Oya Itil | Dokuz Eylül University (original) (raw)
Papers by Oya Itil
Respiratory Medicine, 2007
To discuss the utility of Sit-to-Stand Test (STST) compared to the 6 min walking test (6MWT) for ... more To discuss the utility of Sit-to-Stand Test (STST) compared to the 6 min walking test (6MWT) for the evaluation of functional status in patients with chronic obstructive pulmonary disease (COPD).Fifty-three patients with stable COPD (mean forced expiratory volume in 1 s (FEV1) 46±9% predicted, mean age 71±12 year) and 15 healthy individuals (mean FEV1 101±13% predicted and mean age 63±8) were included.Functional performance was evaluated by STST and 6MWT. During the tests, severity of dyspnea (by Modified Borg Scale), heart rate, pulsed oxygen saturation (SpO2, by Modified Borg Scale) (by pulse oxymeter), blood pressure were measured. The pulmonary function (by spirometry), quadriceps femoris muscle strength (by manual muscle test) and quality of life (by Nottingham Health Profile Survey) were evaluated.The STST and 6MWT results were lower in COPD group than the healthy group (P<0.05). During the 6MWT the rise in the heart rate, systolic blood pressure and the decrease in SpO2 were statistically significant according to STST in COPD groups (P<0.05). The STST and 6MWT were strongly correlated with each other in both groups (P<0.05). Similarly, they were correlated with age, quality of life, peripheral muscle strength and dyspnea severity in COPD groups (P<0.05).Similar to 6MWT, STST is also able to determine the functional state correctly. Additionally, it produces less hemodynamical stress compared to the 6MWT. In conclusion, STST can be used as an alternative of the 6MWT in patients with COPD.
Tüberküloz ve toraks, 2007
Nosocomial infections are an important cause of preventable morbidity and mortality; they also re... more Nosocomial infections are an important cause of preventable morbidity and mortality; they also result in significant socioeconomic cost. Nosocomial pneumonia (NCP) is defined as pneumonia, which occurs 48 hours after hospitalization or after discharge from the hospital. It is the second or third most frequent infection among all hospital acquired infections, and the mortality of NCP is higher than the other hospital acquired infections. Patients, diagnosed as NCP were retrospectively analyzed in order to detect microbiological agent and prognostic factors. We evaluated 173 patients, 67.0% of them were male and 33.0% female. Comorbid diseases were present in 94.2% and a medical procedure had been applied in 75.1% of cases. A single agent was isolated in 79.2% of the cases while a mixt infection was present in 13.3%. In 7.5% of the cases, cultures were negative. Endotracheal aspirates were the most common materials (38.9%) used for detected microorganism and sputum cultures were used ...
The journal of sexual medicine, 2007
Several co-morbid diseases have been shown to affect sexual functions in both genders. In the lit... more Several co-morbid diseases have been shown to affect sexual functions in both genders. In the literature, sexual function status in men with obstructive sleep apnea syndrome (OSAS) has been studied; however, sexual functions in women with OSAS have not yet been studied. In this prospective study, we aimed to determine sexual function status in women with OSAS and its relationship with the disease parameters of OSAS. Women, who were diagnosed with OSAS with polysomnography performed in the sleep center of our university hospital, formed the study population. Women with any genital deformity, postmenopausal women, and women without a regular partner were excluded from the study. General demographic properties, medical histories, polysomnography parameters, and frequency of intercourse per month were noted for each patient. Patients completed the Sexual Function Questionnaire Version 2 (SFQ-V2) and Epworth Sleepiness Scale. The patients were grouped as mild, moderate, and severe OSAS a...
Education for health (Abingdon, England), 2006
Task-based learning (TBL) is an educational strategy recommended for the later years of the medic... more Task-based learning (TBL) is an educational strategy recommended for the later years of the medical education programme. The TBL programme was adopted for clinical years in the 2000-2001 academic year in Dokuz Eylul University School of Medicine (DEUSM). The aim of this paper is to describe the TBL programme of DEUSM. DEUSM outlined 50 clinical tasks for fourth-year students and 37 for fifth-year students. The tasks were grouped into four and five blocks. Interdisciplinary practicals, lectures and patient visits were organised in each task's schedule. The tasks were the focus of learning and each discipline contributed its own learning opportunities to the attached tasks. Formative and summative methods were used to evaluate the programme. Based on the experience and feedback provided by the students and trainers, the authors considered TBL an applicable and advisable approach for the clinical years of medical education.
