Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility (original) (raw)

Abstract

The antiemetic activity, gastric motor activity, and dopamine receptor effects of metoclopramide, dazopride, and sulpiride were assessed to establish if enhancement of gastric motility or antagonism of central dopamine receptors is the predominant action for drug-induced suppression of cisplatin-induced emesis. Emesis produced in dogs by cisplatin is antagonized by metoclopramide and dazopride. The antiemetic actions of metoclopramide and dazopride are associated with their ability to enhance gastric motor activity. Dazopride, unlike metoclopramide, has minimal dopamine receptor antagonist properties. Sulpiride is a potent dopamine receptor antagonist; however, it had no effect on the stomach and was ineffective in suppressing cisplatin-induced emesis.

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Authors and Affiliations

  1. Research and Development Division, A.H. Robins Company, P.O. Box 26609, 23261-6609, Richmond, Virginia
    R. S. Alphin PhD, A. G. Proakis PhD, C. A. Leonard DSc, W. L. Smith PhD, W. N. Dannenburg PhD, W. J. Kinnier PhD, D. N. Johnson PhD, L. F. Sancilio PhD & J. W. Ward PhD

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  1. R. S. Alphin PhD
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  2. A. G. Proakis PhD
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  3. C. A. Leonard DSc
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  4. W. L. Smith PhD
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  5. W. N. Dannenburg PhD
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  6. W. J. Kinnier PhD
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  7. D. N. Johnson PhD
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  8. L. F. Sancilio PhD
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  9. J. W. Ward PhD
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Alphin, R.S., Proakis, A.G., Leonard, C.A. et al. Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility.Digest Dis Sci 31, 524–529 (1986). https://doi.org/10.1007/BF01320319

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