Satyajit Das | C. V. RAMAN COLLEGE OF ENGINEERING (original) (raw)

Papers by Satyajit Das

Infection and Drug Resistance, 2015

Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (INSTI), which has ... more Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (INSTI), which has now been licensed to be used in different countries including the UK. Earlier studies have demonstrated that DTG when used with nucleoside backbone in treatment-naïve and-experienced patients has been well tolerated and demonstrated virological suppression comparable to other INSTIs and superiority against other first-line agents, including efavirenz and boosted protease inhibitors. Like other INSTIs, DTG uses separate metabolic pathways compared to other antiretrovirals and is a minor substrate for CYP-450. It does not appear to have a significant interaction with drugs, which uses the CYP-450 system. Nonetheless, it uses renal solute transporters that may potentially inhibit the transport of other drugs and can have an effect on the elimination of other drugs. However, the impact of this mechanism appears to be very minimal and insignificant clinically. The side effect profiles of DTG are similar to raltegravir and have been found to be well tolerated. DTG has a long plasma half-life and is suitable for once daily use without the need for a boosting agent. DTG has all the potential to be used as a first-line drug in combination with other nucleoside backbones, especially in the form of a single tablet in combination with abacavir and lamivudine. The purpose of this review article is to present the summary of the available key information about the clinical usefulness of DTG in the treatment of HIV infection.

Electronics

Conductive thin films are an essential component of many electronic devices. Measuring their cond... more Conductive thin films are an essential component of many electronic devices. Measuring their conductivity accurately is necessary for quality control and process monitoring. We compare conductivity measurements on films for flexible electronics using three different techniques: four-point probe, microwave resonator and terahertz time-domain spectroscopy. Multiple samples were examined, facilitating the comparison of the three techniques. Sheet resistance values at DC, microwave and terahertz frequencies were obtained and were found to be in close agreement.

JMIR Formative Research

Background: Young people aged 16-24 years are disproportionately affected by sexually transmitted... more Background: Young people aged 16-24 years are disproportionately affected by sexually transmitted infections (STIs). STIs can have serious health consequences for affected individuals and the estimated annual cost of treatment to the National Health Service is £620 million. Accordingly, the UK government has made reducing the rates of STIs among this group a priority. A missed opportunity to intervene to increase condom use is when young people obtain self-sampling kits for STIs via the internet. Objective: Our aim was to develop a theory-based tailored intervention to increase condom use for 16-24-years-olds accessing chlamydia self-sampling websites. Methods: The intervention, Wrapped, was developed using Intervention Mapping and was co-designed with young people. The following steps were performed: (1) identification of important determinants of condom use and evidence of their changeability using computer and digital interventions; (2) setting the intervention goal, performance objectives, and change objectives; (3) identification of Behavior Change Principles (BCPs) and practical strategies to target these determinants; and (4) development of intervention materials able to deliver the BCPs and practical strategies. Results: Users of existing chlamydia self-sampling websites are signposted to Wrapped after placing an order for a sampling kit. Salient barriers to condom use are identified by each user and relevant intervention components are allocated to target these. The components include the following: (1) a sample box of condoms, (2) an online condom distribution service, (3) a product for carrying condoms, (4) a condom demonstration video, (5) a series of videos on communication about condom use, and (6) erotic films of real couples discussing and demonstrating condom use. Conclusions: This intervention will be directed at young people who may be particularly receptive to messages and support for behavior change due to their testing status.

Journal of Derivatives Accounting, 2004

Wilmott, 2011

active in buying sovereign bonds. The program called for European public investment to help reviv... more active in buying sovereign bonds. The program called for European public investment to help revive the Greek economy, dubbed by French President Nicolas Sarkozy the European 'Marshall Plan,' the $13 billion US plan to help rebuild Europe from the effects of World War II. Details of the public investment plan and other elements of the grand compact are sketchy. Significantly, the EU plan recognized the need for writedowns in the outstanding debt of the peripheral economies. The EU accepted that the extension of debt maturities by private lenders would result in a technical, though hopefully short-lived, default. The ECB, which had vociferously opposed any 'default,' was bought off. Other countries agreed to cross-guarantee the (possibly defaulted) Greek

Abstract: Advances in computer technology have provided a significant reduction in application pr... more Abstract: Advances in computer technology have provided a significant reduction in application processing times. This is true even for multimedia applications, which often exhibit a pattern in their execution—they process data frames periodically. Knowledge of ...

Journal of Antimicrobial Chemotherapy, 2010

The life expectancy of people living with HIV infection has improved dramatically since the use o... more The life expectancy of people living with HIV infection has improved dramatically since the use of highly active antiretroviral therapy (HAART). Now that patients with HIV infection are living longer, the focus of its treatment should shift to long-term management spanning decades. Diseases of ageing, including cardiovascular disease (CVD), have now become more important. The evidence of cardiovascular risk associated with HIV infection and antiretroviral therapy is explored and discussed in this article.

