Advancing Pharmacotherapy Development from Preclinical Animal Studies (original) (raw)
References
Addolorato G, Caputo F, Capristo E, Domenicali M, Bernardi M, Janiri L, Agabio R, Colombo G, Gessa GL, Gasbarrini G (2002) Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled study. Alcohol Alcohol 37:504–508 CASPubMed Google Scholar
Addolorato G, Leggio L, Ferrulli A, Cardone S, Vonghia L, Mirijello A, Abenavoli L, D’Angelo C, Caputo F, Zambon A, Haber PS, Gasbarrini G (2007) Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study. Lancet 370:1915–1922 CASPubMed Google Scholar
Addolorato G, Mirijello A, Leggio L (2013) Alcohol addiction: toward a patient-oriented pharmacological treatment. Expert Opin Pharmacother 14:2157–2160 CASPubMedPubMed Central Google Scholar
Adinoff B, Martin PR, Bone GH, Eckardt MJ, Roehrich L, George DT, Moss HB, Eskay R, Linnoila M, Gold PW (1990) Hypothalamic-pituitary-adrenal axis functioning and cerebrospinal fluid corticotropin releasing hormone and corticotropin levels in alcoholics after recent and long-term abstinence. Arch Gen Psychiatry 47(4):325–330 CASPubMed Google Scholar
Adinoff B, Iranmanesh A, Veldhuis J, Fisher L (1998) Disturbances of the stress response: the role of the HPA axis during alcohol withdrawal and abstinence. Alcohol Health Res World 22(1):67–72 CASPubMed Google Scholar
Alaux-Cantin S, Buttolo R, Houchi H, Jeanblanc J, Naassila M (2015) Memantine reduces alcohol drinking but not relapse in alcohol-dependent rats. Addict Biol 20(5):890–901 CASPubMed Google Scholar
Alén F, Orio L, Gorriti MÁ, de Heras RG, Ramírez-López MT, Pozo MÁ, de Fonseca FR (2013) Increased alcohol consumption in rats after subchronic antidepressant treatment. Int J Neuropsychopharmacol 16(8):1809–1818 PubMed Google Scholar
Anderberg RH, Richard JE, Hansson C, Nissbrandt H, Bergquist F, Skibicka KP (2016) GLP-1 is both anxiogenic and antidepressant; divergent effects of acute and chronic GLP-1 on emotionality. Psychoneuroendocrinology 65:54–66 CASPubMed Google Scholar
Anderzhanova E, Kirmeier T, Wotjak CT (2017) Animal models in psychiatric research: the RDoC system as a new framework for endophenotype-oriented translational neuroscience. Neurobiol Stress 7:47–56 PubMedPubMed Central Google Scholar
Anthenelli RM, Heffner JL, Wong E, Tibbs J, Russell K, Isgro M, Dinh E, Wehrle C, Worley MJ, Doran N (2017) A randomized trial evaluating whether topiramate aids smoking cessation and prevents alcohol relapse in recovering alcohol-dependent men. Alcohol Clin Exp Res 41(1):197–206 CASPubMed Google Scholar
Anton RF, Pettinati H, Zweben A, Kranzler HR, Johnson B, Bohn MJ, McCaul ME, Anthenelli R, Salloum I, Galloway G, Garbutt J, Swift R, Gastfriend D, Kallio A, Karhuvaara S (2004) A multi-site dose ranging study of nalmefene in the treatment of alcohol dependence. J Clin Psychopharmacol 24(4):421–428 CASPubMed Google Scholar
Anton RF, O’Malley SS, Ciraulo DA, Cisler RA, Couper D, Donovan DM, Gastfriend DR, Hosking JD, Johnson BA, LoCastro JS, Longabaugh R, Mason BJ, Mattson ME, Miller WR, Pettinati HM, Randall CL, Swift R, Weiss RD, Williams LD, Zweben A (2006) Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial. JAMA 295:2003–2017 CASPubMed Google Scholar
Anton RF, Kranzler H, Breder C, Marcus RN, Carson WH, Han J (2008a) A randomized, multicenter, double-blind, placebo-controlled study of the efficacy and safety of aripiprazole for the treatment of alcohol dependence. J Clin Psychopharmacol 28:5–12 CASPubMed Google Scholar
Anton RF, Oroszi G, O’Malley S, Couper D, Swift R, Pettinati H, Goldman D (2008b) An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry 65(2):135–144 CASPubMedPubMed Central Google Scholar
Arias A, Feinn R, Oncken C, Covault J, Kranzler HR (2010) Placebo-controlled trial of zonisamide for the treatment of alcohol dependence. J Clin Psychopharmacol 30:318–322 CASPubMedPubMed Central Google Scholar
Aujla H, Cannarsa R, Romualdi P, Ciccocioppo R, Martin-Fardon R, Weiss F (2013) Modification of anxiety-like behaviors by nociceptin/orphanin FQ (N/OFQ) and time-dependent changes in N/OFQ-NOP gene expression following ethanol withdrawal. Addict Biol 18(3):467–479 CASPubMed Google Scholar
Bachteler D, Economidou D, Danysz W, Ciccocioppo R, Spanagel R (2005) The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat. Neuropsychopharmacology 30:1104–1110 CASPubMed Google Scholar
Baltieri DA, Daró FR, Ribeiro PL, de Andrade AG (2008) Comparing topiramate with naltrexone in the treatment of alcohol dependence. Addiction 103(12):2035–2044 PubMed Google Scholar
Bartha PFA (2010) By parallel reasoning: the construction and evaluation of analogical arguments. Oxford University Press, New York Google Scholar
Bartlett S, Heilig M (2013) Translational approaches to medication development. Curr Top Behav Neurosci 13:543–582 CASPubMed Google Scholar
Beardsley PM, Lopez OT, Gullikson G, Flynn D (1994) Serotonin 5-HT3 antagonists fail to affect ethanol self-administration of rats. Alcohol 11:389–395 CASPubMed Google Scholar
Bell RL, Lopez MF, Cui C, Egli M, Johnson KW, Franklin KM, Becker HC (2015) Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence. Addict Biol 20(1):38–42 CASPubMed Google Scholar
Bender S, Scherbaum N, Soyka M, Rüther E, Mann K, Gastpar M (2007) The efficacy of the dopamine D2/D3 antagonist tiapride in maintaining abstinence: a randomized, double-blind, placebo-controlled trial in 299 alcohol-dependent patients. Int J Neuropsychopharmacol 10(5):653–660 CASPubMed Google Scholar
Besheer J, Lepoutre V, Hodge CW (2004) GABAB receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice. Psychopharmacology 174:358–366 CASPubMed Google Scholar
Besheer J, Frisbee S, Randall PA, Jaramillo AA, Masciello M (2016) Gabapentin potentiates sensitivity to the interoceptive effects of alcohol and increases alcohol self-administration in rats. Neuropharmacology 101:216–224 CASPubMed Google Scholar
Blaine SK, Sinha R (2017) Alcohol, stress, and glucocorticoids: from risk to dependence and relapse in alcohol use disorders. Neuropharmacology 122:136–147 CASPubMedPubMed Central Google Scholar
Blednov YA, Benavidez JM, Black M, Harris RA (2014) Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice. Front Neurosci 8:129 PubMedPubMed Central Google Scholar
Boismare F, Daoust M, Moore N, Saligaut C, Lhuintre JP, Chretien P, Durlach J (1984) A homotaurine derivative reduces the voluntary intake of ethanol by rats: are cerebral GABA receptors involved? Pharmacol Biochem Behav 21(5):787–789 CASPubMed Google Scholar
Boyle AE, Stewart RB, Macenski MJ, Spiga R, Johnson BA, Meisch RA (1998) Effects of acute and chronic doses of naltrexone on ethanol self-administration in rhesus monkeys. Alcohol Clin Exp Res 22(2):359–366 CASPubMed Google Scholar
Breslin FJ, Johnson BA, Lynch WJ (2010) Effect of topiramate treatment on ethanol consumption in rats. Psychopharmacology 207:529–534 CASPubMed Google Scholar
Bruijnzeel AW, Small E, Pasek TM, Yamada H (2010) Corticotropin-releasing factor mediates the dysphoria-like state associated with alcohol withdrawal in rats. Behav Brain Res 210(2):288–291 CASPubMedPubMed Central Google Scholar
Cherry JA, Davis RL (1999) Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect. J Comp Neurol 407:287–301 CASPubMed Google Scholar
Chick J, Aschauer H, Hornik K, Investigators Group (2004) Efficacy of fluvoxamine in preventing relapse in alcohol dependence: a one-year, double-blind, placebo-controlled multicentre study with analysis by typology. Drug Alcohol Depend 74(1):61–70 CASPubMed Google Scholar
Chu K, Koob GF, Cole M, Zorrilla EP, Roberts AJ (2007) Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout. Pharmacol Biochem Behav 86(4):813–821 CASPubMedPubMed Central Google Scholar
Ciccocioppo R, Panocka I, Polidori C, Regoli D, Massi M (1999) Effect of nociceptin on alcohol intake in alcohol-preferring rats. Psychopharmacology 141(2):220–224 CASPubMed Google Scholar
Ciccocioppo R, Polidori C, Antonelli L, Salvadori S, Guerrini R, Massi M (2002) Pharmacological characterization of the nociceptin receptor which mediates reduction of alcohol drinking in rats. Peptides 23(1):117–125 CASPubMed Google Scholar
Ciccocioppo R, Economidou D, Fedeli A, Angeletti S, Weiss F, Heilig M, Massi M (2004) Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats. Psychopharmacology 172(2):170–178 CASPubMed Google Scholar
