The effects of testosterone on the cavernous tissue and erectile function (original) (raw)

• Baba K, Yajima M, Carrier S, Nagaraju P, Morgan DM, Ekkus E, Rehman J, Nunez L, Lue TF (1995) Effects of testosterone on the number of NADPH-diaphorase-staining nerve fibers in the rat corpus cavernosum and dorsal nerve. J Urol 153: 506A
  Google Scholar
• Bancroft J, Wu FC (1983) Changes in erectile responsiveness during androgen replacement therapy. Arch Sex Behav 12: 59
  PubMed Google Scholar
• Bandyk MG, Sawczuk IS, Olsson CA, Katz AE, Buttyan R (1990) Characterization of the products of a gene expressed during androgen-programmed cell death and their potential use as a marker for urogenital injury. J Urol 143: 407–413
  PubMed Google Scholar
• Baskin HJ (1983) Endocrinologic evaluation of impotence. South Med J 82: 446
  Google Scholar
• Bradshaw WG, Baum MJ, Awh CC (1981) Attenuation by 5alpha-reductase inhibitor of the activational effect of testosterone propionate on penile erections in castrated male rats. Endocrinology 109: 1047–1051
  PubMed Google Scholar
• Buttyan R, Olsson CA, Pintar J, Chang C, Bandyk M, Ng P-Y, Sawczuk IS (1989) Induction of the TRPM 2 gene in cells undergoing programmed cell death. Mol Cell Biol 9: 3473–3481
  PubMed Google Scholar
• Cher ML, Shinohara K, Breslin J, Vapnek J, Carroll PR (1995) High failure rate associated with long-term follow up of neoadjuvant androgen deprivation followed by radical prostatectomy for stage C prostate cancer. Br J Urol 75: 771–777
  PubMed Google Scholar
• Choi SK, et al (1993) Transdermal dihydrotestosterone therapy and its effects on patients with microphallus. J Urol 150: 657
  PubMed Google Scholar
• Colombel M, Olsson CA, Ng P-Y, Buttyan R (1992) Hormoneregulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle. Cancer Res 52: 4313–4319
  PubMed Google Scholar
• Cunningham GR, et al. (1982) The relationship between serum testosterone and prolactin levels and nocturnal penile tumescence (NPT) in impotent men. J Androl 3: 241
  Google Scholar
• Davidson JM, Camargo CA, Smith ER (1979) Effects of androgen on sexual behavior in hypogonadal men. J Clin Endocrinol Metab 48: 955–958
  PubMed Google Scholar
• Delaere KPJ, Van Thillo EL (1991) Flutamide monotherapy as primary treatment in advanced prostatic carcinoma. Semin Oncol 18: 13–18
  PubMed Google Scholar
• Ellis WJ, and Grayhack JT (1963) Sexual function in aging males after orchiectomy and estrogen therapy. J Urol 89: 895
  Google Scholar
• Feldman KW, Smith DW (1975) Fetal phallic growth and penile standards for newborn male infants. J Pediatr 86: 395
  PubMed Google Scholar
• Fenwick PBC, et al (1986) Nocturnal penile tumescence and serum testosterone levels. Arch Sex Behav 15: 12
  Google Scholar
• Fleshner NE, Trachtenberg J (1993) Treatment of advanced prostate cancer with the combination of finasteride plus flutamide: early results. Eur Urol 24[Suppl 2]: 106–111
  Google Scholar
• Frajese G, Lazzari R, Magnani A, Moretti A, Sforzi C, Nerozzi D (1990) Neurotransmitter, opiodergic system, steroid-hormone interaction and involvement in the replacement therapy of sexual disorders. J Steroid Biochem Mol Biol 37: 411
  PubMed Google Scholar
• Friedman DE, et al (1986) Should impotent males who have no clinical evidence of hypogonadism have routine endocrine screening? Lancet I: 1041
  Google Scholar
