Role of the Kynurenine Metabolism Pathway in Inflammation-Induced Depression: Preclinical Approaches (original) (raw)

• Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, Brown C, Mellor AL (1998) Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281(5380):1191–1193
  Article CAS PubMed Google Scholar
• Dantzer R (2001) Cytokine-induced sickness behavior: where do we stand? Brain Behav Immun 15(1):7–24. doi:10.1006/brbi.2000.0613
  Article CAS PubMed Google Scholar
• Capuron L, Ravaud A, Neveu PJ, Miller AH, Maes M, Dantzer R (2002) Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy. Mol Psychiatry 7(5):468–473. doi:10.1038/sj.mp.4000995
  Article CAS PubMed Google Scholar
• Heyes MP, Saito K, Chen CY, Proescholdt MG, Nowak TS Jr, Li J, Beagles KE, Proescholdt MA, Zito MA, Kawai K, Markey SP (1997) Species heterogeneity between gerbils and rats: quinolinate production by microglia and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation. J Neurochem 69(4):1519–1529
  Article CAS PubMed Google Scholar
• Thomas SR, Mohr D, Stocker R (1994) Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon-gamma primed mononuclear phagocytes. J Biol Chem 269(20):14457–14464
  CAS PubMed Google Scholar
• Lestage J, Verrier D, Palin K, Dantzer R (2002) The enzyme indoleamine 2,3-dioxygenase is induced in the mouse brain in response to peripheral administration of lipopolysaccharide and superantigen. Brain Behav Immun 16(5):596–601
  Article CAS PubMed Google Scholar
• Frenois F, Moreau M, O’Connor J, Lawson M, Micon C, Lestage J, Kelley KW, Dantzer R, Castanon N (2007) Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior. Psychoneuroendocrinology 32(5):516–531. doi:10.1016/j.psyneuen.2007.03.005
  Article CAS PubMed PubMed Central Google Scholar
• Capuron L, Gumnick JF, Musselman DL, Lawson DH, Reemsnyder A, Nemeroff CB, Miller AH (2002) Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology 26(5):643–652. doi:10.1016/S0893-133X(01)00407-9
  Article CAS PubMed Google Scholar
• Capuron L, Miller AH (2011) Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol Ther 130(2):226–238. doi:10.1016/j.pharmthera.2011.01.014
  Article CAS PubMed PubMed Central Google Scholar
• Moreau M, Lestage J, Verrier D, Mormede C, Kelley KW, Dantzer R, Castanon N (2005) Bacille Calmette-Guerin inoculation induces chronic activation of peripheral and brain indoleamine 2,3-dioxygenase in mice. J Infect Dis 192(3):537–544. doi:10.1086/431603
  Article CAS PubMed Google Scholar
• Moreau M, Andre C, O’Connor JC, Dumich SA, Woods JA, Kelley KW, Dantzer R, Lestage J, Castanon N (2008) Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior. Brain Behav Immun 22(7):1087–1095. doi:10.1016/j.bbi.2008.04.001
  Article CAS PubMed PubMed Central Google Scholar
• O’Connor JC, Andre C, Wang Y, Lawson MA, Szegedi SS, Lestage J, Castanon N, Kelley KW, Dantzer R (2009) Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin. J Neurosci 29(13):4200–4209. doi:10.1523/JNEUROSCI.5032-08.2009
  Article PubMed PubMed Central Google Scholar
• O’Connor JC, Lawson MA, Andre C, Briley EM, Szegedi SS, Lestage J, Castanon N, Herkenham M, Dantzer R, Kelley KW (2009) Induction of IDO by bacille Calmette-Guerin is responsible for development of murine depressive-like behavior. J Immunol 182(5):3202–3212. doi:10.4049/jimmunol.0802722
  Article PubMed PubMed Central Google Scholar
• O’Connor JC, Lawson MA, Andre C, Moreau M, Lestage J, Castanon N, Kelley KW, Dantzer R (2009) Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol Psychiatry 14(5):511–522. doi:10.1038/sj.mp.4002148
  Article PubMed Google Scholar
• Fatokun AA, Hunt NH, Ball HJ (2013) Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease. Amino Acids 45(6):1319–1329. doi:10.1007/s00726-013-1602-1
  Article CAS PubMed Google Scholar
