Tenofovir‐associated Fanconi syndrome and nephrotic... : Hepatology (original) (raw)
Clinical Observations in Hepatology
Tenofovir‐associated Fanconi syndrome and nephrotic syndrome in a patient with chronic hepatitis B monoinfection
1Division of Nephrology, Department of Internal Medicine, College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea
2Division of Hepatology, Department of Internal Medicine, College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea
*Address reprint requests to: Myeong Jun Song, Division of Hepatology, Department of Internal Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daeheung‐ro 64, Jung‐gu, Daejeon, 301‐723, Republic of Korea. E‐mail: [email protected]; tel: +82‐42‐220‐9291.
Abstract
Tenofovir disoproxil fumarate (TDF) is widely used as an effective first‐line therapy for chronic hepatitis B (CHB) infection. While TDF demonstrates successful viral suppression, it has been linked to the development of renal proximal tubular (PT) dysfunction, leading to Fanconi syndrome. However, Fanconi syndrome has been rarely reported in CHB‐monoinfected patients, and there were no reports of TDF‐associated nephrotic syndrome. Here, we report a case of combined Fanconi and nephrotic syndrome in CHB patients after TDF exposure. (Hepatology 2015;62:1318‐1320)
© 2015 by the American Association for the Study of Liver Diseases