Ciccocioppo R, Economidou D, Rimondini R, Sommer W, Massi M, Heilig M (2007) Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system. Biol Psychiatry 61(1):4–12 CASPubMed Google Scholar
Ciccocioppo R, Stopponi S, Economidou D, Kuriyama M, Kinoshita H, Heilig M, Roberto M, Weiss F, Teshima K (2014) Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat. Neuropsychopharmacology 39(11):2601–2610 CASPubMedPubMed Central Google Scholar
Cifani C, Guerrini R, Massi M, Polidori C (2006) Chronic intracerebroventricular infusion of nociceptin/orphanin FQ increases food and ethanol intake in alcohol-preferring rats. Peptides 27(11):2803–2810 CASPubMed Google Scholar
Cohen C, Perrault G, Sanger DJ (1998) Preferential involvement of D3 versus D2 dopamine receptors in the effects of dopamine receptor ligands on oral ethanol self-administration in rats. Psychopharmacology 140(4):478–485 CASPubMed Google Scholar
Coleman LG, Crews FT (2018) Innate immune signaling and alcohol use disorders. Handb Exp Pharmacol (in press) Google Scholar
Colombo G, Serra S, Brunetti G, Vacca G, Carai MA, Gessa GL (2003) Suppression by baclofen of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats. Drug Alcohol Depend 70:105–108 CASPubMed Google Scholar
Correia D, Martynhak BJ, Pereira M, Siba IP, Ribeiro AF, Camarini R, Boerngen-Lacerda R (2015) Reduction of ethanol intake by corticotropin-releasing factor receptor-1 antagonist in “heavy-drinking” mice in a free-choice paradigm. Psychopharmacology 232(15):2731–2739 CASPubMed Google Scholar
Crabbe JC, Wahlsten D, Dudek BC (1999) Genetics of mouse behavior: interactions with laboratory environment. Science 284(5420):1670–1672 CASPubMed Google Scholar
Crabbe JC, Ozburn AR, Metten P, Barkley-Levenson A, Schlumbohm JP, Spence SE, Hack WR, Huang LC (2017) High Drinking in the Dark (HDID) mice are sensitive to the effects of some clinically relevant drugs to reduce binge-like drinking. Pharmacol Biochem Behav 160:55–62 CASPubMedPubMed Central Google Scholar
Crews FT, Lawrimore CJ, Walter TJ, Coleman LG Jr (2017) The role of neuroimmune signaling in alcoholism. Neuropharmacology 122:56–73 CASPubMedPubMed Central Google Scholar
Cruz MT, Herman MA, Kallupi M, Roberto M (2012) Nociceptin/orphanin FQ blockade of corticotropin-releasing factor-induced gamma-aminobutyric acid release in central amygdala is enhanced after chronic ethanol exposure. Biol Psychiatry 71:666–676 CASPubMed Google Scholar
Cservenka A, Courtney KE, Ghahremani DG, Hutchison KE, Ray LA (2017a) Development, initial testing and challenges of an ecologically valid reward prediction error fMRI task for alcoholism. Alcohol Alcohol 52(5):617–624 PubMedPubMed Central Google Scholar
Cservenka A, Yardley MM, Ray LA (2017b) Review: pharmacogenetics of alcoholism treatment: implications of ethnic diversity. Am J Addict 26(5):516–525 PubMed Google Scholar
Dautzenberg FM, Wichmann J, Higelin J, Py-Lang G, Kratzeisen C, Malherbe P, Kilpatrick GJ, Jenck F (2001) Pharmacological characterization of the novel nonpeptide orphanin FQ/nociceptin receptor agonist Ro 64–6198: rapid and reversible desensitization of the ORL1 receptor in vitro and lack of tolerance in vivo. J Pharmacol Exp Ther 298(2):812–819 CASPubMed Google Scholar
Dayas CV, Liu X, Simms JA, Weiss F (2007) Distinct patterns of neural activation associated with ethanol seeking: effects of naltrexone. Biol Psychiatry 61(8):979–989 CASPubMed Google Scholar
de Bejczy A, Löf E, Walther L, Guterstam J, Hammarberg A, Asanovska G, Franck J, Isaksson A, Söderpalm B (2015) Varenicline for treatment of alcohol dependence: a randomized, placebo-controlled trial. Alcohol Clin Exp Res 39(11):2189–2199 PubMed Google Scholar
de Guglielmo G, Martin-Fardon R, Teshima K, Ciccocioppo R, Weiss F (2015) MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats. Addict Biol 20(4):643–651 PubMed Google Scholar
Doetkotte R, Opitz K, Kiianmaa K, Winterhoff H (2005) Reduction of voluntary ethanol consumption in alcohol-preferring Alko alcohol (AA) rats by desoxypeganine and galanthamine. Eur J Pharmacol 522(1–3):72–77 CASPubMed Google Scholar
Dongier M, Vachon L, Schwartz G (1991) Bromocriptine in the treatment of alcohol dependence. Alcohol Clin Exp Res 15(6):970–977 CASPubMed Google Scholar
Donoghue K, Rose A, Coulton S, Milward J, Reed K, Drummond C, Little H (2016) Double-blind, 12 month follow-up, placebo-controlled trial of mifepristone on cognition in alcoholics: the MIFCOG trial protocol. BMC Psychiatry 16:40 PubMedPubMed Central Google Scholar
Duke AN, Kaminski BJ, Weerts EM (2014) Baclofen effects on alcohol seeking, self-administration and extinction of seeking responses in a within-session design in baboons. Addict Biol 19(1):16–26 CASPubMed Google Scholar
Dundon W, Lynch KG, Pettinati HM, Lipkin C (2004) Treatment outcomes in type A and B alcohol dependence 6 months after serotonergic pharmacotherapy. Alcohol Clin Exp Res 28(7):1065–1073 CASPubMedPubMed Central Google Scholar
Duzzioni M, Duarte FS, Leme LR, Gavioli EC, De Lima TC (2011) Anxiolytic-like effect of central administration of NOP receptor antagonist UFP-101 in rats submitted to the elevated T-maze. Behav Brain Res 222(1):206–211 CASPubMed Google Scholar
Economidou D, Fedeli A, Fardon RM, Weiss F, Massi M, Ciccocioppo R (2006) Effect of novel nociceptin/orphanin FQ-NOP receptor ligands on ethanol drinking in alcohol-preferring msP rats. Peptides 27(12):3299–3306 CASPubMedPubMed Central Google Scholar
Economidou D, Hansson AC, Weiss F, Terasmaa A, Sommer WH, Cippitelli A, Fedeli A, Martin-Fardon R, Massi M, Ciccocioppo R, Heilig M (2008) Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat. Biol Psychiatry 64(3):211–218 CASPubMedPubMed Central Google Scholar
Economidou D, Cippitelli A, Stopponi S, Braconi S, Clementi S, Ubaldi M, Martin-Fardon R, Weiss F, Massi M, Ciccocioppo R (2011) Activation of brain NOP receptors attenuates acute and protracted alcohol withdrawal symptoms in the rat. Alcohol Clin Exp Res 35(4):747–755 CASPubMedPubMed Central Google Scholar
Edwards S, Koob GF (2010) Neurobiology of dysregulated motivational systems in drug addiction. Future Neurol 5(3):393–401 CASPubMedPubMed Central Google Scholar
Edwards S, Guerrero M, Ghoneim OM, Roberts E, Koob GF (2012) Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. Addict Biol 17(1):76–85 CASPubMed Google Scholar
Edwards S, Little HJ, Richardson HN, Vendruscolo LF (2015) Divergent regulation of distinct glucocorticoid systems in alcohol dependence. Alcohol 49(8):811–816 CASPubMedPubMed Central Google Scholar
Egecioglu E, Steensland P, Fredriksson I, Feltmann K, Engel JA, Jerlhag E (2013) The glucagon-like peptide 1 analogue Exendin-4 attenuates alcohol mediated behaviors in rodents. Psychoneuroendocrinology 38(8):1259–1270 CASPubMed Google Scholar
Egli M (2005) Can experimental paradigms and animal models be used to discover clinically effective medications for alcoholism? Addict Biol 10(4):309–319 CASPubMed Google Scholar
Egli M, Koob GF, Edwards S (2012) Alcohol dependence as a chronic pain disorder. Neurosci Biobehav Rev 36(10):2179–2192 PubMedPubMed Central Google Scholar
Egli M, White DA, Acri JB (2016) Considerations in the evaluation of potential efficacy of medications for alcohol and drug use disorders: an editorial. Int Rev Neurobiol 126:1–14 CASPubMed Google Scholar
Eisenhardt M, Hansson AC, Spanagel R, Bilbao A (2015) Chronic intermittent ethanol exposure in mice leads to an up-regulation of CRH/CRHR1 signaling. Alcohol Clin Exp Res 39(4):752–762 CASPubMed Google Scholar
Evans SM, Levin FR, Brooks DJ, Garawi F (2007) A pilot double-blind treatment trial of memantine for alcohol dependence. Alcohol Clin Exp Res 31(5):775–782 CASPubMed Google Scholar
Fahlke C, Eriksson CJ (2000) Effect of adrenalectomy and exposure to corticosterone on alcohol intake in alcohol-preferring and alcohol-avoiding rat lines. Alcohol Alcohol 35(2):139–144 CASPubMed Google Scholar
Fahlke C, Engel JA, Eriksson CJ, Hård E, Söderpalm B (1994) Involvement of corticosterone in the modulation of ethanol consumption in the rat. Alcohol 11(3):195–202 CASPubMed Google Scholar
Farook JM, Lewis B, Littleton JM, Barron S (2009) Topiramate attenuates the stress-induced increase in alcohol consumption and preference in male C57BL/6J mice. Physiol Behav 96(1):189–193 CASPubMed Google Scholar