• Takikawa O (2005) Biochemical and medical aspects of the indoleamine 2,3-dioxygenase-initiated L-tryptophan metabolism. Biochem Biophys Res Commun 338(1):12–19. doi:10.1016/j.bbrc.2005.09.032
  Article CAS PubMed Google Scholar
• Yoshida R, Hayaishi O (1978) Induction of pulmonary indoleamine 2,3-dioxygenase by intraperitoneal injection of bacterial lipopolysaccharide. Proc Natl Acad Sci U S A 75(8):3998–4000
  Article CAS PubMed PubMed Central Google Scholar
• Yoshida R, Urade Y, Tokuda M, Hayaishi O (1979) Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection. Proc Natl Acad Sci U S A 76(8):4084–4086
  Article CAS PubMed PubMed Central Google Scholar
• Taylor MW, Feng GS (1991) Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J 5(11):2516–2522
  CAS PubMed Google Scholar
• Robinson CM, Hale PT, Carlin JM (2006) NF-kappa B activation contributes to indoleamine dioxygenase transcriptional synergy induced by IFN-gamma and tumor necrosis factor-alpha. Cytokine 35(1–2):53–61. doi:10.1016/j.cyto.2006.07.007
  Article CAS PubMed Google Scholar
• Munn DH, Mellor AL (2013) Indoleamine 2,3 dioxygenase and metabolic control of immune responses. Trends Immunol 34(3):137–143. doi:10.1016/j.it.2012.10.001
  Article CAS PubMed Google Scholar
• Cella M, Colonna M (2015) Aryl hydrocarbon receptor: linking environment to immunity. Semin Immunol. doi:10.1016/j.smim.2015.10.002
  PubMed PubMed Central Google Scholar
• Bessede A, Gargaro M, Pallotta MT, Matino D, Servillo G, Brunacci C, Bicciato S, Mazza EM, Macchiarulo A, Vacca C, Iannitti R, Tissi L, Volpi C, Belladonna ML, Orabona C, Bianchi R, Lanz TV, Platten M, Della Fazia MA, Piobbico D, Zelante T, Funakoshi H, Nakamura T, Gilot D, Denison MS, Guillemin GJ, DuHadaway JB, Prendergast GC, Metz R, Geffard M, Boon L, Pirro M, Iorio A, Veyret B, Romani L, Grohmann U, Fallarino F, Puccetti P (2014) Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Nature 511(7508):184–190. doi:10.1038/nature13323
  Article CAS PubMed PubMed Central Google Scholar
• Kimura A, Naka T, Nakahama T, Chinen I, Masuda K, Nohara K, Fujii-Kuriyama Y, Kishimoto T (2009) Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses. J Exp Med 206(9):2027–2035. doi:10.1084/jem.20090560
  Article CAS PubMed PubMed Central Google Scholar
• Mezrich JD, Fechner JH, Zhang X, Johnson BP, Burlingham WJ, Bradfield CA (2010) An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol 185(6):3190–3198. doi:10.4049/jimmunol.0903670
  Article CAS PubMed PubMed Central Google Scholar
• Terness P, Bauer TM, Rose L, Dufter C, Watzlik A, Simon H, Opelz G (2002) Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites. J Exp Med 196(4):447–457
  Article CAS PubMed PubMed Central Google Scholar
• Lehnert H, Wurtman RJ (1993) Amino acid control of neurotransmitter synthesis and release: physiological and clinical implications. Psychother Psychosom 60(1):18–32
  Article CAS PubMed Google Scholar
• Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ (2012) Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci 13(7):465–477. doi:10.1038/nrn3257
  Article CAS PubMed PubMed Central Google Scholar
• Fernstrom JD, Wurtman RJ (1971) Brain serotonin content: physiological dependence on plasma tryptophan levels. Science 173(3992):149–152
  Article CAS PubMed Google Scholar
• Fernstrom JD (1981) Dietary precursors and brain neurotransmitter formation. Annu Rev Med 32:413–425. doi:10.1146/annurev.me.32.020181.002213
  Article CAS PubMed Google Scholar
• Curzon G (1969) Tryptophan pyrrolase—a biochemical factor in depressive illness? Br J Psychiatry 115(529):1367–1374
  Article CAS PubMed Google Scholar
• Curzon G, Bridges PK (1970) Tryptophan metabolism in depression. J Neurol Neurosurg Psychiatry 33(5):698–704
  Article CAS PubMed PubMed Central Google Scholar
