The Relation Between Rat Lymph Node Interdigitating Cells in Situ and Dendritic Cells in Suspension (original) (raw)

Abstract

Interdigitating cells (IDC) are present in the thymus dependent areas of peripheral lymphoid organs such as lymph nodes. They resemble the epidermal Langerhans cells in many aspects: both cell types form the same characteristic interdigitations with the surrounding cells, having the pale cytoplasm and the irregularly shaped, most eccentrically situated nucleus. However, in non-stimulated lymph nodes Birbeck granules, which are the characteristic cell organelles of the Langerhans cells, are usually not present in IDC (1). IDC have a central spot of acid phosphatase (APh) activity and the plasma membrane is strongly Ia positive. These cells may function as accessory cells in antigen presentation to immunocompetent T cells (2).

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References

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Authors and Affiliations

  1. Department of Electron Microscopy, Medical Faculty Free University, Amsterdam, The Netherlands
    E. W. A. Kamperdijk, M. van den Berg & E. C. M. Hoefsmit
  2. Laboratory of Histology and Cell Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    M. Kapsenberg

Authors

  1. E. W. A. Kamperdijk
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  2. M. van den Berg
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  3. M. Kapsenberg
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  4. E. C. M. Hoefsmit
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Editor information

Editors and Affiliations

  1. Nationanl Institute for Medical Research, London, England
    G. G. B. Klaus

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© 1985 Plenum Press, New York

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Kamperdijk, E.W.A., van den Berg, M., Kapsenberg, M., Hoefsmit, E.C.M. (1985). The Relation Between Rat Lymph Node Interdigitating Cells in Situ and Dendritic Cells in Suspension. In: Klaus, G.G.B. (eds) Microenvironments in the Lymphoid System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2463-8\_46

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