Mehmet Emin Arayici | Dokuz Eylül University (original) (raw)

Papers by Mehmet Emin Arayici

Frontiers in oncology, Jun 25, 2024

Country(ies) involved Turkey.

Clinical and Experimental Medicine, Oct 7, 2022

During the COVID-19 pandemic, cancer patients were among the most vulnerable patient groups to th... more During the COVID-19 pandemic, cancer patients were among the most vulnerable patient groups to the SARS-CoV-2 infection effects. This paper aimed to conduct an umbrella review and meta-meta-analysis to determine the severity of disease in cancer patients affected by COVID-19. The umbrella review and meta-meta-analysis were undertaken according to the PRISMA and MOOSE guidelines. The PubMed/Medline, Web of Science, and Scopus databases were searched for published papers from the start of the pandemic through July 18, 2022. The pooled effect sizes (ES) and odds ratios (ORs) were calculated using a random effect model in the 95% confidence interval (CI) for ICU (Intensive Care Unit) admissions and mortality in cancer patients infected with SARS-CoV-2. Egger's linear regression test, schematic illustrations of funnel plots, and Begg and Mazumdar's rank correlation tests were used to quantify the possibility of publication bias. The pooled ES was calculated based on 1,031,783 participants, and mortality was significantly increased in cancer patients affected by COVID-19 (OR = 2.02, %95 CI: 1.74-2.35, p < 0.001). The pooled ES for ICU admission was also significantly increased in cancer patients infected with SARS-CoV-2 (OR = 1.84, %95 CI: 1.44-2.34, p < 0.001). As a result, this synthesis of systematic reviews and meta-analyses by the meta-meta-analysis method revealed that disease severity is higher in cancer patients affected by COVID-19. Since cancer patients are a more sensitive and specific patient group, they should be evaluated more carefully, especially during the COVID-19 pandemic and other pandemics that may occur in the future.

It is a well-established fact that inadequate Vitamin D (Vit-D) levels have negative effects on t... more It is a well-established fact that inadequate Vitamin D (Vit-D) levels have negative effects on the development and progression of malignant diseases, mainly cancer. The purpose of this paper was to elucidate the effects of Vit-D intake and serum 25-hydroxyvitamin-D (25(OH)D) levels on cancer incidence and mortality, the current evidence in this field, and the biases of this evidence using the meta-meta-analysis method. Meta-analyses focusing on Vit-D intake, serum 25(OH)D levels, and cancer risk/mortality were identified. A structured computer literature search was performed in PubMed/Medline, Web of Science (WoS), and Scopus electronic databases using predetermined keyword combinations. Primary and secondary meta-meta-analyses were carried out, combining odds ratios (ORs), risk ratios (RRs), and hazard ratios (HRs) for outcomes reported in selected meta-analyses. A total of 35 eligible meta-analyses assessing the association between Vit-D and cancer incidence and/or mortality were...

Journal of Basic and Clinical Health Sciences, 2022

Prostate cancer is the the second common cancer in men in Turkey. We aimed to share our single ce... more Prostate cancer is the the second common cancer in men in Turkey. We aimed to share our single center experience on the characteristics of patients with metastatic castration sensitive prostate cancer (mCSPC) and the factors affecting survival. Material and Methods: In this retrospective cross-sectional study, 280 patients (aged 18 years and older men) who applied with the diagnosis of metastatic prostate carcinoma were screened between January 2007 and December 2020. Sociodemographic and clinicopathological characteristics of the patients were obtained retrospectively from the hospital database. The study variables of the research were included descriptive characteristics of the patients, metastasis sites, treatment approachs, comorbidities of the patients and overall survival (OS) were evaluated. The descriptive statistics, Chi-Square Test, Fisher Exact Test, Kaplan Meier, and Cox Regression models were used as appropriate for the statistical analysis. Results: A total of 201 patient who applied with the diagnosis of mCSPC were included in this study. The median age of the patients at the time of diagnosis was 68.67 years (43,97-90,48), 43.56% (n=88) of the patients were ≥ 70 years old and 56.43% (n=114) were under 70 years of age. The median follow-up time was 55.5 months, and the median OS was found to be 34.93 months (27.90-41.96). 34.7% of the patients were still alive at the time of date cutoff. The median OS of the patients was found to be significantly lower in individuals ≥70 years old than under 70 years of age (p=0.032). According to the LATITUDE study the median OS of the high-risk group (26.56 months) was statistically significantly lower than in the low-risk group (44.83 months). When the patients were evaluated in terms of disease volume according to CHAARTED, it was found that the median OS of the patient group with high-volume disease (29.03 months) was statistically significantly lower than the group with low-volume disease (46.80 months) (p=0.001). Conclusion: In this study, it was shown that being over 70 years old, a low BMI, high volume disease defined as in the CHAARTED trial, and high risk disease defined as in the LATITUDE trial had a negative impact on survival of patients with mCSPC.

