Ashish Anjankar | Datta Meghe Institute of Medical Sciences (Deemed University) (original) (raw)

Papers by Ashish Anjankar

Cureus, Oct 21, 2022

There are a minimum of five distinct sub-types of ovarian cancer based on histology, each of whic... more There are a minimum of five distinct sub-types of ovarian cancer based on histology, each of which has distinct factors of risk, types of cells, molecular makeups, clinical characteristics, and therapeutic approaches. Ovarian cancer is detected usually at later stages, and there is no reliable screening method. Cytoreductive surgery and chemotherapy which use platinum-containing drugs are the standard treatments used for freshly detected cancer. Chemotherapy, drugs that are anti-angiogenic, poly ADP-ribose polymerase inhibitors, and immunological treatments are all used to treat recurrent cancer. The most frequent type of ovarian cancer to be diagnosed is high-grade serous carcinoma (HGSC), which often responds well to platinum-based chemotherapy when discovered. However, HGSCs commonly relapse and develop increased treatment resistance in addition to the other histologies. As a result, ovarian cancer research is actively focused on understanding the processes causing platinum resistance and developing strategies to combat it. Serous tubal intraepithelial carcinoma is an HGSC precursor lesion. It is one of the early complications seen in ovarian carcinoma. It has been very useful in identifying the people who have a greater chance of developing ovarian cancer and development of strategies to prevent it. This has led to a significant progress for identification of the genes which are found in people with greater chances of development of ovarian carcinoma (for example, the BRCA1 and BRCA2).

Cureus, Feb 9, 2023

The thyroid is a butterfly-shaped gland located in the human body's neck region. The thyroid prod... more The thyroid is a butterfly-shaped gland located in the human body's neck region. The thyroid produces three hormones that are essential for regulating body temperature, energy production, weight, hair and nail growth, and menstrual cycle maintenance. The production of these hormones is controlled by a feedback mechanism. Various factors cause changes in the stimulation and inhibition of these hormones, which ultimately causes either excessive release or a decrease in the levels of thyroid hormones. These causes can be physiological or pathological. One of the physiological causes is pregnancy. Pregnancy is a very complex process in which many changes occur in the body and its functioning. One of which is changes in the maternal thyroid gland. The inability to adequately adapt to the changes leads to the abnormal functioning of the thyroid gland. During pregnancy, there is a variation in the concentration of thyroid hormones which may cause a decrease in levels or inhibition in the production of thyroid hormones. This condition is called hypothyroidism. Hypothyroidism in pregnant mothers can either be gestational or may be a condition that is present way before her pregnancy. Often, gestational hypothyroidism reverts after delivery during the postpartum period but can also be present as subclinical hypothyroidism. In such cases, they pose a significant threat to development, cause growth hindrance to the infant in the womb, and cause abnormalities in the offspring in the future. Some of the changes occur in the gland because of enhancement in levels of thyroid binding globulin, increased clearance rate of iodine from the body in kidneys, altered effects in human chorionic gonadotropin hormone, and decreased consumption of iodine in meals. Iodine disbalance in maternal hypothyroidism is associated with severe health issues like cretinism and mental retardation. Thyroid hormones are crucial for the infant's neural, cognitive, and intelligence quotient development in the womb. Thus, the disturbances in the maternal hormone levels disturb typical early developmental characteristics. In the world of rapidly advancing scientific research, there are many ways in which this condition can be detected early, diagnosed correctly, and given apt and required attention and treatment for causing the least harm to the fetus and the mother.

Journal of Clinical and Diagnostic Research, 2022

Cureus, Oct 13, 2022

Wankhade et al. This is an open access article distributed under the terms of the Creative Common... more Wankhade et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Case Reports, Dec 1, 2022

Cureus, Dec 23, 2022

Many traits and phenotypic characteristics present in the human body such as height, skin, pigmen... more Many traits and phenotypic characteristics present in the human body such as height, skin, pigmentation, hair, and eye color are inherited through many alleles present in different loci. This is known as polygenic inheritance. Congenital rubella syndrome (CRS) is a rare disease characterized by congenital deformities such as chorioretinitis and cataracts. This disease is endemic in India, and it is mainly caused by the rubella virus. We report a case of a 4.5-year-old female child who presented with breathlessness and radiolucent bone disease, for which she was already undergoing surgical interventions. The cell culture line was positive for rubella. The patient was treated with oxygen therapy via continuous positive airway pressure (CPAP) and had a moderate biventricular function.

