Loss of the glycine N‐methyltransferase gene leads to... : Hepatology (original) (raw)

Hepatobiliary Malignancies

Loss of the glycine _N_‐methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice†

Martínez‐Chantar, M. Luz1,‡; Vázquez‐Chantada, Mercedes1,‡; Ariz, Usue1; Martínez, Nuria1; Varela, Marta1; Luka, Zigmund2; Capdevila, Antonieta2; Rodríguez, Juan1; Aransay, Ana M.1; Matthiesen, Rune1; Yang, Heping3; Calvisi, Diego F.4; Esteller, Manel5; Fraga, Mario5; Lu, Shelly C.3; Wagner, Conrad2,6; Mato, José M.*,1,§

1CIC bioGUNE, CIBERehd, Technology Park of Bizkaia, Bizkaia, Spain

2Department of Biochemistry, Vanderbilt University, Nashville, TN

3Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University Southern California, Los Angeles, CA

4Division of Experimental Pathology and Oncology, University of Sassary, Sassary, Italy

5Centro Nacional de Investigaciones Oncológicas, Madrid, Spain

6Tennessee Valley Department of Medical Affairs Medical Center, Nashville, TN

CIC bioGUNE, Technology Park of Bizkaia, 48160 Derio, Bizkaia, Spain===

Received September 10, 2007

Accepted November 26, 2007