Background: In this paper, it was aimed to evaluate the biomarker potential as well as the effect... more Background: In this paper, it was aimed to evaluate the biomarker potential as well as the effect of the prognostic nutritional index (PNI), which is calculated using the albumin level reflecting nutritional status and lymphocyte count reflecting immune status, in determining the prognosis of metastatic castration-sensitive prostate cancer (mCSPC). Methods: This retrospective observational study included the complete data of 108 patients with mCPSC who were treated for at least three months between January 1, 2010, and June 1, 2021. The relationship between cancer specific survival (CSS), overall survival (OS), progression free survival (PFS) and PNI was evaluated. Kaplan-Meier method for OS, PFS, and CSS, as well as univariate and multivariate Cox regression models were used in statistical analyses. Results: The median age of 108 patients included in the study was 68.54 (61.05-74.19) years. While 71.3% (n = 77) of the patient population were high-volume according to CHAARTED, 52.8%...

PLOS ONE

Background The aim of this paper was to evaluate the change in 25-hidroxyvitamin D (25(OH)D) leve... more Background The aim of this paper was to evaluate the change in 25-hidroxyvitamin D (25(OH)D) levels before and during the COVID-19 pandemic. Methods In this retrospective, cross-sectional and methodological study included 86,772 patients (18–75 years) samples who were admitted to the Izmir Dokuz Eylul University Hospital (latitude and longitude (Turkey): 27 E 09; 38 N 25, respectively) for various reasons and whose 25(OH)D levels were measured in the biochemistry unit between 2019–2020 and 2020–2021 (before and during the COVID-19 outbreak). A time series analysis of monthly averages for 25(OH)D was performed. For the purpose of seasonal study, the mean levels of 25(OH)D are grouped by years. Data were modeled in terms of 25(OH)D levels using the MATLAB Curve Fitting Toolbox. Results There was no significant difference between the sexes according to 25(OH)D levels (p>0.05). 25(OH)D levels were significantly higher in the summer months and lower in the winter months (p<0.001). ...

European Geriatric Medicine, Mar 24, 2023

Future Oncology

Aims: The aim of this study was to evaluate the effect of prognostic nutritional index (PNI) on p... more Aims: The aim of this study was to evaluate the effect of prognostic nutritional index (PNI) on prognosis in patients with hormone receptor-positive, HER2-negative metastatic breast cancer who received CDK4/6 inhibitor + endocrine therapy. Methods: Patients receiving a CDK4/6 inhibitor were evaluated, retrospectively. The PNI was calculated as: (10 × serum albumin [g/dl]) + (total lymphocyte count [×109/l] × 5). Results: In a study of 106 patients, a statistically significant survival advantage was observed in the high-PNI group over the low-PNI group (mean overall survival: 28.03 ± 0.487 months vs 22.46 ± 1.14 months; p = 0.013). Conclusion: For the first time in the literature, this study demonstrated the prognostic role of PNI in patients with hormone receptor-positive, HER2-negative metastatic breast cancer treated with CDK4/6 inhibitors.

Brazilian Dental Science

Objective: The aim of the present study was to evaluate the impact of the COVID-19 pandemic on th... more Objective: The aim of the present study was to evaluate the impact of the COVID-19 pandemic on the number of publications in the field of periodontology and implantology in Turkey. Material and Methods: A sensitive search strategy was developed to identify relevant articles, focusing on the periodontology and implantology research fields published two years before and after the declaration of the pandemic (March 2020). The search was performed through Web of Science, Medline, SCOPUS and CENTRAL databases. A three-stage screening (titles, abstract, full-text) was carried out in duplicate and independently by two reviewers. Results: A total of 382 studies were identified before the pandemic and 307 studies during the pandemic. While there was a downward trend in the number of observational studies (185 vs 168), the number of clinical trials (CCT/RCT) slightly increased compared to the pre-pandemic period (72 vs 74). Conclusion: Limited to the selected period of time (two years) and field, publication rate on periodontology and implantology in Turkey was decreased during the pandemic. Although the present research highlights current trends, large-scale investigations are needed to probe consequences of COVID-19 pandemic on research activities in the long-run.

