Suna Asilsoy | Dokuz Eylül University (original) (raw)
Papers by Suna Asilsoy
Türkiye çocuk hastalıkları dergisi, Aug 10, 2017
Objective: Cystic fibrosis (CF) is a life-limiting, multisystemic, autosomal recessive genetic di... more Objective: Cystic fibrosis (CF) is a life-limiting, multisystemic, autosomal recessive genetic disorder that is characterized by digestive and respiratory dysfunction contributing to growth deficit, chronic respiratory infections, progressive lung tissue damage, and premature death. CF patients have several important endocrine abnormalities including exocrine pancreatic insufficiency, poor linear growth, bone diseases, hypogonadism and thyroid dysfunction. In the present study, we aimed to investigate the prevalence of thyroid dysfunction in children with CF and evaluate the general characteristics of these patients in Turkey. Material and Methods: The study was conducted between January 2015 and June 2015. A total of 42 patients (20 male, 22 female) with CF were included in the study. Demographic information; clinical, laboratory and radiological findings; medication use, and genetic analyses were assessed from the medical records. The serum fT4, fT3 and TSH levels were measured by chemiluminescence immunoassay using a DxI800 autoanalyzer (Beckman Coulter Inc., CA, USA). Results: The mean age at the time of diagnosis of CF was 35.5±53.2 (2-194) months in the study population. Eight of the 42 (19%) patients whose TSH, fT4 and fT3 levels were measured had abnormal TSH and fT4 levels (two overt hypothyroidism and six subclinical hypothyroidism). Five (62.5%) of the subjects with thyroid dysfunction were receiving thyroid hormone replacement therapy. Conclusion: Our study presents the first evaluation of the patients with CF for thyroid dysfunction in Turkey. In our study population, we detected eight (19 %) CF patients with thyroid dysfunction and five (62.5%) of them were receiving L-thyroxine treatment. In our opinion, regular evaluation of thyroid function tests in patients with CF may be necessary to prevent problems associated with hypothyroidism.
Journal of pediatric neurology, Jan 30, 2023
Cystic fibrosis is one of the most common inherited diseases. It presents with recurrent respirat... more Cystic fibrosis is one of the most common inherited diseases. It presents with recurrent respiratory infections, pancreatic insufficiency, and growth retardation. Neurological involvement becomes more common as life expectancy increases. Chronic hypoxia, impaired glucose intolerance, autoimmune mechanisms, vasculitis changes, and micronutrient deficiencies seem to cause neuropathy in cystic fibrosis. This study was aimed to investigate peripheral neuropathy in pediatric cystic fibrosis patients. Twenty-one cystic fibrosis patients and 19 healthy control subjects between the ages of 7 and 17 years were included. Their nerve conduction study results and laboratory investigations were analyzed. Participants were classified into four groups; 1. Cystic fibrosis with vitamin D deficiency, 2. Cystic fibrosis with normal vitamin D levels, 3. Healthy subjects with vitamin D deficiency, 4. Healthy subjects with normal vitamin D levels. We found statistically significantly lower sensory median nerve sensorial nerve action potential, sensorial sural nerve conduction velocity, and motor peroneal nerve compound motor action potential in cystic fibrosis patients with vitamin D deficiency than in other cases. We also found that the main difference between cystic fibrosis and control groups was especially in patients with low vitamin D levels. Nerve damage starts at an early age, especially in cystic fibrosis patients especially those with vitamin D deficiency. Electrophysiological evaluation to assess neuropathy is important even in asymptomatic patients. Prevention of hypovitaminosis D is important to prevent neuropathy in cystic fibrosis patients.
İzmir Dr.Behçet Uz çocuk hastanesi dergisi, 2020
Objective: Selective IgA deficiency is the most common immunoglobulin disorder. IgA deficiency ma... more Objective: Selective IgA deficiency is the most common immunoglobulin disorder. IgA deficiency may have different clinical presentations. While some patients are asymptomatic it has been also detected in association with autoimmune and atopic disorders. In our study, we aimed to determine the relationship between Ig A deficiency and atopy and the prevalence of atopy in patients with IgA deficiency.
