Side chain structure determines unique physiologic and... : Hepatology (original) (raw)

Autoimmune, Cholestatic and Biliary Disease

Side chain structure determines unique physiologic and therapeutic properties of _nor_ursodeoxycholic acid in _Mdr2_−/− mice†‡§

Halilbasic, Emina1; Fiorotto, Romina2; Fickert, Peter1; Marschall, Hanns‐Ulrich3; Moustafa, Tarek1; Spirli, Carlo2; Fuchsbichler, Andrea4; Gumhold, Judith1; Silbert, Dagmar1; Zatloukal, Kurt4; Langner, Cord4; Maitra, Uday5; Denk, Helmut4; Hofmann, Alan F.6; Strazzabosco, Mario2,7,8; Trauner, Michael*,1

1Laboratory of Experimental and Molecular Hepatology, Department of Gastroenterology and Hepatology, University Clinic of Internal Medicine, Medical University of Graz, Graz, Austria

2Section of Digestive Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT

3Karolinska University Hospital Huddinge, Stockholm, Sweden

4Institute of Pathology, Medical University of Graz, Graz, Austria

5Department of Organic Chemistry, Indian Institute of Science, Bangalore, India

6Department of Medicine, University of California, San Diego, CA

7CeLiveR, Ospedali Riuniti di Bergamo, Bergamo, Italy

8Department of Clinical Medicine and Prevention, University of Milano‐Bicocca, Milan, Italy

Laboratory of Experimental and Molecular Hepatology, Department of Gastroenterology and Hepatology, Medical University Graz, Auenbruggerplatz 16, 8036 Graz, Austria===

Received September 18, 2008

Accepted January 26, 2009