alloxaninduced diabetic rats by oral administration of extract (200 and 400 mg/kg body wt) for 7 days. The effect was compared with 0.5 mg/kg (i.p) glibenclamide.Results: The alcoholic extract ofHolostemma ada Kodien significantly lowered the blood sugar of hyperglycemic rats. From toxicity study it was observed that EEHK was non toxic upto 5 g/kg body weight and phytochemical studies shows the presence of alkaloids, flavonoids, flavanones, tannins, terpenoids, amino acids and carbohydrates.Conclusion: The results justified the traditional use in the treatment of diabetes.

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Ethanolic root extract from Smilax zeylanica was investigated for its antioxidant and anti catale... more Ethanolic root extract from Smilax zeylanica was investigated for its antioxidant and anti cataleptic effects in the haloperidol-induced catalepsy rat model of the disease by measuring behavioral and biochemical parameters. Catalepsy was induced by administration of haloperidol (1 mg/kg, i.p) in male albino rats. A significant (P < 0.01) reduction in the cataleptic scores were observed in all the drug-treated groups as compared to the haloperidol-treated group; with maximum reduction observed in the Smilax zeylanica (500 mg/kg body weight) administered group. To estimate biochemical parameters: the generation of thiobarbituric acid reactive substances (TBARS); reduced glutathione (GSH) content and glutathione-dependent enzymes; catalase; and superoxide dismutase (SOD), in the brain were assessed. Haloperidol administration increased generation of TBARS and significantly reduced GSH, which were restored to near normal level with the Smilax zeylanica treatment. Catalase and SOD lev...

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Hydro alcoholic root extract from Nardostachys jatamansi was investigated for its antioxidant and... more Hydro alcoholic root extract from Nardostachys jatamansi was investigated for its antioxidant and anti cataleptic effects in the haloperidol-induced catalepsy rat model of the disease by measuring behavioral, biochemical parameters and neurotransmitter levels. Catalepsy was induced by administration of haloperidol (1 mg/kg, i.p) in male wistar rats. A significant (P < 0.01) reduction in the cataleptic scores were observed in all the drug-treated groups as compared to the haloperidol-treated group; with maximum reduction observed in the Nardostachys jatamansi (500 mg/kg body weight) administered group. Haloperidol administration increased generation of TBARS and significantly reduced GSH, which were restored to near normal level with the Nardostachys jatamansi treatment. Catalase and SOD levels were also increased to normal levels, having been reduced significantly by haloperidol administration. Haloperidol administration decreased the dopamine levels significantly, which were res...

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The aim of this study was to investigate the antioxidant activities and phytochemical analysis of... more The aim of this study was to investigate the antioxidant activities and phytochemical analysis of Brassica oleracea L. var. capitata. The phytochemical screening was carried on the leaves extracts of Brassica oleracea L. var. capitata revealed the presence of some active ingredients such as Alkaloids, Tannins, Saponins, Phenols, Glycosides, Steroids, Terpenoids and Flavonoids. The ethanol leaves extract were also evaluated for their total phenolic contents and antioxidant activity using DPPH radical scavenging assay and reducing power assay. The result of the present study showed that the ethanolic leaves extract of Brassica oleracea L. var. capitata which contains highest amount of phenolic compounds exhibited the greatest anti-oxidant activity than Petroleum Ether, ethylacetate, chloroform and aqueous extracts. The high scavenging property of may be due to hydroxyl groups existing in the phenolic compounds.

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Summary �ardostachys jatamansi roots were extracted with water(50%) & ethanol(50%) and analyzed f... more Summary �ardostachys jatamansi roots were extracted with water(50%) & ethanol(50%) and analyzed for its anti-parkinsonism effect by measuring various neurological and behavioral parameters at the test dose of 250mg/kg and 500mg/kg body wt. Haloperidol 1mg/kg body weight was administered i.p in order to induce Parkinsonism. Parkinsonism caused by depletion of dopamine level in substansia nigra. Hydro-alcoholic root extract of �ardostachys jatamansi reversed the haloperidol induced Parkinsonism significantly (p<0.01), when compared to drugs, i.e. combination of L-dopa & Carbidopa (100mg+25mg/kg). From the above studies it could be predict that the symptoms of Parkinsonism may be due to alteration in dopaminergic system, which play important role in the protection from Parkinsonism. The levels altered by haloperidol were restored

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Pharmacognosy Journal, 2011

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Pharmacognosy Journal, 2011

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