Patients with early-onset of wheezing attacks and itchy skin rashes should be investigated for fo... more Patients with early-onset of wheezing attacks and itchy skin rashes should be investigated for food and aeroallergen sensitization Patients with infancy-onset atopic dermatitis are at increased risk of food allergy Patients and families should be educated on avoidance of allergens and irritants and good adherence to treatment Patients with severe atopic dermatitis should be evaluated for primary immunodeficiency diseases
Türkiye çocuk hastalıkları dergisi, Aug 10, 2017
Objective: Cystic fibrosis (CF) is a life-limiting, multisystemic, autosomal recessive genetic di... more Objective: Cystic fibrosis (CF) is a life-limiting, multisystemic, autosomal recessive genetic disorder that is characterized by digestive and respiratory dysfunction contributing to growth deficit, chronic respiratory infections, progressive lung tissue damage, and premature death. CF patients have several important endocrine abnormalities including exocrine pancreatic insufficiency, poor linear growth, bone diseases, hypogonadism and thyroid dysfunction. In the present study, we aimed to investigate the prevalence of thyroid dysfunction in children with CF and evaluate the general characteristics of these patients in Turkey. Material and Methods: The study was conducted between January 2015 and June 2015. A total of 42 patients (20 male, 22 female) with CF were included in the study. Demographic information; clinical, laboratory and radiological findings; medication use, and genetic analyses were assessed from the medical records. The serum fT4, fT3 and TSH levels were measured by chemiluminescence immunoassay using a DxI800 autoanalyzer (Beckman Coulter Inc., CA, USA). Results: The mean age at the time of diagnosis of CF was 35.5±53.2 (2-194) months in the study population. Eight of the 42 (19%) patients whose TSH, fT4 and fT3 levels were measured had abnormal TSH and fT4 levels (two overt hypothyroidism and six subclinical hypothyroidism). Five (62.5%) of the subjects with thyroid dysfunction were receiving thyroid hormone replacement therapy. Conclusion: Our study presents the first evaluation of the patients with CF for thyroid dysfunction in Turkey. In our study population, we detected eight (19 %) CF patients with thyroid dysfunction and five (62.5%) of them were receiving L-thyroxine treatment. In our opinion, regular evaluation of thyroid function tests in patients with CF may be necessary to prevent problems associated with hypothyroidism.
European Archives of Oto-rhino-laryngology, Dec 15, 2018
Propose Allergic rhinitis (AR) is a very common, chronic and global health problem. In the last t... more Propose Allergic rhinitis (AR) is a very common, chronic and global health problem. In the last two decades, the efficiency of barrier-enforcing measures in AR has been investigated. In this study, we aimed to evaluate the effect of allergen-blocker mechanical barrier gel (MBG) (AlerjiSTOP ®) treatment on symptoms and quality of life score (QoLS) in patients with seasonal and perennial allergic rhinitis. Methods A single-center, prospective study was conducted between January 2017 and May 2018. Patients diagnosed with allergic rhinitis with a visual analogue scale (VAS) of 5 or higher (moderate/severe) were enrolled in the study. Patients were evaluated in terms of VAS, nasal symptom score (NSS), ocular symptom score (OSS), total symptom score (TSS) and QoLS at baseline, 1 week and 1 month of MBG treatment. Results A total of 83 patients with AR were enrolled in the study. Clinical and laboratory examinations showed that 50 (60.2%) patients were mono-sensitized. Allergen-blocker mechanical barrier gel treatment was performed as monotherapy in 22 (26.5%) patients. Median VAS, NSS, OSS and TSS decreased from 7 to 4, 8 to 3, 4 to 0 and 12 to 4, respectively (p < 0.0001). Correlation analysis revealed positive correlations between lower pediatric rhinoconjunctivitis quality of life questionnaire scores for patients under 12 years of age and decrease in VAS, NSS and TSS (r = 0.380, p = 0.008; r = 0.544, p < 0.0001; r = 0.543, p < 0.0001). Positive correlations were detected between lower rhinoconjunctivitis quality of life questionnaire (self-administered) scores for patients ≥ 12 years of age and decrease in VAS, NSS, OSS and TSS (r = 0.703, p < 0.0001; r = 0.465, p = 0.005; r = 0.526, p = 0.001; r = 0.624, p < 0.0001). Conclusion In conclusion, we found significant decrease in all symptom scores and improvement in QoLS of patients treated with MBG as monotherapy and combination therapy.
Astım allerji immünoloji, 2017
Turkish thoracic journal, Sep 9, 2019
DergiPark (Istanbul University), Apr 1, 2017