Sleep and Breathing, 2011
Purpose The aim of the study was to assess the effect of breathing and physical exercise on pulmo... more Purpose The aim of the study was to assess the effect of breathing and physical exercise on pulmonary functions, apnea-hypopnea index (AHI), and quality of life in patients with obstructive sleep apnea syndrome (OSAS). Methods Twenty patients with mild to moderate OSAS were included in the study either as exercise or control group. The control group did not receive any treatment, whereas the exercise group received exercise training. Exercise program consisting of breathing and aerobic exercises was applied for 1.5 h 3 days weekly for 12 weeks. Two groups were assessed through clinical and laboratory measurements after 12 weeks. In the evaluations, bicycle ergometer test was used for exercise capacity, pulmonary function test, maximal inspiratory-expiratory pressure for pulmonary functions, polysomnography for AHI, sleep parameters, Functional Outcomes of Sleep Questionnaire (FOSQ), Short Form-36 (SF-36) for quality of sleep and health-related quality of health, Epworth Sleepiness Scale for daytime sleepiness, and anthropometric measurements for anthropometric characteristics.
Sleep and Biological Rhythms, 2013
ABSTRACT Sleep disordered breathing (SDB) represents a major public health problem. We investigat... more ABSTRACT Sleep disordered breathing (SDB) represents a major public health problem. We investigated the risk of SDB and associated factors in the Turkish adult population. We collected data by an interviewer‐administered questionnaire in a nationwide representative sample of 5021 adults (2598 women, 2423 men) with a mean age of 40.7 years (SD:15.1) in 2010. High risk of SDB was defined as the positive response to at least two of the three categories in the Berlin questionnaire (BQ). High risk of SDB was found in 13.7% (men: 11.1%, women: 20.2%). High risk of SDB prevalence was not significantly different between the genders in the analysis stratified for BMI categories. Female gender, older age, lower level of education and smoking in the past were associated with high risk of SDB in the logistic regression analysis models adjusting for age and gender. After the adjustment for age, gender, smoking, BMI and educational status, high risk of SDB, and BQ Category 2 score were associated with previous hospitalization and cardiovascular diseases. Risk due to BQ Category 1 and BQ Category 2 was more than additive in the models for hypertension and heart disease for the age groups 45–65 years and 65 years and over. Higher prevalence of SDB and obesity among women in our population should be addressed in further studies. Association between high risk of SDB and cardiovascular diseases, if confirmed, indicates the public health importance of screening for SDB symptoms.
Respirology, 2005
Cisplatin-gemcitabine (PG) and cisplatin-etoposide (PE) combinations are active regimens for non-... more Cisplatin-gemcitabine (PG) and cisplatin-etoposide (PE) combinations are active regimens for non-small cell lung cancer (NSCLC). The present study aimed to compare PG with PE in the treatment of patients with stage IIIB and IV NSCLC. We conducted a prospective, multicentre trial. A total of 166 patients were enrolled into the study and received either gemcitabine (1,000 mg/m(2)) on days 1, 8 and 15 plus cisplatin (80 mg/m(2)) on day 2 every 4 weeks, or etoposide (100 mg/m(2)) on days 1, 2 and 3 plus cisplatin (80 mg/m(2)) on day 1 every 3 weeks. The overall response rate was superior in the PG group (54.8%vs 39.0%, P=0.045). There was no significant difference in survival between the two groups, with respective median and 1-year survival of 38 weeks and 33.3% for the PG group, and 34 weeks and 23.2% for the PE group. There was also no statistical difference for time to progression between the two groups. Neutropenia and thrombocytopenia were seen more frequently in the PG group (grade 3 neutropenia, 33.3%vs 15.9%, P=0.012; grade 3 thrombocytopenia, 27.4%vs 3.7%, P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001 and grade 4 thrombocytopenia, 10.7%vs 1.2%, P=0.018). PG is an active chemotherapy regimen and has a better response rate than PE in advanced NSCLC, although there was no difference in time to progression and overall survival. A higher incidence of haematological toxicity was seen with PG than with PE.
