mets – NIH Director's Blog (original) (raw)
Putting Bone Metastasis in the Spotlight
Posted on September 13th, 2018 by Dr. Francis Collins
When cancers spread, or metastasize, from one part of the body to another, bone is a frequent and potentially devastating destination. Now, as you can see in this video, an NIH-funded research team has developed a new system that hopefully will provide us with a better understanding of what goes on when cancer cells invade bone.
In this 3D cross-section, you see the nuclei (green) and cytoplasm (red) of human prostate cancer cells growing inside a bioengineered construct of mouse bone (blue-green) that’s been placed in a mouse. The new system features an imaging window positioned next to the new bone, which enabled the researchers to produce the first series of direct, real-time micrographs of cancer cells eroding the interior of bone.
Posted In: Cool Videos
Tags: Bone, bone metastasis, breast cancer, cancer, cancer imaging, imaging, iMPM, intravital multiphoton microscopy, metastases, metastatic cancer, mets, osteoclast, prostate cancer, tissue engineering, translational medicine, zoledronic acid