Fawcett J, Kravitz HM, McGuire M, Easton M, Ross J, Pisani V, Fogg LF, Clark D, Whitney M, Kravitz G, Javaid J, Teas G (2000) Pharmacological treatments for alcoholism: revisiting lithium and considering buspirone. Alcohol Clin Exp Res 24(5):666–674 CASPubMed Google Scholar
Fertig JB, Ryan ML, Falk DE, Litten RZ, Mattson ME, Ransom J, Rickman WJ, Scott C, Ciraulo D, Green AI, Tiouririne NA, Johnson B, Pettinati H, Strain EC, Devine E, Brunette MF, Kampman K, Tompkins DA, Stout R, NCIG 002 Study Group (2012) A double-blind, placebo-controlled trial assessing the efficacy of levetiracetam extended-release in very heavy drinking alcohol-dependent patients. Alcohol Clin Exp Res 36(8):1421–1430 CASPubMedPubMed Central Google Scholar
Fish EW, Agoglia AE, Krouse MC, Muller RG, Robinson JE, Malanga CJ (2014) Levetiracetam results in increased and decreased alcohol drinking with different access procedures in C57BL/6J mice. Behav Pharmacol 25(1):61–70 CASPubMed Google Scholar
Fleischhacker WW, Hinterhuber H, Bauer H, Pflug B, Berner P, Simhandl C, Wolf R, Gerlach W, Jaklitsch H, Sastre-y-Hernandez M (1992) A multicenter double-blind study of three different doses of the new cAMP-phosphodiesterase inhibitor rolipram in patients with major depressive disorder. Neuropsychobiology 26:59–64 CASPubMed Google Scholar
Franklin KM, Hauser SR, Lasek AW, McClintick J, Ding ZM, McBride WJ, Bell RL (2015) Reduction of alcohol drinking of alcohol-preferring (P) and high-alcohol drinking (HAD1) rats by targeting phosphodiesterase-4 (PDE4). Psychopharmacology 232(13):2251–2262 CASPubMedPubMed Central Google Scholar
Froehlich JC, Harts J, Lumeng L, Li T-K (1990) Naloxone attenuates voluntary ethanol intake in rats selectively bred for high ethanol preference. Pharmacol Biochem Behav 35:385–390 CASPubMed Google Scholar
Froehlich JC, Nicholson ER, Dilley JE, Filosa NJ, Rademacher LC, Smith TN (2017) Varenicline reduces alcohol intake during repeated cycles of alcohol reaccess following deprivation in alcohol-preferring (P) rats. Alcohol Clin Exp Res 41(8):1510–1517 CASPubMedPubMed Central Google Scholar
Funk CK, O’Dell LE, Crawford EF, Koob GF (2006) Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats. J Neurosci 26(44):11324–11332 CASPubMed Google Scholar
Funk D, Lo S, Coen K, Lê AD (2016) Effects of varenicline on operant self-administration of alcohol and/or nicotine in a rat model of co-abuse. Behav Brain Res 296:157–162 CASPubMed Google Scholar
Furieri FA, Nakamura-Palacios EM (2007) Gabapentin reduces alcohol consumption and craving: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry 68(11):1691–1700 CASPubMed Google Scholar
Garbutt JC, Kampov-Polevoi AB, Gallop R, Kalka-Juhl L, Flannery BA (2010) Efficacy and safety of baclofen for alcohol dependence: a randomized, double-blind, placebo-controlled trial. Alcohol Clin Exp Res 34:1849–1857 CASPubMedPubMed Central Google Scholar
Gavioli EC, Calò G (2013) Nociceptin/orphanin FQ receptor antagonists as innovative antidepressant drugs. Pharmacol Ther 140(1):10–25 CASPubMed Google Scholar
Gehlert DR, Cippitelli A, Thorsell A, Lê AD, Hipskind PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Ciccocioppo R, Heilig M (2007) 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo [1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism. J Neurosci 27(10):2718–2726 CASPubMed Google Scholar
George DT, Rawlings R, Eckardt MJ, Phillips MJ, Shoaf SE, Linnoila M (1999) Buspirone treatment of alcoholism: age of onset, and cerebrospinal fluid 5-hydroxyindolacetic acid and homovanillic acid concentrations, but not medication treatment, predict return to drinking. Alcohol Clin Exp Res 23:272–278 CASPubMed Google Scholar
George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF (2012) Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proc Natl Acad Sci 109(44):18156–18161 CASPubMed Google Scholar
Gondré-Lewis MC, Warnock KT, Wang H, June HL Jr, Bell KA, Rabe H, Tiruveedhula VV, Cook J, Lüddens H, Aurelian L, June HL Sr (2016) Early life stress is a risk factor for excessive alcohol drinking and impulsivity in adults and is mediated via a CRF/GABA(A) mechanism. Stress 19(2):235–247 PubMedPubMed Central Google Scholar
Gong MF, Wen RT, Xu Y, Pan JC, Fei N, Zhou YM, Xu JP, Liang JH, Zhang HT (2017) Attenuation of ethanol abstinence-induced anxiety- and depressive-like behavior by the phosphodiesterase-4 inhibitor rolipram in rodents. Psychopharmacology 234(20):3143–3151. https://doi.org/10.1007/s00213-017-4697-3 ArticleCASPubMed Google Scholar
Gu G, Roland B, Tomaselli K, Dolman CS, Lowe C, Heilig JS (2013) Glucagon-like peptide-1 in the rat brain: distribution of expression and functional implication. J Comp Neurol 521(10):2235–2261 CASPubMed Google Scholar
Gubner NR, McKinnon CS, Phillips TJ (2014) Effects of varenicline on ethanol-induced conditioned place preference, locomotor stimulation, and sensitization. Alcohol Clin Exp Res 38(12):3033–3042 CASPubMedPubMed Central Google Scholar
Hansson AC, Cippitelli A, Sommer WH, Fedeli A, Björk K, Soverchia L, Terasmaa A, Massi M, Heilig M, Ciccocioppo R (2006) Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress. Proc Natl Acad Sci 103(41):15236–15241 CASPubMed Google Scholar
Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE (2017) Genetic and pharmacologic manipulation of TLR4 has minimal impact on ethanol consumption in rodents. J Neurosci 37(5):1139–1155 CASPubMedPubMed Central Google Scholar
Hedlund L, Wahlström G (1996) Buspirone as an inhibitor of voluntary ethanol intake in male rats. Alcohol Alcohol 31(2):149–156 CASPubMed Google Scholar
Hedlund L, Wahlström G (1999) Acute and long term effects of buspirone treatments on voluntary ethanol intake in a rat model of alcoholism. Alcohol Clin Exp Res 23(5):822–827 CASPubMed Google Scholar
Heilig M, Leggio L (2016) What the alcohol doctor ordered from the neuroscientist: theragnostic biomarkers for personalized treatments. Prog Brain Res 224:401–418 PubMed Google Scholar
Heilig M, Goldman D, Berrettini W, O’Brien CP (2011) Pharmacogenetic approaches to the treatment of alcohol addiction. Nat Rev Neurosci 12(11):670–684 CASPubMedPubMed Central Google Scholar
Heilig M, Sommer WH, Spanagel R (2016) The need for treatment responsive translational biomarkers in alcoholism research. Curr Top Behav Neurosci 28:151–171 CASPubMed Google Scholar
Helms CM, McClintick MN, Grant KA (2012) Social rank, chronic ethanol self-administration, and diurnal pituitary-adrenal activity in cynomolgus monkeys. Psychopharmacology 224(1):133–143 CASPubMedPubMed Central Google Scholar
Hempel CG (1965) Aspects of scientific explanation. In: Aspects of scientific explanation and other essays in the philosophy of science. Free Press, New York, pp 331–496 Google Scholar
Hesse MB (1966) Models and analogies in science. University of Notre Dame Press, Notre Dame Google Scholar
Heyser CJ, Moc K, Koob GF (2003) Effects of naltrexone alone and in combination with acamprosate on the alcohol deprivation effect in rats. Neuropsychopharmacology 28:1463–1471 CASPubMed Google Scholar
Hoel EP, Albantakis L, Tononi G (2013) Quantifying causal emergence shows that macro can beat micro. Proc Natl Acad Sci U S A 110(49):19790–19795 CASPubMedPubMed Central Google Scholar
Hölter SM, Danysz W, Spanagel R (1996) Evidence for alcohol anti-craving properties of memantine. Eur J Pharmacol 314(3):R1–R2 PubMed Google Scholar
Hu W, Lu T, Chen A, Huang Y, Hansen R, Chandler LJ, Zhang HT (2011) Inhibition of phosphodiesterase-4 decreases ethanol intake in mice. Psychopharmacology 218:331–339 CASPubMedPubMed Central Google Scholar
Hwa LS, Debold JF, Miczek KA (2013) Alcohol in excess: CRF1 receptors in the rat and mouse VTA and DRN. Psychopharmacology 225(2):313–327 CASPubMed Google Scholar
Ingman K, Kupila J, Hyytiä P, Korpi ER (2006) Effects of aripiprazole on alcohol intake in an animal model of high-alcohol drinking. Alcohol Alcohol 41(4):391–398 CASPubMed Google Scholar
Jacquot C, Croft AP, Prendergast MA, Mulholland P, Shaw SG, Little HJ (2008) Effects of the glucocorticoid antagonist, mifepristone, on the consequences of withdrawal from long term alcohol consumption. Alcohol Clin Exp Res 32(12):2107–2116 CASPubMed Google Scholar
