Sulfatase 2 up‐regulates glypican 3, promotes fibroblast... : Hepatology (original) (raw)

Hepatobiliary Malignancies

Sulfatase 2 up‐regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma†

Lai, Jin‐Ping*,1,‡; Sandhu, Dalbir S.1; Yu, Chunrong2,7; Han, Tao1; Moser, Catherine D.1; Jackson, Kenard K.1; Guerrero, Ruben Bonilla1; Aderca, Ileana1; Isomoto, Hajime1; Garrity‐Park, Megan M.3; Zou, Hongzhi1; Shire, Abdirashid M.1; Nagorney, David M.4; Sanderson, Schuyler O.3; Adjei, Alex A.2,7; Lee, Ju‐Seog5,6; Thorgeirsson, Snorri S.5; Roberts, Lewis R.*,1,§

1Miles and Shirley Fiterman Center for Digestive Diseases, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN

2Department of Oncology, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN

3Department of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN

4Division of Gastroenterologic and General Surgery, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN

5Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD

6MD Anderson Cancer Center, Houston, TX

7Roswell Park Cancer Institute, Buffalo, NY

Jin‐Ping Lai, Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905=== Lewis R. Roberts, Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905===

Received November 05, 2007

Accepted December 20, 2007