Cureus, Oct 17, 2022

Propofol-related infusion syndrome (PRIS) is a lethal condition characterized by multiple organ s... more Propofol-related infusion syndrome (PRIS) is a lethal condition characterized by multiple organ system failures. It can occur due to prolonged administration of propofol (an anesthetic) in mechanically intubated patients. The main presenting features of this condition include cardiovascular dysfunction with particular emphasis on impairment of cardiovascular contractility, metabolic acidosis, lactic acidosis, rhabdomyolysis, hyperkalaemia, lipidaemia, hepatomegaly, acute renal failure, and eventually mortality in most cases. The significant risk factors that predispose one to PRIS are: critical illnesses, increased serum catecholamines, steroid therapy, obesity, young age (significantly below three years), depleted carbohydrate stores in the body, increased serum lipids, and most importantly, heavy or extended dosage of propofol. The primary pathophysiology behind PRIS is the disruption of the mitochondrial respiratory chain that causes inhibition of adenosine triphosphate (ATP) synthesis and cellular hypoxia. Further, excess lipolysis of adipose tissue occurs, especially in critically ill patients where the energy source is lipid breakdown instead of carbohydrates. This process generates excess free fatty acids (FFAs) that cannot undergo adequate betaoxidation. These FFAs contribute to the clinical pathology of PRIS. It requires prompt management as it is a fatal condition. The clinicians must observe the patient's electrocardiogram (ECG), serum creatine kinase, lipase, amylase, lactate, liver enzymes, and myoglobin levels in urine, under propofol sedation. Doctors should immediately stop propofol infusion upon noticing any abnormality in these parameters. The other essentials of management of various manifestations of PRIS will be discussed in this article, along with a detailed explanation of the condition, its risk factors, diagnosis, pathophysiology, and presenting features. This article aims to make clinicians more aware of the occurrence of this syndrome so that better ways to manage and treat this condition can be formulated in the future.

Indian Journal of Forensic Medicine & Toxicology, 2020

Cureus, Oct 17, 2022

Gastroesophageal reflux disorder (GERD) or chronic acid reflux disorder is a condition in which a... more Gastroesophageal reflux disorder (GERD) or chronic acid reflux disorder is a condition in which acidcontaining contents continuously leak from the stomach and return to the esophagus. Acid reflux disease occurs in nearly every person at some unspecified time. In reality, it is considered as a reoccurrence of acid reflux disease disorder and heartburn, every day. However, when you have acid reflux disorder/heartburn greater than two times every week over numerous weeks, constantly take heartburn medicinal tablets and antacids. However, if your signs and symptoms and symptoms keep returning, you can have superior GERD. Your GERD needs to be handled with the aid of your healthcare employer. Now not simply to alleviate your symptoms, but because of the reality, GERD can result in extra intense issues. Dental erosion (DE) is the shortage of the ground of your tooth because of acids you eat or drink or acids arising from your stomach. Those acids can wash away the tough substance that makes up your enamel, number one to tooth floor loss. Acid also can melt the teeth floor, making it much less complicated to wear away with the beneficial aid of erosion. This is called acid put on or erosive enamel wear. The belly contains many sturdy acids that are used to digest food. Vomiting and reflux can reason those belly acids to enter your mouth. Gastric acids are very sturdy and might purpose considerable harm to the tooth. DE is the lack of the enamel's hard tissues due to the interplay of gastric juice, pepsin, and acid.

Journal of evolution of medical and dental sciences, Apr 6, 2020

BACKGROUND For determination of serum lipid profile, traditionally we use fasting blood sample. T... more BACKGROUND For determination of serum lipid profile, traditionally we use fasting blood sample. Though it has been the most reliable method for testing lipid profile, it has some drawbacks. Fasting is not easy for some people specially children, diabetics and also it is a barrier for population screening. So, intent of our study is to check the authenticity of results obtained using non-fasting samples by correlating it with the results obtained using fasting samples. We wanted to estimate & compare fasting and non-fasting lipid profile values in severe diabetic patients and in apparently healthy controls. METHODS This analytical cross sectional study included 40 apparently healthy controls and 40 diabetic patients as participants confirmed by history and biochemical tests. Blood sample was collected from each patient two times; once after 10-12 hours fasting and other as a random sample. Lipid profile parameters were estimated using standard tests. Statistical analysis was done by using Pearson's correlation coefficient. Data analysis was carried by Statistical Package SPSS and Microsoft Excel and p<0.05 was considered as level of significance. RESULTS In apparently healthy controls differences between fasting and non-fasting concentrations were small and clinically insignificant for lipid profile parameters like total cholesterol (p=0.861), LDL-cholesterol (p=0.203) and HDL-cholesterol (p=0.916). The difference was statistically significant (p=0.001) for triglycerides. CONCLUSIONS Fasting samples are preferable for serum lipid profile measurement in all individuals with serum triglyceride levels greater than 350 mg/dL. But, non-fasting samples for lipid profile can be used for cardiovascular risk determination in the general people as it reduces patient's inconvenience and promotes patient acquiescence towards lipid profile checking.