Jaeger RG, Halliday TR (1998) On confirmatory versus exploratory research. Herpetologica 54:S64–S66 Google Scholar
Johnson BA, Jasinski DR, Galloway GP, Kranzler H, Weinreib R, Anton RF, Mason BJ, Bohn MJ, Pettinati HM, Rawson R, Clyde C (1996) Ritanserin in the treatment of alcohol dependence – a multi-center clinical trial. Ritanserin Study Group. Psychopharmacology 128(2):206–215 CASPubMed Google Scholar
Johnson BA, Roache JD, Javors MA, DiClemente CC, Cloninger CR, Prihoda TJ, Bordnick PS, Ait-Daoud N, Hensler J (2000) Ondansetron for reduction of drinking among biologically predisposed alcoholic patients: a randomized controlled trial. JAMA 284:963–971 CASPubMed Google Scholar
Johnson BA, Ait-Daoud N, Bowden CL, DiClemente CC, Roache JD, Lawson K, Javors MA, Ma JZ (2003) Oral topiramate for treatment of alcohol dependence: a randomised controlled trial. Lancet 361:1677–1685 CASPubMed Google Scholar
Johnson BA, Rosenthal N, Capece JA, Wiegand F, Mao L, Beyers K, McKay A, Ait-Daoud N, Anton RF, Ciraulo DA, Kranzler HR, Mann K, O’Malley SS, Swift R (2007) Topiramate for treating alcohol dependence: a randomized controlled trial. JAMA 298:1641–1651 CASPubMed Google Scholar
Johnson BA, Ait-Daoud N, Seneviratne C, Roache JD, Javors MA, Wang XQ, Liu L, Penberthy JK, DiClemente CC, Li MD (2011) Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking. Am J Psychiatry 168(3):265–275 PubMedPubMed Central Google Scholar
Jones JD, Comer SD, Kranzler HR (2015) The pharmacogenetics of alcohol use disorder. Alcohol Clin Exp Res 39(3):391–402 PubMedPubMed Central Google Scholar
June HL, Cummings R, Eiler WJA II, Foster KL, McKay PF, Seyoum R, Garcia M, McCane S, Grey C, Hawkins SE, Mason D (2004) Central opioid receptors differentially regulate the nalmefene-induced suppression of ethanol- and saccharin-reinforced behaviors in alcohol preferring (P) rats. Neuropsychopharmacology 29:285–299 CASPubMed Google Scholar
Kalin NH, Fox AS, Kovner R, Riedel MK, Fekete EM, Roseboom PH, Tromp DP, Grabow BP, Olsen ME, Brodsky EK, McFarlin DR, Alexander AL, Emborg ME, Block WF, Fudge JL, Oler JA (2016) Overexpressing corticotropin-releasing factor in the primate amygdala increases anxious temperament and alters its neural circuit. Biol Psychiatry 80:345–355 CASPubMedPubMed Central Google Scholar
Kallupi M, Scuppa G, de Guglielmo G, Calò G, Weiss F, Statnick MA, Rorick-Kehn LM, Ciccocioppo R (2017) Genetic deletion of the nociceptin/orphanin FQ receptor in the rat confers resilience to the development of drug addiction. Neuropsychopharmacology 42(3):695–706 CASPubMed Google Scholar
Kaminski BJ, Weerts EM (2014) The effects of varenicline on alcohol seeking and self-administration in baboons. Alcohol Clin Exp Res 38(2):376–383 CASPubMed Google Scholar
Kampman KM, Pettinati HM, Lynch KG, Whittingham T, Macfadden W, Dackis C, Tirado C, Oslin DW, Sparkman T, O’Brien CP (2007) A double-blind, placebo-controlled pilot trial of quetiapine for the treatment of type A and type B alcoholism. J Clin Psychopharmacol 27(4):344–351 CASPubMedPubMed Central Google Scholar
Kaye JT, Bradford DE, Magruder KP, Curtin JJ (2017) Probing for neuroadaptations to unpredictable stressors in addiction: translational methods and emerging evidence. J Stud Alcohol Drugs 78(3):353–371 PubMedPubMed Central Google Scholar
Kimmelman J, Mogil JS, Dirnagl U (2014) Distinguishing between exploratory and confirmatory preclinical research will improve translation. PLoS Biol 12(5):e1001863 PubMedPubMed Central Google Scholar
Kimpel MW, Strother WN, McClintick JN, Carr LG, Liang T, Edenberg HJ, McBride WJ (2007) Functional gene expression differences between inbred alcohol-preferring and-non-preferring rats in five brain regions. Alcohol 41(2):95–132 CASPubMedPubMed Central Google Scholar
Knapp CM, Mercado M, Markley T, Crosby S, Ciraulo DA, Kornetsky C (2007) Zonisamide decreases ethanol intake in rats and mice. Pharmacol Biochem Behav 87:65–72 CASPubMedPubMed Central Google Scholar
Knapp CM, Ciraulo DA, Sarid-Segal O, Richardson MA, Devine E, Streeter CC, Oscar-Berman M, Surprise C, Colaneri L, Putnam M, Waters M, Richambault C (2015) Zonisamide, topiramate, and levetiracetam: efficacy and neuropsychological effects in alcohol use disorders. J Clin Psychopharmacol 35(1):34–42 CASPubMed Google Scholar
Koenig HN, Olive MF (2004) The glucocorticoid receptor antagonist mifepristone reduces ethanol intake in rats under limited access conditions. Psychoneuroendocrinology 29(8):999–1003 CASPubMed Google Scholar
Koob GF (2016) Corticotropin-releasing factor from rodents to primates: translational hope expresses itself, pun intended. Biol Psychiatry 80(5):340–342 CASPubMedPubMed Central Google Scholar
Koob GF, Zimmer A (2012) Animal models of psychiatric disorders. Handb Clin Neurol 106:137–166 PubMed Google Scholar
Koob GF, Zorrilla EP (2012) Update on corticotropin-releasing factor pharmacotherapy for psychiatric disorders: a revisionist view. Neuropsychopharmacology 37(1):308–309 CASPubMed Google Scholar
Koob GF, Kenneth Lloyd G, Mason BJ (2009) Development of pharmacotherapies for drug addiction: a Rosetta stone approach. Nat Rev Drug Discov 8(6):500–515 CASPubMedPubMed Central Google Scholar
Kranzler HR, Burleson JA, Del Boca FK, Babor TF, Korner P, Brown J, Bohn MJ (1994) Buspirone treatment of anxious alcoholics. A placebo-controlled trial. Arch Gen Psychiatry 51(9):720–731 CASPubMed Google Scholar
Kranzler HR, Burleson JA, Korner P, Del Boca FK, Bohn MJ, Brown J, Liebowitz N (1995) Placebo-controlled trial of fluoxetine as an adjunct to relapse prevention in alcoholics. Am J Psychiatry 152(3):391–397 CASPubMed Google Scholar
Krystal JH, Cramer JA, Krol WF, Kirk GF, Rosenheck RA, Veterans Affairs Naltrexone Cooperative Study 425 Group (2001) Naltrexone in the treatment of alcohol dependence. N Engl J Med 345(24):1734–1739 CASPubMed Google Scholar
Kuzmin A, Sandin J, Terenius L, Ogren SO (2003) Acquisition, expression, and reinstatement of ethanol-induced conditioned place preference in mice: effects of opioid receptor-like 1 receptor agonists and naloxone. J Pharmacol Exp Ther 304(1):310–318 CASPubMed Google Scholar
Kuzmin A, Kreek MJ, Bakalkin G, Liljequist S (2007) The nociceptin/orphanin FQ receptor agonist Ro 64-6198 reduces alcohol self-administration and prevents relapse-like alcohol drinking. Neuropsychopharmacology 32(4):902–910 CASPubMed Google Scholar
Kuzmin A, Bazov I, Sheedy D, Garrick T, Harper C, Bakalkin G (2009) Expression of pronociceptin and its receptor is downregulated in the brain of human alcoholics. Brain Res 1305(Suppl):S80–S85 CASPubMedPubMed Central Google Scholar
Kwako LE, Spagnolo PA, Schwandt ML, Thorsell A, George DT, Momenan R, Rio DE, Huestis M, Anizan S, Concheiro M, Sinha R, Heilig M (2015) The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study. Neuropsychopharmacology 40(5):1053–1063 CASPubMed Google Scholar
Kwako LE, Momenan R, Grodin EN, Litten RZ, Koob GF, Goldman D (2017) Addictions neuroclinical assessment: a reverse translational approach. Neuropharmacology 122:254–264 CASPubMedPubMed Central Google Scholar
Lamb RJ, Järbe TU (2001) Effects of fluvoxamine on ethanol-reinforced behavior in the rat. J Pharmacol Exp Ther 297(3):1001–1009 CASPubMed Google Scholar
Lawford BR, Young RM, Rowell JA, Qualichefski J, Fletcher BH, Syndulko K, Ritchie T, Noble EP (1995) Bromocriptine in the treatment of alcoholics with the D2 dopamine receptor A1 allele. Nat Med 1(4):337–341 CASPubMed Google Scholar
Le Magnen J, Tran G, Durlach J, Martin C (1987) Dose-dependent suppression of the high alcohol intake of chronically intoxicated rats by Ca-acetyl homotaurinate. Alcohol 4(2):97–102 PubMed Google Scholar
Lê AD, Poulos CX, Harding S, Watchus J, Juzytsch W, Shaham Y (1999) Effects of naltrexone and fluoxetine on alcohol self-administration and reinstatement of alcohol seeking induced by priming injections of alcohol and exposure to stress. Neuropsychopharmacology 21(3):435–344 PubMed Google Scholar
Lê AD, Funk D, Harding S, Juzytsch W, Fletcher PJ, Shaham Y (2006) Effects of dexfenfluramine and 5-HT3 receptor antagonists on stress-induced reinstatement of alcohol seeking in rats. Psychopharmacology 186:82–92 PubMed Google Scholar
Lê AD, Funk D, Coen K, Li Z, Shaham Y (2013) Role of corticotropin-releasing factor in the median raphe nucleus in yohimbine-induced reinstatement of alcohol seeking in rats. Addict Biol 18(3):448–451 PubMed Google Scholar
