Piyush S Desai | Veer Narmad South Gujarat University (original) (raw)
Papers by Piyush S Desai
Results in Surfaces and Interfaces, Jan 31, 2024
The inhibition effectiveness of diverse concentrations of Datura Fruit Extract (DFE) on the corro... more The inhibition effectiveness of diverse concentrations of Datura Fruit Extract (DFE) on the corrosion of zinc in 0.05-0.1 M HCl solutions was examined by weight loss (WL), Electrochemical Impedance Spectroscopy (EIS), potentiodynamic polarization (PDP), and surface analysis techniques. The mass loss method's results demonstrated that raising the DFE concentration improved the efficiency of the inhibition. The maximum inhibition efficiency was 99.40% at 2.0 g/L of DFE. In the temperature ranging from 303 to 333 K, the effect of temperature on the corrosion behavior while adding DFE was also investigated. A DFE extract had been adsorbed on the surface of the metal by Langmuir adsorption isotherm models. It was established that the DFE's activation parameters and negative Gibb's free energy show that rates of adsorption have been spontaneous. According to polarization analysis, DFE regulates both the cathodic and the anodic response. Images obtained using a SEM (Scanning Electron Microscope) reveal that the DFE reduces surface damage. The adsorption inhibition mechanism is supported by the AFM analysis findings. FT-IR (Fourier transform infrared) spectroscopy has been utilized to ascertain the functional group of the DFE. All of the applicable approaches' experimental findings are in good agreement.
Social Science Research Network, 2023
Results in Surfaces and Interfaces , 2024
The inhibition effectiveness of diverse concentrations of Datura Fruit Extract (DFE) on the corro... more The inhibition effectiveness of diverse concentrations of Datura Fruit Extract (DFE) on the corrosion of zinc in 0.05-0.1 M HCl solutions was examined by weight loss (WL), Electrochemical Impedance Spectroscopy (EIS), potentiodynamic polarization (PDP), and surface analysis techniques. The mass loss method's results demonstrated that raising the DFE concentration improved the efficiency of the inhibition. The maximum inhibition efficiency was 99.40% at 2.0 g/L of DFE. In the temperature ranging from 303 to 333 K, the effect of temperature on the corrosion behavior while adding DFE was also investigated. A DFE extract had been adsorbed on the surface of the metal by Langmuir adsorption isotherm models. It was established that the DFE's activation parameters and negative Gibb's free energy show that rates of adsorption have been spontaneous. According to polarization analysis, DFE regulates both the cathodic and the anodic response. Images obtained using a SEM (Scanning Electron Microscope) reveal that the DFE reduces surface damage. The adsorption inhibition mechanism is supported by the AFM analysis findings. FT-IR (Fourier transform infrared) spectroscopy has been utilized to ascertain the functional group of the DFE. All of the applicable approaches' experimental findings are in good agreement.
AIMS Environmental Science , 2023
Metal corrosion is a significant and growing area of study in industrial problems, which has foun... more Metal corrosion is a significant and growing area of study in industrial problems, which has found productive research ground in the field of green chemistry. In the last 10 years, green chemistry has been highlighting the importance of safeguarding human as well as the environmental well-being, in an economically advantageous way aiming at keeping away from reducing waste hazardous toxins, and pollutants. The era of metal degradation, commonly faced due to the usage of hazardous chemicals became very relevant and useful in the research area of chemistry. Even though several experiments have been conducted and, several research articles were published on this topic of nature-friendly green and clean inhibitors still there are yet a lot of things to be explored in this field for sustainable eco-friendly existence of human and natural interconnected existence. The main aim of the study is to provide a summary and describe the past authentic research that accounted in the research literature to employ eco-friendly corrosion inhibitors, especially extraction from leaves, stems, seeds, and fruits of the plants for aluminum alloy in acid solutions in the past decade. Weight loss and electrochemical
approaches are among the most often utilized methods to measure corrosion rate and to evaluate the effectiveness of green corrosion inhibitors. The relevance of the area prompted the further study, leading to a large number of substances being evaluated.
AIMS Environmental Science
Metal corrosion is a significant and growing area of study in industrial problems, which has foun... more Metal corrosion is a significant and growing area of study in industrial problems, which has found productive research ground in the field of green chemistry. In the last 10 years, green chemistry has been highlighting the importance of safeguarding human as well as the environmental well-being, in an economically advantageous way aiming at keeping away from reducing waste hazardous toxins, and pollutants. The era of metal degradation, commonly faced due to the usage of hazardous chemicals became very relevant and useful in the research area of chemistry. Even though several experiments have been conducted and, several research articles were published on this topic of nature-friendly green and clean inhibitors still there are yet a lot of things to be explored in this field for sustainable eco-friendly existence of human and natural interconnected existence. The main aim of the study is to provide a summary and describe the past authentic research that accounted in the research lite...
