Makii Muthalib | Deakin University (original) (raw)
Papers by Makii Muthalib
Faculty of Health Institute of Health and Biomedical Innovation School of Exercise Nutrition Sciences, Jun 2, 2013
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2011
This article provides a snapshot of muscle near-infrared spectroscopy (NIRS) at the end of 2010 s... more This article provides a snapshot of muscle near-infrared spectroscopy (NIRS) at the end of 2010 summarizing the recent literature, offering the present status and perspectives of the NIRS instrumentation and methods, describing the main NIRS studies on skeletal muscle physiology, posing open questions and outlining future directions. So far, different NIRS techniques (e.g. continuous-wave (CW) and spatially, time- and frequency-resolved spectroscopy) have been used for measuring muscle oxygenation during exercise. In the last four years, approximately 160 muscle NIRS articles have been published on different physiological aspects (primarily muscle oxygenation and haemodynamics) of several upper- and lower-limb muscle groups investigated by using mainly two-channel CW and spatially resolved spectroscopy commercial instruments. Unfortunately, in only 15 of these studies were the advantages of using multi-channel instruments exploited. There are still several open questions in the application of NIRS in muscle studies: (i) whether NIRS can be used in subjects with a large fat layer; (ii) the contribution of myoglobin desaturation to the NIRS signal during exercise; (iii) the effect of scattering changes during exercise; and (iv) the effect of changes in skin perfusion, particularly during prolonged exercise. Recommendations for instrumentation advancements and future muscle NIRS studies are provided.
Annals of Physical and Rehabilitation Medicine, 2015
Frontiers in Human Neuroscience, 2015
Journal of Science and Medicine in Sport, 2000
Frontiers in Aging Neuroscience, 2015
The use of virtual reality games (known as "exer... more The use of virtual reality games (known as "exergaming") as a neurorehabilitation tool is gaining interest. Therefore, we aim to collate evidence for the effects of exergaming on the balance and postural control of older adults and people with idiopathic Parkinson's disease (IPD). Six electronic databases were searched, from inception to April 2015, to identify relevant studies. Standardized mean differences (SMDs) and 95% confidence intervals (CI) were used to calculate effect sizes between experimental and control groups. I (2) statistics were used to determine levels of heterogeneity. 325 older adults and 56 people with IPD who were assessed across 11 -studies. The results showed that exergaming improved static balance (SMD 1.069, 95% CI 0.563-1.576), postural control (SMD 0.826, 95% CI 0.481-1.170), and dynamic balance (SMD -0.808, 95% CI -1.192 to -0.424) in healthy older adults. Two IPD studies showed an improvement in static balance (SMD 0.124, 95% CI -0.581 to 0.828) and postural control (SMD 2.576, 95% CI 1.534-3.599). Our findings suggest that exergaming might be an appropriate therapeutic tool for improving balance and postural control in older adults, but more -large-scale trials are needed to determine if the same is true for people with IPD.
Journal of Sport and Health Science, 2014
Journal of Biomedical Optics, 2010
Advances in Experimental Medicine and Biology, 2011
nodal transcranial direct current stimulation (a-tDCS) is a noninvasive electrical brain stimulat... more nodal transcranial direct current stimulation (a-tDCS) is a noninvasive electrical brain stimulation technique that has been shown to increase cortical neuronal excitability and activity [1]. An indirect marker of increases in cortical neuronal activity is the subsequent increase in the regional cerebral blood flow (rCBF). Functional near-infrared spectroscopy (fNIRS) is a noninvasive neuroimaging method, which measures changes in regional cortical hemodynamics (rCHD) via oxyhemoglobin (HbO2) and deoxyhemoglobin (HHb) concentrations, such that an increase in HbO2 and decrease in HHb are considered a good index of increases in rCBF [2]. A previous fNIRS study [3] showed that 10 min of a-tDCS on the left prefrontal cortex (PFC) with the cathode on the right PFC induced an increase in rCHD in the cortical regions under the anode and cathode after a-tDCS (offline effects). However, the time course of changes in rCHD during a-tDCS (online effects) revealing an index of neuronal modulatio...
