Predictive Adaptive Control of the Bispectral Index of the EEG (BIS) – Using the Intravenous Anaesthetic Drug Propofol (original) (raw)

Abstract

The problem of controlling the level of unconsciousness measured by the Bispectral Index of the EEG (BIS) of patients under anaesthesia, is considered. It is assumed that the manipulated variable is the infusion rate of the hypnotic drug propofol, while the drug remifentanil is also administered for analgesia. Since these two drugs interact, the administration rate of remifentanil is considered as an accessible disturbance. In order to tackle the high uncertain present on the system, the predictive adaptive controller MUSMAR is used. The performance of the controller is illustrated by means of simulation with 45 patient individual adjusted models, which incorporate the effect of the drugs interaction on BIS. This controller structure proved to be robust to the remifentanil disturbance, different reference values and noise. A reduction of propofol consumption was also observed when comparing to the real clinical dose used for a similar BIS trend.

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Authors and Affiliations

  1. Faculdade de Ciências da Universidade do Porto, Departamento de Matemática Aplicada, Rua do Campo Alegre 687, 4169-007, Porto, Portugal
    Catarina S. Nunes, Teresa F. Mendonça & Hugo Magalhães
  2. UI&D Matemática e Aplicações, Universidade de Aveiro, Portugal
    Teresa F. Mendonça & Hugo Magalhães
  3. INESC-ID/IST, Portugal
    João M. Lemos
  4. Serviço de Anestesiologia, Hospital Geral de Santo António, Portugal
    Pedro Amorim

Authors

  1. Catarina S. Nunes
  2. Teresa F. Mendonça
  3. Hugo Magalhães
  4. João M. Lemos
  5. Pedro Amorim

Editor information

Editors and Affiliations

  1. School of Design, Engineering and Computing, Bournemouth University, UK
    Bogdan Gabrys
  2. Centre for SMART Systems, School of Environment and Technology, University of Brighton, BN2 4GJ, Brighton, UK
    Robert J. Howlett
  3. School of Electrical and Information Engineering, Knowledge Based Intelligent Engineering Systems Centre, University of South Australia, SA, 5095, Mawson Lakes, Australia
    Lakhmi C. Jain

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© 2006 Springer-Verlag Berlin Heidelberg

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Nunes, C.S., Mendonça, T.F., Magalhães, H., Lemos, J.M., Amorim, P. (2006). Predictive Adaptive Control of the Bispectral Index of the EEG (BIS) – Using the Intravenous Anaesthetic Drug Propofol. In: Gabrys, B., Howlett, R.J., Jain, L.C. (eds) Knowledge-Based Intelligent Information and Engineering Systems. KES 2006. Lecture Notes in Computer Science(), vol 4252. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11893004\_158

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