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NIH’s CARE for Health Primary Care Research Network: Connecting the Lab, the Clinic, and the Community

Posted on October 8th, 2024 by Dr. Monica M. Bertagnolli

Since I became NIH Director last year, one key principle has guided my vision and approach: Our work is not finished when we deliver scientific discoveries; our work is finished when all people are living long and healthy lives. But unfortunately, we’re seeing some alarming trends in the health of...

Since I became NIH Director last year, one key principle has guided my vision and approach: Our work is not finished when we deliver scientific discoveries; our work is finished when all people are living long and healthy lives.

But unfortunately, we’re seeing some alarming trends in the health of the U.S. population. It’s a bit of a puzzle. On one hand, significant advances in biomedical research over the last several decades have led to lifesaving interventions for a range of diseases and conditions. At the same time, the overall health of the people in this country appears to be stalled and even getting worse.

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Concentric rings of symbols circle an area in a field of microscopy images

AI Model Takes New Approach to Performing Diagnostic Tasks in Multiple Cancer Types

In recent years, medical researchers have been looking for ways to use artificial intelligence (AI) technology for diagnosing cancer. So far, most AI models have been developed to perform specific tasks in cancer diagnosis, such as detecting cancer presence or predicting a tumor’s genetic profile in certain cancer types. But what if an AI system could be more flexible, like a large language model such as ChatGPT, performing a variety of diagnostic tasks across multiple cancer types?

As reported in the journal Nature, researchers have developed an AI system that can perform a wide range of cancer evaluation tasks and outperforms current AI methods in tasks like cancer cell detection and tumor origin identification. It was tested on 19 cancer types, leading the researchers to refer to it as “ChatGPT-like” in its flexibility. According to the research team, whose work is supported in part by NIH, this is also the first AI model based on analyzing slide images to not only accurately predict if a cancer is likely to respond to treatment, but also to validate these predictions across multiple patient groups around the world.

A field of DNA strands. One glowing strand is in the shape of a question mark

Dr. Bertagnolli sits in her office with artwork framed on the wall behind her

Taking Inspiration from Art Created by a Patient’s Granddaughter

I have a specific ritual when moving into a new office, as I did when I became NIH Director in 2023: I hang a very special framed screen print on the wall. This piece of art has followed me through several different offices, representing different positions I have held as a cancer surgeon, researcher, and educator. It’s always the first thing I want to see as I settle into a new workplace. It serves as an inspiration for my work, for what so many of us involved in health care strive to do. I’d like to take this opportunity to tell you the story behind it.