Primary Health Care Research & Development, 2013
Chronic obstructive pulmonary disease (COPD) may cause some psychiatric disorders such as depress... more Chronic obstructive pulmonary disease (COPD) may cause some psychiatric disorders such as depression and anxiety, similar to other chronic diseases. Treatment adherence may be affected by worsening of cognitive functions. We aimed to show whether the symptoms of anxiety and depression affect treatment adherence by patients. Seventy-eight COPD patients were analysed at the first visit. The use of bronchodilator therapy was revised for standardization before they attended a second visit after six months. Hospital Anxiety and Depression Scale (HADS), Anxiety Sensitivity Index-3 (ASI-3) and SF-36 Questionnaire were carried out at that visit. &amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;National Guide of Turkish Thoracic Society for Asthma&amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; was used for scoring method of use of the bronchodilator and evaluating treatment adherence (including maintenance therapy). Sixty-two of 78 patients, 53 (85.5%) men and nine (14.5%) women with a mean age of 64.9 ± 9.9 joined the second visit. Thirty-three patients (53.2%) had a high-treatment adherence (HTA), whereas 29 (46.8%) had a low-treatment adherence (LTA). There were high scores of anxiety in 18 (29%) and depression in 11 (17.7%) patients. There was no statistical difference between the HTA and LTA groups in means of age, gender, educational level, presence of comorbidity, classification of COPD, high anxiety scores according to HADS and ASI-3 scores. Of the patients, 41.4% in the LTA group were still smoking, whereas it was only 12.1% in the HTA group (P = 0.009). The LTA group had higher depression scores (P = 0.004) than the HTA group. Dyspnea was found more frequent in LTA patients (P = 0.047); vitality score was also statistically low in this group (P = 0.01). As a result, continuing smoking and the presence of depression symptoms may decrease adherence to treatment. Therefore, to increase the adherence to treatment and reduce symptoms such as dyspnea, it is important to treat any depressive symptoms that are present and to help patients cease smoking.
The Journal of Sexual Medicine, 2007
Introduction. Several co-morbid diseases have been shown to affect sexual functions in both gende... more Introduction. Several co-morbid diseases have been shown to affect sexual functions in both genders. In the literature, sexual function status in men with obstructive sleep apnea syndrome (OSAS) has been studied; however, sexual functions in women with OSAS have not yet been studied. Aims. In this prospective study, we aimed to determine sexual function status in women with OSAS and its relationship with the disease parameters of OSAS. Methods. Women, who were diagnosed with OSAS with polysomnography performed in the sleep center of our university hospital, formed the study population. Women with any genital deformity, postmenopausal women, and women without a regular partner were excluded from the study. General demographic properties, medical histories, polysomnography parameters, and frequency of intercourse per month were noted for each patient. Patients completed the Sexual Function Questionnaire Version 2 (SFQ-V2) and Epworth Sleepiness Scale. The patients were grouped as mild, moderate, and severe OSAS according to the level of respiratory disturbance index (RDI). Main Outcome Measures. Scores of sexual function domains were determined from SFQ, and their relationships with parameters of polysomnography and demographics were studied. Results. Twenty-five patients were included in the study. Mean age was 48.1 ± 2.7 years. All were married with a mean marriage duration of 25.6 ± 3.3 years. Mean frequency of intercourse per month was 3.3 ± 1.8. All domains of sexual functions except pain and enjoyment significantly decreased with increasing severity of OSAS. When we controlled for factors of age and co-morbid diseases, correlation analyses showed significant negative correlation between levels of RDI and all domains of sexual functions except pain and enjoyment (P < 0.05). Conclusions. Obstructive sleep apnea syndrome negatively impacts sexual function in women independent of age and associated co-morbid diseases. Köseo lu N, Köseo lu H, Itil O, Öztura , Baklan B, Ikiz AO, and Esen AA. Sexual function status in women with obstructive sleep apnea syndrome. J Sex Med 2007;4:1352-1357.
Journal of Asthma, 2006
This study was carried out with 127 asthmatic patients and 127 controls, which aimed to compare a... more This study was carried out with 127 asthmatic patients and 127 controls, which aimed to compare and evaluate the environmental conditions in the homes of asthmatic patients and the control group. Air samples were obtained by using an air sampler and the mean mould colony counts were established. Aspergillus and Penicillium were the most common isolated species. No significant difference was observed with regard to various house conditions and the mean mould colony counts between the houses of patients and controls. The mould colony counts were found to be lower in houses with wooden parquet flooring. The odds ratio for stone floors vs. wood floors was 2.3 (95% CI 1.08-4.98) for mould growth.
Japanese Heart Journal, 2004
The ratio of cardiac involvement of Echinoccocus granulosus is 0.02-2% and although seen rarely, ... more The ratio of cardiac involvement of Echinoccocus granulosus is 0.02-2% and although seen rarely, involvement of the interatrial septum has also been reported in the published literature. The present case was a 19-year-old male university student admitted to hospital with complaints of headache and dizziness. Computerized tomography of the cranium revealed a cystic mass located at the frontal region and enucleation of the cyst was performed during surgery. A cystic lesion 5 x 4 cm in size was detected within the interatrial septum on two-dimensional transthoracic echocardiography during the postoperative period and the patient was referred to our clinic. Open heart surgery was performed and a hydatid cyst that involved the interatrial septum was enucleated. The cyst wall was sutured to the interatrial septum. No complications developed during the postoperative period. The patient was discharged on the fifth day of hospitalization and medical therapy was started with albendazole.
