Epigenetics – Potential Contribution to Fetal Programming (original) (raw)

Whilst the primary DNA sequence sets the limits of potential gene expression, the pattern of gene expression in a given cell under particular circumstances is determined by several factors including the epigenetic marking of the genome. These marks include DNA methylation and post-translational modification of the histones around which DNA is wrapped when packaged in the nucleus. Importantly, these marks are malleable in response to environmental exposures and contribute to phenotypic plasticity in the context of a fixed genotype. There is now proof of principle that maternal diet can have a profound impact on the epigenome and so determine gene expression patterns and health throughout the life-course. Studies of altered epigenetic marking will be of profound importance for mechanistic understanding of the role of nutrition in health but especially for studies of the developmental origins of health.

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References

• Bastow, R., J.S. Mylne, C. Lister, Z. Lippman, R.A. Martienssen and C. Dean (2004) “Vernalization requires epigenetic silencing of FLC by histone methylation.” Nature 427: 164–167.
  Article PubMed CAS Google Scholar
• Bernstein, B.E., A. Meissner and E.S. Lander (2007) “The mammalian epigenome.” Cell 128: 669–681.
  Article PubMed CAS Google Scholar
• Bertram, C.E. and M.A. Hanson (2001) “Animal models and programming of the metabolic syndrome.” Brit Med Bull 60: 103–121.
  Article PubMed CAS Google Scholar
• Bird, A. (2002) “DNA methylation patterns and epigenetic memory.” Genes Dev 16: 6–21.
  Article PubMed CAS Google Scholar
• Dolinoy, D.C., J.R. Weidman, R.A. Waterland and R.L. Jirtle (2006) “Maternal genistein alters coat colour and protects Avy mouse offspring from obesity by modifying the fetal epigenome.” Environ Health Perspect 114(4): 567–572.
  Article PubMed CAS Google Scholar
• Fraga, M.F., E. Ballestar, M.F. Paz, S. Ropero, F. Setien, M.L. Ballestar, D. Heine-Suner, J.C. Cigudosa, M. Urioste, J. Benitez, M. Boix-Chornet, A. Sanchez-Aguilera, C. Ling, E. Carlsson, P. Poulsen, A. Vaag, Z. Stephan, T.D. Spector, Y.Z. Wu, C. Plass and M. Esteller (2005) “Epigenetic differences arise during the lifetime of monozygotic twins.” Proc Natl Acad Sci USA 102(30): 10604–10609.
  Article PubMed CAS Google Scholar
• Jirtle, R.L. and M.K. Skinner (2007) “Environmental epigenomics and disease susceptibility.” Nat Rev Genet 8: 253–262.
  Article PubMed CAS Google Scholar
• Lillycrop, K.A., E.S. Phillips, A.A. Jackson, M.A. Hanson and G.C. Burdge (2005) “Dietary restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring.” J Nutr 135: 1382–1386.
  PubMed CAS Google Scholar
• Poulsen, P., M. Esteller, A. Vaag and M.F. Fraga (2007) “The epigenetic basis of twin discordance in age-related diseases.” Pediatr Res 61(5): 38R–42R.
  Article PubMed Google Scholar
• Reik, W., W. Dean and J. Walter (2001) “Epigenetic reprogramming in mammalian development.” Science 293: 1089–1093.
  Article PubMed CAS Google Scholar
• Waterland, R.A. and R.L. Jirtle (2003) “Transposable elements: targets for early nutritional effects on epigenetic gene regulation.” Mol Cell Biol 23: 5293–5300.
  Article PubMed CAS Google Scholar

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Authors and Affiliations

1. Human Nutrition Research Centre, School of Clinical Medical Sciences, Newcastle University, William Leech Building, Framlington Place, Newcastle on Tyne, NE2 4HH, UK
   J. C. Mathers

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1. J. C. Mathers
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2. Jill A. McKay
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Correspondence toJ. C. Mathers .

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Editors and Affiliations

1. Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University of Munich, Germany
   Berthold Koletzko
2. Department of Paediatrics, University of Pécs, József A. u. 7., 7623, Pécs, Hungary
   Tamás Decsi & Dées Molnár &
3. Ashwell Associates (Europe) Ltd., Ashwell Street, SG7 5PZ, Ashwell Hertfordshire, UK
   Anne de la Hunty

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Mathers, J.C., McKay, J.A. (2009). Epigenetics – Potential Contribution to Fetal Programming. In: Koletzko, B., Decsi, T., Molnár, D., de la Hunty, A. (eds) Early Nutrition Programming and Health Outcomes in Later Life. Advances in Experimental Medicine and Biology, vol 646. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9173-5\_13

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• DOI: https://doi.org/10.1007/978-1-4020-9173-5\_13
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