fNIRS 2014, October 10-12, Montreal, Canada
PLOS ONE, 2015
Neuroimaging studies have shown neuromuscular electrical stimulation (NMES)-evoked movements acti... more Neuroimaging studies have shown neuromuscular electrical stimulation (NMES)-evoked movements activate regions of the cortical sensorimotor network, including the primary sensorimotor cortex (SMC), premotor cortex (PMC), supplementary motor area (SMA), and secondary somatosensory area (S2), as well as regions of the prefrontal cortex (PFC) known to be involved in pain processing. The aim of this study, on nine healthy subjects, was to compare the cortical network activation profile and pain ratings during NMES of the right forearm wrist extensor muscles at increasing current intensities up to and slightly over the individual maximal tolerated intensity (MTI), and with reference to voluntary (VOL) wrist extension movements. By exploiting the capability of the multi-channel time domain functional near-infrared spectroscopy technique to relate depth information to the photon time-of-flight, the cortical and superficial oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin concentrations were estimated. The O2Hb and HHb maps obtained using the General Linear Model (NIRS-SPM) analysis method, showed that the VOL and NMES-evoked movements significantly increased activation (i.e., increase in O2Hb and corresponding decrease in HHb) in the cortical layer of the contralateral sensorimotor network (SMC, PMC/SMA, and S2). However, the level and area of contralateral sensorimotor network (including PFC) activation was significantly greater for NMES than VOL. Furthermore, there was greater bilateral sensorimotor network activation with the high NMES current intensities which corresponded with increased pain ratings. In conclusion, our findings suggest that greater bilateral sensorimotor network activation profile with high NMES current intensities could be in part attributable to increased attentional/pain processing and to increased bilateral sensorimotor integration in these cortical regions.
Frontiers in Aging Neuroscience, 2015
Exercise immunology review, 2006
We compared changes in markers of muscle damage and systemic inflammation after submaximal and ma... more We compared changes in markers of muscle damage and systemic inflammation after submaximal and maximal lengthening muscle contractions of the elbow flexors. Using a cross-over design, 10 healthy young men not involved in resistance training completed a submaximal trial (10 sets of 60 lengthening contractions at 10% maximum isometric strength, 1 min rest between sets), followed by a maximal trial (10 sets of three lengthening contractions at 100% maximum isometric strength, 3 min rest between sets). Lengthening contractions were performed on an isokinetic dynamometer. Opposite arms were used for the submaximal and maximal trials, and the trials were separated by a minimum of two weeks. Blood was sampled before, immediately after, 1 h, 3 h, and 1-4 d after each trial. Total leukocyte and neutrophil numbers, and the serum concentration of soluble tumor necrosis factor-alpha receptor 1 were elevated after both trials (P < 0.01), but there were no differences between the trials. Serum...
2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2012
Faculty of Health Institute of Health and Biomedical Innovation School of Exercise Nutrition Sciences, Jun 2, 2013
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2011
This article provides a snapshot of muscle near-infrared spectroscopy (NIRS) at the end of 2010 s... more This article provides a snapshot of muscle near-infrared spectroscopy (NIRS) at the end of 2010 summarizing the recent literature, offering the present status and perspectives of the NIRS instrumentation and methods, describing the main NIRS studies on skeletal muscle physiology, posing open questions and outlining future directions. So far, different NIRS techniques (e.g. continuous-wave (CW) and spatially, time- and frequency-resolved spectroscopy) have been used for measuring muscle oxygenation during exercise. In the last four years, approximately 160 muscle NIRS articles have been published on different physiological aspects (primarily muscle oxygenation and haemodynamics) of several upper- and lower-limb muscle groups investigated by using mainly two-channel CW and spatially resolved spectroscopy commercial instruments. Unfortunately, in only 15 of these studies were the advantages of using multi-channel instruments exploited. There are still several open questions in the application of NIRS in muscle studies: (i) whether NIRS can be used in subjects with a large fat layer; (ii) the contribution of myoglobin desaturation to the NIRS signal during exercise; (iii) the effect of scattering changes during exercise; and (iv) the effect of changes in skin perfusion, particularly during prolonged exercise. Recommendations for instrumentation advancements and future muscle NIRS studies are provided.
Annals of Physical and Rehabilitation Medicine, 2015
Frontiers in Human Neuroscience, 2015
Journal of Science and Medicine in Sport, 2000
Frontiers in Aging Neuroscience, 2015
The use of virtual reality games (known as &amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;exer... more The use of virtual reality games (known as &amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;exergaming&amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;) as a neurorehabilitation tool is gaining interest. Therefore, we aim to collate evidence for the effects of exergaming on the balance and postural control of older adults and people with idiopathic Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease (IPD). Six electronic databases were searched, from inception to April 2015, to identify relevant studies. Standardized mean differences (SMDs) and 95% confidence intervals (CI) were used to calculate effect sizes between experimental and control groups. I (2) statistics were used to determine levels of heterogeneity. 325 older adults and 56 people with IPD who were assessed across 11 -studies. The results showed that exergaming improved static balance (SMD 1.069, 95% CI 0.563-1.576), postural control (SMD 0.826, 95% CI 0.481-1.170), and dynamic balance (SMD -0.808, 95% CI -1.192 to -0.424) in healthy older adults. Two IPD studies showed an improvement in static balance (SMD 0.124, 95% CI -0.581 to 0.828) and postural control (SMD 2.576, 95% CI 1.534-3.599). Our findings suggest that exergaming might be an appropriate therapeutic tool for improving balance and postural control in older adults, but more -large-scale trials are needed to determine if the same is true for people with IPD.