Objective: Hypersensitivity reactions to beta-lactams are often reported in children. Although ma... more Objective: Hypersensitivity reactions to beta-lactams are often reported in children. Although many of these children are considered to be allergic, a careful evaluation only confirms a low percentage. The aim of this study was to evaluate the clinical data and diagnostic methods used in children with a clinical history of hypersensitivity reactions to betalactams. Material and Methods: The medical records of patients presenting with suspected beta-lactam allergy were evaluated retrospectively between June 2013 to December 2015 at the Dokuz Eylul University’s Department of Pediatric Allergy and Immunology. results: In total, data of 33 patients were obtained from medical records. Only 5 (13.8%) of the patients had an allergy. Skin prick test, intradermal test and oral provocation test (OPT) were administered to 15 (45.4%) patients and 3 of the patients were diagnosed as having hypersensitivity to culprit drugs (1 amoxicillin, 1 cefuroxime and 1 both cefuroxime and ampicillin). A total of 18 patients with non-immediate cutaneous reactions without systemic symptoms were administered penicilloyl Gand V-specific immunoglobulin E (IgE) and OPT and 2 patients were diagnosed as having isolated clavulanic acid allergy. conclusion: Beta-lactam allergies could be overdiagnosed and a careful evaluation should be performed for accurate diagnosis. For children with non-immediate cutaneous reactions, OPTs are safe and effective. key Words: Child, Beta-lactam allergy, Drug 1Buca Kadın Doğum ve Çocuk Hastalıkları Hastanesi, Çocuk Alerji Bölümü, İzmir, Türkiye 2Dokuz Eylül Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Alerji ve İmmünoloji Bilim Dalı, İzmir, Türkiye 3Süreyyapaşa Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Çocuk İmmünoloji ve Alerji Bölümü, İstanbul, Türkiye 4Diyarbakır Eğitim ve Araştırma Hastanesi, Çocuk İmmünoloji ve Alerji Bölümü, Diyarbakır, Türkiye Şule ÇAĞLAYAN SÖZMEN1, Seda KÖSE2, Dilek TEZCAN2, Sakine IŞIK3, Zeynep ARIKAN AYYILDIZ4, Suna ASİLSOY2, Nevin UZUNER2, Özden ANAL2, Özkan KARAMAN2 Beta Laktam Alerji Şüphesi Olan Çocukların Değerlendirilmesi: Retrospektif Bir Çalışma Evaluation of Children with Suspected Beta Lactam Allergy: A Retrospective Study
Asthma Allergy Immunology, Dec 4, 2016
Primer immün yetmezlikli olgularda yineleyen infeksiyonların yanı sıra allerjik, otoimmün, hemato... more Primer immün yetmezlikli olgularda yineleyen infeksiyonların yanı sıra allerjik, otoimmün, hematolojik ve malign hastalıklara eğilim olduğu bilinmektedir. Çalışmamızda antikor eksikliği olan hastalarda allerjik hastalık sıklığının belirlenmesi ve atopinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Hastanemiz immünoloji polikliniğinde bir yıllık dönemde antikor eksikliği tanısı ile izlenen 93 hasta çalışmaya alınmıştır. Hastaların yaş, cinsiyet, eşlik eden allerjik hastalık ve ailede allerjik hastalık parametreleri kaydedilmiştir. Hastalardan serum total IgE düzeyi, serum spesifik IgE panelleri istenmiş ve allerji deri testi (prick test) uygulanmıştır. Bulgular: Hastaların %63.4'ü erkek olup, yaş ortalaması 6.4 ± 2.7 yıl olarak bulunmuştur. Hasta grupları; IgA eksikliği (%53.8), IgA ve IgG subgrup eksikliği (%21.5), IgG subgrup eksikliği (%15.1) ve diğerleri (%9.7) şeklinde dağılmıştır. Eşlik eden allerjik hastalıklar sırasıyla astım (%44.1), astım + allerjik rinit (%9.7), allerjik deri hastalıkları (%7.5), allerjik rinit (%3.2) olup en sık allerjik hastalık IgG ABSTRACT Objective: Primary immune deficiencies are suggested to be associated with high incidence of allergic, autoimmune, hematological, and malignant disorders. The aim of this study was to evaluate the frequency of allergic disorders in children with antibody deficiency. Materials and Methods: Ninety-three patients diagnosed as antibody deficiency in a one-year period were included in this study. Their ages and accompanying allergic disorders and allergic disorders in their families were evaluated retrospectively. Serum total IgE levels and serum allergen specific IgE panels of patients were obtained, and allergen skin testing (prick test) was performed. Results: 63.4% of the patients were male and the mean age was 6.4 ± 2.7 years. IgA deficiency was present in 53.8% of the patients followed by IgG subclass deficiency (15.1%), IgG and IgA subclass deficiencies (21.5%), and others (9.7%). Accompanying allergic disorders were asthma (44.1%), asthma and allergic rhinitis (9.7%), allergic skin diseases (7.5%), and allergic rhinitis (3.2%). The most
Allergologia et immunopathologia, Mar 1, 2017
Please cite this article in press as: Işık S, et al. Knowledge, perspectives and attitudes about ... more Please cite this article in press as: Işık S, et al. Knowledge, perspectives and attitudes about allergen-specific immunotherapy for respiratory allergic disease among paediatricians in Turkey. Allergol Immunopathol (Madr). 2016.
Astım allerji immünoloji, 2009
... NUH YILMAZ, DEMET CAN, SUNA ASİLSOY, SANİYE GÜLLE; Yazışma Adresi/Address for Correspondence ... more ... NUH YILMAZ, DEMET CAN, SUNA ASİLSOY, SANİYE GÜLLE; Yazışma Adresi/Address for Correspondence Uzm. Dr. Nuh YILMAZ Dr. Behçet Uz Çocuk Hastalıkları ve Cerrahisi Eğitim ve Araştırma Hastanesi, Alsancak-İzmir, Türkiye; ÖZET: ...
Journal of Pediatric Hematology/Oncology
Background: Respiratory system involvement is common in congenital plasminogen deficiency. Althou... more Background: Respiratory system involvement is common in congenital plasminogen deficiency. Although many treatment approaches have been tried, there is still no definitive treatment for respiratory system involvement. Observation(s): We report 2 congenital plasminogen deficiency cases, who presented with severe respiratory symptoms, for whom a novel treatment modality was tried. After intravenous administration of FFP (fresh frozen plasma), tissue plasminogen activator and FFP were administered intratracheally, and respiratory system findings improved. Conclusions: Intratracheal administration of tissue plasminogen activator and FFP is an available treatment modality for patients with lung involvement. Fibrin plaques should be carefully removed and new lesion formation should be prevented.