Lee S, Rivier C (1997) An initial, three-day-long treatment with alcohol induces a long-lasting phenomenon of selective tolerance in the activity of the rat hypothalamic-pituitary-adrenal axis. J Neurosci 17(22):8856–8866 CASPubMed Google Scholar
Leggio L, Zywiak WH, Edwards SM, Tidey JW, Swift RM, Kenna GA (2015) A preliminary double-blind, placebo-controlled randomized study of baclofen effects in alcoholic smokers. Psychopharmacology 232(1):233–243 CASPubMed Google Scholar
Likhitsathian S, Uttawichai K, Booncharoen H, Wittayanookulluk A, Angkurawaranon C, Srisurapanont M (2013) Topiramate treatment for alcoholic outpatients recently receiving residential treatment programs: a 12-week, randomized, placebo-controlled trial. Drug Alcohol Depend 133(2):440–446 CASPubMed Google Scholar
Litten RZ, Fertig JB, Falk DE, Ryan ML, Mattson ME, Collins JF, Murtaugh C, Ciraulo D, Green AI, Johnson B, Pettinati H, Swift R, Afshar M, Brunette MF, Tiouririne NA, Kampman K, Stout R, NCIG 001 Study Group (2012) A double-blind, placebo-controlled trial to assess the efficacy of quetiapine fumarate XR in very heavy-drinking alcohol-dependent patients. Alcohol Clin Exp Res 36(3):406–416 CASPubMed Google Scholar
Litten RZ, Castle IJ, Falk D, Ryan M, Fertig J, Chen CM, Yi HY (2013a) The placebo effect in clinical trials for alcohol dependence: an exploratory analysis of 51 naltrexone and acamprosate studies. Alcohol Clin Exp Res 37(12):2128–2137 CASPubMed Google Scholar
Litten RZ, Ryan ML, Fertig JB, Falk DE, Johnson B, Dunn KE, Green AI, Pettinati HM, Ciraulo DA, Sarid-Segal O, Kampman K, Brunette MF, Strain EC, Tiouririne NA, Ransom J, Scott C, Stout R, NCIG (2013b) A double-blind, placebo-controlled trial assessing the efficacy of varenicline tartrate for alcohol dependence. J Addict Med 7:277–286 CASPubMedPubMed Central Google Scholar
Litten RZ, Ryan ML, Falk DE, Reilly M, Fertig JB, Koob GF (2015) Heterogeneity of alcohol use disorder: understanding mechanisms to advance personalized treatment. Alcohol Clin Exp Res 39(4):579–584 PubMed Google Scholar
Litten RZ, Wilford BB, Falk DE, Ryan ML, Fertig JB (2016) Potential medications for the treatment of alcohol use disorder: an evaluation of clinical efficacy and safety. Subst Abus 37(2):286–298 PubMed Google Scholar
Litten RZ, Falk DE, Ryan ML, Fertig J, Leggio L (2018) Advances in pharmacotherapy development: human clinical studies. Handb Exp Pharmacol (in press) Google Scholar
Little HJ, Croft AP, O’Callaghan MJ, Brooks SP, Wang G, Shaw SG (2008) Selective increases in regional brain glucocorticoid: a novel effect of chronic alcohol. Neuroscience 156(4):1017–1027 CASPubMed Google Scholar
Liu X, Weiss F (2002) Additive effect of stress and drug cues on reinstatement of ethanol seeking: exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms. J Neurosci 22(18):7856–7861 CASPubMed Google Scholar
Liu X, Hao PD, Yang MF, Sun JY, Mao LL, Fan CD, Zhang ZY, Li DW, Yang XY, Sun BL, Zhang HT (2017) The phosphodiesterase-4 inhibitor roflumilast decreases ethanol consumption in C57BL/6J mice. Psychopharmacology 234(16):2409–2419 CASPubMed Google Scholar
Logrip ML, Zorrilla EP (2012) Stress history increases alcohol intake in relapse: relation to phosphodiesterase 10A. Addict Biol 17:920–933 CASPubMedPubMed Central Google Scholar
Logrip ML, Zorrilla EP (2014) Differential changes in amygdala and frontal cortex Pde10a expression during acute and protracted withdrawal. Front Integr Neurosci 8:30 PubMedPubMed Central Google Scholar
Logrip ML, Vendruscolo LF, Schlosburg JE, Koob GF, Zorrilla EP (2014) Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats. Neuropsychopharmacology 39:1722–1731 CASPubMedPubMed Central Google Scholar
Lu YL, Richardson HN (2014) Alcohol, stress hormones, and the prefrontal cortex: a proposed pathway to the dark side of addiction. Neuroscience 277:139–151 CASPubMed Google Scholar
Lu SX, Higgins GA, Hodgson RA, Hyde LA, Del Vecchio RA, Guthrie DH, Kazdoba T, McCool MF, Morgan CA, Bercovici A, Ho GD, Tulshian D, Parker EM, Hunter JC, Varty GB (2011) The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8 azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): comparison of efficacy and side effects across rodent species. Eur J Pharmacol 661(1–3):63–71 CASPubMed Google Scholar
Lynch WJ, Bond C, Breslin FJ, Johnson BA (2011) Severity of drinking as a predictor of efficacy of the combination of ondansetron and topiramate in rat models of ethanol consumption and relapse. Psychopharmacology 217:3–12 CASPubMedPubMed Central Google Scholar
Maccioni P, Zaru A, Loi B, Lobina C, Carai MA, Gessa GL, Capra A, Mugnaini C, Pasquini S, Corelli F, Hyytiä P, Lumeng L, Colombo G (2012) Comparison of the effect of the GABAB receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in 3 different lines of alcohol-preferring rats. Alcohol Clin Exp Res 36(10):1748–1766 CASPubMedPubMed Central Google Scholar
Malcolm R, Anton RF, Randall CL, Johnston A, Brady K, Thevos A (1992) A placebo-controlled trial of buspirone in anxious inpatient alcoholics. Alcohol Clin Exp Res 16(6):1007–1013 CASPubMed Google Scholar
Malec E, Malec T, Gagné MA, Dongier M (1996) Buspirone in the treatment of alcohol dependence: a placebo-controlled trial. Alcohol Clin Exp Res 20(2):307–312 CASPubMed Google Scholar
Malpass GE, Williams HL, McMillen BA (2010) Effects of the non-competitive NMDA receptor antagonist memantine on the volitional consumption of ethanol by alcohol-preferring rats. Basic Clin Pharmacol Toxicol 106(5):435–444 CASPubMed Google Scholar
Mann K, Ackermann K, Diehl A, Ebert D, Mundle G, Nakovics H, Reker T, Richter G, Schmidt LG, Driessen M, Rettig K, Opitz K, Croissant B (2006) Galantamine: a cholinergic patch in the treatment of alcoholism: a randomized, placebo-controlled trial. Psychopharmacology 184(1):115–121 CASPubMed Google Scholar
Mann K, Torup L, Sørensen P, Gual A, Swift R, Walker B, van den Brink W (2016) Nalmefene for the management of alcohol dependence: review on its pharmacology, mechanism of action and meta-analysis on its clinical efficacy. Eur Neuropsychopharmacol 26(12):1941–1949 CASPubMed Google Scholar
Mardones J, Quintanilla ME (1996) Effects of bromocriptine on the voluntary consumption of ethanol, water, and solid food by UChA and UChB rats. Alcohol 13(4):355–357 CASPubMed Google Scholar
Marinelli PW, Funk D, Juzytsch W, Harding S, Rice KC, Shaham Y, Lê AD (2007) The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats. Psychopharmacology 195(3):345–355 CASPubMed Google Scholar
Martin-Fardon R, Ciccocioppo R, Massi M, Weiss F (2000) Nociceptin prevents stress-induced ethanol- but not cocaine-seeking behavior in rats. Neuroreport 11(9):1939–1943 CASPubMed Google Scholar
Mason BJ, Higley AE (2013) A translational approach to novel medication development for protracted abstinence. Curr Top Behav Neurosci 13:647–670 CASPubMed Google Scholar
Mason BJ, Quello S, Goodell V, Shadan F, Kyle M, Begovic A (2014) Gabapentin treatment for alcohol dependence: a randomized clinical trial. JAMA 174:70–77 CAS Google Scholar
Maurel S, De Vry J, De Beun R, Schreiber R (1999) 5-HT2A and 5-HT2C/5-HT1B receptors are differentially involved in alcohol preference and consummatory behavior in cAA rats. Pharmacol Biochem Behav 62(1):89–96 CASPubMed Google Scholar
McCaul ME, Wand GS, Weerts EM, Xu X (2017) A paradigm for examining stress effects on alcohol-motivated behaviors in participants with alcohol use disorder. Addict Biol. https://doi.org/10.1111/adb.12511
McGeehan AJ, Olive MF (2003) The anti-relapse compound acamprosate inhibits the development of a conditioned place preference to ethanol and cocaine but not morphine. Br J Pharmacol 138(1):9–12 CASPubMedPubMed Central Google Scholar
Meinhardt MW, Sommer WH (2015) Postdependent state in rats as a model for medication development in alcoholism. Addict Biol 20(1):1–21 PubMed Google Scholar
Meunier JC, Mollereau C, Toll L, Suaudeau C, Moisand C, Alvinerie P, Butour JL, Guillemot JC, Ferrara P, Monsarrat B, Mazarguil H, Vassart G, Parmentier G, Costentin J (1995) Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 377(6549):532–535 CASPubMed Google Scholar