F1000Research

Among the most prevalent types of extrapulmonary TB is abdominal (TB). The diagnosis of abdominal... more Among the most prevalent types of extrapulmonary TB is abdominal (TB). The diagnosis of abdominal TB is difficult. This disorder is thought to be a good imitator of other abdominal illnesses. To reduce morbidity and mortality, early diagnosis, antitubercular medication start-up, and surgical treatment are crucial. Only seldom is surgery necessary because most patients benefit from antitubercular therapy. Imaging is crucial to the diagnosis and care of these individuals. The following patient, aged about 53 years old female, complained of stomach pain, vomiting, loss of appetite, and weight loss when she first arrived. A swollen ileocaecal junction with a cystic lesion was discovered on an ultrasound of the whole abdomen. The patient received antitubercular medication for six months, and she responded favorably to it.

Cureus

Massive pulmonary embolism (PE) is an uncommon but severe complication of pregnancy or during the... more Massive pulmonary embolism (PE) is an uncommon but severe complication of pregnancy or during the first few weeks after giving birth. Our intention was to thoroughly analyze the information available to its management methods. Significant bleeding of mother survival and early deliveries in fetal survivals were having hemorrhage and were having key outcomes. We found 127 severe PE cases that have had at least one form of treatment (at least 83% big; 23% with cardiac arrest). The 83 women who received thrombolysis had a 94% (95%) survival rate. Cardiac arrest in pregnancy is uncommon, although maintaining current competency can be challenging. While maternal mortality rates have decreased globally over the past 25 years, they have increased in the United States. The intricacy of the maternal mortality issue is a result of a number of clinical and socioeconomic problems such as unequal healthcare access, racial and ethnic disparities, maternal comorbidities, and bias in epidemiologic ascertainment. The importance of doctors being prepared to react to a potential maternal cardiac arrest in any situation where they are providing treatment for pregnant women is highlighted by the rise in maternal mortality. For the treatment of maternal cardiac arrest, an interdisciplinary team with expertise in both the maternal resuscitation procedure and the physiological changes that take place during pregnancy is necessary. Additionally offered are basic and advanced cardiac life support protocols. Techniques to remove obstacles like aortocaval compression that could impair the effectiveness of resuscitation should be used.

International Journal of Clinical Biochemistry and Research, Jan 15, 2021

Introduction: Glucometer is widely used at hospitals and homes as a first line tool to get an ide... more Introduction: Glucometer is widely used at hospitals and homes as a first line tool to get an idea about the current blood glucose levels. Since glucometers are used for making important decisions, it is essential that their accuracy should be comparable to those of standard laboratory analyzers. So the present study was aimed to compare and correlate the glucose levels using glucometer and GOD-POD method in diabetic patients. Methods: 60 diagnosed type 2 diabetes mellitus patients were selected for the study after institutional ethical committee's clearance was obtained. These were divided into three groups based on their plasma glucose levels by GOD-POD method. Group 1: 20 Patients having plasma glucose levels ≤ 110 mg/dl. Group 2: 20 Patients having plasma glucose levels between 111 mg/dl to 250 mg/dl. Group 3: 20 Patients having plasma glucose levels ≥ 251 mg/dl. In this study, we measured plasma glucose levels of each patient simultaneously with glucometer and GOD-POD method (semiautomatic analyzer) in the clinical laboratory. Results: In our study, we found that that at very high glucose readings (i.e. in group 3 patients having plasma glucose levels ≥ 251 mg/dl), glucometer overestimates glucose results. So, these values do not accurately reflect actual plasma glucose levels. Conclusions: Very high glucose values obtained using glucometers should be cautiously interpreted and verified with centralized laboratory. The current practice of performing only single readings with glucometers can lead to misdiagnosis. Medical professionals should depict diabetic patients the importance of periodic centralized laboratory glucose testing.

