adult worms – NIH Director's Blog (original) (raw)
Creative Minds: The Worm Tissue-ome Teaches Developmental Biology for Us All
Posted on November 17th, 2016 by Dr. Francis Collins
Caption: An adult Caenorhabditis elegans, 5 days
Credit: Coleen Murphy, Princeton University, Princeton, NJ
In the nearly 40 years since Nobel Prize-winning scientist Sydney Brenner proposed using a tiny, transparent soil worm called Caenorhabditis elegans as a model organism for biomedical research_,_ C. elegans has become one of the most-studied organisms on the planet. Researchers have determined that C. elegans has exactly 959 cells, 302 of which are neurons. They have sequenced and annotated its genome, developed an impressive array of tools to study its DNA, and characterized the development of many of its tissues.
But what researchers still don’t know is exactly how all of these parts work together to coordinate this little worm’s response to changes in nutrition, environment, health status, and even the aging process. To learn more, 2015 NIH Director’s Pioneer Award winner Coleen Murphy of Princeton University, Princeton, NJ, has set out to analyze which genes are active, or transcribed, in each of the major tissues of adult C. elegans, building the framework for what’s been dubbed the C. elegans “tissue-ome.”
Tags: 2015 NIH Director’s Pioneer Award, adult worms, aging, aging research, C. elegans, Caenorhabditis elegans, daf-2, developmental biology, genetics, genomics, gerontology, learning, lifespan, metabolism, model organism, nutrition, tissue-ome, transcriptome, worm