HIGHLY ACTIVE ANTICANCER CURCUMIN ANALOGUES (original) (raw)
References
1. B. J. Druker, C. L. Sawyers, H. Kantarjian, D. J. Resta, S. F. Reese, J. M. Ford, R. Capdeville, and M. Talpaz, Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med344(14), 1038–1042 (2001). ArticlePubMedCAS Google Scholar
2. M. A. Cobleigh, C. L. Vogel, D. Tripathy, N. J. Robert, S. Scholl, L. Fehrenbacher, J. M. Wolter, V. Paton, S. Shark, G. Lieberman, and D. J. Slamon, Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol17(9), 2639–2648 (1999). PubMedCAS Google Scholar
3. R. B. Weiss, R. C. Donehower, P. H. Wiernik, T. Ohnuma, R. J. Gralla, D. L. Trump, J. R. Baker, Jr., D. A. Van Echo, D. D. Van Hoff, and B. Leyland-Jones, Hypersensitivity reactions from taxol. J Clin Oncol8(7), 1263–1268 (1990). PubMedCAS Google Scholar
4. E. A. Eisenhauer, W. W. ten Bokkel Huinink, K. D. Swenerton, L. Gianni, J. Myles, M. E. van der Burg, I. Kerr, J. B. Vermorken, K. Buser, and N. Colombo, European–Canadian randomized trial of paclitaxel in relapsed ovarian cancer: high dose versus low-dose and long versus short infusion. J Clin Oncol12(12), 2654–2666 (1994). PubMedCAS Google Scholar
5. D. Raghavan, B. Koczwara, and M. Javle, Evolving strategies of cytotoxic chemotherapy for advanced prostate cancer. Eur J Cancer33(4), 566–574 (1997). ArticlePubMedCAS Google Scholar
6. S. Shishodia, G. Sethi, and B. B. Aggarwal, Curcumin: Getting back to the roots. Ann NY Acad Sci1056, 206–217 (2005). ArticlePubMedCAS Google Scholar
7. A. L. Cheng, C. H. Hsu, J. K. Lin, M. M. Hsu, Y. F. Ho, T. S. Shen, J. Y. Ko, J. T. Lin, B. R. Lin, W. Ming-Shiang, H. S. Yu, S. H. Jee, G. S. Chen, T. M. Chen, C. A. Chen, M. K. Lai, Y. S. Pu, M. H. Pan, Y. J. Wang, C. C. Tsai, and C. Y. Hsieh, Phase I clinical trials of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res21(4B), 2895–2900 (2001). PubMedCAS Google Scholar
8. B. B. Aggarwal, A. Kumar, and A. C. Bharti, Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Res23(1A), 363–398 (2003). PubMedCAS Google Scholar
9. A. Duviox, R. Blasius, S. Delhalle, M. Schnekenburger, F. Morceau, E. Henry, M. Dicato, and M. Diederich, Chemopreventive and therapeutic effects of curcumin, Cancer Lett223(2), 181–190 (2005). ArticleCAS Google Scholar
10. R. A. Sharma, A. J. Gescher, and W. P. Steward, Curcumin: The story so far. Eur J Cancer41(13), 1955–1968 (2005). ArticlePubMedCAS Google Scholar
11. A. T. Dinkova-Kostova, C. Abeygunawardana, and P. Talalay, Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: Correlation of potencies as phase 2 enzyme inducers and radical scavengers. J Med Chem41(26), 5287–5296 (1998). ArticlePubMedCAS Google Scholar
12. B. Mutus, J. D. Wagner, C. J. Talpas, J. R. Dimmock, O. A. Phillips, and R. S. Reid, 1-p-chlorophenyl-4,4-dimethyl-5-ethylamino-1-penten-3-one hydrobromide, a sulfhydryl-specific compound which reacts irreversibly with protein thiols but reversibly with smaller molecular weight thiols. Anal Biochem177(2), 237–243 (1989). ArticlePubMedCAS Google Scholar