Numerous studies have contributed to the development of natural and synthetic antimicrobial pepti... more Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.
Our existence on planet earth blossom due to blessing of mother earth, she is the goddess of natu... more Our existence on planet earth blossom due to blessing of mother earth, she is the goddess of nature according to Hindu mythology. She is the Supreme elixir of our existence on earth. She continuously plays her role from our being to perishing on this planet she sustains our life cycle in her own accordance. But our acts are not complimentary to her sustenance, thus by abusing the earth we are endangering our own existence. Increasing natural hazards are the result of our atrocious acts of exploiting our earth. Ancient Indian texts reveal the concern for environmental issues in form of mythology and tradition. This paper examines some of the beliefs and practices underlying traditional Hindu religions’ attitude towards nature and its strategic extension as a tool for Environmental conservation. It is high time we turn to our ancestral roots because by protecting environment we shall protect the entire humanity, let us pass on the rich Vedic heritage and its teachings to our future ge...
Advances in Bioinformatics, 2014
Diabetic retinopathy is the leading cause of blindness worldwide. It is caused by the abnormal gr... more Diabetic retinopathy is the leading cause of blindness worldwide. It is caused by the abnormal growth of the retinal blood vessels. Plasminogen activator inhibitor1 (PAI1) is the key growth factor and the inhibition of PAI1 can reduce the angiogenesis. In this study, currently available inhibitors are taken and tested for the toxicity, binding affinity, and bioactivities of the compounds byin silicoapproach. Five toxic free inhibitors were identified, among which N-acetyl-D-glucosamine shows the significant binding affinity and two of the molecules are having the better bioactivity properties. The molecular optimization of 2-(acetylamino)-2-deoxy-A-D-glucopyranose and alpha-L-fucose can be used for the treatment of diabetic retinopathy.
International Journal of Current Research in Chemistry and Pharmaceutical Sciences, 2016
Derivatives of piperazine (Tert-butyl-4-(2-(ethoxycarbonyl)benzofuran-5-yl)-piperazine-1-carboxyl... more Derivatives of piperazine (Tert-butyl-4-(2-(ethoxycarbonyl)benzofuran-5-yl)-piperazine-1-carboxylate, Ethyl 5-(piperazin-1-yl)benzofuran-2-carboxylate and 3tert-butyl 4-(2-carbamoylbenzofuran-5-yl)piperazine-1-carboxylate) were used as corrosion inhibitors for mild steel in hydrochloric acid solution. The inhibition efficiency depended on the concentration and type of the piperazines. The inhibition efficiency ranged between 90 and 94 % at the highest concentration (25 mM), and between 44 and 62% at the lowest concentration (5 mM) of inhibitor in 1 M HCl solution. Inhibition efficiency decreased with rise in temperature, this corresponded to surface coverage of the metal by the inhibitor. Potentiodynamic polarization measurements have been carried out at room temperature, which clearly reveal the fact that all investigated inhibitors are of mixed type and they inhibit corrosion of mild steel by blocking the active sites of the metal surface. The results also showed that, the inhibitors were adsorbed on the mild steel surface according to Langmuir adsorption isotherm.
Inhibition of aluminum corrosion in 0.4-0.6 M hydrochloric acid solution in the presence and abse... more Inhibition of aluminum corrosion in 0.4-0.6 M hydrochloric acid solution in the presence and absence of using Calotropis gigantea (Aankado) leaves ark’s has been studied employing gravimetric and electrochemical techniques. The results showed that the C. gigantea barks could serve as an effective inhibitor for the corrosion of aluminum in HCl solutions. Inhibition was found to increase with increasing concentration of the extract but decreases with increasing acid concentration. The adsorption study support that Freundlich isotherm best fit to the metal surface interaction with the C. gigantea leaves ark’s with the finest exposure time for the adsorb to the metal surface at all concentrations. Polarization study reveals that the inhibitors functions as a mixed type of inhibitor.
Asian Journal of Chemistry, 2021
In this work, 5-bromoanthranilic acid was condensed with 1-(5-benzoyl-1H-1,2,3-benzotriazole-1-yl... more In this work, 5-bromoanthranilic acid was condensed with 1-(5-benzoyl-1H-1,2,3-benzotriazole-1-yl)-2-chloro-ethanone to form 2-{[2- (5-benzoyl-1H-benzotriazol-1-yl)-2-oxoethyl]amino}-5-bromobenzoic acid. The newly synthesized ligand and its metal(II) complexes with first transition metal series (Cu(II), Ni(II), Co(II), Zn(II) and Mn(II)) have been synthesized and characterized by using elemental analysis, infrared and electronic spectra. The IR spectra, NMR spectra and atomic absorption analysis show that the benzotriazole ligand formed chelates with metal in a 2:1 (ligand:metal) stochiometry. All the metal(II) complexes were screened for their antibacterial activity against Gram-positive and Gram-negative bacteria. Among the synthesized metal(II) complexes, Cu(II) complex showed the highest antibacterial activity.
