K252a and Staurosporine Microbial Alkaloid Toxins as Prototype of Neurotropic Drugs (original) (raw)
To whom correspondence should be addressed.
References
- Albina, J.E., Abate, J.A., and Henry, W.L.Jr (1991). Nitric oxide production is required for murine resident peritoneal macrophages to supress mitogen stimulated T-cell proliferation. The American Association of lmmunologists, 147, 144 – 148.
CAS Google Scholar - Ashall, F. and Goate, A.M. (1994). Role of the ß-amyloid precursor protein in Alzheimer’s disease. Trends in Biochem. Sci., 19, 42 – 45.
Article CAS Google Scholar - Berg, M.M., Sternberg, D.W., Parada, L.F. and Chao, M.V. (1992). K252a inhibits nerve growth factor induced trk proto-oncogene tyrosine phosphorylation and kinase activity. J. Biol. Chem., 267, 13 – 16.
PubMed CAS Google Scholar - Buxbaum, J.D., Oishi, M., Chen, H.I., Pinkas-Kramarski, R., Jaffe, E.A., Gandy, S.E. and Greengard, P. (1992). Cholinergic agonists and interleukin 1 regulate processing and secretion of Alzheimer ß/A4 amyloid protein precursor. Proc. Natl. Acad. Sci. USA, 89, 10075 – 10078.
Article PubMed CAS Google Scholar - Caporaso, G.L., Gandy, S.E., Buxbaum, J.D., Ramabhadran, T.V. and Greengard, P. (1992). Protein phosphorylation regulates secretion of Alzheimer ß/A4 amyloid precursor protein. Proc. Natl. Acad. Sci. USA, 89, 3055 – 3059.
Article PubMed CAS Google Scholar - Carrieri, P.B. (1994). The role of cytokines in the pathogenesis of multiple sclerosis. Int. Multiple Sclerosis, 1, 53 – 59.
Google Scholar - Couchie, D., Mavilia, C, Georgieff, I.S., Lien, R.K.H., Shelanski, M.L. and Nunez, J. (1992). Primary structure of high molecular weight tau present in the peripheral nervous system. Proc. Natl. Acad. Sci. USA, 89, 4378 – 4381.
Article PubMed CAS Google Scholar - Denis, M. (1991). Interferon-gamma treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates. Cellular Immunology, 132, 150 – 157.
Article PubMed CAS Google Scholar - Dyrks, T., Weidemann, A., Multhaup, G., Salbaum, J.M., Lemaire, H.G., Kang, J., Muller-Hill, B., Masters, C.L. and Beyreuther, K. (1988). Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer–s disease. EMBO J 7, 94–-957.
Google Scholar - Edelman, A.M., Blumenthal, D.K. and Krebs, E.G. (1987). Protein serine/threonine kinases. Ann. Rev. Biochem., 56, 567 — 613.
Article PubMed CAS Google Scholar - Hunter, T. (1991). Protein kinases classification. Methods Enzymol, 200, 3 – 38.
Article PubMed CAS Google Scholar - Jansson, L., Olsson, T., Hojeberg, B. and Holmdahl, R. (1991). Chronic experimental autoimmune encephalomyelitis induced by the 89-101 myelin basic protein peptide in B10RIII (H-2r) mice. Eur. J, Immunol., 21, 693 — 699.
Article CAS Google Scholar - Kaplan, D.R., Hempstead, B.L., Martin-Zanca, D., Chao, M.V. and Parada, L.F. (1991). The trk proto-oncogene product: a signal transduction receptor for nerve growth factor. Science, 252, 554 – 557.
Article PubMed CAS Google Scholar - Kikkawa, U. and Nishizuka, Y. (1986). The role of protein kinase C in transmembrane signaling. Ann. Rev. Cell. Biol, 2, 149 – 178.
Article PubMed CAS Google Scholar - Koizumi, S., Contreras, M,L., Matsuda, Y, Hama, T., Lazarovici, P. and Guroff, G. (1988). K252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells. J. Neurosci., 8, 715 – 721.
PubMed CAS Google Scholar - Lazarovici, P., Levi, B.Z., Lelkes, P.I., Kuizumi, S., Fujita, K., Matsuda, Y, Ozato, K. and Guroff, G. (1989). K252a inhibits the increase in _c-fos_transcription and the increase in intracellular calcium produced by nerve growth factor in PC 12 cells. J. Neurosci. Res., 23, 1 – 8.
