CD30 and type 2 T helper (Th2) responses (original) (raw)
Journal Article
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Istituto di Clinica Medica 3, University of Florence
Reprint requests: Sergio Romagnani, Immunologia Clinica e Allergologia, Istituto di Clinica Medica 3, Viale Morgagni, 85 50134-Florence, Italy.
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Istituto di Clinica Medica 3, University of Florence
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Istituto di Clinica Medica 3, University of Florence
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Istituto di Anatomia Patologica, University of Verona
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Federico Caligaris-Cappio
Istituto di Anatomia Patologica, University of Verona
Dipartimento di Scienze Biomediche e oncologia, University of Turin
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Cattedra di Ematologia, University of Verona
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Verona
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Italy
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Received:
05 December 1994
Accepted:
12 January 1995
Cite
Sergio Romagnani, Gianfranco Del Prete, Enrico Maggi, Marco Chilosi, Federico Caligaris-Cappio, Giovanni Pizzolo, CD30 and type 2 T helper (Th2) responses, Journal of Leukocyte Biology, Volume 57, Issue 5, May 1995, Pages 726–730, https://doi.org/10.1002/jlb.57.5.726
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Abstract
CD30 is one of the members of the tumor necrosis factor receptor superfamily, originally described as a marker of Reed-Sternberg and Hodgkin’s cells in Hodgkin’s lymphoma. CD30 appears to be preferentially expressed on, and its soluble form (sCD30) released by, CD4+ and CD8+ T cell clones capable of producing T helper 2 (Th2)-type cytokines. In nonneoplastic conditions, CD30+ T cells are barely detectable in vivo; however, a few allergen-specific CD4+CD30+ T cells inducible to the production of Th2-type cytokines could be sorted out from the circulation of allergic subjects after allergen exposure. Moreover, high numbers of CD30+ T cells were found in the lymph node of a patient suffering from Omenn’s syndrome, a rare congenital Th2-mediated immunodeficiency disorder. More importantly, high serum levels of sCD30 were observed in some conditions in which a pathogenetic role for Th2 cells has been suggested, such as Omenn’s syndrome, atopy, systemic lupus erythematosus, and after infection with measles virus or human immunodeficiency virus. Thus, detection of CD30+ T cells and/or of increased levels of sCD30 may reflect the presence of immune responses or immune alterations characterized by the prevalent activation of Th2-like cells. J. Leukoc. Biol. 57: 726-730; 1995.
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© 1995 Society for Leukocyte Biology
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