The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology (original) (raw)
Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, von Boehmer H, Bronson R, Dierich A, Benoist C, Mathis D (2002) Projection of an immunological self shadow within the thymus by the Aire protein. Science 298:1395–1401 ArticlePubMedCAS Google Scholar
Apostolou I, Sarukhan A, Klein L, von Boehmer H (2002) Origin of regulatory T cells with known specificity for antigen. Nat Immunol 3:756–763 PubMedCAS Google Scholar
Apostolou I, von Boehmer H (2004) In vivo instruction of suppressor commitment in naive T cells. J Exp Med 199:1401–1408 ArticlePubMedCAS Google Scholar
Barton GM, Beers C, deRoos P, Eastman SR, Gomez ME, Forbush KA, Rudensky AY (2002) Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes. Proc Nat Acad Sci U S A 99:6937–6942 CAS Google Scholar
Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL (2002) CD4+ CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420:502–507 ArticlePubMedCAS Google Scholar
Bensinger SJ, Bandeira A, Jordan MS, Caton AJ, Laufer TM (2001) Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4+ CD25+ immunoregulatory T cells. J Exp Med 194:427–438 ArticlePubMedCAS Google Scholar
Bluestone JA, Abbas AK (2003) Natural versus adaptive regulatory T cells. Nat Rev Immunol 3:253–257 ArticlePubMedCAS Google Scholar
Chen W, Jin W, Hardegen N, Lei, K-J, Li L, Marinos N, McGrady G, Wahl SM (2003) Conversion of peripheral CD4+ CD25− naive T cells to CD4+ CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198:1875–1886 ArticlePubMedCAS Google Scholar
Cozzo C, Larkin III J, Caton AJ (2003) Cutting edge: self-peptides drive the peripheral expansion of CD4+ CD25+ regulatory T cells. J Immunol 171:5678–5682 PubMedCAS Google Scholar
Dubois B, Chapat L, Goubier A, Papiernik M, Nicolas J-F, Kaiserlian D (2003) Innate CD4+ CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation. Blood 102:3295–3301 ArticlePubMedCAS Google Scholar
Fisson S, Darrasee-Jeze G, Litvinova E, Septier F, Klatzmann D, Liblau R, Salomon BL (2003) Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state. J Exp Med 198:737–746 ArticlePubMedCAS Google Scholar
Gavin MA, Clarke SR, Negrou E, Gallegos A, Rudensky A (2002) Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo. Nat Immunol 3:33–41 PubMedCAS Google Scholar
Green EA, Choi Y, Flavell RA (2002) Pancreatic lymph node-derived CD4+ CD25+ Treg Cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity 16:183–191 ArticlePubMedCAS Google Scholar
Hori S, Haury M, Coutinho A, Demengeot J (2002) Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice. Proc Nat Acad Sci U S A 99:8213–8218 CAS Google Scholar
Hsieh C-S, Liang Y, Tyznik AJ, Self SG, Liggitt D, Rudensky AY (2004) Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 21:267–277 ArticlePubMedCAS Google Scholar
Itoh M, Takahashi T, Sakaguchi N, Kuniyasu Y, Shimizu J, Otsuka F, Sakaguchi S (1999) Thymus and autoimmunity: production of CD25+ CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 162:5317–5326 PubMedCAS Google Scholar
Jooss K, Gjata B, Danos O, von Boehmer H, Sarukhan A (2001) Regulatory function of in vivo anergized CD4+ T cells. Proc Nat Acad Sci U S A 98:8738–8743 CAS Google Scholar
Jordan MS, Boesteanu A, Petrone AL, Holenbeck AE, Lerman MA, Naji A, Caton AJ (2001) Thymic selection of CD4+ CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol 2:301–306 ArticlePubMedCAS Google Scholar
Kasow KA, Chen X, Knowles J, Wichlan D, Handgretinger R, Riberdy JM (2004) Human CD4+ CD25+ regulatory T cells share equally complex and comparable repertoires with CD4+ CD25− counterparts. J Immunol 172:6123–6128 PubMedCAS Google Scholar
Klein L, Khazaie K, von Boehmer H (2003) In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc Nat Acad Sci U S A 100:8886–8891 CAS Google Scholar
Kovats S, Grubin CE, Eastman SE, deRoos P, Dongre A, Van Kaer L, Rudensky AY (1998) Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. J Exp Med 187:245–251 ArticlePubMedCAS Google Scholar
Kullberg MC, Jankovic D, Gorelick PL, Caspar P, Letterio JJ, Cheever AW, Sher A (2002) Bacteria-triggered CD4+ T regulatory cells suppress _Helicobacter hepaticus_-induced colitis. J Exp Med 196:505–515 ArticlePubMedCAS Google Scholar