• Greenwood MH, Lader MH, Kantameneni BD, Curzon G (1975) The acute effects of oral (--)-tryptophan in human subjects. Br J Clin Pharmacol 2(2):165–172
  Article CAS PubMed PubMed Central Google Scholar
• Young SN (2013) The effect of raising and lowering tryptophan levels on human mood and social behaviour. Philos Trans R Soc Lond B Biol Sci 368(1615):20110375. doi:10.1098/rstb.2011.0375
  Google Scholar
• Ruhe HG, Mason NS, Schene AH (2007) Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. Mol Psychiatry 12(4):331–359. doi:10.1038/sj.mp.4001949
  Article CAS PubMed Google Scholar
• Strasser B, Sperner-Unterweger B, Fuchs D, Gostner JM. Tryptophan and phenylalanine metabolism pathways in inflammation-induced depression. Curr Topics Behav Neurosci
  Google Scholar
• Lapin IP (1972) Interaction of kynurenine and its metabolites with tryptamine, serotonin and its precursors and oxotremorine. Psychopharmacologia 26(3):237–247
  Article CAS PubMed Google Scholar
• Lapin IP (1978) Stimulant and convulsive effects of kynurenines injected into brain ventricles in mice. J Neural Transm 42(1):37–43
  Article CAS PubMed Google Scholar
• Lapin IP (1983) Antagonism of kynurenine-induced seizures by picolinic, kynurenic and xanthurenic acids. J Neural Transm 56(2–3):177–185
  Article CAS PubMed Google Scholar
• Guillemin GJ, Smythe G, Takikawa O, Brew BJ (2005) Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons. Glia 49(1):15–23. doi:10.1002/glia.20090
  Article PubMed Google Scholar
• Muller N, Myint AM, Schwarz MJ (2009) The impact of neuroimmune dysregulation on neuroprotection and neurotoxicity in psychiatric disorders—relation to drug treatment. Dialogues Clin Neurosci 11(3):319–332
  PubMed PubMed Central Google Scholar
• Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9(1):46–56. doi:10.1038/nrn2297
  Article CAS PubMed PubMed Central Google Scholar
• Walker AK, Budac DP, Bisulco S, Lee AW, Smith RA, Beenders B, Kelley KW, Dantzer R (2013) NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice. Neuropsychopharmacology 38(9):1609–1616. doi:10.1038/npp.2013.71
  Article CAS PubMed PubMed Central Google Scholar
• Dantzer R, Walker AK (2014) Is there a role for glutamate-mediated excitotoxicity in inflammation-induced depression? J Neural Transm (Vienna) 121(8):925–932. doi:10.1007/s00702-014-1187-1
  Article CAS Google Scholar
• Fukui S, Schwarcz R, Rapoport SI, Takada Y, Smith QR (1991) Blood–brain barrier transport of kynurenines: implications for brain synthesis and metabolism. J Neurochem 56(6):2007–2017
  Article CAS PubMed Google Scholar
• Kita T, Morrison PF, Heyes MP, Markey SP (2002) Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain. J Neurochem 82(2):258–268
  Article CAS PubMed Google Scholar
• Speciale C, Hares K, Schwarcz R, Brookes N (1989) High-affinity uptake of L-kynurenine by a Na+-independent transporter of neutral amino acids in astrocytes. J Neurosci 9(6):2066–2072
  CAS PubMed Google Scholar
• Sekine A, Okamoto M, Kanatani Y, Sano M, Shibata K, Fukuwatari T (2015) Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro. SpringerPlus 4:48. doi:10.1186/s40064-015-0826-9
  Article PubMed PubMed Central Google Scholar
• Bridges RJ, Natale NR, Patel SA (2012) System xc(−) cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS. Br J Pharmacol 165(1):20–34. doi:10.1111/j.1476-5381.2011.01480.x
  Article CAS PubMed PubMed Central Google Scholar
• Kigerl KA, Ankeny DP, Garg SK, Wei P, Guan Z, Lai W, McTigue DM, Banerjee R, Popovich PG (2012) System x(c)(−) regulates microglia and macrophage glutamate excitotoxicity in vivo. Exp Neurol 233(1):333–341. doi:10.1016/j.expneurol.2011.10.025
  Article CAS PubMed Google Scholar
• Tilleux S, Hermans E (2007) Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J Neurosci Res 85(10):2059–2070. doi:10.1002/jnr.21325