Cureus, Oct 21, 2022

There are a minimum of five distinct sub-types of ovarian cancer based on histology, each of whic... more There are a minimum of five distinct sub-types of ovarian cancer based on histology, each of which has distinct factors of risk, types of cells, molecular makeups, clinical characteristics, and therapeutic approaches. Ovarian cancer is detected usually at later stages, and there is no reliable screening method. Cytoreductive surgery and chemotherapy which use platinum-containing drugs are the standard treatments used for freshly detected cancer. Chemotherapy, drugs that are anti-angiogenic, poly ADP-ribose polymerase inhibitors, and immunological treatments are all used to treat recurrent cancer. The most frequent type of ovarian cancer to be diagnosed is high-grade serous carcinoma (HGSC), which often responds well to platinum-based chemotherapy when discovered. However, HGSCs commonly relapse and develop increased treatment resistance in addition to the other histologies. As a result, ovarian cancer research is actively focused on understanding the processes causing platinum resistance and developing strategies to combat it. Serous tubal intraepithelial carcinoma is an HGSC precursor lesion. It is one of the early complications seen in ovarian carcinoma. It has been very useful in identifying the people who have a greater chance of developing ovarian cancer and development of strategies to prevent it. This has led to a significant progress for identification of the genes which are found in people with greater chances of development of ovarian carcinoma (for example, the BRCA1 and BRCA2).

Cureus, Feb 9, 2023

The thyroid is a butterfly-shaped gland located in the human body's neck region. The thyroid prod... more The thyroid is a butterfly-shaped gland located in the human body's neck region. The thyroid produces three hormones that are essential for regulating body temperature, energy production, weight, hair and nail growth, and menstrual cycle maintenance. The production of these hormones is controlled by a feedback mechanism. Various factors cause changes in the stimulation and inhibition of these hormones, which ultimately causes either excessive release or a decrease in the levels of thyroid hormones. These causes can be physiological or pathological. One of the physiological causes is pregnancy. Pregnancy is a very complex process in which many changes occur in the body and its functioning. One of which is changes in the maternal thyroid gland. The inability to adequately adapt to the changes leads to the abnormal functioning of the thyroid gland. During pregnancy, there is a variation in the concentration of thyroid hormones which may cause a decrease in levels or inhibition in the production of thyroid hormones. This condition is called hypothyroidism. Hypothyroidism in pregnant mothers can either be gestational or may be a condition that is present way before her pregnancy. Often, gestational hypothyroidism reverts after delivery during the postpartum period but can also be present as subclinical hypothyroidism. In such cases, they pose a significant threat to development, cause growth hindrance to the infant in the womb, and cause abnormalities in the offspring in the future. Some of the changes occur in the gland because of enhancement in levels of thyroid binding globulin, increased clearance rate of iodine from the body in kidneys, altered effects in human chorionic gonadotropin hormone, and decreased consumption of iodine in meals. Iodine disbalance in maternal hypothyroidism is associated with severe health issues like cretinism and mental retardation. Thyroid hormones are crucial for the infant's neural, cognitive, and intelligence quotient development in the womb. Thus, the disturbances in the maternal hormone levels disturb typical early developmental characteristics. In the world of rapidly advancing scientific research, there are many ways in which this condition can be detected early, diagnosed correctly, and given apt and required attention and treatment for causing the least harm to the fetus and the mother.

Journal of Clinical and Diagnostic Research, 2022

Cureus, Oct 13, 2022

Wankhade et al. This is an open access article distributed under the terms of the Creative Common... more Wankhade et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Case Reports, Dec 1, 2022

Cureus, Dec 23, 2022

Many traits and phenotypic characteristics present in the human body such as height, skin, pigmen... more Many traits and phenotypic characteristics present in the human body such as height, skin, pigmentation, hair, and eye color are inherited through many alleles present in different loci. This is known as polygenic inheritance. Congenital rubella syndrome (CRS) is a rare disease characterized by congenital deformities such as chorioretinitis and cataracts. This disease is endemic in India, and it is mainly caused by the rubella virus. We report a case of a 4.5-year-old female child who presented with breathlessness and radiolucent bone disease, for which she was already undergoing surgical interventions. The cell culture line was positive for rubella. The patient was treated with oxygen therapy via continuous positive airway pressure (CPAP) and had a moderate biventricular function.