European Journal of Anaesthesiology, 2006
... Bodur, H.1; Savran, Y.1; Koca, U.2; Kilinç, O.3; Albayrak, S.3; Itil, O.3; Akoğlu, S.4. ... U... more ... Bodur, H.1; Savran, Y.1; Koca, U.2; Kilinç, O.3; Albayrak, S.3; Itil, O.3; Akoğlu, S.4. ... Upon sedation and intubation, another arterial blood sample showed a PaO 2 /F i O 2 ratio of 85 and the patient was transferred to the medical intensive care unit (ICU) with the diagnosis of ...
Education for Health: Change in Learning & Practice, 2006
Context: Task-based learning (TBL) is an educational strategy recommended for the later years of ... more Context: Task-based learning (TBL) is an educational strategy recommended for the later years of the medical education programme. The TBL programme was adopted for clinical years in the 2000-2001 academic year in Dokuz Eylul University School of Medicine (DEUSM).
Clinical & Experimental Metastasis, 2005
Endobronchial metastases (EBM) from extrapulmonary malignant tumors are rare. The most common ext... more Endobronchial metastases (EBM) from extrapulmonary malignant tumors are rare. The most common extrathoracic malignancies associated with EBM are breast, renal and colorectal carcinomas. In this study, we aimed to evaluate the clinical, radiographic and bronchoscopic aspects of patients with EBM who were diagnosed between 1992 and 2002. Data about patients' clinical conditions, symptoms, radiographic and endoscopic findings, and histopathological examination results were investigated. EBM was defined as bronchoscopically visible lesions histopathologically identical to the primary tumor in patients with extrapulmonary malignancies. We found 15 cases with EBM. Primary tumors included breast , and renal carcinomas; Malignant Melanoma (2); synovial sarcoma (1), ampulla of Vater adenocarcinoma (1), pheochromocytoma (1), hypernephroma (1), and Hodgkin's Disease (1). The most common symptoms were dyspnea (80%), cough (66.6%) and hemoptysis (33.3%). Multiple (40%) or single (13.3%) pulmonary nodules, mediastinal or hilar lymphadenopathy (40%), and effusion (40%) were the most common radiographic findings. The mean interval from initial diagnosis to diagnosis of EBM was 32.8 months (range, 0-96 months) and median survival time was 18 months (range, 4-84). As a conclusion, various extrapulmonary tumors can metastasize to the bronchus. Symptoms and radiographic findings are similar with those in primary lung cancer. Therefore, EBM should be discriminated from primary lung cancer histopathologically. Although mean survival time is usually short, long-term survivors were reported. Consequently, treatment must be planned according to the histology of the primary tumor, evidence of metastasis to other sites and medical status of the patient.
Turk Toraks Dergisi
... Duygu Ilgın 1 , Hayriye Kul Karaali 1 , Sevgi Özalevli 1 , Oya İtil 2 , Eyüp Sabri Uçan 2. ..... more ... Duygu Ilgın 1 , Hayriye Kul Karaali 1 , Sevgi Özalevli 1 , Oya İtil 2 , Eyüp Sabri Uçan 2. ... Results: The mean apnea-hypopnea index (AHI), FEV 1 of OSAS patients, and the mean FEV 1 of COPD patients were 38.4±17.5, 83.2±8.8%, and 73.2±11.3%, respectively. ...
Indoor and Built Environment, 2008
In an attempt to determine the relationship between the features of houses and moulds growing ind... more In an attempt to determine the relationship between the features of houses and moulds growing indoors, 242 houses were examined in Izmir, a city on the west coast of Turkey with a mild climate. During house visits a questionnaire was given and air was sampled using an 'air IDEAL' air sampler for quantitative fungal culture. The moulds most commonly isolated were Aspergillus, Penicillium, and Mucor spp. Aspergillus growth in houses older than 20 years was more common than other species when the features of houses and isolated fungi were compared. Mucor grew significantly more in houses where the air was humid, the temperature was cooler and there were pot plants. Penicillium grew more frequently in houses where visible mould was present and birds were bred. However, no relationship could be demonstrated between the method of heating, the number of household members, exposure to sun, type of building and flooring with a specific mould. As a conclusion, many household factors suggested as risk factors for mould growth have been examined and only a few relationships could be established between certain features of houses and moulds. However, mould growth is much affected by many conditions and the environment in a house is one of many factors that may facilitate growth.
