Extracellular matrix modulates sensitivity of hepatocytes... : Hepatology (original) (raw)

Liver Biology/Pathobiology

Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor β–induced apoptosis†

Godoy, Patricio1,2; Hengstler, Jan G.2; Ilkavets, Iryna1; Meyer, Christoph1; Bachmann, Anastasia1; Müller, Alexandra1; Tuschl, Gregor3; Mueller, Stefan O.3; Dooley, Steven*,1

1Molecular Alcohol Research in Gastroenterology, Department of Medicine II, Faculty of Medicine at Mannheim, University of Heidelberg, Germany

2IfADo‐Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany

3Merck KGaA, Merck Serono, Early and Explanatory Toxicology, Darmstadt, Germany

Department of Medicine II, Gastroenterology and Hepatology, University Hospital, Mannheim, Germany, Theodor‐Kutzer Ufer 1‐3, 68135 Mannheim, Germany===

Received July 22, 2008

Accepted January 21, 2009