13. S. Mathews and M. N. A. Rao, Interaction of curcumin with glutathione. Int J Pharm76(3), 257–259 (1991). ArticleCAS Google Scholar
14. S. Awasthi, U. Pandya, S. S. Singhal, J. T. Lin, V. Thiviyanathan, W. E. Seifert, Y. C. Awasthi, and G. A. S. Ansara, Curcumin-glutathione interactions and the role of human glutathione S-transferase P1-1. Chemico-Biol Interact128(1), 19–38 (2000). ArticleCAS Google Scholar
15. H. M. Wortelboer, M. Usta, A. E. Van der Velde, M. G. Boersma, B. Spenkelink, J. J. Van Zanden, J. Jelmer, I. M. C. M. Rietjens, P. J. Van Bladeren, and N. H. Cnubben, Interplay between MRP inhibition and metabolism of MRP inhibitors: The case of curcumin. Chem Res Toxicol16(12), 1642–1651 (2003). ArticlePubMedCAS Google Scholar
16. Y. J. Wang, M. H. Pan, A. L. Cheng, L. I. Lin, Y. S. Ho, C. Y. Hsieh, and J. K. Lin, Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed Anal15(12), 1867–1876 (1997). ArticlePubMedCAS Google Scholar
17. M. J. Ansari, S. Ahmad, K. Kohli, J. Ali, and R. K. Khar, Stability-indicating HPTLC determination of curcumin in bulk drug and pharmaceutical formulations. J Pharm Biomed Anal9(1–2), 132–138 (2005). ArticleCAS Google Scholar
18. J. R. Dimmock, P. Kumar, A. J. Nazarali, N. L. Motaganahalli, T. P. Kowalchuk, M. A. Beazely, J. W. Quail, E. O. Oloo, T. M. Allen, J. Szydlowski, E. De Clerq, and J. Balzarini, Cytotoxic 2,6-bis(arylidene)cyclohexanones and related compounds. Eur J Med Chem35(11), 967–977 (2000). ArticlePubMedCAS Google Scholar
19. J. R. Dimmock, M. P. Padmanilayam, G. A. Zello, K. H. Nienaber, T. M. Allen, C. L. Santos, E. De Clerq, J. Balzarini, E. K. Manavathu, and J. P. Stables, Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones. Eur J Med Chem38(2), 169–177 (2003). ArticlePubMedCAS Google Scholar
20. J. R. Dimmock, M. P. Padmanilayam, R. N. Puthucode, A. J. Nazarali, N. L. Motaganahalli, G. A. Zello, J. W. Quail, E. O. Oloo, H.-B. Kraatz, J. S. Prisciak, T. M. Allen, C. L. Santos, J. Balzarini, E. De Clerq, and E. K. Manavathu, A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues. J Med Chem44(4), 586–593 (2001). ArticlePubMedCAS Google Scholar
21. J. R. Dimmock, A. Jha, G. A. Zello, J. W. Quail, E. O. Oloo, K. H. Nienaber, E. S. Kowalczyk, T. M. Allen, C. L. Santos, E. De Clerq, J. Balzerini, E. K. Manavathu, and J. P. Stables, Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones and related compounds. Eur J Med Chem37(12), 961–972 (2002). ArticlePubMedCAS Google Scholar
22. H. I. El-Subbagh, S. M. Abu-Zaid, M. A. Mahran, F. A. Badria, and A. M. Al-Obaid, Synthesis and biological evaluation of certain α, β-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents. J Med Chem43(14), 2915–2921 (2000). ArticlePubMedCAS Google Scholar
23. J. R. Dimmock, U. Das, H. I. Gul, M. Kawase, H. Sakagami, Z. Baráth, I. Ocsovsky, and J. Molnár, 3-Arylidene-1(4-nitrophenylmethylene)-3,4-dihydro-1_H_-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells. Bioorg Med Chem Lett15, 1633–1636 (2005). ArticlePubMedCAS Google Scholar