Respiratory Medicine, 2007
To discuss the utility of Sit-to-Stand Test (STST) compared to the 6 min walking test (6MWT) for ... more To discuss the utility of Sit-to-Stand Test (STST) compared to the 6 min walking test (6MWT) for the evaluation of functional status in patients with chronic obstructive pulmonary disease (COPD).Fifty-three patients with stable COPD (mean forced expiratory volume in 1 s (FEV1) 46±9% predicted, mean age 71±12 year) and 15 healthy individuals (mean FEV1 101±13% predicted and mean age 63±8) were included.Functional performance was evaluated by STST and 6MWT. During the tests, severity of dyspnea (by Modified Borg Scale), heart rate, pulsed oxygen saturation (SpO2, by Modified Borg Scale) (by pulse oxymeter), blood pressure were measured. The pulmonary function (by spirometry), quadriceps femoris muscle strength (by manual muscle test) and quality of life (by Nottingham Health Profile Survey) were evaluated.The STST and 6MWT results were lower in COPD group than the healthy group (P<0.05). During the 6MWT the rise in the heart rate, systolic blood pressure and the decrease in SpO2 were statistically significant according to STST in COPD groups (P<0.05). The STST and 6MWT were strongly correlated with each other in both groups (P<0.05). Similarly, they were correlated with age, quality of life, peripheral muscle strength and dyspnea severity in COPD groups (P<0.05).Similar to 6MWT, STST is also able to determine the functional state correctly. Additionally, it produces less hemodynamical stress compared to the 6MWT. In conclusion, STST can be used as an alternative of the 6MWT in patients with COPD.
Tüberküloz ve toraks, 2007
Nosocomial infections are an important cause of preventable morbidity and mortality; they also re... more Nosocomial infections are an important cause of preventable morbidity and mortality; they also result in significant socioeconomic cost. Nosocomial pneumonia (NCP) is defined as pneumonia, which occurs 48 hours after hospitalization or after discharge from the hospital. It is the second or third most frequent infection among all hospital acquired infections, and the mortality of NCP is higher than the other hospital acquired infections. Patients, diagnosed as NCP were retrospectively analyzed in order to detect microbiological agent and prognostic factors. We evaluated 173 patients, 67.0% of them were male and 33.0% female. Comorbid diseases were present in 94.2% and a medical procedure had been applied in 75.1% of cases. A single agent was isolated in 79.2% of the cases while a mixt infection was present in 13.3%. In 7.5% of the cases, cultures were negative. Endotracheal aspirates were the most common materials (38.9%) used for detected microorganism and sputum cultures were used ...
The journal of sexual medicine, 2007
Several co-morbid diseases have been shown to affect sexual functions in both genders. In the lit... more Several co-morbid diseases have been shown to affect sexual functions in both genders. In the literature, sexual function status in men with obstructive sleep apnea syndrome (OSAS) has been studied; however, sexual functions in women with OSAS have not yet been studied. In this prospective study, we aimed to determine sexual function status in women with OSAS and its relationship with the disease parameters of OSAS. Women, who were diagnosed with OSAS with polysomnography performed in the sleep center of our university hospital, formed the study population. Women with any genital deformity, postmenopausal women, and women without a regular partner were excluded from the study. General demographic properties, medical histories, polysomnography parameters, and frequency of intercourse per month were noted for each patient. Patients completed the Sexual Function Questionnaire Version 2 (SFQ-V2) and Epworth Sleepiness Scale. The patients were grouped as mild, moderate, and severe OSAS a...
Education for health (Abingdon, England), 2006
Task-based learning (TBL) is an educational strategy recommended for the later years of the medic... more Task-based learning (TBL) is an educational strategy recommended for the later years of the medical education programme. The TBL programme was adopted for clinical years in the 2000-2001 academic year in Dokuz Eylul University School of Medicine (DEUSM). The aim of this paper is to describe the TBL programme of DEUSM. DEUSM outlined 50 clinical tasks for fourth-year students and 37 for fifth-year students. The tasks were grouped into four and five blocks. Interdisciplinary practicals, lectures and patient visits were organised in each task's schedule. The tasks were the focus of learning and each discipline contributed its own learning opportunities to the attached tasks. Formative and summative methods were used to evaluate the programme. Based on the experience and feedback provided by the students and trainers, the authors considered TBL an applicable and advisable approach for the clinical years of medical education.