Misra K, Pandey SC (2006) The decreased cyclic-AMP dependent protein kinase a function in the nucleus accumbens: a role in alcohol drinking but not in anxiety-like behaviors in rats. Neuropsychopharmacology 31:1406–1419 CASPubMed Google Scholar
Mitchell JM, Grossman LE, Coker AR, Messing RO (2012a) The anticonvulsant levetiracetam potentiates alcohol consumption in non-treatment seeking alcohol abusers. J Clin Psychopharmacol 32(2):269–272 CASPubMed Google Scholar
Mitchell JM, Teague CH, Kayser AS, Bartlett SE, Fields HL (2012b) Varenicline decreases alcohol consumption in heavy-drinking smokers. Psychopharmacology 223:299–306 CASPubMedPubMed Central Google Scholar
Möller C, Sommer W, Thorsell A, Rimondini R, Heilig M (2002) Anxiogenic-like action of centrally administered glucagon-like peptide-1 in a punished drinking test. Prog Neuro-Psychopharmacol Biol Psychiatry 26(1):119–122 Google Scholar
Müller CA, Geisel O, Petz P, Higl V, Kruger J, Stickel A, Beck A, Wernecke KD, Hellweg R, Heinz A (2015) High-dose baclofen for the treatment of alcohol dependence (BACLAD study): a randomized, placebo-controlled trial. Eur Neuropsychopharmacol 25:1167–1177 PubMed Google Scholar
Mulligan MK, Ponomarev I, Hitzemann RJ, Belknap JK, Tabakoff B, Harris RA, Crabbe JC, Blednov YA, Grahame NJ, Phillips TJ, Finn DA, Hoffman PL, Iyer VR, Koob GF, Bergeson SE (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proc Natl Acad Sci U S A 103:6368–6373 CASPubMedPubMed Central Google Scholar
Murphy NP (2010) The nociceptin/orphanin FQ system as a target for treating alcoholism. CNS Neurol Disord Drug Targets 9(1):87–93 CASPubMed Google Scholar
Murphy JM, Waller MB, Gatto GJ, McBride WJ, Lumeng L, Li T-K (1988) Effects of fluoxetine on the intragastric self-administration of ethanol in the alcohol preferring P line of rats. Alcohol 5:283–286 CASPubMed Google Scholar
Nadal R, Prat G, Pallarés M, Hernández-Torres M, Ferré N (1996) Effects of bromocriptine on self-administration of sweetened ethanol solutions in rats. Psychopharmacology 128(1):45–53 CASPubMed Google Scholar
Naranjo CA, Kadlec KE, Sanhueza P, Woodley-Remus D, Sellers EM (1990) Fluoxetine differentially alters alcohol intake and other consummatory behaviors in problem drinkers. Clin Pharmacol Ther 47(4):490–498 CASPubMed Google Scholar
Naranjo CA, Dongier M, Bremner KE (1997) Long-acting injectable bromocriptine does not reduce relapse in alcoholics. Addiction 92(8):969–978 CASPubMed Google Scholar
Narendran R, Ciccocioppo R, Lopresti B, Paris J, Himes ML, Mason NS (2017) Nociceptin receptors in alcohol use disorders: a positron emission tomography study using [(11)C]NOP-1A. Biol Psychiatry 17:31621–31629. https://doi.org/10.1016/j.biopsych.2017.05.019 ArticleCAS Google Scholar
Ng GY, George SR (1994) Dopamine receptor agonist reduces ethanol self-administration in the ethanol-preferring C57BL/6J inbred mouse. Eur J Pharmacol 269(3):365–374 CASPubMed Google Scholar
Nirogi R, Kandikere V, Jayarajan P, Bhyrapuneni G, Saralaya R, Muddana N, Abraham R (2013) Aripiprazole in an animal model of chronic alcohol consumption and dopamine D2 receptor occupancy in rats. Am J Drug Alcohol Abuse 39(2):72–79 PubMed Google Scholar
Norman KJ, Seiden JA, Klickstein JA, Han X, Hwa LS, DeBold JF, Miczek KA (2015) Social stress and escalated drug self-administration in mice I. Alcohol and corticosterone. Psychopharmacology 232(6):991–1001 CASPubMed Google Scholar
O’Brien ES, Legastelois R, Houchi H, Vilpoux C, Alaux-Cantin S, Pierrefiche O, André E, Naassila M (2011) Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats. Neuropsychopharmacology 36(7):1518–1530 PubMed Central Google Scholar
O’Donnell JM, Marek GJ, Seiden LS (2005) Antidepressant effects assessed using behavior maintained under a differential-reinforcement-of-low-rate (DRL) operant schedule. Neurosci Biobehav Rev 29(4–5):785–798 PubMed Google Scholar
Oakley RH, Cidlowski JA (2013) The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease. J Allergy Clin Immunol 132(5):1033–1044 CASPubMedPubMed Central Google Scholar
Oberlin BG, Bristow RE, Heighton ME, Grahame NJ (2010) Pharmacologic dissociation between impulsivity and alcohol drinking in high alcohol preferring mice. Alcohol Clin Exp Res 34(8):1363–1375 CASPubMedPubMed Central Google Scholar
Oslin DW, Leong SH, Lynch KG, Berrettini W, O’Brien CP, Gordon AJ, Rukstalis M (2015) Naltrexone vs placebo for the treatment of alcohol dependence: a randomized clinical trial. JAMA Psychiat 72:430–437 Google Scholar
Osterndorff-Kahanek EA, Becker HC, Lopez MF, Farris SP, Tiwari GR, Nunez YO, Harris RA, Mayfield RD (2015) Chronic ethanol exposure produces time- and brain region-dependent changes in gene coexpression networks. PLoS One 10(3):e0121522 PubMedPubMed Central Google Scholar
Overmier JB, Patterson J (1988) Animal models of human psychopathology. Animal Models Psychiat Disord 1:1–35 Google Scholar
Pahng AR, McGinn MA, Paulsen RI, Edwards S (2017) The prefrontal cortex as a critical gate of negative affect and motivation in alcohol use disorder. Curr Opin Behav Sci 13:139–143 PubMedPubMed Central Google Scholar
Palpacuer C, Laviolle B, Boussageon R, Reymann JM, Bellissant E, Naudet F (2015) Risks and benefits of nalmefene in the treatment of adult alcohol dependence: a systematic literature review and meta-analysis of published and unpublished double-blind randomized controlled trials. PLoS Med 12(12):e1001924 PubMedPubMed Central Google Scholar
Pandey SC, Zhang H, Roy A, Xu T (2005) Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism. J Clin Invest 115:2762–2773 CASPubMedPubMed Central Google Scholar
Phillips TJ, Reed C, Pastor R (2015) Preclinical evidence implicating corticotropin-releasing factor signaling in ethanol consumption and neuroadaptation. Genes Brain Behav 14(1):98–135 CASPubMedPubMed Central Google Scholar
Piazza PV, Le Moal M (1997) Glucocorticoids as a biological substrate of reward: physiological and pathophysiological implications. Brain Res Brain Res Rev 25(3):359–372 CASPubMed Google Scholar
Plebani JG, Lynch KG, Rennert L, Pettinati HM, O’Brien CP, Kampman KM (2013) Results from a pilot clinical trial of varenicline for the treatment of alcohol dependence. Drug Alcohol Depend 133(2):754–758 CASPubMed Google Scholar
Pleil KE, Rinker JA, Lowery-Gionta EG, Mazzone CM, McCall NM, Kendra AM, Olson DP, Lowell BB, Grant KA, Thiele TE, Kash TL (2015) NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci 18(4):545–552 CASPubMedPubMed Central Google Scholar
Ponizovsky AM, Rosca P, Aronovich E, Weizman A, Grinshpoon A (2015) Baclofen as add-on to standard psychosocial treatment for alcohol dependence: a randomized, double-blind, placebo-controlled trial with 1 year follow-up. J Subst Abus Treat 52:24–30 Google Scholar
Popper KR (1959) The logic of scientific discovery. Basic, New York Google Scholar
Post A, Smart TS, Jackson K, Mann J, Mohs R, Rorick-Kehn L, Statnick M, Anton R, O’Malley SS, Wong CJ (2016) Proof-of-concept study to assess the nociceptin receptor antagonist LY2940094 as a new treatment for alcohol dependence. Alcohol Clin Exp Res 40(9):1935–1944 CASPubMed Google Scholar
Powell BJ, Campbell JL, Landon JF, Liskow BI, Thomas HM, Nickel EJ, Dale TM, Penick EC, Samuelson SD, Lacoursiere RB (1995) A double-blind, placebo-controlled study of nortriptyline and bromocriptine in male alcoholics subtyped by comorbid psychiatric disorders. Alcohol Clin Exp Res 19(2):462–468 CASPubMed Google Scholar
Pratley RE, Gilbert M (2008) Targeting incretins in type 2 diabetes: role of GLP-1 receptor agonists and DPP-4 inhibitors. Rev Diabet Stud 5(2):73–94 PubMedPubMed Central Google Scholar
Quadros IM, Hwa LS, Shimamoto A, Carlson J, DeBold JF, Miczek KA (2014) Prevention of alcohol-heightened aggression by CRF-R1 antagonists in mice: critical role for DRN-PFC serotonin pathway. Neuropsychopharmacology 39(12):2874–2883 CASPubMedPubMed Central Google Scholar
Quadros IM, Macedo GC, Domingues LP, Favoretto CA (2016) An update on CRF mechanisms underlying alcohol use disorders and dependence. Front Endocrinol (Lausanne) 7:134 Google Scholar
Rasmussen DD, Boldt BM, Bryant CA, Mitton DR, Larsen SA, Wilkinson CW (2000) Chronic daily ethanol and withdrawal: 1. Long-term changes in the hypothalamo-pituitary-adrenal axis. Alcohol Clin Exp Res 24(12):1836–1849 CASPubMed Google Scholar
Ray LA, Mackillop J, Leggio L, Morgan M, Hutchison KE (2009) Effects of naltrexone on cortisol levels in heavy drinkers. Pharmacol Biochem Behav 91(4):489–494 CASPubMed Google Scholar
