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Papers by mariana morales

Environmental Research, 2010

Human exposure to inorganic arsenic (iAs) has been associated with cancer and serious injury to v... more Human exposure to inorganic arsenic (iAs) has been associated with cancer and serious injury to various internal organs, as well as peripheral neuropathy, endocrine disruption and diverse effects in the central nervous system (CNS). Using rodent models, it is possible to demonstrate As accumulation in the brain that leads to defects in operant learning, behavioral changes, and affect pituitary gonadotrophins. iAs biomethylation in the CNS is a significant process, yielding products that are more reactive and toxic than the parent compound. Mice received 2.5, 5, and 10 mg/kg/day sodium arsenite orally for 9 days. We investigated the distribution of iAs and its metabolites as well as the mRNA and protein expression of arsenic (III) methyltransferase (AS3MT), which encodes the key enzyme in iAs metabolism, in the cerebral cortex, hippocampus, striatum, mesencephalon, thalamus, cerebellum, hypothalamus, pons, medulla oblongata, and pituitary of mouse brain. Our findings show that methylated As metabolites are present in all brain regions studied suggesting that AS3MT is ubiquitously expressed in the brain and it is not inducible by dose of arsenite. There is also a doserelated accumulation of As species in all brain regions, with the highest accumulation observed in the pituitary. The higher distribution of arsenicals in pituitary can help to explain the neuroendocrine effects associated with iAs exposure.

Success of college engineering education is determined by more than the achievement of theoretica... more Success of college engineering education is determined by more than the achievement of theoretical knowledge and the development of practical skills. It means a more complex process of change in the person which, most desirably, will lead to the development of maturity, responsibility, and commitment with the social and the natural environments. This paper presents the results of a study conducted at the Iberoamericana University, Mexico City, dealing with the design and application of an instrument for evaluating several aspects of Human Development in engineering college students (Openness to Experience, Responsibility,

Environmental Research, 2010

Human exposure to inorganic arsenic (iAs) has been associated with cancer and serious injury to v... more Human exposure to inorganic arsenic (iAs) has been associated with cancer and serious injury to various internal organs, as well as peripheral neuropathy, endocrine disruption and diverse effects in the central nervous system (CNS). Using rodent models, it is possible to demonstrate As accumulation in the brain that leads to defects in operant learning, behavioral changes, and affect pituitary gonadotrophins. iAs biomethylation in the CNS is a significant process, yielding products that are more reactive and toxic than the parent compound. Mice received 2.5, 5, and 10 mg/kg/day sodium arsenite orally for 9 days. We investigated the distribution of iAs and its metabolites as well as the mRNA and protein expression of arsenic (III) methyltransferase (AS3MT), which encodes the key enzyme in iAs metabolism, in the cerebral cortex, hippocampus, striatum, mesencephalon, thalamus, cerebellum, hypothalamus, pons, medulla oblongata, and pituitary of mouse brain. Our findings show that methylated As metabolites are present in all brain regions studied suggesting that AS3MT is ubiquitously expressed in the brain and it is not inducible by dose of arsenite. There is also a doserelated accumulation of As species in all brain regions, with the highest accumulation observed in the pituitary. The higher distribution of arsenicals in pituitary can help to explain the neuroendocrine effects associated with iAs exposure.

Success of college engineering education is determined by more than the achievement of theoretica... more Success of college engineering education is determined by more than the achievement of theoretical knowledge and the development of practical skills. It means a more complex process of change in the person which, most desirably, will lead to the development of maturity, responsibility, and commitment with the social and the natural environments. This paper presents the results of a study conducted at the Iberoamericana University, Mexico City, dealing with the design and application of an instrument for evaluating several aspects of Human Development in engineering college students (Openness to Experience, Responsibility,