Sleep and Breathing, 2011
Purpose The aim of the study was to assess the effect of breathing and physical exercise on pulmo... more Purpose The aim of the study was to assess the effect of breathing and physical exercise on pulmonary functions, apnea-hypopnea index (AHI), and quality of life in patients with obstructive sleep apnea syndrome (OSAS). Methods Twenty patients with mild to moderate OSAS were included in the study either as exercise or control group. The control group did not receive any treatment, whereas the exercise group received exercise training. Exercise program consisting of breathing and aerobic exercises was applied for 1.5 h 3 days weekly for 12 weeks. Two groups were assessed through clinical and laboratory measurements after 12 weeks. In the evaluations, bicycle ergometer test was used for exercise capacity, pulmonary function test, maximal inspiratory-expiratory pressure for pulmonary functions, polysomnography for AHI, sleep parameters, Functional Outcomes of Sleep Questionnaire (FOSQ), Short Form-36 (SF-36) for quality of sleep and health-related quality of health, Epworth Sleepiness Scale for daytime sleepiness, and anthropometric measurements for anthropometric characteristics.
Sleep and Biological Rhythms, 2013
ABSTRACT Sleep disordered breathing (SDB) represents a major public health problem. We investigat... more ABSTRACT Sleep disordered breathing (SDB) represents a major public health problem. We investigated the risk of SDB and associated factors in the Turkish adult population. We collected data by an interviewer‐administered questionnaire in a nationwide representative sample of 5021 adults (2598 women, 2423 men) with a mean age of 40.7 years (SD:15.1) in 2010. High risk of SDB was defined as the positive response to at least two of the three categories in the Berlin questionnaire (BQ). High risk of SDB was found in 13.7% (men: 11.1%, women: 20.2%). High risk of SDB prevalence was not significantly different between the genders in the analysis stratified for BMI categories. Female gender, older age, lower level of education and smoking in the past were associated with high risk of SDB in the logistic regression analysis models adjusting for age and gender. After the adjustment for age, gender, smoking, BMI and educational status, high risk of SDB, and BQ Category 2 score were associated with previous hospitalization and cardiovascular diseases. Risk due to BQ Category 1 and BQ Category 2 was more than additive in the models for hypertension and heart disease for the age groups 45–65 years and 65 years and over. Higher prevalence of SDB and obesity among women in our population should be addressed in further studies. Association between high risk of SDB and cardiovascular diseases, if confirmed, indicates the public health importance of screening for SDB symptoms.
Respirology, 2005
Cisplatin-gemcitabine (PG) and cisplatin-etoposide (PE) combinations are active regimens for non-... more Cisplatin-gemcitabine (PG) and cisplatin-etoposide (PE) combinations are active regimens for non-small cell lung cancer (NSCLC). The present study aimed to compare PG with PE in the treatment of patients with stage IIIB and IV NSCLC. We conducted a prospective, multicentre trial. A total of 166 patients were enrolled into the study and received either gemcitabine (1,000 mg/m(2)) on days 1, 8 and 15 plus cisplatin (80 mg/m(2)) on day 2 every 4 weeks, or etoposide (100 mg/m(2)) on days 1, 2 and 3 plus cisplatin (80 mg/m(2)) on day 1 every 3 weeks. The overall response rate was superior in the PG group (54.8%vs 39.0%, P=0.045). There was no significant difference in survival between the two groups, with respective median and 1-year survival of 38 weeks and 33.3% for the PG group, and 34 weeks and 23.2% for the PE group. There was also no statistical difference for time to progression between the two groups. Neutropenia and thrombocytopenia were seen more frequently in the PG group (grade 3 neutropenia, 33.3%vs 15.9%, P=0.012; grade 3 thrombocytopenia, 27.4%vs 3.7%, P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001 and grade 4 thrombocytopenia, 10.7%vs 1.2%, P=0.018). PG is an active chemotherapy regimen and has a better response rate than PE in advanced NSCLC, although there was no difference in time to progression and overall survival. A higher incidence of haematological toxicity was seen with PG than with PE.