Cureus, Oct 17, 2022

Propofol-related infusion syndrome (PRIS) is a lethal condition characterized by multiple organ s... more Propofol-related infusion syndrome (PRIS) is a lethal condition characterized by multiple organ system failures. It can occur due to prolonged administration of propofol (an anesthetic) in mechanically intubated patients. The main presenting features of this condition include cardiovascular dysfunction with particular emphasis on impairment of cardiovascular contractility, metabolic acidosis, lactic acidosis, rhabdomyolysis, hyperkalaemia, lipidaemia, hepatomegaly, acute renal failure, and eventually mortality in most cases. The significant risk factors that predispose one to PRIS are: critical illnesses, increased serum catecholamines, steroid therapy, obesity, young age (significantly below three years), depleted carbohydrate stores in the body, increased serum lipids, and most importantly, heavy or extended dosage of propofol. The primary pathophysiology behind PRIS is the disruption of the mitochondrial respiratory chain that causes inhibition of adenosine triphosphate (ATP) synthesis and cellular hypoxia. Further, excess lipolysis of adipose tissue occurs, especially in critically ill patients where the energy source is lipid breakdown instead of carbohydrates. This process generates excess free fatty acids (FFAs) that cannot undergo adequate betaoxidation. These FFAs contribute to the clinical pathology of PRIS. It requires prompt management as it is a fatal condition. The clinicians must observe the patient's electrocardiogram (ECG), serum creatine kinase, lipase, amylase, lactate, liver enzymes, and myoglobin levels in urine, under propofol sedation. Doctors should immediately stop propofol infusion upon noticing any abnormality in these parameters. The other essentials of management of various manifestations of PRIS will be discussed in this article, along with a detailed explanation of the condition, its risk factors, diagnosis, pathophysiology, and presenting features. This article aims to make clinicians more aware of the occurrence of this syndrome so that better ways to manage and treat this condition can be formulated in the future.

Indian Journal of Forensic Medicine & Toxicology, 2020

Cureus, Oct 17, 2022

Gastroesophageal reflux disorder (GERD) or chronic acid reflux disorder is a condition in which a... more Gastroesophageal reflux disorder (GERD) or chronic acid reflux disorder is a condition in which acidcontaining contents continuously leak from the stomach and return to the esophagus. Acid reflux disease occurs in nearly every person at some unspecified time. In reality, it is considered as a reoccurrence of acid reflux disease disorder and heartburn, every day. However, when you have acid reflux disorder/heartburn greater than two times every week over numerous weeks, constantly take heartburn medicinal tablets and antacids. However, if your signs and symptoms and symptoms keep returning, you can have superior GERD. Your GERD needs to be handled with the aid of your healthcare employer. Now not simply to alleviate your symptoms, but because of the reality, GERD can result in extra intense issues. Dental erosion (DE) is the shortage of the ground of your tooth because of acids you eat or drink or acids arising from your stomach. Those acids can wash away the tough substance that makes up your enamel, number one to tooth floor loss. Acid also can melt the teeth floor, making it much less complicated to wear away with the beneficial aid of erosion. This is called acid put on or erosive enamel wear. The belly contains many sturdy acids that are used to digest food. Vomiting and reflux can reason those belly acids to enter your mouth. Gastric acids are very sturdy and might purpose considerable harm to the tooth. DE is the lack of the enamel's hard tissues due to the interplay of gastric juice, pepsin, and acid.

Journal of evolution of medical and dental sciences, Apr 6, 2020

BACKGROUND For determination of serum lipid profile, traditionally we use fasting blood sample. T... more BACKGROUND For determination of serum lipid profile, traditionally we use fasting blood sample. Though it has been the most reliable method for testing lipid profile, it has some drawbacks. Fasting is not easy for some people specially children, diabetics and also it is a barrier for population screening. So, intent of our study is to check the authenticity of results obtained using non-fasting samples by correlating it with the results obtained using fasting samples. We wanted to estimate & compare fasting and non-fasting lipid profile values in severe diabetic patients and in apparently healthy controls. METHODS This analytical cross sectional study included 40 apparently healthy controls and 40 diabetic patients as participants confirmed by history and biochemical tests. Blood sample was collected from each patient two times; once after 10-12 hours fasting and other as a random sample. Lipid profile parameters were estimated using standard tests. Statistical analysis was done by using Pearson's correlation coefficient. Data analysis was carried by Statistical Package SPSS and Microsoft Excel and p<0.05 was considered as level of significance. RESULTS In apparently healthy controls differences between fasting and non-fasting concentrations were small and clinically insignificant for lipid profile parameters like total cholesterol (p=0.861), LDL-cholesterol (p=0.203) and HDL-cholesterol (p=0.916). The difference was statistically significant (p=0.001) for triglycerides. CONCLUSIONS Fasting samples are preferable for serum lipid profile measurement in all individuals with serum triglyceride levels greater than 350 mg/dL. But, non-fasting samples for lipid profile can be used for cardiovascular risk determination in the general people as it reduces patient's inconvenience and promotes patient acquiescence towards lipid profile checking.