Rasayan Journal of Chemistry, 2020
To established novel 5-oxopyrrolidine-3-carboxylic acid derivatives with improved anti-inflammato... more To established novel 5-oxopyrrolidine-3-carboxylic acid derivatives with improved anti-inflammatory activity. We are reporting here the synthesis and in-vitro anti-inflammatory evaluation of a series of pyrrolidinone derivatives. A series of new 5-oxopyrrolidine-3-carboxylic acid derivatives were synthesized from the reaction of 2-(5-((5benzoyl-1H-benzo[d][1,2,3] triazol-1-yl) methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl) acetohydrazide with aromatic aldehydes and succinic anhydride reaction. Anti-inflammatory activity of all the compounds was screened against MMP-2 and MMP-9, all results are excellent, 3d, 3e, and 3f compounds are quite promising against matrix metalloproteins (MMPs). All the isolated compounds were characterized by elemental analysis, 1 HNMR, 13 CNMR, and mass spectral analysis.
International Journal of Emerging Research in Management and Technology, 2018
The purpose of this paper to find out the effect of Azardirachta indica (Neem) leaves ark’s on th... more The purpose of this paper to find out the effect of Azardirachta indica (Neem) leaves ark’s on the corrosion of aluminum in 0.4, 0.5 and 0.6M hydrochloric acid (HCl), and elucidates the mechanism of the inhibition system. Gravimetric and galvanostatic polarization methods were used to investigate the effect of aluminum corrosion in HCl solutions. The outcome revealed that maximum inhibitor efficiency which corresponds to the lowest corrosion rate was obtained at most favorable inhibitor concentration of 1.25% with reduction in the corrosion rate observed to follow in order of increasing extract concentration. The adsorption study promote that Langmuir isotherm best described the metal surface interaction with the Azardirachta indica (Neem) leaves ark’s with the best exposure time for the Azardirachta indica (Neem) leaves ark’s to adsorb to the metal surface at all concentrations. Polarization study reveals that the inhibitors functions as a mixed inhibitor.
Chemistry Africa, 2019
In an effort for the development of novel antimicrobial, antimalarial and antitubercular agents, ... more In an effort for the development of novel antimicrobial, antimalarial and antitubercular agents, series of quinoline carboxylic acid derivatives bearing substituted pyrazole moiety were synthesized from derivatives of substituted pyrazole aldehydes, substituted aniline and pyruvic acid, through a one-pot Doebner reaction. Then the Carboxylic group was converted to an acyl chloride, N-(3-(dimethylamino) propyl) carboxamide, and alcohol functional groups. All the compounds were characterized by elemental analysis, MS, 1 H NMR and 13 C NMR spectroscopy and were screened against bacterial strains. Majority of these compounds showed potent antibacterial and antifungal activities against the tested strains of bacteria and fungi. Compounds were also screened for antitubercular and antimalarial activities. Quinoline-Pyrazole clubbed derivative showed better results when compared with the reference drugs based on their MIC values. Thus, these studies suggest that quinoline derivatives bearing pyrazole moiety are interesting scaffolds for the development of novel antimicrobial, antimalarial, and antimycobacterial agents.
International Journal of Current Research in Chemistry and Pharmaceutical Sciences, 2016
Derivatives of benzofuran ((E)-ethyl-5-(2-phenyldiazenyl) benzofuran-2-carboxylate and ethyl 5-am... more Derivatives of benzofuran ((E)-ethyl-5-(2-phenyldiazenyl) benzofuran-2-carboxylate and ethyl 5-aminobenzofuran-2-carboxylate) were used as corrosion inhibitors for mild steel in hydrochloric acid solution. The inhibition efficiency depended on the concentration and type of the benzofurans. The inhibition efficiency ranged between 75 and 85 % at the highest concentration (25 mM), and between 35 and 40 % at the lowest concentration (5 mM) of inhibitor in 1 M HCl solution. Inhibition efficiency decreased with rise in temperature, this corresponded to surface coverage of the metal by the inhibitor. Potentiodynamic polarization measurements have been carried out at room temperature, which clearly reveal the fact that all investigated inhibitors are of mixed type and they inhibit corrosion of mild steel by blocking the active sites of the metal surface. The results also showed that, the inhibitors were adsorbed on the mild steel surface according to Langmuir adsorption isotherm.