24. N. M. Pandya, N. S. Dhalla, and D. D. Santani, Angiogenesis: A new target for future therapy. Vasc Pharmacol44(5), 265–274 (2006). ArticleCAS Google Scholar
25. J. L. Arbiser, N. Klauber, R. Rohan, R. Van Leeuwen, M. Huang, C. Fisher, E. Flynn, and H. R. Byers, Curcumin is an in vivo inhibitor of angiogenesis. Mol Med4(6), 376–383 (1998). PubMedCAS Google Scholar
26. T. P. Robinson, T. Ehlers, R. B. Hubbard, X. Bai, J. L. Arbiser, D. J. Goldsmith, and J. P. Bowen, Design, synthesis, and biological evaluation of angiogenesis inhibitors: Aromatic enone and dienone analogues of curcumin. Bioorg Med Chem Lett13(1), 115–117 (2003). ArticlePubMedCAS Google Scholar
27. J. R. Dimmock, N. M. Kandepu, M. Hetherington, J. W. Quail, U. Pugazhenthi, A. M. Sudom, M. Chamankhah, P. Rose, E. Pass, T. M. Allen, S. Halleran, J. Szydlowski, B. Mutus, M. Tannous, E. K. Manavathu, T. G. Meyers, De Clerq, E., and J. Balzarini, Cytotoxic activities of Mannich bases of chalcones and related compounds. J Med Chem41(7), 1014–1026 (1998). ArticlePubMedCAS Google Scholar
28. Y. Satomi, Inhibitory effects of 3′-methyl-3-hydroxychalcone on proliferation of human malignant tumor cells and on skin carcinogenesis. Int J Cancer55(3), 506–514 (1993). ArticlePubMedCAS Google Scholar
29. L. W. Wattenberg, J. B. Coccia, and A. R. Galbraith, Inhibition of carcinogen-induced pulmonary and mammary carcinogenesis by chalcone administered subsequent to carcinogen exposure. Cancer Lett83(1–2), 165–169 (1994). ArticlePubMedCAS Google Scholar
30. M. L. Edwards, D. M. Stemerick, and P. S. Sunkara, Chalcones: A new class of antimitotic agents. J Med Chem33(7), 1948–1954 (1990). ArticlePubMedCAS Google Scholar
31. Y. Xia, Z. Yang, P. Xia, K. F. Bastow, Y. Nakanishi, and K. Lee, Antitumor agents. Part 202: Novel 2′-aminochalcones: Design, synthesis, and biological evaluation. Bioorg Med Chem Lett10(8), 699–701 (2000). ArticlePubMedCAS Google Scholar
32. T. P. Robinson, R. B. Hubbard, T. J. Ehlers, J. L. Arbiser, D. J. Goldsmith, and J. P. Bowen, Synthesis and biological evaluation of aromatic enones related to curcumin. Bioorg Med Chem13(12), 4007–4013 (2005). ArticlePubMedCAS Google Scholar
33. C. M. Ahn, W. Shin, H. B. Woo, S. Lee, and H. Lee, Synthesis of symmetrical bis-alkynyl or alkyl pyridine and thiophene derivatives and their antiangiogenic activities. Bioorg Med Chem Lett14(15), 3893–3896 (2004). ArticlePubMedCAS Google Scholar
34. J. S. Shim, J. H. Kim, H. Y. Cho, Y. N. Yum, S. H. Kim, H. Park, B. S. Shim, S. H. Choi, and H. J. Kwon, Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin. Chem Biol10(8), 695–704 (2003). ArticlePubMedCAS Google Scholar
35. E. Hahm, Y. S. Gho, S. Park, C. Park, K. Kim, and C. Yang, Synthetic curcumin analogs inhibit activator protein-1 transcription and tumor-induced angiogenesis. Biochem Biophys Res Commun321(2), 337–344 (2004). ArticlePubMedCAS Google Scholar
36. K. Singletary and C. MacDonald, Inhibition of benzo[a]pyrene- and 1,6-dinitropyrene-DNA adduct formation in human mammary epithelial cells by dibenzoylmethane and sulforaphane. Cancer Lett155(1), 47–54 (2000). ArticlePubMedCAS Google Scholar