  Article CAS PubMed Google Scholar
• Lawson MA, Kelley KW, Dantzer R (2011) Intracerebroventricular administration of HIV-1 Tat induces brain cytokine and indoleamine 2,3-dioxygenase expression: a possible mechanism for AIDS comorbid depression. Brain Behav Immun 25(8):1569–1575. doi:10.1016/j.bbi.2011.05.006
  Article CAS PubMed PubMed Central Google Scholar
• Fu X, Lawson MA, Kelley KW, Dantzer R (2011) HIV-1 Tat activates indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures in a p38 mitogen-activated protein kinase-dependent manner. J Neuroinflammation 8:88. doi:10.1186/1742-2094-8-88
  Article CAS PubMed PubMed Central Google Scholar
• Gibney SM, McGuinness B, Prendergast C, Harkin A, Connor TJ (2013) Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression. Brain Behav Immun 28:170–181. doi:10.1016/j.bbi.2012.11.010
  Article CAS PubMed Google Scholar
• Too LK, McQuillan JA, Ball HJ, Kanai M, Nakamura T, Funakoshi H, McGregor IS, Hunt NH (2014) The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. Behav Brain Res 270:179–195. doi:10.1016/j.bbr.2014.05.018
  Article CAS PubMed Google Scholar
• Li Y, Eskelund AR, Zhou H, Budac DP, Sanchez C, Gulinello M (2015) Behavioral deficits are accompanied by immunological and neurochemical changes in a mouse model for neuropsychiatric lupus (NP-SLE). Int J Mol Sci 16(7):15150–15171. doi:10.3390/ijms160715150
  Article CAS PubMed PubMed Central Google Scholar
• Cathomas F, Fuertig R, Sigrist H, Newman GN, Hoop V, Bizzozzero M, Mueller A, Luippold A, Ceci A, Hengerer B, Seifritz E, Fontana A, Pryce CR (2015) CD40-TNF activation in mice induces extended sickness behavior syndrome co-incident with but not dependent on activation of the kynurenine pathway. Brain Behav Immun 50:125–140. doi:10.1016/j.bbi.2015.06.184
  Article CAS PubMed Google Scholar
• Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G (2000) Inflamm-aging: an evolutionary perspective on immunosenescence. Ann N Y Acad Sci 908:244–254
  Article CAS PubMed Google Scholar
• Godbout JP, Moreau M, Lestage J, Chen J, Sparkman NL, O’Connor J, Castanon N, Kelley KW, Dantzer R, Johnson RW (2008) Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system. Neuropsychopharmacology 33(10):2341–2351. doi:10.1038/sj.npp.1301649
  Article CAS PubMed Google Scholar
• Henry CJ, Huang Y, Wynne AM, Godbout JP (2009) Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines. Brain Behav Immun 23(3):309–317. doi:10.1016/j.bbi.2008.09.002
  Article CAS PubMed Google Scholar
• Kelley KW, O’Connor JC, Lawson MA, Dantzer R, Rodriguez-Zas SL, McCusker RH (2013) Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guerin. Brain Behav Immun 32:63–69. doi:10.1016/j.bbi.2013.02.003
  Article CAS PubMed PubMed Central Google Scholar
• Kim H, Chen L, Lim G, Sung B, Wang S, McCabe MF, Rusanescu G, Yang L, Tian Y, Mao J (2012) Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression. J Clin Invest 122(8):2940–2954. doi:10.1172/JCI61884
  Article CAS PubMed PubMed Central Google Scholar
• Zhou W, Dantzer R, Budac DP, Walker AK, Mao-Ying QL, Lee AW, Heijnen CJ, Kavelaars A (2015) Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice. Brain Behav Immun 46:147–153. doi:10.1016/j.bbi.2015.01.013
  Article CAS PubMed PubMed Central Google Scholar
• Laugeray A, Launay JM, Callebert J, Surget A, Belzung C, Barone PR (2010) Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression. Behav Brain Res 210(1):84–91. doi:10.1016/j.bbr.2010.02.014
  Article CAS PubMed Google Scholar
• Gracia-Rubio I, Moscoso-Castro M, Pozo OJ, Marcos J, Nadal R, Valverde O (2016) Maternal separation induces neuroinflammation and long-lasting emotional alterations in mice. Prog Neuropsychopharmacol Biol Psychiatry 65:104–117. doi:10.1016/j.pnpbp.2015.09.003