Purpose One of the most common extracranial childhood solid tumors is neuroblastoma. In this stud... more Purpose One of the most common extracranial childhood solid tumors is neuroblastoma. In this study, it was aimed to perform a systematic review and meta-analysis to evaluate the risk of neuroblastoma in both high and low birth weight. Methods The PRISMA and MOOSE guidelines were followed during the design, analysis, and reporting of this study. A comprehensive literature search was performed for the published papers in Embase, PubMed/Medline, Scopus, and Web of Science databases. The odds ratio (OR) of neuroblastoma in high and low birth weight groups, with 95% confidence intervals (CIs), were calculated using the random-effects and fixed-effects model. Results A total of 16 papers and 4,361,141 participants were included in this study. In this meta-analysis, it was observed a U-shaped relationship between birth weight and neuroblastoma. Individuals with both high and low birth weights may face an increased risk of developing neuroblastoma later in life (OR = 1.17, 95% CI: 1.06–1.29...

International Journal of Diabetes in Developing Countries

Purpose The aim of this paper was to evaluate the change in 25-hidroxyvitamin D (25(OH)D) levels ... more Purpose The aim of this paper was to evaluate the change in 25-hidroxyvitamin D (25(OH)D) levels before and during the COVID-19 pandemic. Methods In this retrospective, cross-sectional and methodological study included 86,772 patients (18–75 years) samples who were admitted to the University Hospital for various reasons and whose 25(OH)D levels were measured in the biochemistry unit between 2019–2020 and 2020–2021 (before and during the COVID-19 outbreak). A time series analysis of monthly averages for 25(OH)D was performed. For the purpose of seasonal study, the mean levels of 25(OH)D are grouped by years. Data were modeled in terms of 25(OH)D levels using the MATLAB Curve Fitting Toolbox. Results There was no significant difference between the sexes according to 25(OH)D levels (p > .05). 25(OH)D levels were significantly higher in the summer months and lower in the winter months (p < .001). When comparing the spring months, 25(OH)D levels in 2020 were found to be significant...

Background: The combination of endocrine therapy and CDK 4/6 inhibitors in the treatment of hormo... more Background: The combination of endocrine therapy and CDK 4/6 inhibitors in the treatment of hormone receptor positive, HER-2 negative metastatic breast cancer resulted in significant increases in survival.In general, the presence of malnutrition in cancer patients is a condition that negatively affects the success of treatment. For this reason, it is important to evaluate the nutritional status of cancer patients and to give appropriate nutritional support. One of the most widely used nutritional assessment methods in the literature is the Prognostic Nutritional Index (PNI). In this study, it was aimed to evaluate the effect of PNI on treatment response and prognosis in patients with HR+ HER-2- metastatic breast cancer who received CDK 4/6 inhibitor together with endocrine therapy. Materials and Methods: Patients with HR+ HER-2- metastatic breast cancer who received CDK 4/6 inhibitor together with endocrine therapy were evaluated retrospectively. In all patients, PNI values were rec...

Purpose: The aim of this paper was to evaluate the level of hope, coping methods, and the factors... more Purpose: The aim of this paper was to evaluate the level of hope, coping methods, and the factors affecting them in patients aged 60 years and over who were diagnosed with breast and prostate cancer, who underwent surgery and/or chemotherapy according to the condition of the disease, and who were at the stage of radiotherapy (RT). Method: A total of 66 patients, 37 breast cancer and 29 prostate cancer patients, were included in this cross-sectional study. RT and treatment information of the patients were collected by using the records in the hospital database. The personal information of the participants was also collected through the personal information form and scales [HHI (Heart Hope Index), COPE (Coping Attitudes Assessment Scale), VAS (Visual Analogue Scale)]. Results:The median age of the participants was 65 (min-max: 60-80) years. There was a decrease in the weight and waist circumference of the participants after RT (p<0.05). There was no significant change in the HHI an...

Türk Üroloji Dergisi/Turkish Journal of Urology