The development of novel compounds, hydrazones have shown that they possess a wide variety of bio... more The development of novel compounds, hydrazones have shown that they possess a wide variety of biological activities. Hydrazones/azomethines/imines possess -NHN=CH- and constitute an important class of compounds for new drug development. We have undertaken a library synthesis of (1H-benzo[d][1,2,3]triazole-5-yl)(phenyl) methanone clubbed 1,3,4-oxadiazole derivatives bearing substituted hydrazone moiety were synthesized. We have synthesized a collection of 14 compounds and characterized by elemental analysis, MS, 1H NMR, and 13C NMR spectral data and were screened, against the anticancer and antituberculosis activity. Where the majority of these compounds showed good anticancer and antitubercular activities against the tested strains of M. tuberculosis H37Rv and lung NCI H-522, ovary PA-1, liver Hep G2 compared with the reference drugs. Compounds 5d, 5e, 5g, and 5n showed excellent potency against M. tuberculosis H37Rv strain compares to standard drugs whereas, against lung NCI H-52...
![Research paper thumbnail of SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF LIGAND 2-{[2-(5-BENZOYL-1H-1,2,3- BENZOTRIAZOLE-1-YL)-2-OXOETHYL]AMINO} PROPIONIC ACID](https://attachments.academia-assets.com/66726059/thumbnails/1.jpg)
](Rasayan Journal of Chemistry, 2021
2-amino propionic acid (Alanine), is extensively used as complex-forming reagents. Alanine was co... more 2-amino propionic acid (Alanine), is extensively used as complex-forming reagents. Alanine was condensed with 1-(5-benzoyl-1H-1,2,3 benzotriazole-1-yl) 2-chloroethanone and yield 2-{[2-(5-benzoyl-1H-1,2,3 benzotriazole-1-yl)-2-oxoethyl]amino} propionic acid.The newly synthesized ligands and their complexes with first transitions series metal had been prepared, were analyzed and characterized by using different techniques, such as elemental analysis, infrared and electronics spectra. The IR spectra, NMR spectra and atomic absorption analysis show that the benzotriazole ligand forming chelates with 2:1 (Ligand: Metal) stoichiometry. Metal complexes were evaluator in-vitro antibacterial activity against Negative and Positive bacteria. The complexes showed significant antibacterial activity.
Chemistry Africa , 2020
In an effort for the development of novel antimicrobial, antimalarial and antitubercular agents, ... more In an effort for the development of novel antimicrobial, antimalarial and antitubercular agents, series of quinoline carboxylic acid derivatives bearing substituted pyrazole moiety were synthesized from derivatives of substituted pyrazole aldehydes, substituted aniline and pyruvic acid, through a one-pot Doebner reaction. Then the Carboxylic group was converted to an acyl chloride, N-(3-(dimethylamino) propyl) carboxamide, and alcohol functional groups. All the compounds were characterized by elemental analysis, MS, 1 H NMR and 13 C NMR spectroscopy and were screened against bacterial strains. Majority of these compounds showed potent antibacterial and antifungal activities against the tested strains of bacteria and fungi. Compounds were also screened for antitubercular and antimalarial activities. Quinoline-Pyrazole clubbed derivative showed better results when compared with the reference drugs based on their MIC values. Thus, these studies suggest that quinoline derivatives bearing pyrazole moiety are interesting scaffolds for the development of novel antimicrobial, antimalarial, and antimycobacterial agents. Electronic supplementary material The online version of this article (https ://doi.org/10.1007/s4225 0-019-00096-5) contains supplementary material, which is available to authorized users.
World Journal of Pharmaceutical Research, 2018
Heterocyclic compounds play an important role in medicinal chemistry. Motifs such as triazoles, p... more Heterocyclic compounds play an important role in medicinal chemistry. Motifs such as triazoles, pyrazoles, oxazoles, imidazoles, thiazoles, etc are routinely observed in several compounds of pharmacological interest. These paper my effort on the development of the synthesis of some novel functionalized heterocyclic compounds as potent antibacterial agents. The biological evaluation of these synthetic derivatives showed some promise as antibacterial agents.
Chemistry & Biology Interface, 2018
To design, synthesize and characterize a novel series of N-(2-Substituted-3-chloro-4-oxoazeti-din... more To design, synthesize and characterize a novel series of N-(2-Substituted-3-chloro-4-oxoazeti-dine-1-yl)-2-(5-((5-benzoyl-1H-benzo[d][1,2,3] triazol-1-yl)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl) acetamide and evaluate for antimicrobial activity. All compounds were structurally elucidated on the basis of spectroscopic and elemental analysis. The microbial screening was carried out by employing a broth dilution method. The zone of inhibition (µg/mL) of each compound was determined and compared with that of standard drugs Penicillin and Streptomycin. Some of the derivatives found to be potent against the bacterial strain.