Maloy KJ, Powrie, F (2001) Regulatory T cells in the control of immune pathology. Nat Immunol 2:816–822 ArticlePubMedCAS Google Scholar
McHugh RS, Whitters MJ, Piccirillo CA, Young DA, Shevach EM, Collins M, Byrne MC (2002) CD4+ CD25+ Immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16:311–323 ArticlePubMedCAS Google Scholar
Montagnoli C, Bacci A, Bozza S, Gaziano R, Mosci P, Sharpe AH, Romani, L (2002) B7/CD28-dependent CD4+ CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans. J Immunol 169:6298–6308 PubMedCAS Google Scholar
Nagler-Anderson C, Bhan AK, Podolsky DK, Terhorst C (2004) Control freaks: immune regulatory cells. Nat Immunol 5:119–122 ArticlePubMedCAS Google Scholar
Nishikawa H, Kato T, Tanida K, Hiasa A, Tawara I, Ikeda H, Ikarashi Y, Wakasugi H, Kronenberg M, Nakayama T et al (2003) CD4+ CD25+ T cells responding to serologically defined autoantigens suppress antitumor immune responses. Proc Nat Acad Sci U S A 100:10902–10906 CAS Google Scholar
Olivares-Villagomez D, Wang Y, Lafaille JJ (1998) Regulatory CD4+ T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J Exp Med 188:1883–1894 ArticlePubMedCAS Google Scholar
Pacholczyk P, Kraj P, Ignatowicz L (2002) Peptide specificity of thymic selection of CD4+ CD25+ T cells. J Immunol 168:613–620 PubMedCAS Google Scholar
Pasare C, Medzhitov R (2003) Toll pathway-dependent blockade of CD4+ CD25+ T cell-mediated suppression by dendritic cells. Science 299:1033–1036 ArticlePubMedCAS Google Scholar
Romagnoli P, Hudrisier D, van Meerwijk JPM (2002) Preferential recognition of self antigens despite normal thymic deletion of CD4+ CD25+ regulatory T cells. J Immunol 168:1644–1648 PubMedCAS Google Scholar
Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). J Immunol 155:1151–1164 PubMedCAS Google Scholar
Seddon B, Mason D (1999) Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4+ CD45RC− cells and CD4+ CD8− thymocytes. J Exp Med 189:279–288 PubMedCAS Google Scholar
Shimizu J, Yamazaki S, Sakaguchi S (1999) Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J Immunol 163:5211–5218 PubMedCAS Google Scholar
Taguchi O, Kontani K, Ikeda H, Kezuka T, Takeuchi M, Takahashi T (1994) Tissuespecific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens. Immunology 82:365–369 PubMedCAS Google Scholar
Takahashi T, Kuniyasu Y, Toda M, Sakaguchi N, Itoh M, Iwata M, Shimizu J, Sakaguchi S (1998) Immunologic self-tolerance maintained by CD25+ CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 10:1969–1980 ArticlePubMedCAS Google Scholar
Tang Q, Henriksen KJ, Boden EK, Tooley AJ, Ye J, Subudhi SK, Zheng XX, Strom TB, Bluestone JA (2003) Cutting edge: CD28 controls peripheral homeostasis of CD4+ CD25+ regulatory T cells. J Immunol 171:3348–3352 PubMedCAS Google Scholar
Thornton AM, Shevach EM (1998) CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 188:287–296 ArticlePubMedCAS Google Scholar
Thorstenson KM, Khoruts A (2001) Generation of anergic and potentially immunoregulatory CD25+ CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J Immunol 167:188–195 PubMedCAS Google Scholar
van Santen H-M, Benoist C, Mathis D (2004) Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J Exp Med 200:1221–1230 PubMed Google Scholar
Walker LS, Chodos A, Eggena M, Dooms H, Abbas AK (2003a) Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. J Exp Med 198:249–258 ArticlePubMedCAS Google Scholar
Walker MR, Kasprowicz DJ, Gersuk VH, Benard A, Van Landeghen M, Buckner JH, Ziegler SF (2003b) Induction of Foxp3 and acquisition of T regulatory activity by stimulated human CD4+ CD25− T cells. J Clin Invest 112:1437–1443 ArticlePubMedCAS Google Scholar
Wang HY, Lee DA, Peng G, Guo Z, Li Y, Kiniwa Y, Shevach EM, Wang R-F (2004) Tumor-specific human CD4+ regulatory T cells and their ligands: implications for immunotherapy. Immunity 20:107–118 PubMedCAS Google Scholar
Yamazaki S, Iyoda T, Tarbell K, Olson K, Velinzon K, Inaba K, Steinman RM (2003) Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med 198:235–247 ArticlePubMedCAS Google Scholar