Allergy and Asthma Proceedings
Background: In recent years, the epithelial barrier hypothesis has been emphasized in the formati... more Background: In recent years, the epithelial barrier hypothesis has been emphasized in the formation of allergic diseases. Transepidermal water loss (TEWL) occurs through diffusion and evaporation from the skin to the external environment. There are few studies on TEWL in allergic diseases. Objective: This study evaluated the relationship between patients with atopic diseases and healthy controls and hygiene habits in TEWL. Methods: The study was conducted on patients who were followed up for atopic disease (asthma, allergic rhinitis, immunoglobulin E mediated food allergy, and atopic dermatitis) and healthy children. TEWL measurement was in a room that was stable in terms of humidity and temperature by using a widely validated open room system. During the measurement, the participants reported their frequency of taking a shower and cleaning product use. Results: In the study group, TEWL was measured in 182 patients, and the median (min-max) TEWL was 21.3 g/hm2 (7.8‐101.3 g/hm2) in t...
Türkiye çocuk hastalıkları dergisi, Nov 2, 2022
DergiPark (Istanbul University), Aug 19, 2022
Allergologia et immunopathologia, Nov 22, 2022
Background: Cystic fibrosis (CF) is an inherited autosomal recessive disorder that causes chronic... more Background: Cystic fibrosis (CF) is an inherited autosomal recessive disorder that causes chronic airway disease. In addition to genetic factors, environmental factors may affect the clinical phenotype of CF. In this study, the presence of aeroallergen sensitivity in our patients with CF and its effects on clinical findings are evaluated. Methods: In this study, patients included were diagnosed with CF and followed in the Pediatric Respiratory and Allergy Clinic of the
Journal of Child Science
Objective A misdiagnosed “penicillin allergy” is a common problem in childhood. Recently, skippin... more Objective A misdiagnosed “penicillin allergy” is a common problem in childhood. Recently, skipping skin tests (STs) and performing a direct oral challenge test (OCT) have become an increasingly common approach in children with suspected β-lactam (BL) allergy. In our study, we aimed to evaluate the safety and efficacy of OCT without using ST in children who had a history of hypersensitivity reactions with BL antibiotics. Materials and Methods We retrospectively evaluated direct OCT outcomes in children with both nonimmediate and immediate-type reaction history with BL antibiotics. STs were not performed before the challenge test. The patients were monitored for 4 hours after the challenge and continued using the drug in two divided doses for 3 days at home. Results In this study, 72 patients were included, with median age of 7 years (interquartile range: 4; min: 1 year to max: 16 years), and of these, 56% were male. Forty-five subjects (63%) reported immediate-type adverse reactions....
Medical Science and Discovery
Objective: Urticaria is a condition characterized by the development of blisters (hives), angioed... more Objective: Urticaria is a condition characterized by the development of blisters (hives), angioedema, or both. Acute urticaria is the appearance of rashes lasting 6 weeks or less, angioedema, or both. It is recommended to use the urticaria control test to evaluate disease control in patients with CSU. This study aimed to evaluate the factors affecting urticaria control in patients followed up with the diagnosis of chronic spontaneous urticaria. Material and Methods: Urticaria control results of children diagnosed with chronic urticaria were evaluated retrospectively and factors that could affect urticaria control were investigated. Results: Relationships between the urticaria control test and age, gender, onset time of the complaint, family history of atopy, and laboratory values such as anti-nuclear antibody (ANA) and c4 were examined. Conclusion: Although chronic urticaria has a mild course in children, parameters such as gender, age, and ANA positivity may affect the control of ...
Background: Cystic fibrosis (CF) is an inherited autosomal recessive disorder that causes chronic... more Background: Cystic fibrosis (CF) is an inherited autosomal recessive disorder that causes chronic airway disease. In addition to genetic factors, environmental factors may affects the clinical phenotype of CF. In our study, the presence of aeroallergen sensitivity in our patients with CF and its effects on clinical findings were evaluated. Materials and Methods: Demographic characteristics, clinical and laboratory findings, skin prick test (SPT) results, and Modified Shwachman-Kulczycki (MSK) scores of patients diagnosed with CF followed in the Pediatric Respiratory and Allergy Clinic of Dokuz Eylul University Faculty of Medicine were evaluated. Results: We evaluated 51 patients with CF with a median age of 10 (6-18) years. The mean MSK score of the patients was 72.54±11.50, and the mean predictive value of forced expiratory volume (FEV1) in the first second of 41 patients was 80.43±19.50. According to SPT, aeroallergen sensitivity was detected in 17 (33.3%). The frequency of bacterial colonization and bronchiectasis was higher, MSK scores were lower in AF-sensitive patients (p[?]0.01). However, there was no similar difference in other allergen sensitivities. MSK scores and predictive FEV1 values of 25 (49%) patients with bacterial colonization were significantly lower than those without colonization (p=0.001, p=0.005, respectively). Conclusion: Aeroallergen sensitivity was detected in approximately 1/3 of CF patients. Although it has been emphasized in studies that environmental factors may have an impact on lung functions and clinical conditions in CF, the effect of allergens other than AF sensitivity may be less important compared to other environmental factors such as the presence of bacterial colonization.