Results in Surfaces and Interfaces, Jan 31, 2024
The inhibition effectiveness of diverse concentrations of Datura Fruit Extract (DFE) on the corro... more The inhibition effectiveness of diverse concentrations of Datura Fruit Extract (DFE) on the corrosion of zinc in 0.05-0.1 M HCl solutions was examined by weight loss (WL), Electrochemical Impedance Spectroscopy (EIS), potentiodynamic polarization (PDP), and surface analysis techniques. The mass loss method's results demonstrated that raising the DFE concentration improved the efficiency of the inhibition. The maximum inhibition efficiency was 99.40% at 2.0 g/L of DFE. In the temperature ranging from 303 to 333 K, the effect of temperature on the corrosion behavior while adding DFE was also investigated. A DFE extract had been adsorbed on the surface of the metal by Langmuir adsorption isotherm models. It was established that the DFE's activation parameters and negative Gibb's free energy show that rates of adsorption have been spontaneous. According to polarization analysis, DFE regulates both the cathodic and the anodic response. Images obtained using a SEM (Scanning Electron Microscope) reveal that the DFE reduces surface damage. The adsorption inhibition mechanism is supported by the AFM analysis findings. FT-IR (Fourier transform infrared) spectroscopy has been utilized to ascertain the functional group of the DFE. All of the applicable approaches' experimental findings are in good agreement.
Social Science Research Network, 2023
Results in Surfaces and Interfaces , 2024
The inhibition effectiveness of diverse concentrations of Datura Fruit Extract (DFE) on the corro... more The inhibition effectiveness of diverse concentrations of Datura Fruit Extract (DFE) on the corrosion of zinc in 0.05-0.1 M HCl solutions was examined by weight loss (WL), Electrochemical Impedance Spectroscopy (EIS), potentiodynamic polarization (PDP), and surface analysis techniques. The mass loss method's results demonstrated that raising the DFE concentration improved the efficiency of the inhibition. The maximum inhibition efficiency was 99.40% at 2.0 g/L of DFE. In the temperature ranging from 303 to 333 K, the effect of temperature on the corrosion behavior while adding DFE was also investigated. A DFE extract had been adsorbed on the surface of the metal by Langmuir adsorption isotherm models. It was established that the DFE's activation parameters and negative Gibb's free energy show that rates of adsorption have been spontaneous. According to polarization analysis, DFE regulates both the cathodic and the anodic response. Images obtained using a SEM (Scanning Electron Microscope) reveal that the DFE reduces surface damage. The adsorption inhibition mechanism is supported by the AFM analysis findings. FT-IR (Fourier transform infrared) spectroscopy has been utilized to ascertain the functional group of the DFE. All of the applicable approaches' experimental findings are in good agreement.
AIMS Environmental Science , 2023
Metal corrosion is a significant and growing area of study in industrial problems, which has foun... more Metal corrosion is a significant and growing area of study in industrial problems, which has found productive research ground in the field of green chemistry. In the last 10 years, green chemistry has been highlighting the importance of safeguarding human as well as the environmental well-being, in an economically advantageous way aiming at keeping away from reducing waste hazardous toxins, and pollutants. The era of metal degradation, commonly faced due to the usage of hazardous chemicals became very relevant and useful in the research area of chemistry. Even though several experiments have been conducted and, several research articles were published on this topic of nature-friendly green and clean inhibitors still there are yet a lot of things to be explored in this field for sustainable eco-friendly existence of human and natural interconnected existence. The main aim of the study is to provide a summary and describe the past authentic research that accounted in the research literature to employ eco-friendly corrosion inhibitors, especially extraction from leaves, stems, seeds, and fruits of the plants for aluminum alloy in acid solutions in the past decade. Weight loss and electrochemical
approaches are among the most often utilized methods to measure corrosion rate and to evaluate the effectiveness of green corrosion inhibitors. The relevance of the area prompted the further study, leading to a large number of substances being evaluated.
AIMS Environmental Science
Metal corrosion is a significant and growing area of study in industrial problems, which has foun... more Metal corrosion is a significant and growing area of study in industrial problems, which has found productive research ground in the field of green chemistry. In the last 10 years, green chemistry has been highlighting the importance of safeguarding human as well as the environmental well-being, in an economically advantageous way aiming at keeping away from reducing waste hazardous toxins, and pollutants. The era of metal degradation, commonly faced due to the usage of hazardous chemicals became very relevant and useful in the research area of chemistry. Even though several experiments have been conducted and, several research articles were published on this topic of nature-friendly green and clean inhibitors still there are yet a lot of things to be explored in this field for sustainable eco-friendly existence of human and natural interconnected existence. The main aim of the study is to provide a summary and describe the past authentic research that accounted in the research lite...