37. H. Ohtsu, Z. Xiao, J. Ishida, M. Nagai, H. Wang, H. Itokawa, C. Su, C. Shih, T. Chiang, E. Chang, Y. Lee, M. Tsai, C. Chang, and K. Lee, Antitumor Agents 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents. J Med Chem45(23), 5037–5042 (2002). ArticlePubMedCAS Google Scholar
38. L. Lin, Q. Shi, A. K. Nyarko, K. F. Bastow, C.-C. Wu, C. Y. Su, C. C. Shih, and K. H. Lee, Antitumor Agents 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents. J Med Chem49(13), 3963–3972 (2006). ArticlePubMedCAS Google Scholar
40. A. C. Bharti, S. Shishodia, J. M. Reuben, D. Weber, R. Alexanian, S. Raj-Vadhan ETALN. Donato, and B. B. Aggarwal, Nulear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors lead to apoptosis. Blood103(8), 3175–3184 (2004). ArticlePubMedCAS Google Scholar
41. S. Singh and B. B. Aggarwal, Activation of transcription factor NF-kappaB is suppressed by curcumin (diferuloylmethane). J Biol Chem270(42), 24,995–25,000 (1995). CAS Google Scholar
42. S. M. Plummer, K. A. Holloway, A. Karen, M. M. Manson, R. J. L. Munks, A. Kaptein, S. Farrow, and L. Howells, Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signaling complex. Oncogene18(44), 6013–6020 (1999). ArticlePubMedCAS Google Scholar
43. C. E. Eberhart and R. N. Dubois, Eicosanoids and the gastrointestinal tract. Gastroenterology109(1), 285–301 (1995). ArticlePubMedCAS Google Scholar
44. C. Thiemermann, The spice of life: curcumin reduces the mortality associated with experimental sepsis. Crit Care Med34, 2009–2011 (2006). ArticlePubMed Google Scholar
45. A. M. Siddiqui, X. Cui, R. Wu, W. Dong, M. Zhou, M. Hu, H. H. Simms, and P. Wang, The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma. Crit Care Med34, 1874–1882 (2006). ArticlePubMedCAS Google Scholar
46. M. L. P. S. van Iersel, J. H. T. M. Ploemen, I. Struik, C. van Amersfoort, A. E. Keyzer, J. G. Schefferlie, and P. J. Van Bladeren, Inhibition of glutathione S-transferase activity in human melanoma cells by alpha, beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal. Chem-Biol Interact102(2), 117–132 (1996). ArticlePubMedCAS Google Scholar
47. A. T. Dinkova-Kostova and P. Talalay, Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes. Carcinogenesis20(5), 911–914 (1999). ArticlePubMedCAS Google Scholar
48. A. T. Dinkova-Kostova, M. A. Massiah, R. E. Bozak, R. J. Hicks, and P. Talalay, Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. Proc Natl Acad Sci USA98(6), 3404–3409 (2001). ArticlePubMedCAS Google Scholar
49. W. M. Weber, L. A. Hunsaker, S. F. Abcouwer, L. M. Deck, J. Vander, and L. David, Anti-oxidant activities of curcumin and related enones. Bioorg Med Chem13(11), 3811–3820 (2005). ArticlePubMedCAS Google Scholar
50. K. M. Youssef and M. A. El-Sherbeny, Synthesis and antitumor activity of some curcumin analogs. Arch Pharmazie (Weinheim, Germany)338(4), 181–189 (2005). ArticleCAS Google Scholar
51. K. M. Youssef, A. M. Ezzo, M. I. El-Sayed, A. A. Hazzaa, A. H. El-Medany, and M. Arafa, Curcumin analogs as anticancer agents: 1) preclinical safety evaluation in mice and rats. 2) Chemopreventive effects in DMH-Induced colon cancer in albino rats model, submitted. Google Scholar