• Geneser F (1986) Textbook of histology. Munksgaard, Copenhagen; p 644
  Google Scholar
• Godec CJ, Bates H, Labrosse K (1985) Testosterone receptors in corpora cavernosa of penis. Urology 26: 237
  PubMed Google Scholar
• Goldman BD, et al (1972) Modification of phallus development and sexual behavior in rats treated with gonadotropin antiserum neonatally. Endocrinology 90: 1025
  PubMed Google Scholar
• Guthrie RD, Smith DW, Graham CB (1973) Testosterone treatment for micropenis during early childhood. J Pediatr 83: 247
  PubMed Google Scholar
• Hart BJ (1967) Testosterone regulation of sexual reflexes in spinal male rats. Science 155: 1283–1284
  PubMed Google Scholar
• Hart BJ, Wallach SJ, Melese-D'Hopital PY (1983) Differences in responsiveness to testosterone of penile reflexes and copulatory behavior of male rats. Horm Behav 17: 274–283
  PubMed Google Scholar
• Heaton JPW, Varrin SJ (1994) Effects of castration and exogenous testosterone supplementation in an animal model of penile erection. J Urol 151: 797–800
  PubMed Google Scholar
• Heim N (1981) Sexual behavior of castrated sex offenders. Arch Sex Behav 10: 11
  PubMed Google Scholar
• Immergut M, et al (1971) The local application of testosterone cream to the prepubertal phallus. J Urol 105: 905
  PubMed Google Scholar
• Johansson JE, Anderson SO, Beckman KW, Lingardh C, Zador G (1987) Clinical evaluation of flutamide and estramustine as initial treatment of metastatic carcinoma of prostate. Urology 29: 55–59
  PubMed Google Scholar
• Johnson AR III, Jarow JP (1992) Is routine endocrine testing of impotent men necessary? J Urol 147: 1542
  PubMed Google Scholar
• Kozlowski JM, Grayhack IT (1987) Carcinoma of the prostate. In: Gillenwater JY, Grayhack IT, Howards SS, Duckett JW (eds) Adult and pediatric urology, vol 34. YBMP, Chicago, pp 1126–1219
  Google Scholar
• Kwan M, Greenleaf W, et al (1983) The nature of androgen action on male sexuality: a combined laboratory self report study on hypogonadal men. J Clin Endocrinol Metab 57: 557–562
  PubMed Google Scholar
• Kyprianou N, Isaacs IT (1988) Activation of programmed cell death in the rat ventral prostate after castration. Endocrinology 122:552–562
  PubMed Google Scholar
• Lange JD, et al (1980) Serum testosterone concentration and penile tumescence changes in men. Horm Behav 14: 267
  PubMed Google Scholar
• Leedy MG, Beattie MS, Bresnahan JC (1987) Testosteroneinduced plasticity of synaptic inputs to adult mammalian motoneurons. Brain Res 424: 386–390
  PubMed Google Scholar
• Lugg JA, Rajfer J, Gonzalez-Cadavid NF (1995) Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat. Endocrinology 136: 1495–1501
  PubMed Google Scholar
• Luisi M, Franchi F (1980) Double blind group comparative study of testosterone undecanoate and mesterolone in hypogonadal male patients. J Endocrinol Invest 3: 305
  Google Scholar
• Lund F, Rasmussen F (1988) Flutamide versus stilbestrol in the management of advanced prostate cancer. A controlled prospective study. Br J Urol 61: 140–142
  PubMed Google Scholar
• Maatman TJ, Montague DK (1986) Routine endocrine screening in impotence. Urology 27: 499
  PubMed Google Scholar
• Matsumoto A, Arnold AP, Zampighi GA, Micevych PE (1988) Androgenic regulation of gap junctions between motoneurons in the rat spinal cord. J Neurosci 8: 4177–4183
  PubMed Google Scholar
• McClure RD (1988) Endocrine evaluation and therapy of erectile dysfunction. Urol Clin North Am 15: 53–64