Numerous studies have contributed to the development of natural and synthetic antimicrobial pepti... more Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.
Our existence on planet earth blossom due to blessing of mother earth, she is the goddess of natu... more Our existence on planet earth blossom due to blessing of mother earth, she is the goddess of nature according to Hindu mythology. She is the Supreme elixir of our existence on earth. She continuously plays her role from our being to perishing on this planet she sustains our life cycle in her own accordance. But our acts are not complimentary to her sustenance, thus by abusing the earth we are endangering our own existence. Increasing natural hazards are the result of our atrocious acts of exploiting our earth. Ancient Indian texts reveal the concern for environmental issues in form of mythology and tradition. This paper examines some of the beliefs and practices underlying traditional Hindu religions’ attitude towards nature and its strategic extension as a tool for Environmental conservation. It is high time we turn to our ancestral roots because by protecting environment we shall protect the entire humanity, let us pass on the rich Vedic heritage and its teachings to our future ge...
Advances in Bioinformatics, 2014
Diabetic retinopathy is the leading cause of blindness worldwide. It is caused by the abnormal gr... more Diabetic retinopathy is the leading cause of blindness worldwide. It is caused by the abnormal growth of the retinal blood vessels. Plasminogen activator inhibitor1 (PAI1) is the key growth factor and the inhibition of PAI1 can reduce the angiogenesis. In this study, currently available inhibitors are taken and tested for the toxicity, binding affinity, and bioactivities of the compounds byin silicoapproach. Five toxic free inhibitors were identified, among which N-acetyl-D-glucosamine shows the significant binding affinity and two of the molecules are having the better bioactivity properties. The molecular optimization of 2-(acetylamino)-2-deoxy-A-D-glucopyranose and alpha-L-fucose can be used for the treatment of diabetic retinopathy.
International Journal of Current Research in Chemistry and Pharmaceutical Sciences, 2016
Derivatives of piperazine (Tert-butyl-4-(2-(ethoxycarbonyl)benzofuran-5-yl)-piperazine-1-carboxyl... more Derivatives of piperazine (Tert-butyl-4-(2-(ethoxycarbonyl)benzofuran-5-yl)-piperazine-1-carboxylate, Ethyl 5-(piperazin-1-yl)benzofuran-2-carboxylate and 3tert-butyl 4-(2-carbamoylbenzofuran-5-yl)piperazine-1-carboxylate) were used as corrosion inhibitors for mild steel in hydrochloric acid solution. The inhibition efficiency depended on the concentration and type of the piperazines. The inhibition efficiency ranged between 90 and 94 % at the highest concentration (25 mM), and between 44 and 62% at the lowest concentration (5 mM) of inhibitor in 1 M HCl solution. Inhibition efficiency decreased with rise in temperature, this corresponded to surface coverage of the metal by the inhibitor. Potentiodynamic polarization measurements have been carried out at room temperature, which clearly reveal the fact that all investigated inhibitors are of mixed type and they inhibit corrosion of mild steel by blocking the active sites of the metal surface. The results also showed that, the inhibitors were adsorbed on the mild steel surface according to Langmuir adsorption isotherm.
Inhibition of aluminum corrosion in 0.4-0.6 M hydrochloric acid solution in the presence and abse... more Inhibition of aluminum corrosion in 0.4-0.6 M hydrochloric acid solution in the presence and absence of using Calotropis gigantea (Aankado) leaves ark’s has been studied employing gravimetric and electrochemical techniques. The results showed that the C. gigantea barks could serve as an effective inhibitor for the corrosion of aluminum in HCl solutions. Inhibition was found to increase with increasing concentration of the extract but decreases with increasing acid concentration. The adsorption study support that Freundlich isotherm best fit to the metal surface interaction with the C. gigantea leaves ark’s with the finest exposure time for the adsorb to the metal surface at all concentrations. Polarization study reveals that the inhibitors functions as a mixed type of inhibitor.
