Computer Aided Diagnosis for the Alzheimer Type Dementia (original) (raw)

Abstract

We have proposed a new dementia diagnostic method by human eye light reflexes, which demands only few seconds to measure the miotic responses and which is highly reliable as well as safe to the patients. We found that the 35 demented patients are clearly different from the 36 normal elders in the miotic parameters (p<0.01 in Alzheimer type dementia and p<0.05 in vascular dementia.) But the eliciting mechanisms of light reflexis not so simple and it is nor easy to understand the measured results in the clinical settings. In this study an attempt is studied to elucidate the neuro-physiological mechanism of the light reflexes with mathematical modeling and computer simulations.

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Authors and Affiliations

  1. Institute of Biomedical Engineering, Nagaoka University of Technology, Kamitomioka 1603-1, Nagaoka-city, Niigata, Japan, 940-2188
    Ichiro Fukumoto MD. Ph.D. Prof.

Authors

  1. Ichiro Fukumoto MD. Ph.D. Prof.

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Editors and Affiliations

  1. Image Sciences Institute, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Wiro J. Niessen & Max A. Viergever &

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© 2001 Springer-Verlag Berlin Heidelberg

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Fukumoto, I. (2001). Computer Aided Diagnosis for the Alzheimer Type Dementia. In: Niessen, W.J., Viergever, M.A. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2001. MICCAI 2001. Lecture Notes in Computer Science, vol 2208. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45468-3\_239

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