Article PubMed CAS Google Scholar - Levi-Montalcini, R. (1987). The nerve growth factor: thirty-five years later. Science, 237, 1154 – 1164.
Article PubMed CAS Google Scholar - Matsuda, Y. (1993). Screening of bioactive substances of microbial origin based on enzyme and receptor binding assays. Actinomycetology, 7, 110 — 118.
Article Google Scholar - McFarlin, D.E., Blank, S.E. and Kibler, R.F. (1974). Recurrent experimental allergic encephalomyelitis in the Lewis rats. J. Immunol, 113, 712 – 715.
PubMed CAS Google Scholar - Moncada, S., Palmer, R.M.J, and Higgs, E.A. (1991). Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109 – 136.
PubMed CAS Google Scholar - Nabeshima, T., Ogawa, S.I., Nishimura, H., Fuji, K., Kameyama, T. and Sasaki, Y (1991). Staurosporine facilitates recovery from the basal forebrain-lesion-induced impairment of learning and deficit of cholinergic neurons in rats. J. Pharmacol. Exp. Therap., 257, 562 – 566.
CAS Google Scholar - Nairn, A.C., Hemmings, H.S. and Greengard, P. (1985). Protein kinases in the brain. Ann. Rev. Biochem., 54, 931 – 976.
Article PubMed CAS Google Scholar - Parker, P.J., Cook, P.P., Olivier, A.R., Pears, C, Ways, D.K. and Webster, C. (1992). Second messenger systems as pharmacological targets. Biochem. Soc. Trans., 20, 415 – 418.
PubMed CAS Google Scholar - Quarles, R.H., Morell, P. and McFarlin, D.E. (1989). Diseases involving myelin. In: Basic Neurochemistry( Siegel, G., Agranoff, G., Albeis, R.W. and Molinoff, P. eds.), 697 – 713, Raven press, New York.
Google Scholar - Rasouly, D., Rahamim, E., Lester, D., Matsuda, Y. and Lazarovici, P. (1992). Staurosporine-induced neurite outgrowth in PC12 cells is independent of protein kinase C inhibition. Mol. Pharmacol, 42, 35 – 43.
PubMed CAS Google Scholar - Rasouly, D., Rahamim, E., Ringel, I., Ginzburg, I., Muarakata, C, Matsuda, Y and Lazarovici, P. (1994). Neurites induced by staurosporine in PC12 cells are resistant to colchicine and express high levels of tau proteins. Mol. Pharmacol, 45, 29 – 35.
PubMed CAS Google Scholar - Rasouly, D. and Lazarovici, P. (1994). Staurosporine, a kinase inhibitor with neurotropic effects, induces the tyrosine phosphorylation of a 145 kD protein, but does not activate trk in PC12 cells. Europ. J. Pharmacol. — Mol. Sec, 269, 255 – 264.
Article CAS Google Scholar - Rasouly, D., Matsuda, Y. and Lazarovici, P. (1995). Biochemical and pharmacological properties of K252b microbial alkaloids. In: The Toxic Action of Marine and Terrestrial Alkaloids( Blum, M.S. ed), pp. 161 – 190, Alaken Inc., Fort Collins, CO., USA.
Google Scholar - Rasouly, D., Matsuda, Y. and Lazarovici, P. (1995). Biochemical and pharmacological properties of K252b microbial alkaloids. In: The Toxic Action of Marine and Terrestrial Alkaloids( Blum, M.S. ed), pp. 161 – 190, Alaken Inc., Fort Collins, CO., USA.
Google Scholar - Sadot, E., Barg, J., Rasouly, D., Lazarovici, P. and Ginzburg, I. (1995). Short-term and long-term mechanisms of tau regulation in PC12 cells. J. Cell Sci.108, 2857 – 2864.
PubMed CAS Google Scholar - Slack, B.E., Nitsch, R.M., Livneh, E., Kunz, G.M., Breu, J., Eldar, H. and Wurtman, R.J. (1993). Regulation by phorbol esters of amyloid precursor protein release from swiss 3T3 fibroblasts overexpressing protein kinase Ca. J. Biol. Chem, 268, 21097 – 21101.
PubMed CAS Google Scholar - Tamaoki, T. (1991). Use and specificity of staurosporine, UCN-01 and calphostin C as protein kinase inhibitors. Methods Enzymol, 201, 340 – 347
Article PubMed CAS Google Scholar