Amiodarone-induced hepatic phospholipidosis: Correlation of ... : Hepatology (original) (raw)
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Amiodarone-induced hepatic phospholipidosis: Correlation of morphological and biochemical findings in an animal model
Pirovino, Mauro M.D.*, 1; Müller, Otfried1; Zysset, Thomas1; Honegger, Ueli1
1Departments of Internal Medicine, Anatomy, Clinical Pharmacology and Pharmacology, University Hospital, CH-3010 Berne, Switzerland
*Address reprint requests to: Department of ernal Medicine, University Hospital, CH-3010 Berne, Switzerland.
Received April 02, 1987; Accepted November 04, 1987; previously published online December 06, 2005
Abstract
Morphological and biochemical investigations were performed in guinea pigs after 1, 3, 5 and 16 weeks of amiodarone feeding. The most prominent morphological finding was an increase in dense bodies in hepatocytes, Kupffer cells and in bile duct epithelia, reaching a maximum after 5 weeks of treatment according to morphometric analysis. Similar time courses were observed for the serum and liver tissue concentrations of amiodarone and desethylamiodarone and the—albeit minimal—extent of hepatocellular necrosis. Phospholipids in the liver homogenate were unchanged after 1 week, but significantly increased after prolonged amiodarone treatment. There was no significant alteration in the pattern of individual phospholipids. Serum and tissue concentrations as well as the extent of phospholipidosis do not appear to be a function of the duration of drug application. A very close correlation, however, was observed between the liver tissue concentration of amiodarone and the amount of dense bodies as a morphological expression of phospholipidosis.
Copyright © 1988 American Association for the Study of Liver Diseases.