  Article CAS PubMed Google Scholar
• Miura H, Ando Y, Noda Y, Isobe K, Ozaki N (2011) Long-lasting effects of inescapable-predator stress on brain tryptophan metabolism and the behavior of juvenile mice. Stress 14(3):262–272. doi:10.3109/10253890.2010.541539
  Article CAS PubMed Google Scholar
• Gibney SM, Fagan EM, Waldron AM, O’Byrne J, Connor TJ, Harkin A (2014) Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour. Int J Neuropsychopharmacol 17(6):917–928. doi:10.1017/S1461145713001673
  Article CAS PubMed Google Scholar
• Jackman KA, Brait VH, Wang Y, Maghzal GJ, Ball HJ, McKenzie G, De Silva TM, Stocker R, Sobey CG (2011) Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice. Naunyn Schmiedebergs Arch Pharmacol 383(5):471–481. doi:10.1007/s00210-011-0611-4
  Article CAS PubMed Google Scholar
• Spalletta G, Bossu P, Ciaramella A, Bria P, Caltagirone C, Robinson RG (2006) The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines. Mol Psychiatry 11(11):984–991. doi:10.1038/sj.mp.4001879
  Article CAS PubMed Google Scholar
• Xie W, Cai L, Yu Y, Gao L, Xiao L, He Q, Ren Z, Liu Y (2014) Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy. J Neuroinflammation 11:41. doi:10.1186/1742-2094-11-41
  Article CAS PubMed PubMed Central Google Scholar
• An L, Li J, Yu ST, Xue R, Yu NJ, Chen HX, Zhang LM, Zhao N, Li YF, Zhang YZ (2015) Effects of the total flavonoid extract of Xiaobuxin-Tang on depression-like behavior induced by lipopolysaccharide and proinflammatory cytokine levels in mice. J Ethnopharmacol 163:83–87. doi:10.1016/j.jep.2015.01.022
  Article CAS PubMed Google Scholar
• Ji WW, Wang SY, Ma ZQ, Li RP, Li SS, Xue JS, Li W, Niu XX, Yan L, Zhang X, Fu Q, Qu R, Ma SP (2014) Effects of perillaldehyde on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration. Pharmacol Biochem Behav 116:1–8. doi:10.1016/j.pbb.2013.10.026
  Article CAS PubMed Google Scholar
• Kang A, Hao H, Zheng X, Liang Y, Xie Y, Xie T, Dai C, Zhao Q, Wu X, Xie L, Wang G (2011) Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy. J Neuroinflammation 8:100. doi:10.1186/1742-2094-8-100
  Article CAS PubMed PubMed Central Google Scholar
• Li R, Zhao D, Qu R, Fu Q, Ma S (2015) The effects of apigenin on lipopolysaccharide-induced depressive-like behavior in mice. Neurosci Lett 594:17–22. doi:10.1016/j.neulet.2015.03.040
  Article CAS PubMed Google Scholar
• Manosso LM, Neis VB, Moretti M, Daufenbach JF, Freitas AE, Colla AR, Rodrigues AL (2013) Antidepressant-like effect of alpha-tocopherol in a mouse model of depressive-like behavior induced by TNF-alpha. Prog Neuropsychopharmacol Biol Psychiatry 46:48–57. doi:10.1016/j.pnpbp.2013.06.012
  Article CAS PubMed Google Scholar
• Sulakhiya K, Kumar P, Jangra A, Dwivedi S, Hazarika NK, Baruah CC, Lahkar M (2014) Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice. Eur J Pharmacol 744:124–131. doi:10.1016/j.ejphar.2014.09.049
  Article CAS PubMed Google Scholar
• Wang Z, Zhang Q, Yuan L, Wang S, Liu L, Yang X, Li G, Liu D (2014) The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration. Behav Brain Res 274:282–290. doi:10.1016/j.bbr.2014.08.018
  Article CAS PubMed Google Scholar
• Walker FR (2013) A critical review of the mechanism of action for the selective serotonin reuptake inhibitors: do these drugs possess anti-inflammatory properties and how relevant is this in the treatment of depression? Neuropharmacology 67:304–317. doi:10.1016/j.neuropharm.2012.10.002
  Article CAS PubMed Google Scholar
• Vilar-Pereira G, Silva AA, Pereira IR, Silva RR, Moreira OC, de Almeida LR, de Souza AS, Rocha MS, Lannes-Vieira J (2012) Trypanosoma cruzi-induced depressive-like behavior is independent of meningoencephalitis but responsive to parasiticide and TNF-targeted therapeutic interventions. Brain Behav Immun 26(7):1136–1149. doi:10.1016/j.bbi.2012.07.009