Primary Health Care Research & Development, 2013
Chronic obstructive pulmonary disease (COPD) may cause some psychiatric disorders such as depress... more Chronic obstructive pulmonary disease (COPD) may cause some psychiatric disorders such as depression and anxiety, similar to other chronic diseases. Treatment adherence may be affected by worsening of cognitive functions. We aimed to show whether the symptoms of anxiety and depression affect treatment adherence by patients. Seventy-eight COPD patients were analysed at the first visit. The use of bronchodilator therapy was revised for standardization before they attended a second visit after six months. Hospital Anxiety and Depression Scale (HADS), Anxiety Sensitivity Index-3 (ASI-3) and SF-36 Questionnaire were carried out at that visit. &amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;National Guide of Turkish Thoracic Society for Asthma&amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; was used for scoring method of use of the bronchodilator and evaluating treatment adherence (including maintenance therapy). Sixty-two of 78 patients, 53 (85.5%) men and nine (14.5%) women with a mean age of 64.9 ± 9.9 joined the second visit. Thirty-three patients (53.2%) had a high-treatment adherence (HTA), whereas 29 (46.8%) had a low-treatment adherence (LTA). There were high scores of anxiety in 18 (29%) and depression in 11 (17.7%) patients. There was no statistical difference between the HTA and LTA groups in means of age, gender, educational level, presence of comorbidity, classification of COPD, high anxiety scores according to HADS and ASI-3 scores. Of the patients, 41.4% in the LTA group were still smoking, whereas it was only 12.1% in the HTA group (P = 0.009). The LTA group had higher depression scores (P = 0.004) than the HTA group. Dyspnea was found more frequent in LTA patients (P = 0.047); vitality score was also statistically low in this group (P = 0.01). As a result, continuing smoking and the presence of depression symptoms may decrease adherence to treatment. Therefore, to increase the adherence to treatment and reduce symptoms such as dyspnea, it is important to treat any depressive symptoms that are present and to help patients cease smoking.
The Journal of Sexual Medicine, 2007
Introduction. Several co-morbid diseases have been shown to affect sexual functions in both gende... more Introduction. Several co-morbid diseases have been shown to affect sexual functions in both genders. In the literature, sexual function status in men with obstructive sleep apnea syndrome (OSAS) has been studied; however, sexual functions in women with OSAS have not yet been studied. Aims. In this prospective study, we aimed to determine sexual function status in women with OSAS and its relationship with the disease parameters of OSAS. Methods. Women, who were diagnosed with OSAS with polysomnography performed in the sleep center of our university hospital, formed the study population. Women with any genital deformity, postmenopausal women, and women without a regular partner were excluded from the study. General demographic properties, medical histories, polysomnography parameters, and frequency of intercourse per month were noted for each patient. Patients completed the Sexual Function Questionnaire Version 2 (SFQ-V2) and Epworth Sleepiness Scale. The patients were grouped as mild, moderate, and severe OSAS according to the level of respiratory disturbance index (RDI). Main Outcome Measures. Scores of sexual function domains were determined from SFQ, and their relationships with parameters of polysomnography and demographics were studied. Results. Twenty-five patients were included in the study. Mean age was 48.1 ± 2.7 years. All were married with a mean marriage duration of 25.6 ± 3.3 years. Mean frequency of intercourse per month was 3.3 ± 1.8. All domains of sexual functions except pain and enjoyment significantly decreased with increasing severity of OSAS. When we controlled for factors of age and co-morbid diseases, correlation analyses showed significant negative correlation between levels of RDI and all domains of sexual functions except pain and enjoyment (P < 0.05). Conclusions. Obstructive sleep apnea syndrome negatively impacts sexual function in women independent of age and associated co-morbid diseases. Köseo lu N, Köseo lu H, Itil O, Öztura , Baklan B, Ikiz AO, and Esen AA. Sexual function status in women with obstructive sleep apnea syndrome. J Sex Med 2007;4:1352-1357.
Journal of Asthma, 2006
This study was carried out with 127 asthmatic patients and 127 controls, which aimed to compare a... more This study was carried out with 127 asthmatic patients and 127 controls, which aimed to compare and evaluate the environmental conditions in the homes of asthmatic patients and the control group. Air samples were obtained by using an air sampler and the mean mould colony counts were established. Aspergillus and Penicillium were the most common isolated species. No significant difference was observed with regard to various house conditions and the mean mould colony counts between the houses of patients and controls. The mould colony counts were found to be lower in houses with wooden parquet flooring. The odds ratio for stone floors vs. wood floors was 2.3 (95% CI 1.08-4.98) for mould growth.
Japanese Heart Journal, 2004
The ratio of cardiac involvement of Echinoccocus granulosus is 0.02-2% and although seen rarely, ... more The ratio of cardiac involvement of Echinoccocus granulosus is 0.02-2% and although seen rarely, involvement of the interatrial septum has also been reported in the published literature. The present case was a 19-year-old male university student admitted to hospital with complaints of headache and dizziness. Computerized tomography of the cranium revealed a cystic mass located at the frontal region and enucleation of the cyst was performed during surgery. A cystic lesion 5 x 4 cm in size was detected within the interatrial septum on two-dimensional transthoracic echocardiography during the postoperative period and the patient was referred to our clinic. Open heart surgery was performed and a hydatid cyst that involved the interatrial septum was enucleated. The cyst wall was sutured to the interatrial septum. No complications developed during the postoperative period. The patient was discharged on the fifth day of hospitalization and medical therapy was started with albendazole.