Asian Journal of Chemistry, 2021
In this work, 5-bromoanthranilic acid was condensed with 1-(5-benzoyl-1H-1,2,3-benzotriazole-1-yl... more In this work, 5-bromoanthranilic acid was condensed with 1-(5-benzoyl-1H-1,2,3-benzotriazole-1-yl)-2-chloro-ethanone to form 2-{[2- (5-benzoyl-1H-benzotriazol-1-yl)-2-oxoethyl]amino}-5-bromobenzoic acid. The newly synthesized ligand and its metal(II) complexes with first transition metal series (Cu(II), Ni(II), Co(II), Zn(II) and Mn(II)) have been synthesized and characterized by using elemental analysis, infrared and electronic spectra. The IR spectra, NMR spectra and atomic absorption analysis show that the benzotriazole ligand formed chelates with metal in a 2:1 (ligand:metal) stochiometry. All the metal(II) complexes were screened for their antibacterial activity against Gram-positive and Gram-negative bacteria. Among the synthesized metal(II) complexes, Cu(II) complex showed the highest antibacterial activity.
Rasayan Journal of Chemistry, 2020
To established novel 5-oxopyrrolidine-3-carboxylic acid derivatives with improved anti-inflammato... more To established novel 5-oxopyrrolidine-3-carboxylic acid derivatives with improved anti-inflammatory activity. We are reporting here the synthesis and in-vitro anti-inflammatory evaluation of a series of pyrrolidinone derivatives. A series of new 5-oxopyrrolidine-3-carboxylic acid derivatives were synthesized from the reaction of 2-(5-((5benzoyl-1H-benzo[d][1,2,3] triazol-1-yl) methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl) acetohydrazide with aromatic aldehydes and succinic anhydride reaction. Anti-inflammatory activity of all the compounds was screened against MMP-2 and MMP-9, all results are excellent, 3d, 3e, and 3f compounds are quite promising against matrix metalloproteins (MMPs). All the isolated compounds were characterized by elemental analysis, 1 HNMR, 13 CNMR, and mass spectral analysis.
International Journal of Emerging Research in Management and Technology, 2018
The purpose of this paper to find out the effect of Azardirachta indica (Neem) leaves ark’s on th... more The purpose of this paper to find out the effect of Azardirachta indica (Neem) leaves ark’s on the corrosion of aluminum in 0.4, 0.5 and 0.6M hydrochloric acid (HCl), and elucidates the mechanism of the inhibition system. Gravimetric and galvanostatic polarization methods were used to investigate the effect of aluminum corrosion in HCl solutions. The outcome revealed that maximum inhibitor efficiency which corresponds to the lowest corrosion rate was obtained at most favorable inhibitor concentration of 1.25% with reduction in the corrosion rate observed to follow in order of increasing extract concentration. The adsorption study promote that Langmuir isotherm best described the metal surface interaction with the Azardirachta indica (Neem) leaves ark’s with the best exposure time for the Azardirachta indica (Neem) leaves ark’s to adsorb to the metal surface at all concentrations. Polarization study reveals that the inhibitors functions as a mixed inhibitor.
Chemistry Africa, 2019
In an effort for the development of novel antimicrobial, antimalarial and antitubercular agents, ... more In an effort for the development of novel antimicrobial, antimalarial and antitubercular agents, series of quinoline carboxylic acid derivatives bearing substituted pyrazole moiety were synthesized from derivatives of substituted pyrazole aldehydes, substituted aniline and pyruvic acid, through a one-pot Doebner reaction. Then the Carboxylic group was converted to an acyl chloride, N-(3-(dimethylamino) propyl) carboxamide, and alcohol functional groups. All the compounds were characterized by elemental analysis, MS, 1 H NMR and 13 C NMR spectroscopy and were screened against bacterial strains. Majority of these compounds showed potent antibacterial and antifungal activities against the tested strains of bacteria and fungi. Compounds were also screened for antitubercular and antimalarial activities. Quinoline-Pyrazole clubbed derivative showed better results when compared with the reference drugs based on their MIC values. Thus, these studies suggest that quinoline derivatives bearing pyrazole moiety are interesting scaffolds for the development of novel antimicrobial, antimalarial, and antimycobacterial agents.
International Journal of Current Research in Chemistry and Pharmaceutical Sciences, 2016
Derivatives of benzofuran ((E)-ethyl-5-(2-phenyldiazenyl) benzofuran-2-carboxylate and ethyl 5-am... more Derivatives of benzofuran ((E)-ethyl-5-(2-phenyldiazenyl) benzofuran-2-carboxylate and ethyl 5-aminobenzofuran-2-carboxylate) were used as corrosion inhibitors for mild steel in hydrochloric acid solution. The inhibition efficiency depended on the concentration and type of the benzofurans. The inhibition efficiency ranged between 75 and 85 % at the highest concentration (25 mM), and between 35 and 40 % at the lowest concentration (5 mM) of inhibitor in 1 M HCl solution. Inhibition efficiency decreased with rise in temperature, this corresponded to surface coverage of the metal by the inhibitor. Potentiodynamic polarization measurements have been carried out at room temperature, which clearly reveal the fact that all investigated inhibitors are of mixed type and they inhibit corrosion of mild steel by blocking the active sites of the metal surface. The results also showed that, the inhibitors were adsorbed on the mild steel surface according to Langmuir adsorption isotherm.