Türkiye çocuk hastalıkları dergisi, Aug 10, 2017
Objective: Cystic fibrosis (CF) is a life-limiting, multisystemic, autosomal recessive genetic di... more Objective: Cystic fibrosis (CF) is a life-limiting, multisystemic, autosomal recessive genetic disorder that is characterized by digestive and respiratory dysfunction contributing to growth deficit, chronic respiratory infections, progressive lung tissue damage, and premature death. CF patients have several important endocrine abnormalities including exocrine pancreatic insufficiency, poor linear growth, bone diseases, hypogonadism and thyroid dysfunction. In the present study, we aimed to investigate the prevalence of thyroid dysfunction in children with CF and evaluate the general characteristics of these patients in Turkey. Material and Methods: The study was conducted between January 2015 and June 2015. A total of 42 patients (20 male, 22 female) with CF were included in the study. Demographic information; clinical, laboratory and radiological findings; medication use, and genetic analyses were assessed from the medical records. The serum fT4, fT3 and TSH levels were measured by chemiluminescence immunoassay using a DxI800 autoanalyzer (Beckman Coulter Inc., CA, USA). Results: The mean age at the time of diagnosis of CF was 35.5±53.2 (2-194) months in the study population. Eight of the 42 (19%) patients whose TSH, fT4 and fT3 levels were measured had abnormal TSH and fT4 levels (two overt hypothyroidism and six subclinical hypothyroidism). Five (62.5%) of the subjects with thyroid dysfunction were receiving thyroid hormone replacement therapy. Conclusion: Our study presents the first evaluation of the patients with CF for thyroid dysfunction in Turkey. In our study population, we detected eight (19 %) CF patients with thyroid dysfunction and five (62.5%) of them were receiving L-thyroxine treatment. In our opinion, regular evaluation of thyroid function tests in patients with CF may be necessary to prevent problems associated with hypothyroidism.
Journal of pediatric neurology, Jan 30, 2023
Cystic fibrosis is one of the most common inherited diseases. It presents with recurrent respirat... more Cystic fibrosis is one of the most common inherited diseases. It presents with recurrent respiratory infections, pancreatic insufficiency, and growth retardation. Neurological involvement becomes more common as life expectancy increases. Chronic hypoxia, impaired glucose intolerance, autoimmune mechanisms, vasculitis changes, and micronutrient deficiencies seem to cause neuropathy in cystic fibrosis. This study was aimed to investigate peripheral neuropathy in pediatric cystic fibrosis patients. Twenty-one cystic fibrosis patients and 19 healthy control subjects between the ages of 7 and 17 years were included. Their nerve conduction study results and laboratory investigations were analyzed. Participants were classified into four groups; 1. Cystic fibrosis with vitamin D deficiency, 2. Cystic fibrosis with normal vitamin D levels, 3. Healthy subjects with vitamin D deficiency, 4. Healthy subjects with normal vitamin D levels. We found statistically significantly lower sensory median nerve sensorial nerve action potential, sensorial sural nerve conduction velocity, and motor peroneal nerve compound motor action potential in cystic fibrosis patients with vitamin D deficiency than in other cases. We also found that the main difference between cystic fibrosis and control groups was especially in patients with low vitamin D levels. Nerve damage starts at an early age, especially in cystic fibrosis patients especially those with vitamin D deficiency. Electrophysiological evaluation to assess neuropathy is important even in asymptomatic patients. Prevention of hypovitaminosis D is important to prevent neuropathy in cystic fibrosis patients.
İzmir Dr.Behçet Uz çocuk hastanesi dergisi, 2020
Objective: Selective IgA deficiency is the most common immunoglobulin disorder. IgA deficiency ma... more Objective: Selective IgA deficiency is the most common immunoglobulin disorder. IgA deficiency may have different clinical presentations. While some patients are asymptomatic it has been also detected in association with autoimmune and atopic disorders. In our study, we aimed to determine the relationship between Ig A deficiency and atopy and the prevalence of atopy in patients with IgA deficiency.