Journal of Sport and Health Science, 2014
Journal of Biomedical Optics, 2010
Advances in Experimental Medicine and Biology, 2011
nodal transcranial direct current stimulation (a-tDCS) is a noninvasive electrical brain stimulat... more nodal transcranial direct current stimulation (a-tDCS) is a noninvasive electrical brain stimulation technique that has been shown to increase cortical neuronal excitability and activity [1]. An indirect marker of increases in cortical neuronal activity is the subsequent increase in the regional cerebral blood flow (rCBF). Functional near-infrared spectroscopy (fNIRS) is a noninvasive neuroimaging method, which measures changes in regional cortical hemodynamics (rCHD) via oxyhemoglobin (HbO2) and deoxyhemoglobin (HHb) concentrations, such that an increase in HbO2 and decrease in HHb are considered a good index of increases in rCBF [2]. A previous fNIRS study [3] showed that 10 min of a-tDCS on the left prefrontal cortex (PFC) with the cathode on the right PFC induced an increase in rCHD in the cortical regions under the anode and cathode after a-tDCS (offline effects). However, the time course of changes in rCHD during a-tDCS (online effects) revealing an index of neuronal modulatio...
fNIRS 2014, October 10-12, Montreal, Canada
PLOS ONE, 2015
Neuroimaging studies have shown neuromuscular electrical stimulation (NMES)-evoked movements acti... more Neuroimaging studies have shown neuromuscular electrical stimulation (NMES)-evoked movements activate regions of the cortical sensorimotor network, including the primary sensorimotor cortex (SMC), premotor cortex (PMC), supplementary motor area (SMA), and secondary somatosensory area (S2), as well as regions of the prefrontal cortex (PFC) known to be involved in pain processing. The aim of this study, on nine healthy subjects, was to compare the cortical network activation profile and pain ratings during NMES of the right forearm wrist extensor muscles at increasing current intensities up to and slightly over the individual maximal tolerated intensity (MTI), and with reference to voluntary (VOL) wrist extension movements. By exploiting the capability of the multi-channel time domain functional near-infrared spectroscopy technique to relate depth information to the photon time-of-flight, the cortical and superficial oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin concentrations were estimated. The O2Hb and HHb maps obtained using the General Linear Model (NIRS-SPM) analysis method, showed that the VOL and NMES-evoked movements significantly increased activation (i.e., increase in O2Hb and corresponding decrease in HHb) in the cortical layer of the contralateral sensorimotor network (SMC, PMC/SMA, and S2). However, the level and area of contralateral sensorimotor network (including PFC) activation was significantly greater for NMES than VOL. Furthermore, there was greater bilateral sensorimotor network activation with the high NMES current intensities which corresponded with increased pain ratings. In conclusion, our findings suggest that greater bilateral sensorimotor network activation profile with high NMES current intensities could be in part attributable to increased attentional/pain processing and to increased bilateral sensorimotor integration in these cortical regions.
Frontiers in Aging Neuroscience, 2015
Exercise immunology review, 2006
We compared changes in markers of muscle damage and systemic inflammation after submaximal and ma... more We compared changes in markers of muscle damage and systemic inflammation after submaximal and maximal lengthening muscle contractions of the elbow flexors. Using a cross-over design, 10 healthy young men not involved in resistance training completed a submaximal trial (10 sets of 60 lengthening contractions at 10% maximum isometric strength, 1 min rest between sets), followed by a maximal trial (10 sets of three lengthening contractions at 100% maximum isometric strength, 3 min rest between sets). Lengthening contractions were performed on an isokinetic dynamometer. Opposite arms were used for the submaximal and maximal trials, and the trials were separated by a minimum of two weeks. Blood was sampled before, immediately after, 1 h, 3 h, and 1-4 d after each trial. Total leukocyte and neutrophil numbers, and the serum concentration of soluble tumor necrosis factor-alpha receptor 1 were elevated after both trials (P < 0.01), but there were no differences between the trials. Serum...
2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2012