  PubMed Google Scholar
• Meisel RL, O'Hanlon JK, Sachs BD (1984) Differential maintenance of penile responses and copulatory behavior by gonadal hormones in castrated male rats. Horm Behav 18: 56–64
  PubMed Google Scholar
• Meyaard MJ, Otto SA, Jonker RR, Mijnster MJ, Keet RP, Miedema F (1992) Programmed death of T-cells in HIV-1 infection. Science 257: 217–219
  PubMed Google Scholar
• Mills MT, Wiedmeier VT, Stopper VS (1992) Androgen maintenance of erectile function in the rat penis. Biol Reprod 46: 342–348
  PubMed Google Scholar
• Muller SC, Hsieh JT, Lue TF, Tanagho EA (1988) Castration and erection: an animal study. Eur Urol 15: 118–124
  PubMed Google Scholar
• Mulligan T, Schmitt B (1993) Testosterone for erectile failure, clinical review. J Gen Intern Med 8: 517–521
  PubMed Google Scholar
• Nickel JC, et al (1984) Endocrine dysfunction in impotence: incidence, significance and cost-effective screening. J Urol 132: 40
  PubMed Google Scholar
• Nonomura K, et al (1990) Androgen binding activity in the spongy tissue of mammalian penis. J Urol 144: 52
  Google Scholar
• O'Carroll R, Bancroft J (1985) Effects of androgen replacement on sexual behaviour and nocturnal erections in hypogonadal men. Clin Endocrinol 23: 527
  Google Scholar
• Proscar (1996) Information package insert
• Rajfer J, Namkung PC, Petra PH (1980) Identification, partial characterization and age-related changes of a cytoplasmic androgen receptor in the rat penis. J Steroid Biochem 13: 1489
  PubMed Google Scholar
• Raymond J, Miller M, Olsson CA, O'Toole K, Buttyan R, Shabsigh R (1996) Androgen induction of DNA synthesis in the rat penis. J Urol (in press)
• Rubin HB, et al (1979) The relationship between men's endogenous levels of testosterone and their penile responses to erotic stimuli. Behav Res Ther 17: 305
  PubMed Google Scholar
• Santarosa R, Te AE, Colombel MC, Koo HP, Olsson CA, Buttyan R, Shabsigh R (1996) Induction of apoptosis in the rat penis after castration. J Urol (in press)
• Schiavi RC, White D (1976) Androgen and male sexual function: a review of human studies. J Sex Marital Ther 2: 214
  PubMed Google Scholar
• Shabsigh R (1993): Medication related impotence. Contemp Urol 5: 51–61
  Google Scholar
• Shah RS, et al (1988) Hypothalamic-hypophyseal-testicular abnormalities and erectile dysfunction. Arch Androl 20: 137
  PubMed Google Scholar
• Skakkeback NE, Bancroft J, et al (1983) Androgen replacement with oral testosterone undecanoate in hypogonadal men: a double blind controlled study. Clin Endocrinol 14: 49–61
  Google Scholar
• Slag MF, et al (1983) Impotence in medical clinic outpatients. JAMA 249: 1736
  PubMed Google Scholar
• Sogani PC, Vagaiwala MR, Whitmore WF (1984) Experience with flutamide in patients with advanced prostatic cancer without prior endocrine therapy. Cancer 54: 744–750
  PubMed Google Scholar
• Spark RF, White RA, Connolly PB (1980) Impotence is not always psychogenic. Newer insights into hypothalamic-pituitary-gonadal dysfunction. JAMA 243: 750
  PubMed Google Scholar
• Takane KK, Husmann DA, McPhaul MJ, Wilson JD (1991) Androgen receptor levels in the rat penis are controlled differently in distinctive cell types. Endocrinology 128: 224
  Google Scholar
• Walsh PC, et al (1978) Clinical and endocrinological evaluation of patients with congenital microphallus. J Urol 120: 90
  PubMed Google Scholar