Patients with early-onset of wheezing attacks and itchy skin rashes should be investigated for fo... more Patients with early-onset of wheezing attacks and itchy skin rashes should be investigated for food and aeroallergen sensitization Patients with infancy-onset atopic dermatitis are at increased risk of food allergy Patients and families should be educated on avoidance of allergens and irritants and good adherence to treatment Patients with severe atopic dermatitis should be evaluated for primary immunodeficiency diseases
Türkiye çocuk hastalıkları dergisi, Aug 10, 2017
Objective: Cystic fibrosis (CF) is a life-limiting, multisystemic, autosomal recessive genetic di... more Objective: Cystic fibrosis (CF) is a life-limiting, multisystemic, autosomal recessive genetic disorder that is characterized by digestive and respiratory dysfunction contributing to growth deficit, chronic respiratory infections, progressive lung tissue damage, and premature death. CF patients have several important endocrine abnormalities including exocrine pancreatic insufficiency, poor linear growth, bone diseases, hypogonadism and thyroid dysfunction. In the present study, we aimed to investigate the prevalence of thyroid dysfunction in children with CF and evaluate the general characteristics of these patients in Turkey. Material and Methods: The study was conducted between January 2015 and June 2015. A total of 42 patients (20 male, 22 female) with CF were included in the study. Demographic information; clinical, laboratory and radiological findings; medication use, and genetic analyses were assessed from the medical records. The serum fT4, fT3 and TSH levels were measured by chemiluminescence immunoassay using a DxI800 autoanalyzer (Beckman Coulter Inc., CA, USA). Results: The mean age at the time of diagnosis of CF was 35.5±53.2 (2-194) months in the study population. Eight of the 42 (19%) patients whose TSH, fT4 and fT3 levels were measured had abnormal TSH and fT4 levels (two overt hypothyroidism and six subclinical hypothyroidism). Five (62.5%) of the subjects with thyroid dysfunction were receiving thyroid hormone replacement therapy. Conclusion: Our study presents the first evaluation of the patients with CF for thyroid dysfunction in Turkey. In our study population, we detected eight (19 %) CF patients with thyroid dysfunction and five (62.5%) of them were receiving L-thyroxine treatment. In our opinion, regular evaluation of thyroid function tests in patients with CF may be necessary to prevent problems associated with hypothyroidism.
European Archives of Oto-rhino-laryngology, Dec 15, 2018
Propose Allergic rhinitis (AR) is a very common, chronic and global health problem. In the last t... more Propose Allergic rhinitis (AR) is a very common, chronic and global health problem. In the last two decades, the efficiency of barrier-enforcing measures in AR has been investigated. In this study, we aimed to evaluate the effect of allergen-blocker mechanical barrier gel (MBG) (AlerjiSTOP ®) treatment on symptoms and quality of life score (QoLS) in patients with seasonal and perennial allergic rhinitis. Methods A single-center, prospective study was conducted between January 2017 and May 2018. Patients diagnosed with allergic rhinitis with a visual analogue scale (VAS) of 5 or higher (moderate/severe) were enrolled in the study. Patients were evaluated in terms of VAS, nasal symptom score (NSS), ocular symptom score (OSS), total symptom score (TSS) and QoLS at baseline, 1 week and 1 month of MBG treatment. Results A total of 83 patients with AR were enrolled in the study. Clinical and laboratory examinations showed that 50 (60.2%) patients were mono-sensitized. Allergen-blocker mechanical barrier gel treatment was performed as monotherapy in 22 (26.5%) patients. Median VAS, NSS, OSS and TSS decreased from 7 to 4, 8 to 3, 4 to 0 and 12 to 4, respectively (p < 0.0001). Correlation analysis revealed positive correlations between lower pediatric rhinoconjunctivitis quality of life questionnaire scores for patients under 12 years of age and decrease in VAS, NSS and TSS (r = 0.380, p = 0.008; r = 0.544, p < 0.0001; r = 0.543, p < 0.0001). Positive correlations were detected between lower rhinoconjunctivitis quality of life questionnaire (self-administered) scores for patients ≥ 12 years of age and decrease in VAS, NSS, OSS and TSS (r = 0.703, p < 0.0001; r = 0.465, p = 0.005; r = 0.526, p = 0.001; r = 0.624, p < 0.0001). Conclusion In conclusion, we found significant decrease in all symptom scores and improvement in QoLS of patients treated with MBG as monotherapy and combination therapy.
Astım allerji immünoloji, 2017
Turkish thoracic journal, Sep 9, 2019
DergiPark (Istanbul University), Apr 1, 2017