Infection and Drug Resistance, 2015

Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (INSTI), which has ... more Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (INSTI), which has now been licensed to be used in different countries including the UK. Earlier studies have demonstrated that DTG when used with nucleoside backbone in treatment-naïve and-experienced patients has been well tolerated and demonstrated virological suppression comparable to other INSTIs and superiority against other first-line agents, including efavirenz and boosted protease inhibitors. Like other INSTIs, DTG uses separate metabolic pathways compared to other antiretrovirals and is a minor substrate for CYP-450. It does not appear to have a significant interaction with drugs, which uses the CYP-450 system. Nonetheless, it uses renal solute transporters that may potentially inhibit the transport of other drugs and can have an effect on the elimination of other drugs. However, the impact of this mechanism appears to be very minimal and insignificant clinically. The side effect profiles of DTG are similar to raltegravir and have been found to be well tolerated. DTG has a long plasma half-life and is suitable for once daily use without the need for a boosting agent. DTG has all the potential to be used as a first-line drug in combination with other nucleoside backbones, especially in the form of a single tablet in combination with abacavir and lamivudine. The purpose of this review article is to present the summary of the available key information about the clinical usefulness of DTG in the treatment of HIV infection.

Electronics

Conductive thin films are an essential component of many electronic devices. Measuring their cond... more Conductive thin films are an essential component of many electronic devices. Measuring their conductivity accurately is necessary for quality control and process monitoring. We compare conductivity measurements on films for flexible electronics using three different techniques: four-point probe, microwave resonator and terahertz time-domain spectroscopy. Multiple samples were examined, facilitating the comparison of the three techniques. Sheet resistance values at DC, microwave and terahertz frequencies were obtained and were found to be in close agreement.

JMIR Formative Research

Background: Young people aged 16-24 years are disproportionately affected by sexually transmitted... more Background: Young people aged 16-24 years are disproportionately affected by sexually transmitted infections (STIs). STIs can have serious health consequences for affected individuals and the estimated annual cost of treatment to the National Health Service is £620 million. Accordingly, the UK government has made reducing the rates of STIs among this group a priority. A missed opportunity to intervene to increase condom use is when young people obtain self-sampling kits for STIs via the internet. Objective: Our aim was to develop a theory-based tailored intervention to increase condom use for 16-24-years-olds accessing chlamydia self-sampling websites. Methods: The intervention, Wrapped, was developed using Intervention Mapping and was co-designed with young people. The following steps were performed: (1) identification of important determinants of condom use and evidence of their changeability using computer and digital interventions; (2) setting the intervention goal, performance objectives, and change objectives; (3) identification of Behavior Change Principles (BCPs) and practical strategies to target these determinants; and (4) development of intervention materials able to deliver the BCPs and practical strategies. Results: Users of existing chlamydia self-sampling websites are signposted to Wrapped after placing an order for a sampling kit. Salient barriers to condom use are identified by each user and relevant intervention components are allocated to target these. The components include the following: (1) a sample box of condoms, (2) an online condom distribution service, (3) a product for carrying condoms, (4) a condom demonstration video, (5) a series of videos on communication about condom use, and (6) erotic films of real couples discussing and demonstrating condom use. Conclusions: This intervention will be directed at young people who may be particularly receptive to messages and support for behavior change due to their testing status.

Journal of Derivatives Accounting, 2004

Wilmott, 2011

active in buying sovereign bonds. The program called for European public investment to help reviv... more active in buying sovereign bonds. The program called for European public investment to help revive the Greek economy, dubbed by French President Nicolas Sarkozy the European 'Marshall Plan,' the $13 billion US plan to help rebuild Europe from the effects of World War II. Details of the public investment plan and other elements of the grand compact are sketchy. Significantly, the EU plan recognized the need for writedowns in the outstanding debt of the peripheral economies. The EU accepted that the extension of debt maturities by private lenders would result in a technical, though hopefully short-lived, default. The ECB, which had vociferously opposed any 'default,' was bought off. Other countries agreed to cross-guarantee the (possibly defaulted) Greek

Abstract: Advances in computer technology have provided a significant reduction in application pr... more Abstract: Advances in computer technology have provided a significant reduction in application processing times. This is true even for multimedia applications, which often exhibit a pattern in their execution—they process data frames periodically. Knowledge of ...

Journal of Antimicrobial Chemotherapy, 2010

The life expectancy of people living with HIV infection has improved dramatically since the use o... more The life expectancy of people living with HIV infection has improved dramatically since the use of highly active antiretroviral therapy (HAART). Now that patients with HIV infection are living longer, the focus of its treatment should shift to long-term management spanning decades. Diseases of ageing, including cardiovascular disease (CVD), have now become more important. The evidence of cardiovascular risk associated with HIV infection and antiretroviral therapy is explored and discussed in this article.