  Article CAS PubMed Google Scholar
• Kaster MP, Gadotti VM, Calixto JB, Santos AR, Rodrigues AL (2012) Depressive-like behavior induced by tumor necrosis factor-alpha in mice. Neuropharmacology 62(1):419–426. doi:10.1016/j.neuropharm.2011.08.018
  Article CAS PubMed Google Scholar
• Norden DM, Devine R, Bicer S, Jing R, Reiser PJ, Wold LE, Godbout JP, McCarthy DO (2015) Fluoxetine prevents the development of depressive-like behavior in a mouse model of cancer related fatigue. Physiol Behav 140:230–235. doi:10.1016/j.physbeh.2014.12.045
  Article CAS PubMed Google Scholar
• Norden DM, McCarthy DO, Bicer S, Devine RD, Reiser PJ, Godbout JP, Wold LE (2015) Ibuprofen ameliorates fatigue- and depressive-like behavior in tumor-bearing mice. Life Sci 143:65–70. doi:10.1016/j.lfs.2015.10.020
  Article CAS PubMed PubMed Central Google Scholar
• Vijaya Kumar K, Rudra A, Sreedhara MV, Siva Subramani T, Prasad DS, Das ML, Murugesan S, Yadav R, Trivedi RK, Louis JV, Li YW, Bristow LJ, Naidu PS, Vikramadithyan RK (2014) Bacillus Calmette-Guerin vaccine induces a selective serotonin reuptake inhibitor (SSRI)-resistant depression like phenotype in mice. Brain Behav Immun 42:204–211. doi:10.1016/j.bbi.2014.06.205
  Article CAS PubMed Google Scholar
• De Bandt JP, Cynober L (2006) Therapeutic use of branched-chain amino acids in burn, trauma, and sepsis. J Nutr 136(1 Suppl):308S–313S
  PubMed Google Scholar
• Fromentin G, Darcel N, Chaumontet C, Marsset-Baglieri A, Nadkarni N, Tome D (2012) Peripheral and central mechanisms involved in the control of food intake by dietary amino acids and proteins. Nutr Res Rev 25(1):29–39. doi:10.1017/S0954422411000175
  Article CAS PubMed Google Scholar
• Rosario FJ, Kanai Y, Powell TL, Jansson T (2013) Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells. J Physiol 591(Pt 3):609–625. doi:10.1113/jphysiol.2012.238014
  Article CAS PubMed Google Scholar
• Walker AK, Vichaya E, Wing E, Banks W, Dantzer R (2015) Leucine blocks lipopolysaccharide-induced depression like behavior by interfering with kynurenine influx into the brain. Brain Behav Immun 49, e36
  Article Google Scholar
• Heisler JM, O’Connor JC (2015) Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism mediates inflammation-induced deficit in recognition memory. Brain Behav Immun 50:115–124. doi:10.1016/j.bbi.2015.06.022
  Article CAS PubMed PubMed Central Google Scholar
• Zwilling D, Huang SY, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu HQ, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, Giorgini F, Moussaoui S, Laue G, Rassoulpour A, Flik G, Huang Y, Muchowski JM, Masliah E, Schwarcz R, Muchowski PJ (2011) Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Cell 145(6):863–874. doi:10.1016/j.cell.2011.05.020
  Article CAS PubMed PubMed Central Google Scholar
• Beconi MG, Yates D, Lyons K, Matthews K, Clifton S, Mead T, Prime M, Winkler D, O’Connell C, Walter D, Toledo-Sherman L, Munoz-Sanjuan I, Dominguez C (2012) Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048. Drug Metab Dispos 40(12):2297–2306. doi:10.1124/dmd.112.046532
  Article CAS PubMed Google Scholar
• Ward JL, Harting MT, Cox CS Jr, Mercer DW (2011) Effects of ketamine on endotoxin and traumatic brain injury induced cytokine production in the rat. J Trauma 70(6):1471–1479. doi:10.1097/TA.0b013e31821c38bd
  Article CAS PubMed PubMed Central Google Scholar
• Zhu X, Li P, Hao X, Wei K, Min S, Luo J, Xie F, Jin J (2015) Ketamine-mediated alleviation of electroconvulsive shock-induced memory impairment is associated with the regulation of neuroinflammation and soluble amyloid-beta peptide in depressive-like rats. Neurosci Lett 599:32–37. doi:10.1016/j.neulet.2015.05.022
  Article CAS PubMed Google Scholar