F1000Research

Among the most prevalent types of extrapulmonary TB is abdominal (TB). The diagnosis of abdominal... more Among the most prevalent types of extrapulmonary TB is abdominal (TB). The diagnosis of abdominal TB is difficult. This disorder is thought to be a good imitator of other abdominal illnesses. To reduce morbidity and mortality, early diagnosis, antitubercular medication start-up, and surgical treatment are crucial. Only seldom is surgery necessary because most patients benefit from antitubercular therapy. Imaging is crucial to the diagnosis and care of these individuals. The following patient, aged about 53 years old female, complained of stomach pain, vomiting, loss of appetite, and weight loss when she first arrived. A swollen ileocaecal junction with a cystic lesion was discovered on an ultrasound of the whole abdomen. The patient received antitubercular medication for six months, and she responded favorably to it.

Cureus

Massive pulmonary embolism (PE) is an uncommon but severe complication of pregnancy or during the... more Massive pulmonary embolism (PE) is an uncommon but severe complication of pregnancy or during the first few weeks after giving birth. Our intention was to thoroughly analyze the information available to its management methods. Significant bleeding of mother survival and early deliveries in fetal survivals were having hemorrhage and were having key outcomes. We found 127 severe PE cases that have had at least one form of treatment (at least 83% big; 23% with cardiac arrest). The 83 women who received thrombolysis had a 94% (95%) survival rate. Cardiac arrest in pregnancy is uncommon, although maintaining current competency can be challenging. While maternal mortality rates have decreased globally over the past 25 years, they have increased in the United States. The intricacy of the maternal mortality issue is a result of a number of clinical and socioeconomic problems such as unequal healthcare access, racial and ethnic disparities, maternal comorbidities, and bias in epidemiologic ascertainment. The importance of doctors being prepared to react to a potential maternal cardiac arrest in any situation where they are providing treatment for pregnant women is highlighted by the rise in maternal mortality. For the treatment of maternal cardiac arrest, an interdisciplinary team with expertise in both the maternal resuscitation procedure and the physiological changes that take place during pregnancy is necessary. Additionally offered are basic and advanced cardiac life support protocols. Techniques to remove obstacles like aortocaval compression that could impair the effectiveness of resuscitation should be used.

International Journal of Clinical Biochemistry and Research, Jan 15, 2021

Introduction: Glucometer is widely used at hospitals and homes as a first line tool to get an ide... more Introduction: Glucometer is widely used at hospitals and homes as a first line tool to get an idea about the current blood glucose levels. Since glucometers are used for making important decisions, it is essential that their accuracy should be comparable to those of standard laboratory analyzers. So the present study was aimed to compare and correlate the glucose levels using glucometer and GOD-POD method in diabetic patients. Methods: 60 diagnosed type 2 diabetes mellitus patients were selected for the study after institutional ethical committee's clearance was obtained. These were divided into three groups based on their plasma glucose levels by GOD-POD method. Group 1: 20 Patients having plasma glucose levels ≤ 110 mg/dl. Group 2: 20 Patients having plasma glucose levels between 111 mg/dl to 250 mg/dl. Group 3: 20 Patients having plasma glucose levels ≥ 251 mg/dl. In this study, we measured plasma glucose levels of each patient simultaneously with glucometer and GOD-POD method (semiautomatic analyzer) in the clinical laboratory. Results: In our study, we found that that at very high glucose readings (i.e. in group 3 patients having plasma glucose levels ≥ 251 mg/dl), glucometer overestimates glucose results. So, these values do not accurately reflect actual plasma glucose levels. Conclusions: Very high glucose values obtained using glucometers should be cautiously interpreted and verified with centralized laboratory. The current practice of performing only single readings with glucometers can lead to misdiagnosis. Medical professionals should depict diabetic patients the importance of periodic centralized laboratory glucose testing.