Ray LA, Bujarski S, Shoptaw S, Roche DJ, Heinzerling K, Miotto K (2017a) Development of the neuroimmune modulator ibudilast for the treatment of alcoholism: a randomized, placebo-controlled, human laboratory trial. Neuropsychopharmacology 42(9):1776–1788 CASPubMedPubMed Central Google Scholar
Ray LA, Bujarski S, Yardley MM, Roche DJO, Hartwell EE (2017b) Differences between treatment-seeking and non-treatment-seeking participants in medication studies for alcoholism: do they matter? Am J Drug Alcohol Abuse 20:1–8 Google Scholar
Redish AD, Gordon JA (2016) Computational psychiatry: new perspectives on mental illness. MIT Press, Cambridge Google Scholar
Reinscheid RK, Nothacker HP, Bourson A, Ardati A, Henningsen RA, Bunzow JR, Grandy DK, Langen H, Monsma FJ Jr, Civelli O (1995) Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor. Science 270(5237):792–794 CASPubMed Google Scholar
Reynaud M, Aubin HJ, Trinquet F, Zakine B, Dano C, Dematteis M, Trojak B, Paille F, Detilleux M (2017) A randomized, placebo-controlled study of high-dose baclofen in alcohol-dependent patients – the ALPADIR study. Alcohol Alcohol 52(4):439–446 CASPubMed Google Scholar
Richardson HN, Lee SY, O’Dell LE, Koob GF, Rivier CL (2008) Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state. Eur J Neurosci 28(8):1641–1653 PubMedPubMed Central Google Scholar
Richter SH, Garner JP, Würbel H (2009) Environmental standardization: cure or cause of poor reproducibility in animal experiments? Nat Methods 6(4):257–261 CASPubMed Google Scholar
Richter C, Effenberger S, Bschor T, Bonnet U, Haasen C, Preuss UW, Heinz A, Förg A, Volkmar K, Glauner T, Schaefer M (2012) Efficacy and safety of levetiracetam for the prevention of alcohol relapse in recently detoxified alcohol-dependent patients: a randomized trial. J Clin Psychopharmacol 32(4):558–562 CASPubMed Google Scholar
Roberto M, Siggins GR (2006) Nociceptin/orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase of GABA release in central amygdala. Proc Natl Acad Sci U S A 103(25):9715–9720 CASPubMedPubMed Central Google Scholar
Roberto M, Gilpin NW, O’Dell LE, Cruz MT, Morse AC, Siggins GR, Koob GF (2008) Cellular and behavioral interactions of gabapentin with alcohol dependence. J Neurosci 28(22):5762–5771 CASPubMed Google Scholar
Roberto M, Cruz MT, Gilpin NW, Sabino V, Schweitzer P, Bajo M, Cottone P, Madamba SG, Stouffer DG, Zorrilla EP, Koob GF, Siggins GR, Parsons LH (2010) Corticotropin releasing factor-induced amygdala gamma-aminobutyric acid release plays a key role in alcohol dependence. Biol Psychiatry 67(9):831–839 CASPubMedPubMed Central Google Scholar
Roberto M, Patel RR, Bajo M (2018) Ethanol and cytokines in the central nervous system. Handb Exp Pharmacol. https://doi.org/10.1007/164_2017_77
Robinson G, Most D, Ferguson LB, Mayfield J, Harris RA, Blednov YA (2014) Neuroimmune pathways in alcohol consumption: evidence from behavioral and genetic studies in rodents and humans. Int Rev Neurobiol 118:13–39 PubMedPubMed Central Google Scholar
Rodi D, Zucchini S, Simonato M, Cifani C, Massi M, Polidori C (2008) Functional antagonism between nociceptin/orphanin FQ (N/OFQ) and corticotropin-releasing factor (CRF) in the rat brain: evidence for involvement of the bed nucleus of the stria terminalis. Psychopharmacology 196(4):523–531 CASPubMed Google Scholar
Rohn MC, Lee MR, Kleuter SB, Schwandt ML, Falk DE, Leggio L (2017) Differences between treatment-seeking and nontreatment-seeking alcohol-dependent research participants: an exploratory analysis. Alcohol Clin Exp Res 41(2):414–420 PubMed Google Scholar
Romach MK, Sellers EM, Kaplan HL, Somer GR, Gomez-Mancilla B (2000) Efficacy of dexfenfluramine in the treatment of alcohol dependence. Alcohol Clin Exp Res 24:1534–1541 CASPubMed Google Scholar
Rorick-Kehn LM, Ciccocioppo R, Wong CJ, Witkin JM, Martinez-Grau MA, Stopponi S, Adams BL, Katner JS, Perry KW, Toledo MA, Diaz N, Lafuente C, Jiménez A, Benito A, Pedregal C, Weiss F, Statnick MA (2016) A novel, orally bioavailable nociceptin receptor antagonist, LY2940094, reduces ethanol self-administration and ethanol seeking in animal models. Alcohol Clin Exp Res 40(5):945–954 CASPubMedPubMed Central Google Scholar
Rose AK, Shaw SG, Prendergast MA, Little HJ (2010) The importance of glucocorticoids in alcohol dependence and neurotoxicity. Alcohol Clin Exp Res 34(12):2011–2018 CASPubMedPubMed Central Google Scholar
Rotter A, Biermann T, Amato D, Schumann G, Desrivieres S, Kornhuber J, Müller CP (2012) Glucocorticoid receptor antagonism blocks ethanol-induced place preference learning in mice and attenuates dopamine D2 receptor adaptation in the frontal cortex. Brain Res Bull 88(5):519–524 CASPubMed Google Scholar
Ruse M (1973) The nature of scientific models: formal v. material analogy. Phil Soc Sci 3:63–80 Google Scholar
Ryan ML, Falk DE, Fertig JB, Rendenbach-Mueller B, Katz DA, Tracy KA, Strain EC, Dunn KE, Kampman K, Mahoney E, Ciraulo DA, Sickles-Colaneri L, Ait-Daoud N, Johnson BA, Ransom J, Scott C, Koob GF, Litten RZ (2017) A phase2, double-blind, placebo-controlled randomized trial assessing the efficacy of ABT-436, a novel V1b receptor antagonist, for alcohol dependence. Neuropsychopharmacology 42:1012–1023 CASPubMed Google Scholar
Sabino V, Narayan AR, Zeric T, Steardo L, Cottone P (2013) mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats. Behav Brain Res 15(247):9–16 Google Scholar
Schacht JP, Randall PK, Latham PK, Voronin KE, Book SW, Myrick H, Anton RF (2017) Predictors of naltrexone response in a randomized trial: reward-related brain activation, OPRM1 genotype, and smoking status. Neuropsychopharmacology 42(13):2640–2653 CASPubMedPubMed Central Google Scholar
Schreiber AL, Gilpin NW (2018) Corticotropin-releasing factor (CRF) neurocircuitry and neuropharmacology in alcohol drinking. Handb Exp Pharmacol (in press) Google Scholar
Schwandt ML, Lindell SG, Higley JD, Suomi SJ, Heilig M, Barr CS (2011) OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques. Psychoneuroendocrinology 36(9):1303–1311 CASPubMedPubMed Central Google Scholar
Schwandt ML, Cortes CR, Kwako LE, George DT, Momenan R, Sinha R, Grigoriadis DE, Pich EM, Leggio L, Heilig M (2016) The CRF1 antagonist verucerfont in anxious alcohol-dependent women: translation of neuroendocrine, but not of anti-craving effects. Neuropsychopharmacology 41(12):2818–2829 CASPubMedPubMed Central Google Scholar
Scuppa G, Cippitelli A, Toll L, Ciccocioppo R, Ubaldi M (2015) Varenicline decreases nicotine but not alcohol self-administration in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats. Drug Alcohol Depend 156:126–132 CASPubMedPubMed Central Google Scholar
Sellers EM, Toneatto T, Romach MK, Somer GR, Sobell LC, Sobell MB (1994) Clinical efficacy of the 5-HT3 antagonist ondansetron in alcohol abuse and dependence. Alcohol Clin Exp Res 18:879–885 CASPubMed Google Scholar
Shirazi RH, Dickson SL, Skibicka KP (2013) Gut peptide GLP-1 and its analogue, Exendin-4, decrease alcohol intake and reward. PLoS One 8(4):e61965 CASPubMedPubMed Central Google Scholar
Simms JA, Haass-Koffler CL, Bito-Onon J, Li R, Bartlett SE (2012) Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking. Neuropsychopharmacology 37(4):906–918 CASPubMed Google Scholar
Skinner BF (1959) In: Cole JO, Girard RW (eds) Psychopharmacology: problems in evaluation. National Academy of Sciences, Washington, pp 224–235 Google Scholar
Skinner MD, Lahmek P, Pham H, Aubin HJ (2014) Disulfiram efficacy in the treatment of alcohol dependence: a meta-analysis. PLoS One 9(2):e87366 PubMedPubMed Central Google Scholar
Somkuwar SS, Vendruscolo LF, Fannon MJ, Schmeichel BE, Nguyen TB, Guevara J, Sidhu H, Contet C, Zorrilla EP, Mandyam CD (2017) Abstinence from prolonged ethanol exposure affects plasma corticosterone, glucocorticoid receptor signaling and stress-related behaviors. Psychoneuroendocrinology 84:17–31 CASPubMedPubMed Central Google Scholar
Sommer WH, Rimondini R, Hansson AC, Hipskind PA, Gehlert DR, Barr CS, Heilig MA (2008) Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence. Biol Psychiatry 63(2):139–145 PubMed Google Scholar
Sørensen G, Caine SB, Thomsen M (2016) Effects of the GLP-1 agonist exendin-4 on intravenous ethanol self-administration in mice. Alcohol Clin Exp Res 40(10):2247–2252 PubMedPubMed Central Google Scholar