52. B. M. Markaverich, T. H. Schauweker, R. R. Gregory, M. Varma, F. S. Kittrell, D. Medina, and R. S. Rajender, Nuclear type II sites and malignant cell proliferation: Inhibition by 2,6-bisbenzylidenecyclohexanones. CancerRes52(9), 2482–2488 (1992). PubMedCAS Google Scholar
53. B. K. Adams, E. M. Ferstl, M. C. Davis, M. Herold, S. Kurtkaya, R. F. Camalier, M. G. Hollingshead, G. Kaur, E. A. Sausville, F. R. Rickles, J. P. Snyder, D. C. Liotta, and M. Shoji, Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents. Bioorg Med Chem12(14), 3871–3883 (2004). ArticlePubMedCAS Google Scholar
54. R. J. Anto, J. George, K. V. Dinesh Babu, K. N. Rajasekharan, and R. Kuttan, Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids. Mutat Res370(2), 127–131 (1996). ArticlePubMedCAS Google Scholar
55. S. M. McElvain and R. E. McMahon, Piperidine derivatives. XXI. 4-Piperidone, 4-piperidinol, and certain of their derivatives. J Am Chem Soc71, 901–906 (1949). ArticleCAS Google Scholar
56. B. K. Adams, J. Cai, J. Armstrong, M. Harold, Y. J. Lu, A. Sun, J. P. Snyder, D. C. Liotta, D. P. Jones, and M. Shoji, EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. Anti-cancer Drugs16(3), 263–275 (2005). ArticlePubMedCAS Google Scholar
57. C. Syung-ai, A. L. Kumari, and A. Khar, Effect of curcumin on normal and tumor cells: Role of glutathione and bcl-2. Mol Cancer Ther3, 1101–1108 (2004). Google Scholar
58. A. Laurent, C. Nicco, C. Chéreau, C. Goulvestre, J. Alexandre, A. Alves, E. Lévy, F. Goldwasser, Y. Panis, O. Soubrane, B. Weill, and F. Batteux, Controlling tumor growth by modulating endogenous production of reactive oxygen species. Cancer Res65, 948–956 (2005). PubMedCAS Google Scholar
59. R. M. Kluck, E. Bossy-Wetzel, D. R. Green, and D. D. Newmeyer, The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science275(5303), 1132–1136 (1997). ArticlePubMedCAS Google Scholar
60. T. Kuwana and D. D. Newmeyer, Bcl-2-family proteins and the role of mitochondria in apoptosis. Curr Opin Cell Biol15(16), 691–699 (2003). ArticlePubMedCAS Google Scholar
61. H. Zou, W. J. Henzel, X. Liu, A. Lutschg, and X. Wang, Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell90(3), 405–413 (1997). ArticlePubMedCAS Google Scholar
62. N. A. Thornberry and Y. Lazebnik, Caspases: Enemies within, Science281(5381), 1312–1316 (1998). ArticlePubMedCAS Google Scholar
63. P. Li, D. Nijhawan, I. Budihardjo, S. M. Srinivasula, M. Ahmad, E. S. Alnemri, and X. Wang, Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell91(4), 479–489 (1997). ArticlePubMedCAS Google Scholar
64. M. H. Pan, W. L. Chang, S. Y. Lin-Shiau, C. T. Ho, and J. K. Lin, Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspase in human leukemia HL-60 cells. J Agric Food Chem49(3), 1464–1474 (2001). ArticlePubMedCAS Google Scholar
65. D. Morin, S. Barthelemy, R. Zini, S. Labidalle, and J. Tillement, Curcumin induces the mitochondrial permeability transition pore mediated by membrane protein thiol oxidation. FEBS Lett495(1–2), 131–136 (2001). ArticlePubMedCAS Google Scholar