Objective: Hypersensitivity reactions to beta-lactams are often reported in children. Although ma... more Objective: Hypersensitivity reactions to beta-lactams are often reported in children. Although many of these children are considered to be allergic, a careful evaluation only confirms a low percentage. The aim of this study was to evaluate the clinical data and diagnostic methods used in children with a clinical history of hypersensitivity reactions to betalactams. Material and Methods: The medical records of patients presenting with suspected beta-lactam allergy were evaluated retrospectively between June 2013 to December 2015 at the Dokuz Eylul University’s Department of Pediatric Allergy and Immunology. results: In total, data of 33 patients were obtained from medical records. Only 5 (13.8%) of the patients had an allergy. Skin prick test, intradermal test and oral provocation test (OPT) were administered to 15 (45.4%) patients and 3 of the patients were diagnosed as having hypersensitivity to culprit drugs (1 amoxicillin, 1 cefuroxime and 1 both cefuroxime and ampicillin). A total of 18 patients with non-immediate cutaneous reactions without systemic symptoms were administered penicilloyl Gand V-specific immunoglobulin E (IgE) and OPT and 2 patients were diagnosed as having isolated clavulanic acid allergy. conclusion: Beta-lactam allergies could be overdiagnosed and a careful evaluation should be performed for accurate diagnosis. For children with non-immediate cutaneous reactions, OPTs are safe and effective. key Words: Child, Beta-lactam allergy, Drug 1Buca Kadın Doğum ve Çocuk Hastalıkları Hastanesi, Çocuk Alerji Bölümü, İzmir, Türkiye 2Dokuz Eylül Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Alerji ve İmmünoloji Bilim Dalı, İzmir, Türkiye 3Süreyyapaşa Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Çocuk İmmünoloji ve Alerji Bölümü, İstanbul, Türkiye 4Diyarbakır Eğitim ve Araştırma Hastanesi, Çocuk İmmünoloji ve Alerji Bölümü, Diyarbakır, Türkiye Şule ÇAĞLAYAN SÖZMEN1, Seda KÖSE2, Dilek TEZCAN2, Sakine IŞIK3, Zeynep ARIKAN AYYILDIZ4, Suna ASİLSOY2, Nevin UZUNER2, Özden ANAL2, Özkan KARAMAN2 Beta Laktam Alerji Şüphesi Olan Çocukların Değerlendirilmesi: Retrospektif Bir Çalışma Evaluation of Children with Suspected Beta Lactam Allergy: A Retrospective Study
Asthma Allergy Immunology, Dec 4, 2016
Primer immün yetmezlikli olgularda yineleyen infeksiyonların yanı sıra allerjik, otoimmün, hemato... more Primer immün yetmezlikli olgularda yineleyen infeksiyonların yanı sıra allerjik, otoimmün, hematolojik ve malign hastalıklara eğilim olduğu bilinmektedir. Çalışmamızda antikor eksikliği olan hastalarda allerjik hastalık sıklığının belirlenmesi ve atopinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Hastanemiz immünoloji polikliniğinde bir yıllık dönemde antikor eksikliği tanısı ile izlenen 93 hasta çalışmaya alınmıştır. Hastaların yaş, cinsiyet, eşlik eden allerjik hastalık ve ailede allerjik hastalık parametreleri kaydedilmiştir. Hastalardan serum total IgE düzeyi, serum spesifik IgE panelleri istenmiş ve allerji deri testi (prick test) uygulanmıştır. Bulgular: Hastaların %63.4'ü erkek olup, yaş ortalaması 6.4 ± 2.7 yıl olarak bulunmuştur. Hasta grupları; IgA eksikliği (%53.8), IgA ve IgG subgrup eksikliği (%21.5), IgG subgrup eksikliği (%15.1) ve diğerleri (%9.7) şeklinde dağılmıştır. Eşlik eden allerjik hastalıklar sırasıyla astım (%44.1), astım + allerjik rinit (%9.7), allerjik deri hastalıkları (%7.5), allerjik rinit (%3.2) olup en sık allerjik hastalık IgG ABSTRACT Objective: Primary immune deficiencies are suggested to be associated with high incidence of allergic, autoimmune, hematological, and malignant disorders. The aim of this study was to evaluate the frequency of allergic disorders in children with antibody deficiency. Materials and Methods: Ninety-three patients diagnosed as antibody deficiency in a one-year period were included in this study. Their ages and accompanying allergic disorders and allergic disorders in their families were evaluated retrospectively. Serum total IgE levels and serum allergen specific IgE panels of patients were obtained, and allergen skin testing (prick test) was performed. Results: 63.4% of the patients were male and the mean age was 6.4 ± 2.7 years. IgA deficiency was present in 53.8% of the patients followed by IgG subclass deficiency (15.1%), IgG and IgA subclass deficiencies (21.5%), and others (9.7%). Accompanying allergic disorders were asthma (44.1%), asthma and allergic rhinitis (9.7%), allergic skin diseases (7.5%), and allergic rhinitis (3.2%). The most
Allergologia et immunopathologia, Mar 1, 2017
Please cite this article in press as: Işık S, et al. Knowledge, perspectives and attitudes about ... more Please cite this article in press as: Işık S, et al. Knowledge, perspectives and attitudes about allergen-specific immunotherapy for respiratory allergic disease among paediatricians in Turkey. Allergol Immunopathol (Madr). 2016.
Astım allerji immünoloji, 2009
... NUH YILMAZ, DEMET CAN, SUNA ASİLSOY, SANİYE GÜLLE; Yazışma Adresi/Address for Correspondence ... more ... NUH YILMAZ, DEMET CAN, SUNA ASİLSOY, SANİYE GÜLLE; Yazışma Adresi/Address for Correspondence Uzm. Dr. Nuh YILMAZ Dr. Behçet Uz Çocuk Hastalıkları ve Cerrahisi Eğitim ve Araştırma Hastanesi, Alsancak-İzmir, Türkiye; ÖZET: ...
Journal of Pediatric Hematology/Oncology
Background: Respiratory system involvement is common in congenital plasminogen deficiency. Althou... more Background: Respiratory system involvement is common in congenital plasminogen deficiency. Although many treatment approaches have been tried, there is still no definitive treatment for respiratory system involvement. Observation(s): We report 2 congenital plasminogen deficiency cases, who presented with severe respiratory symptoms, for whom a novel treatment modality was tried. After intravenous administration of FFP (fresh frozen plasma), tissue plasminogen activator and FFP were administered intratracheally, and respiratory system findings improved. Conclusions: Intratracheal administration of tissue plasminogen activator and FFP is an available treatment modality for patients with lung involvement. Fibrin plaques should be carefully removed and new lesion formation should be prevented.