European Journal of Anaesthesiology, 2006
... Bodur, H.1; Savran, Y.1; Koca, U.2; Kilinç, O.3; Albayrak, S.3; Itil, O.3; Akoğlu, S.4. ... U... more ... Bodur, H.1; Savran, Y.1; Koca, U.2; Kilinç, O.3; Albayrak, S.3; Itil, O.3; Akoğlu, S.4. ... Upon sedation and intubation, another arterial blood sample showed a PaO 2 /F i O 2 ratio of 85 and the patient was transferred to the medical intensive care unit (ICU) with the diagnosis of ...
Education for Health: Change in Learning & Practice, 2006
Context: Task-based learning (TBL) is an educational strategy recommended for the later years of ... more Context: Task-based learning (TBL) is an educational strategy recommended for the later years of the medical education programme. The TBL programme was adopted for clinical years in the 2000-2001 academic year in Dokuz Eylul University School of Medicine (DEUSM).
Clinical & Experimental Metastasis, 2005
Endobronchial metastases (EBM) from extrapulmonary malignant tumors are rare. The most common ext... more Endobronchial metastases (EBM) from extrapulmonary malignant tumors are rare. The most common extrathoracic malignancies associated with EBM are breast, renal and colorectal carcinomas. In this study, we aimed to evaluate the clinical, radiographic and bronchoscopic aspects of patients with EBM who were diagnosed between 1992 and 2002. Data about patients' clinical conditions, symptoms, radiographic and endoscopic findings, and histopathological examination results were investigated. EBM was defined as bronchoscopically visible lesions histopathologically identical to the primary tumor in patients with extrapulmonary malignancies. We found 15 cases with EBM. Primary tumors included breast , and renal carcinomas; Malignant Melanoma (2); synovial sarcoma (1), ampulla of Vater adenocarcinoma (1), pheochromocytoma (1), hypernephroma (1), and Hodgkin's Disease (1). The most common symptoms were dyspnea (80%), cough (66.6%) and hemoptysis (33.3%). Multiple (40%) or single (13.3%) pulmonary nodules, mediastinal or hilar lymphadenopathy (40%), and effusion (40%) were the most common radiographic findings. The mean interval from initial diagnosis to diagnosis of EBM was 32.8 months (range, 0-96 months) and median survival time was 18 months (range, 4-84). As a conclusion, various extrapulmonary tumors can metastasize to the bronchus. Symptoms and radiographic findings are similar with those in primary lung cancer. Therefore, EBM should be discriminated from primary lung cancer histopathologically. Although mean survival time is usually short, long-term survivors were reported. Consequently, treatment must be planned according to the histology of the primary tumor, evidence of metastasis to other sites and medical status of the patient.
Turk Toraks Dergisi
... Duygu Ilgın 1 , Hayriye Kul Karaali 1 , Sevgi Özalevli 1 , Oya İtil 2 , Eyüp Sabri Uçan 2. ..... more ... Duygu Ilgın 1 , Hayriye Kul Karaali 1 , Sevgi Özalevli 1 , Oya İtil 2 , Eyüp Sabri Uçan 2. ... Results: The mean apnea-hypopnea index (AHI), FEV 1 of OSAS patients, and the mean FEV 1 of COPD patients were 38.4±17.5, 83.2±8.8%, and 73.2±11.3%, respectively. ...
Indoor and Built Environment, 2008
In an attempt to determine the relationship between the features of houses and moulds growing ind... more In an attempt to determine the relationship between the features of houses and moulds growing indoors, 242 houses were examined in Izmir, a city on the west coast of Turkey with a mild climate. During house visits a questionnaire was given and air was sampled using an 'air IDEAL' air sampler for quantitative fungal culture. The moulds most commonly isolated were Aspergillus, Penicillium, and Mucor spp. Aspergillus growth in houses older than 20 years was more common than other species when the features of houses and isolated fungi were compared. Mucor grew significantly more in houses where the air was humid, the temperature was cooler and there were pot plants. Penicillium grew more frequently in houses where visible mould was present and birds were bred. However, no relationship could be demonstrated between the method of heating, the number of household members, exposure to sun, type of building and flooring with a specific mould. As a conclusion, many household factors suggested as risk factors for mould growth have been examined and only a few relationships could be established between certain features of houses and moulds. However, mould growth is much affected by many conditions and the environment in a house is one of many factors that may facilitate growth.