Sotomayor-Zarate R, Gysling K, Busto UE, Cassels BK, Tampier L, Quintanilla ME (2013) Varenicline and cytisine: two nicotinic acetylcholine receptor ligands reduce ethanol intake in University of Chile bibulous rats. Psychopharmacology 227:287–298 CASPubMed Google Scholar
Spagnolo PA, Colloca L, Heilig M (2015) The role of expectation in the therapeutic outcomes of alcohol and drug addiction treatments. Alcohol Alcohol 50(3):282–285 PubMedPubMed Central Google Scholar
Sparta DR, Hopf FW, Gibb SL, Cho SL, Stuber GD, Messing RO, Ron D, Bonci A (2013) Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area. Alcohol Clin Exp Res 37(10):1680–1687 CASPubMedPubMed Central Google Scholar
Spierling SR, Zorrilla EP (2017) Don’t stress about CRF: assessing the translational failures of CRF(1)antagonists. Psychopharmacology 234(9–10):1467–1481 CASPubMedPubMed Central Google Scholar
Sprow GM, Thiele TE (2012) The neurobiology of binge-like ethanol drinking: evidence from rodent models. Physiol Behav 106(3):325–331 CASPubMedPubMed Central Google Scholar
Steensland P, Simms JA, Holgate J, Richards JK, Bartlett SE (2007) Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking. Proc Natl Acad Sci U S A 104:12518–12523 CASPubMedPubMed Central Google Scholar
Suchankova P, Yan J, Schwandt ML, Stangl BL, Caparelli EC, Momenan R, Jerlhag E, Engel JA, Hodgkinson CA, Egli M, Lopez MF, Becker HC, Goldman D, Heilig M, Ramchandani VA, Leggio L (2015) The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence. Transl Psychiatry 5(6):e583. https://doi.org/10.1038/tp.2015.68 ArticleCASPubMedPubMed Central Google Scholar
Tabakoff B, Jafee RC, Ritzmann RF (1978) Corticosterone concentrations in mice during ethanol drinking and withdrawal. J Pharm Pharmacol 30(6):371–374 CASPubMed Google Scholar
Thomsen M, Dencker D, Wörtwein G, Weikop P, Egecioglu E, Jerlhag E, Fink-Jensen A, Molander A (2017) The glucagon-like peptide 1 receptor agonist Exendin-4 decreases relapse-like drinking in socially housed mice. Pharmacol Biochem Behav 160:14–20 CASPubMed Google Scholar
Tomkins DM, Le AD, Sellers EM (1995) Effect of the 5-HT3 antagonist ondansetron on voluntary ethanol intake in rats and mice maintained on a limited access procedure. Psychopharmacology 117(4):479–485 CASPubMed Google Scholar
Tuesta LM, Chen Z, Duncan A, Fowler CD, Ishikawa M, Lee BR, Liu XA, Lu Q, Cameron M, Hayes MR, Kamenecka TM, Pletcher M, Kenny PJ (2017) GLP-1 acts on habenular avoidance circuits to control nicotine intake. Nat Neurosci 20(5):708–716 CASPubMedPubMed Central Google Scholar
Tunstall BJ, Carmack SA, Koob GF, Vendruscolo LF (2017) Dysregulation of brain stress systems mediates compulsive alcohol drinking. Curr Opin Behav Sci 13:85–90 PubMed Google Scholar
Vallöf D, Maccioni P, Colombo G, Mandrapa M, Jörnulf JW, Egecioglu E, Engel JA, Jerlhag E (2016) The glucagon-like peptide 1 receptor agonist liraglutide attenuates the reinforcing properties of alcohol in rodents. Addict Biol 21(2):422–437 PubMed Google Scholar
Vendruscolo LF, Barbier E, Schlosburg JE, Misra KK, Whitfield TW Jr, Logrip ML, Rivier C, Repunte-Canonigo V, Zorrilla EP, Sanna PP, Heilig M, Koob GF (2012) Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. J Neurosci 32(22):7563–7571 CASPubMedPubMed Central Google Scholar
Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ (2015) Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals. J Clin Invest 125(8):3193–3197 PubMedPubMed Central Google Scholar
Vengeliene V, Olevska A, Spanagel R (2015) Long-lasting effect of NMDA receptor antagonist memantine on ethanol-cue association and relapse. J Neurochem 135(6):1080–1085 CASPubMed Google Scholar
Vitale G, Arletti R, Ruggieri V, Cifani C, Massi M (2006) Anxiolytic-like effects of nociceptin/orphanin FQ in the elevated plus maze and in the conditioned defensive burying test in rats. Peptides 27(9):2193–2200 CASPubMed Google Scholar
Wagenmakers E-J, Wetzels R, Borsboom D, van der Maas HLJ, Kievet RA (2012) An agenda for purely confirmatory research. Perspect Psychol Sci 7:632–638 PubMed Google Scholar
Walker BM, Koob GF (2007) The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats. Alcohol Clin Exp Res 31:11–18 CASPubMedPubMed Central Google Scholar
Wand GS, Dobs AS (1991) Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking alcoholics. J Clin Endocrinol Metab 72(6):1290–1295 CASPubMed Google Scholar
Weiss F, Mitchiner M, Bloom FE, Koob GF (1990) Free-choice responding for ethanol versus water in alcohol preferring (P) and unselected Wistar rats is differentially modified by naloxone, bromocriptine, and methysergide. Psychopharmacology 101(2):178–186 CASPubMed Google Scholar
Wen RT, Zhang M, Qin WJ, Liu Q, Wang WP, Lawrence AJ, Zhang HT, Liang JH (2012) The phosphodiesterase-4 (PDE4) inhibitor rolipram decreases EtOH seeking and consumption in alcohol preferring fawn-hooded rats. Alcohol Clin Exp Res 36:2157–2167 CASPubMedPubMed Central Google Scholar
Wen RT, Feng WY, Liang JH, Zhang HT (2015) Role of phosphodiesterase 4-mediated cyclic AMP signaling in pharmacotherapy for substance dependence. Curr Pharm Des 21(3):355–364 CASPubMed Google Scholar
Wiesbeck GA, Weijers HG, Chick J, Naranjo CA, Boening J (1999) Ritanserin in relapse prevention in abstinent alcoholics: results from a placebo-controlled double-blind international multicenter trial. Ritanserin in Alcoholism Work Group. Alcohol Clin Exp Res 23(2):230–235 CASPubMed Google Scholar
Wiesbeck GA, Weijers HG, Lesch OM, Glaser T, Toennes PJ, Boening J (2001) Flupenthixol decanoate and relapse prevention in alcoholics: results from a placebo-controlled study. Alcohol Alcohol 36(4):329–334 CASPubMed Google Scholar
Witkiewitz K, Hallgren KA, Kranzler HR, Mann KF, Hasin DS, Falk DE, Litten RZ, O’Malley SS, Anton RF (2017) Clinical validation of reduced alcohol consumption after treatment for alcohol dependence using the World Health Organization risk drinking levels. Alcohol Clin Exp Res 41(1):179–186 PubMed Google Scholar
Witkin JM, Statnick MA, Rorick-Kehn LM, Pintar JE, Ansonoff M, Chen Y, Tucker RC, Ciccocioppo R (2014) The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence. Pharmacol Ther 141(3):283–299 CASPubMed Google Scholar
Wolstenholme JT, Warner JA, Capparuccini MI, Archer KJ, Shelton KL, Miles MF (2011) Genomic analysis of individual differences in ethanol drinking: evidence for non-genetic factors in C57BL/6 mice. PLoS One 6(6):e21100 CASPubMedPubMed Central Google Scholar
Wong CJ, Witcher J, Mallinckrodt C, Dean RA, Anton RF, Chen Y, Fijal BA, Ouyang H, Dharia S, Sundseth SS, Schuh KJ, Kinon BJ (2014) A phase 2, placebo-controlled study of the opioid receptor antagonist LY2196044 for the treatment of alcohol dependence. Alcohol Clin Exp Res 38(2):511–520 CASPubMed Google Scholar
Wouda JA, Riga D, De Vries W, Stegeman M, van Mourik Y, Schetters D, Schoffelmeer ANM, Pattij T, De Vries TJ (2011) Varenicline attenuates cue-induced relapse to alcohol, but not nicotine seeking, while reducing inhibitory response control. Psychopharmacology 216:267–277 CASPubMedPubMed Central Google Scholar
Yardley MM, Ray LA (2017) Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models. Addict Biol 22(3):581–615 PubMed Google Scholar
Yoshimura A, Kimura M, Nakayama H, Matsui T, Okudaira F, Akazawa S, Ohkawara M, Cho T, Kono Y, Hashimoto K, Kumagai M, Sahashi Y, Roh S, Higuchi S (2014) Efficacy of disulfiram for the treatment of alcohol dependence assessed with a multicenter randomized controlled trial. Alcohol Clin Exp Res 38(2):572–578 CASPubMed Google Scholar
Zalewska-Kaszubska J, Bajer B, Czarnecka E, Dyr W, Gorska D (2011) Voluntary alcohol consumption and plasma beta-endorphin levels in alcohol preferring rats chronically treated with levetiracetam: a preliminary study. Physiol Behav 102(5):538–541 CASPubMed Google Scholar
Zhou Y, Colombo G, Carai MA, Ho A, Gessa GL, Kreek MJ (2011) Involvement of arginine vasopressin and V1b receptor in alcohol drinking in Sardinian alcohol-preferring rats. Alcohol Clin Exp Res 35(10):1876–1883 CASPubMedPubMed Central Google Scholar
Zorrilla EP, Logrip ML, Koob GF (2014) Corticotropin releasing factor: a key role in the neurobiology of addiction. Front Neuroendocrinol 35(2):234–244 CASPubMedPubMed Central Google Scholar