66. R. J. Anto, A. Mukhopadhyay, K. Denning, and B. B. Aggarwal, Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: Its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogensis23(1), 143–150 (2002). ArticleCAS Google Scholar
67. L. Ghibelli, S. Coppola, G. Rotilio, E. Lafavia, V. Maresca, and M. R. Ciriolo, Non-oxidative loss of glutathione in apoptosis via GSH extrusion. Biochem Biophys Res Commun216(1), 462–469 (1995). Article Google Scholar
68. S. Tan, Y. Sagara, Y. Liu, P. Maher, and D. Schubert, The regulation of reactive oxygen species production during programmed cell death. J Cell Biol141(16), 1423–1432 (1998). ArticlePubMedCAS Google Scholar
69. H. Fu, S. Thomas, D. C. Liotta, and J. P. Snyder, in preparation. Google Scholar
70. A. Brown, H. Shim, and J. P. Snyder, in preparation. Google Scholar
71. A. Sun, S. Mao, Y. Lu, M. Shojii, D. C. Liotta, and J. P. Snyder, in preparation. Google Scholar
72. T. Ouchi, E. Yamabe, K. Hara, M. Hirai, and Y. Ohya, Design of attachment type of drug delivery systems by complex formation of avidin with biotinyl drug model and biotinyl saccharide, J Cont Release94, 281–291 (2004). ArticleCAS Google Scholar
73. G. Schoellmann and E. Shaw, Direct evidence for the presence of histidine in the active center of chymotrypsin. Biochemistry2, 252–255 (1963). ArticlePubMedCAS Google Scholar
74. N. S. Callander, N. Varki, and L. V. Rao, Immunohistochemical identification of tissue factor in solid tumors. Cancer70(5), 1194–1201 (1992). ArticlePubMedCAS Google Scholar
75. J. Contrino, G. Hair, D. L. Kreutzer, and F. R. Rickles, In situ detection of tissue factor in vascular endothelial cells: Correlation with the malignant phenotype of human breast disease. Nature Med2(2), 209–215 (1996). ArticlePubMedCAS Google Scholar
76. C. B. Hansen, C. Pyke, L. C. Petersen, and L. V. M. Rao, Tissue factor-mediated endocytosis, recycling, and degradation of factor VIIa by a clathrin-independent mechanism not requiring the cytoplasmic domain of tissue factor. Blood97(6), 1712–1720 (2001). ArticlePubMedCAS Google Scholar
77. A. Sun, M. Shoji, Y. J. Lu, D. C. Liotta, and J. P. Snyder, Synthesis of EF24-tripeptide chloromethylketone: A novel curcumin-related anticancer drug delivery system. J Med Chem49(11), 3153–3158 (2006). ArticlePubMedCAS Google Scholar
78. M. Shoji, A. Sun, W. Kisiel, Yang J. Lu, H. Shim, B. E. McCarey, C. Nichols, E. T. Parker, J. Pohl, A. R. Alizadeh, C. Mosley, D. C. Liotta, and J. P. Snyder, submitted. Google Scholar
79. C. Kettner and E. Shaw, Synthesis of peptides of arginine chloromethyl ketone. Selective inactivation of human plasma kallikrein. Biochemistry17(1), 4778–4784 (1978). ArticlePubMedCAS Google Scholar
80. S. A. Buhrow, J. M. Reid, L. Jia, M. Shojii, J. P. Snyder, D. C. Liotta, and M. M. Ames. AACR abstract (2005); part of an NCI subcontract to the Mayo Clinic under the Rapid Access to NCI Discovery (RAND) program sponsored by the NCI. Google Scholar