Allergy and Asthma Proceedings
Background: In recent years, the epithelial barrier hypothesis has been emphasized in the formati... more Background: In recent years, the epithelial barrier hypothesis has been emphasized in the formation of allergic diseases. Transepidermal water loss (TEWL) occurs through diffusion and evaporation from the skin to the external environment. There are few studies on TEWL in allergic diseases. Objective: This study evaluated the relationship between patients with atopic diseases and healthy controls and hygiene habits in TEWL. Methods: The study was conducted on patients who were followed up for atopic disease (asthma, allergic rhinitis, immunoglobulin E mediated food allergy, and atopic dermatitis) and healthy children. TEWL measurement was in a room that was stable in terms of humidity and temperature by using a widely validated open room system. During the measurement, the participants reported their frequency of taking a shower and cleaning product use. Results: In the study group, TEWL was measured in 182 patients, and the median (min-max) TEWL was 21.3 g/hm2 (7.8‐101.3 g/hm2) in t...
Türkiye çocuk hastalıkları dergisi, Nov 2, 2022
DergiPark (Istanbul University), Aug 19, 2022
Allergologia et immunopathologia, Nov 22, 2022
Background: Cystic fibrosis (CF) is an inherited autosomal recessive disorder that causes chronic... more Background: Cystic fibrosis (CF) is an inherited autosomal recessive disorder that causes chronic airway disease. In addition to genetic factors, environmental factors may affect the clinical phenotype of CF. In this study, the presence of aeroallergen sensitivity in our patients with CF and its effects on clinical findings are evaluated. Methods: In this study, patients included were diagnosed with CF and followed in the Pediatric Respiratory and Allergy Clinic of the
Journal of Child Science
Objective A misdiagnosed “penicillin allergy” is a common problem in childhood. Recently, skippin... more Objective A misdiagnosed “penicillin allergy” is a common problem in childhood. Recently, skipping skin tests (STs) and performing a direct oral challenge test (OCT) have become an increasingly common approach in children with suspected β-lactam (BL) allergy. In our study, we aimed to evaluate the safety and efficacy of OCT without using ST in children who had a history of hypersensitivity reactions with BL antibiotics. Materials and Methods We retrospectively evaluated direct OCT outcomes in children with both nonimmediate and immediate-type reaction history with BL antibiotics. STs were not performed before the challenge test. The patients were monitored for 4 hours after the challenge and continued using the drug in two divided doses for 3 days at home. Results In this study, 72 patients were included, with median age of 7 years (interquartile range: 4; min: 1 year to max: 16 years), and of these, 56% were male. Forty-five subjects (63%) reported immediate-type adverse reactions....
Medical Science and Discovery
Objective: Urticaria is a condition characterized by the development of blisters (hives), angioed... more Objective: Urticaria is a condition characterized by the development of blisters (hives), angioedema, or both. Acute urticaria is the appearance of rashes lasting 6 weeks or less, angioedema, or both. It is recommended to use the urticaria control test to evaluate disease control in patients with CSU. This study aimed to evaluate the factors affecting urticaria control in patients followed up with the diagnosis of chronic spontaneous urticaria. Material and Methods: Urticaria control results of children diagnosed with chronic urticaria were evaluated retrospectively and factors that could affect urticaria control were investigated. Results: Relationships between the urticaria control test and age, gender, onset time of the complaint, family history of atopy, and laboratory values such as anti-nuclear antibody (ANA) and c4 were examined. Conclusion: Although chronic urticaria has a mild course in children, parameters such as gender, age, and ANA positivity may affect the control of ...
Background: Cystic fibrosis (CF) is an inherited autosomal recessive disorder that causes chronic... more Background: Cystic fibrosis (CF) is an inherited autosomal recessive disorder that causes chronic airway disease. In addition to genetic factors, environmental factors may affects the clinical phenotype of CF. In our study, the presence of aeroallergen sensitivity in our patients with CF and its effects on clinical findings were evaluated. Materials and Methods: Demographic characteristics, clinical and laboratory findings, skin prick test (SPT) results, and Modified Shwachman-Kulczycki (MSK) scores of patients diagnosed with CF followed in the Pediatric Respiratory and Allergy Clinic of Dokuz Eylul University Faculty of Medicine were evaluated. Results: We evaluated 51 patients with CF with a median age of 10 (6-18) years. The mean MSK score of the patients was 72.54±11.50, and the mean predictive value of forced expiratory volume (FEV1) in the first second of 41 patients was 80.43±19.50. According to SPT, aeroallergen sensitivity was detected in 17 (33.3%). The frequency of bacterial colonization and bronchiectasis was higher, MSK scores were lower in AF-sensitive patients (p[?]0.01). However, there was no similar difference in other allergen sensitivities. MSK scores and predictive FEV1 values of 25 (49%) patients with bacterial colonization were significantly lower than those without colonization (p=0.001, p=0.005, respectively). Conclusion: Aeroallergen sensitivity was detected in approximately 1/3 of CF patients. Although it has been emphasized in studies that environmental factors may have an impact on lung functions and clinical conditions in CF, the effect of allergens other than AF sensitivity may be less important compared to other environmental factors such as the presence of bacterial colonization.