Risk factors for cholangiocarcinoma : Hepatology (original) (raw)

Hepatobiliary Malignancies

1_Sections of Gastroenterology and Health Services Research at the Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX_

Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030 E-mail:[email protected]

Potential conflict of interest: Nothing to report

This work was partly funded by National Institutes of Health grant T32 DK083266–01A1 and partly by the Houston VA Health Services Research and Development Center of Excellence (HFP90–020).

Dr. El-Serag is the Chief of the Gastroenterology and Hepatology Section at the Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine.

fax: 713–798–0951

Abstract

Cholangiocarcinoma (CC) is the second most common primary hepatic malignancy after hepatocellular cancer. CC accounts for approximately 10%-25% of all hepatobiliary malignancies. There are considerable geographic and demographic variations in the incidence of CC. There are several established risk factors for CC, including parasitic infections, primary sclerosing cholangitis, biliary-duct cysts, hepatolithiasis, and toxins. Other less-established potential risk factors include inflammatory bowel disease, hepatitis C virus, hepatitis B virus, cirrhosis, diabetes, obesity, alcohol drinking, tobacco smoking, and host genetic polymorphisms. In studies where the distinction between intra- and extrahepatic CC was used, some potential risk factors seem to have a differential effect on CC, depending on the site. Therefore, the consistent use of a more refined classification would allow a better understanding of risk factors for CC. (HEPATOLOGY 2011;)