Poisoning by toxic honey in Turkey (original) (raw)

Abstract

One of the food intoxications encountered in Turkey is the case caused by toxic honey made by bees from_Rhododendron_ species.R.luteum and_R.ponticum_ are the two species which grow in the north regions of Turkey. Grayanotoxins, mainly Grayanotoxin I (Andromedotoxin) occurring only in Ericaceae plants, are the compounds responsible for poisoning. In this investigation, the diagnosis and treatment of 11 cases of poisoning admitted to Kartal Occupational Diseases Hospital between 1983 and 1988 are presented. The results of the light microscopic and chemical analysis of toxic honey samples are compared with those of the ordinary honey samples and the extract of_Rhododendron_ leaves.

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References

• Baytop T (1984), Türkiye'de bitkilerle tedavi (Therapy with medicinal plants in Turkey). Ist. Üniv. Yay. No. 3255, Sanal Matbaasi, Istanbul, p 178
  Google Scholar
• Bucak AM (1938) Zehirli bal (Toxic honey). Farmakoloğ 8: 33–40
  Google Scholar
• Çakaloğlu Y, Kaymakoğlu S, Erden S, Çalangu S (1988) Bal zehirlenmesi ve tedavisi (Honey intoxication and its treatment). Tip Fak Mecm 49: 94–97
  Google Scholar
• Constantine Jr, GH, Shet K, Catalfomo P (1967) Grayanotoxin I. Occurrence in additional Ericaceae species. J Pharm Sci 56: 1518–1519
  PubMed Google Scholar
• Cooper MR, Johnson AW (1984) Poisonous plants in Britain and their effects on animals and man. Ministry of Agriculture Fisheries and Food, London, pp 110–112
  Google Scholar
• Godin P (1954) A new spray reagent for paper chromatography of polyols and cetoses. Nature 174: 134
  Google Scholar
• Hikino H, Ohizumi Y, Konno C, Hashimoto K, Wakasa H (1979) Subcronic toxicity of Ericaceous toxins and_Rhododendron_ leaves. Chem Pharm Bull 27: 874–879
  PubMed Google Scholar
• Karakaya AE (1977), Zehirli balin Grayanotoksin içeriği ve_Rhododendron_ türleri ile ilişkisinin araştirilmasi (Grayanotoxin content of the toxic honey and research on its relation with the_Rhododendron_ species. J Fac Pharm Ankara 7: 111–115
  Google Scholar
• Omurtag AC, Evliya B, Aydin A, Akin A, Erinç N, Dolgun Y (1973) Yurdumuz zehirli ballannin laboratuvar diyagnostiği üzerinde araştirma (The research for the laboratory diagnosis of poisonous honey of Turkey). J Fac Pharm Ankara 3: 55–70
  Google Scholar
• Pulewka P (1949) Andromedotoxin ihtiva eden bal ve bunun zehirliligini. tayin için biyolojik bir metod hakkinda (Über Andromedotoxinhaltigen Honig und eine biologische Methode zur Bestimmung seiner Giftigkeit). Türk Hijyen ve Tecrübi Biyoloji Dergisi 9: 7–17
  Google Scholar
• Scott PM, Coldwell BB, Wiberg GS (1971) Grayanotoxins. Occurrence and analysis in honey and a comparison of toxicities in mice. Fd Cosmet Toxicol 9: 179–184
  Article Google Scholar
• Shindler H (1962) Über Acethylandromedol (Andromedotoxin) in verschiedenen Ericaceen, insbesondere in_Rhododendron_, und seine annähernde Bestimmung. Planta Med 10: 232–237
  Google Scholar
• Stevens PF (1978)Rhododendron L. In: Davis PH (ed) Flora of Turkey and the East Aegean Islands, vol. 6. University Press, Edinburgh, pp 90–94
  Google Scholar
• Tallent WH, Riethof ML, Horning EC (1957) Studies on the occurrence and structure of Acetylandromedol (Andromedotoxin), J Am Chem Soc 79: 4548–4554
  Google Scholar
• Ungan A (1941) Şimali Anadolu'nun zehirli bali (Toxic honey of Northern Anatolia). Türk Hijyen ve Tecrübi Biyoloji Dergisi 2: 161
  Google Scholar
• Wood Jr, HB, Stomberg UL, Keresztesy JC, Horning EC (1954) Andromedotoxin. A potent hypotensive agent from_Rhododendron maximum_, J Am Chem Soc 76: 5689–5692
  Article Google Scholar
• Zymalkowsky F, Pachaly P, Keller S (1968) Die Bestimmung von Acetylandromedol (Grayanotoxin I) in Extrakten von_Rhododendron ponticum_. Planta Med 17: 8–13
  Google Scholar

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Author notes

1. Nurhayat Sütlüpmar
   Present address: Department of Pharmacognosy, Faculty of Pharmacy, University of Istanbul, 34452, Istanbul, Turkey

Authors and Affiliations

1. Department of Pharmacognosy, Faculty of Pharmacy, University of Istanbul, 34452, Istanbul, Turkey
   Afife Mat
2. Kartal Occupational Diseases Hospital, Istanbul, Turkey
   Yurdagül Satganoglu

Authors

1. Nurhayat Sütlüpmar
2. Afife Mat
3. Yurdagül Satganoglu

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Sütlüpmar, N., Mat, A. & Satganoglu, Y. Poisoning by toxic honey in Turkey.Arch Toxicol 67, 148–150 (1993). https://doi.org/10.1007/BF01973687

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• Received: 19 August 1992
• Accepted: 13 October 1992
• Issue date: February 1993
• DOI: https://doi.org/10.1007/BF01973687

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