Rosin Nanoparticles as a Drug Delivery Carrier for the Controlled Release of Hydrocortisone (original) (raw)

Abstract

Hydrocortisone (HC)-loaded rosin nanoparticles were prepared by a dispersion and dialysis method without addition of surfactant. They were spherical: 167–332 nm diam. The drug was loaded approximately 50% of initial feeding amount in all formulation. Release of hydrocortisone from the nanoparticles in vitro gradually decreased with increasing initial rosin content at pH 7.4. HC was also released very slowly at pH 1.2. Nanoparticles based on rosin thus are potentially useful as a drug delivery system.

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Authors and Affiliations

1. Interdisciplinary Program of Biomedical Engineering, Chonnam National University, 500-757, Gwangju, South Korea
   Chang-Moon Lee
2. Ecobio Inc., Business Incubation Center, Chonnam National University, 500-757, Gwangju, South Korea
   Seung Lim & Gwang-Yun Kim
3. Department of Clinical Pathology, Gwang-Yang Health College, 545-703, Jeonnam, South Korea
   Dong-Woon Kim
4. Department of Microbiology, Chonnam National University Medical School, 501-190, Gwangju, South Korea
   Joon Haeng Rhee
5. Department of Applied Chemical Engineering & The Research Institute for Catalysis, Chonnam National University, 500-757, Gwangju, South Korea
   Ki-Young Lee

Authors

1. Chang-Moon Lee
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2. Seung Lim
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3. Gwang-Yun Kim
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4. Dong-Woon Kim
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5. Joon Haeng Rhee
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6. Ki-Young Lee
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Correspondence toKi-Young Lee.

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Lee, CM., Lim, S., Kim, GY. et al. Rosin Nanoparticles as a Drug Delivery Carrier for the Controlled Release of Hydrocortisone.Biotechnol Lett 27, 1487–1490 (2005). https://doi.org/10.1007/s10529-005-1316-x

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• Received: 18 March 2005
• Accepted: 19 July 2005
• Issue Date: October 2005
• DOI: https://doi.org/10.1007/s10529-005-1316-x

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