The development of novel compounds, hydrazones have shown that they possess a wide variety of bio... more The development of novel compounds, hydrazones have shown that they possess a wide variety of biological activities. Hydrazones/azomethines/imines possess -NHN=CH- and constitute an important class of compounds for new drug development. We have undertaken a library synthesis of (1H-benzo[d][1,2,3]triazole-5-yl)(phenyl) methanone clubbed 1,3,4-oxadiazole derivatives bearing substituted hydrazone moiety were synthesized. We have synthesized a collection of 14 compounds and characterized by elemental analysis, MS, 1H NMR, and 13C NMR spectral data and were screened, against the anticancer and antituberculosis activity. Where the majority of these compounds showed good anticancer and antitubercular activities against the tested strains of M. tuberculosis H37Rv and lung NCI H-522, ovary PA-1, liver Hep G2 compared with the reference drugs. Compounds 5d, 5e, 5g, and 5n showed excellent potency against M. tuberculosis H37Rv strain compares to standard drugs whereas, against lung NCI H-52...
Rasayan Journal of Chemistry, 2021
2-amino propionic acid (Alanine), is extensively used as complex-forming reagents. Alanine was co... more 2-amino propionic acid (Alanine), is extensively used as complex-forming reagents. Alanine was condensed with 1-(5-benzoyl-1H-1,2,3 benzotriazole-1-yl) 2-chloroethanone and yield 2-{[2-(5-benzoyl-1H-1,2,3 benzotriazole-1-yl)-2-oxoethyl]amino} propionic acid.The newly synthesized ligands and their complexes with first transitions series metal had been prepared, were analyzed and characterized by using different techniques, such as elemental analysis, infrared and electronics spectra. The IR spectra, NMR spectra and atomic absorption analysis show that the benzotriazole ligand forming chelates with 2:1 (Ligand: Metal) stoichiometry. Metal complexes were evaluator in-vitro antibacterial activity against Negative and Positive bacteria. The complexes showed significant antibacterial activity.
Chemistry Africa , 2020
In an effort for the development of novel antimicrobial, antimalarial and antitubercular agents, ... more In an effort for the development of novel antimicrobial, antimalarial and antitubercular agents, series of quinoline carboxylic acid derivatives bearing substituted pyrazole moiety were synthesized from derivatives of substituted pyrazole aldehydes, substituted aniline and pyruvic acid, through a one-pot Doebner reaction. Then the Carboxylic group was converted to an acyl chloride, N-(3-(dimethylamino) propyl) carboxamide, and alcohol functional groups. All the compounds were characterized by elemental analysis, MS, 1 H NMR and 13 C NMR spectroscopy and were screened against bacterial strains. Majority of these compounds showed potent antibacterial and antifungal activities against the tested strains of bacteria and fungi. Compounds were also screened for antitubercular and antimalarial activities. Quinoline-Pyrazole clubbed derivative showed better results when compared with the reference drugs based on their MIC values. Thus, these studies suggest that quinoline derivatives bearing pyrazole moiety are interesting scaffolds for the development of novel antimicrobial, antimalarial, and antimycobacterial agents. Electronic supplementary material The online version of this article (https ://doi.org/10.1007/s4225 0-019-00096-5) contains supplementary material, which is available to authorized users.
World Journal of Pharmaceutical Research, 2018
Heterocyclic compounds play an important role in medicinal chemistry. Motifs such as triazoles, p... more Heterocyclic compounds play an important role in medicinal chemistry. Motifs such as triazoles, pyrazoles, oxazoles, imidazoles, thiazoles, etc are routinely observed in several compounds of pharmacological interest. These paper my effort on the development of the synthesis of some novel functionalized heterocyclic compounds as potent antibacterial agents. The biological evaluation of these synthetic derivatives showed some promise as antibacterial agents.
Chemistry & Biology Interface, 2018
To design, synthesize and characterize a novel series of N-(2-Substituted-3-chloro-4-oxoazeti-din... more To design, synthesize and characterize a novel series of N-(2-Substituted-3-chloro-4-oxoazeti-dine-1-yl)-2-(5-((5-benzoyl-1H-benzo[d][1,2,3] triazol-1-yl)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl) acetamide and evaluate for antimicrobial activity. All compounds were structurally elucidated on the basis of spectroscopic and elemental analysis. The microbial screening was carried out by employing a broth dilution method. The zone of inhibition (µg/mL) of each compound was determined and compared with that of standard drugs Penicillin and Streptomycin. Some of the derivatives found to be potent against the bacterial strain.